Paul E Marik

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. doi request reprint Venous thromboembolism in pregnancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, EVMS Internal Medicine, Eastern Virginia Medical School, HH Suite 410, 825 Fairfax Avenue, Norfolk VA 23507, USA
    Clin Chest Med 31:731-40. 2010
  2. pmc Colonic flora, Probiotics, Obesity and Diabetes
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Front Endocrinol (Lausanne) 3:87. 2012
  3. doi request reprint Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 41:1774-81. 2013
  4. doi request reprint Neonatal incubators: a toxic sound environment for the preterm infant?*
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine and Division of Medical and Experimental Ultrasound, Eastern Virginia Medical School, Norfolk, VA, USA
    Pediatr Crit Care Med 13:685-9. 2012
  5. doi request reprint Narrative review: the management of acute decompensated heart failure
    Paul E Marik
    Department of Medicine, Eastern Virginia Medial School, Norfolk, VA 23507, USA
    J Intensive Care Med 27:343-53. 2012
  6. ncbi request reprint Characteristics of patients with the "malignant obesity hypoventilation syndrome" admitted to an ICU
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Intensive Care Med 28:124-30. 2013
  7. ncbi request reprint The use of bioreactance and carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Sentara Norfolk General Hospital, Norfolk, VA 23507, USA
    Chest 143:364-70. 2013
  8. doi request reprint Therapeutic effect of conivaptan bolus dosing in hyponatremic neurosurgical patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Pharmacotherapy 33:51-5. 2013
  9. doi request reprint Hypertensive emergencies: an update
    Paul E Marik
    Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Curr Opin Crit Care 17:569-80. 2011
  10. pmc Delirium in the ICU: an overview
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care, Eastern Virginia Medical School, Norfolk, VA, USA
    Ann Intensive Care 2:49. 2012

Detail Information

Publications91

  1. doi request reprint Venous thromboembolism in pregnancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, EVMS Internal Medicine, Eastern Virginia Medical School, HH Suite 410, 825 Fairfax Avenue, Norfolk VA 23507, USA
    Clin Chest Med 31:731-40. 2010
    ..The indications for antepartum anticoagulant prophylaxis are somewhat controversial. This article reviews the management of VTE during pregnancy and in the postpartum period...
  2. pmc Colonic flora, Probiotics, Obesity and Diabetes
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Front Endocrinol (Lausanne) 3:87. 2012
    ..The gut microbiota is, therefore, a potential nutritional and pharmacological target for the management of obesity and obesity-related disorders...
  3. doi request reprint Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 41:1774-81. 2013
    ..Despite a previous meta-analysis that concluded that central venous pressure should not be used to make clinical decisions regarding fluid management, central venous pressure continues to be recommended for this purpose...
  4. doi request reprint Neonatal incubators: a toxic sound environment for the preterm infant?*
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine and Division of Medical and Experimental Ultrasound, Eastern Virginia Medical School, Norfolk, VA, USA
    Pediatr Crit Care Med 13:685-9. 2012
    ..Knowledge of the contribution of each component and source is important to develop effective strategies to reduce noise within the incubator...
  5. doi request reprint Narrative review: the management of acute decompensated heart failure
    Paul E Marik
    Department of Medicine, Eastern Virginia Medial School, Norfolk, VA 23507, USA
    J Intensive Care Med 27:343-53. 2012
    ..The goal of this review is to provide evidence-based recommendations for the diagnosis and management of ADHF...
  6. ncbi request reprint Characteristics of patients with the "malignant obesity hypoventilation syndrome" admitted to an ICU
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Intensive Care Med 28:124-30. 2013
    ..We have coined the term the malignant obesity hypoventilation syndrome (MOHS) to describe this entity...
  7. ncbi request reprint The use of bioreactance and carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Sentara Norfolk General Hospital, Norfolk, VA 23507, USA
    Chest 143:364-70. 2013
    ..A secondary end point was to evaluate the change in carotid Doppler fl ow following the PLR maneuver...
  8. doi request reprint Therapeutic effect of conivaptan bolus dosing in hyponatremic neurosurgical patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Pharmacotherapy 33:51-5. 2013
    ..To determine the natremic response of a single 20-mg bolus dose of conivaptan, an arginine vasopressin antagonist, in hyponatremic neurosurgical patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH)...
  9. doi request reprint Hypertensive emergencies: an update
    Paul E Marik
    Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Curr Opin Crit Care 17:569-80. 2011
    ..However, only patients with true hypertensive emergencies require the immediate and controlled reduction of blood pressure with an intravenous antihypertensive agent...
  10. pmc Delirium in the ICU: an overview
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care, Eastern Virginia Medical School, Norfolk, VA, USA
    Ann Intensive Care 2:49. 2012
    ..Second-generation antipsychotics have emerged as an alternative for the treatment of delirium, and they may have a better safety profile. Dexmedetomidine may prove to be a valuable adjunctive agent for patients with delirium in the ICU...
  11. ncbi request reprint Goal directed fluid therapy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Curr Pharm Des 18:6215-24. 2012
    ..This review focuses on methods to assess fluid responsiveness and the application of these methods for goal directed fluid therapy in critically ill and peri-operative patients...
  12. doi request reprint The malignant obesity hypoventilation syndrome (MOHS)
    P E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Obes Rev 13:902-9. 2012
    ..Bariatric surgery reverses or improves the multiple metabolic and organ dysfunctions associated with MOHS and should be strongly considered in these patients...
  13. doi request reprint The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: a systematic review of the literature and meta-analysis
    Paul E Marik
    Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 40:2479-85. 2012
    ..However, the risk of catheter-related bloodstream infections from femoral as compared to subclavian and internal jugular venous catheterization has not been systematically reviewed...
  14. ncbi request reprint The effect of APRV ventilation on ICP and cerebral hemodynamics
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Respiratory Services, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 410, Norfolk, VA 23507, USA
    Neurocrit Care 17:219-23. 2012
    ..APRV is associated with a higher mean airway pressure than conventional ventilation and has therefore not been evaluated in patients with acute neurological injuries...
  15. doi request reprint Do dietary supplements have beneficial health effects in industrialized nations: what is the evidence?
    Paul E Marik
    Department of Medicine and the Nutrition Study Group, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    JPEN J Parenter Enteral Nutr 36:159-68. 2012
    ..Dietary supplements are regularly used by at least half of the American population, yet the health benefits of these agents are unclear...
  16. ncbi request reprint Immunonutrition in the surgical patient
    P E Marik
    Pulmonary and Critical Care Medicine, Critical Care Nutrition, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Minerva Anestesiol 78:336-42. 2012
    ..These immunomodulating enteral formulas should be strongly considered in surgical patients undergoing major surgery and following severe trauma...
  17. doi request reprint Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 38:2222-8. 2010
    ..Stress ulcer prophylaxis may, however, increase the risk of hospital-acquired pneumonia and Clostridia difficile infection...
  18. pmc Glucocorticoids in sepsis: dissecting facts from fiction
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 410, Norfolk, VA 23507, USA
    Crit Care 15:158. 2011
    ..Severe sepsis is, however, associated with complex alterations of the HPA axis, which may result in decreased production of cortisol as well as glucocorticoid tissue resistance...
  19. doi request reprint Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Clin 27:589-607. 2011
    ..The authors recommend prolonged methylprednisolone at 1 mg/kg/d initially in early ARDS, increasing to 2 mg/kg/d after 7 to 9 days of no improvement...
  20. doi request reprint Immunonutrition in high-risk surgical patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    JPEN J Parenter Enteral Nutr 34:378-86. 2010
    ..The goal of this meta-analysis was to determine the impact of IMDs on the clinical outcomes of high-risk patients undergoing elective surgery...
  21. pmc Hemodynamic parameters to guide fluid therapy
    Paul E Marik
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Ann Intensive Care 1:1. 2011
    ..The stroke volume is measured continuously and in real-time by minimally invasive or noninvasive technologies, including Doppler methods, pulse contour analysis, and bioreactance...
  22. pmc Surviving sepsis: going beyond the guidelines
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Ann Intensive Care 1:17. 2011
    ..This paper reviews the validity of the Surviving Sepsis Campaign 6-hour bundle and provides a more evidence-based approach to the initial resuscitation of patients with severe sepsis...
  23. doi request reprint Early goal-directed therapy: on terminal life support?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Am J Emerg Med 28:243-5. 2010
    ..Although the concept of early resuscitation is a scientifically sound concept, we believe that the major elements of the sepsis bundle are fatally flawed...
  24. doi request reprint Pulmonary aspiration syndromes
    Paul E Marik
    Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23507, USA
    Curr Opin Pulm Med 17:148-54. 2011
    ..These syndromes are often misdiagnosed and their management is frequently suboptimal. This paper reviews the clinical features and management of the most common aspiration syndromes...
  25. doi request reprint Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Chest 137:544-51. 2010
    ..The goal of this systematic review was to determine the benefits and risks of tight glycemic control in ICU patients and to explain the differences in outcomes among reported trials...
  26. ncbi request reprint Aspiration syndromes: aspiration pneumonia and pneumonitis
    Paul E Marik
    Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Hosp Pract (1995) 38:35-42. 2010
    ..Treatment of aspiration pneumonitis is essentially supportive; however, corticosteroids and other immunomodulating agents may have a role in these patients...
  27. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  28. doi request reprint Changes in end-tidal carbon dioxide and volumetric carbon dioxide as predictors of volume responsiveness in hemodynamically unstable patients
    Alisha Young
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Cardiothorac Vasc Anesth 27:681-4. 2013
    ..The purpose of this study was to determine whether changes in PETCO2 and exhaled CO2 (VCO2) can predict fluid responsiveness after a preload challenge...
  29. ncbi request reprint Hypertensive crises: challenges and management
    Paul E Marik
    Department of Pulmonary and Critical Care, Thomas Jefferson University, Philadelphia, PA USA
    Chest 131:1949-62. 2007
    ..This article reviews definitions, current concepts, common misconceptions, and pitfalls in the diagnosis and management of patients with acutely elevated BP as well as special clinical situations in which BP must be controlled...
  30. doi request reprint Immunonutrition in critically ill patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intensive Care Med 34:1980-90. 2008
    ..The role of immuno-modulating diets (IMDs) in critically ill patients is controversial...
  31. ncbi request reprint Enteral nutrition in the critically ill: myths and misconceptions
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA
    Crit Care Med 42:962-9. 2014
    ..Optimal provision of calories and protein has been demonstrated to reduce morbidity, mortally, and length of ICU and hospital stay. Yet, a large proportion of ICU patients receive inadequate nutrition...
  32. ncbi request reprint Noninvasive hemodynamic monitoring in the intensive care unit
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Crit Care Clin 23:383-400. 2007
    ..In addition this article reviews some of the surrogate markers that can be used to assess adequacy of cardiac output...
  33. doi request reprint The role of head computer tomographic scans on the management of MICU patients with neurological dysfunction
    Daniel Salerno
    Division of Pulmonary and Critical Care Medicine, Christiana Health Care System, Newark, Delaware 19805, USA
    J Intensive Care Med 24:372-5. 2009
    ..This study suggests that clinicians should have a low threshold for ordering a CT scan in MICU patients with acute neurological dysfunction...
  34. ncbi request reprint Fungal infections in bone marrow transplant recipients
    Tuhina Raman
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Expert Opin Pharmacother 7:307-15. 2006
    ..Treatment options include therapy with azoles, including the newer agent voriconazole, amphotericin and caspofungin...
  35. ncbi request reprint Techniques for assessment of intravascular volume in critically ill patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Intensive Care Med 24:329-37. 2009
    ..This paper reviews the evolution and accuracy of methods for assessing fluid responsiveness in critically ill patients...
  36. ncbi request reprint Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study
    Kirsi Maija Kaukonen
    1Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia 2Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan 3Intensive Care Unit, Geelong Hospital, Barwon Health, Geelong, Australia 4Intensive Care Unit, Austin Health, Heidelberg, Australia 5Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA
    Crit Care Med 42:1379-85. 2014
    ..To study the effect of stress hyperlactatemia on the association between stress hyperglycemia and mortality...
  37. doi request reprint Norepinephrine or dopamine for septic shock: systematic review of randomized clinical trials
    Tajender S Vasu
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 27:172-8. 2012
    ..According to current guidelines either dopamine or norepinephrine may be considered as the first-line agent for the management of refractory hypotension of septic shock...
  38. ncbi request reprint Intensive insulin therapy in the ICU: is it now time to jump off the bandwagon?
    Paul E Marik
    Pulmonary and Critical Care, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, United States
    Resuscitation 74:191-3. 2007
    ..Indeed, recent randomized controlled studies have been unable to demonstrate any benefit from tight glucemic control. We suggest that the widespread adoption of tight glycemic control be abandoned at this time...
  39. ncbi request reprint The definition of septic shock: implications for treatment
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Resusc 9:101-3. 2007
    ....
  40. ncbi request reprint Noninvasive positive-pressure ventilation in patients with malignancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 24:417-21. 2007
    ..In rare instances, NIPPV may have a role in treating patients with advanced cancer who have intractable dyspnea; however, NIPPV should not be used for the sole purpose of prolonging life in patients with terminal respiratory failure...
  41. ncbi request reprint The hospital-survival and prognostic factors of patients with solid tumors admitted to an ICU
    Vinia Mendoza
    Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 25:240-3. 2008
    ..The relatively high survival rate of this cohort of patients should prompt a reevaluation of the ICU admission criteria for patients with solid tumors who become critically ill...
  42. doi request reprint Association between time of admission to the ICU and mortality: a systematic review and metaanalysis
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Chest 138:68-75. 2010
    ..A change in the ICU staffing structure frequently occurs at nighttime and on weekends (off-hours). We postulated that patients who are admitted to an ICU during off hours may be at an increased risk of death...
  43. ncbi request reprint Inferior vena cava variation compared to pulse contour analysis as predictors of fluid responsiveness: a prospective cohort study
    Enrique Machare-Delgado
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 26:116-24. 2011
    ..Accurately predicting fluid responsiveness (FRes) allows for optimization of cardiac performance while avoiding fluid overload and prolonged mechanical ventilation...
  44. doi request reprint Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Chest 136:1631-43. 2009
    ..75; 95% CI, 0.63 to 0.89; p < 0.001; I(2), 43%) and for those treated before day 14 (RR, 0.71; 95% CI, 0.59 to 0.85; p < 0.001; I(2), 40%)...
  45. doi request reprint Is the band count useful in the diagnosis of infection? An accuracy study in critically ill patients
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 25:353-7. 2010
    ..However, the literature regarding the diagnostic accuracy of an elevated band count for the diagnosis of infection is limited...
  46. doi request reprint Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine PEM, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 37:2642-7. 2009
    ..Dynamic changes in systolic pressure, pulse pressure, and stroke volume in patients undergoing mechanical ventilation have emerged as useful techniques to assess volume responsiveness...
  47. ncbi request reprint Stress hyperglycemia and adrenal insufficiency in the critically ill
    Murugan Raghavan
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Semin Respir Crit Care Med 27:274-85. 2006
    ....
  48. doi request reprint Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
    ..Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed...
  49. doi request reprint Inhaled nitric oxide as salvage therapy in massive pulmonary embolism: a case series
    Douglas T Summerfield
    Eastern Virginia Medical School, Norfolk, VA, USA
    Respir Care 57:444-8. 2012
    ..We describe 4 cases in which INO was used as a temporizing agent to decrease right ventricular after-load following massive near-fatal pulmonary embolism. All 4 patients survived to hospital discharge...
  50. ncbi request reprint Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cardiol 32:365-72. 2009
    ..The clinical benefit of dietary fish oil supplementation in preventing cardiovascular events in both high and low risk patients is unclear...
  51. doi request reprint Perioperative hypertension: a review of current and emerging therapeutic agents
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Anesth 21:220-9. 2009
    ..While sodium nitroprusside and nitroglycerin are commonly used to treat these conditions, these agents are less than ideal. Intravenous beta blockers and calcium channel blockers have particular appeal in this setting...
  52. doi request reprint Natriuretic peptides in acute pulmonary embolism: a systematic review
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Intensive Care Med 34:2147-56. 2008
    ..Patients with pulmonary embolism (PE) have a high risk of death, and it is important to recognize factors associated with higher mortality. Recently, several biomarkers have been studied for risk stratification in patients with PE...
  53. ncbi request reprint Requirement of perioperative stress doses of corticosteroids: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Ste 650, Philadelphia, PA 19107, USA
    Arch Surg 143:1222-6. 2008
    ..Patients receiving therapeutic dosages of corticosteroids frequently require surgery; these patients are almost universally treated with stress doses of corticosteroids during the perioperative period...
  54. doi request reprint Critical illness-related corticosteroid insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 135:181-93. 2009
    ..The paper reviews cortisol physiology, CIRCI, and the role of corticosteroid therapy in critically ill patients...
  55. doi request reprint Pulmonary complications of novel antineoplastic agents for solid tumors
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Chest 133:528-38. 2008
    ..The approach to diagnosis, risk factors, and possible mechanisms of antineoplastic agent-induced pulmonary toxicity are discussed in this article...
  56. doi request reprint Multidisciplinary family meetings in the ICU facilitate end-of-life decision making
    Enrique Machare Delgado
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 26:295-302. 2009
    ..The aim of this study was to assess the feasibility of establishing a multi-disciplinary family meeting (MDFM) program and the impact of such a program on the end-of-life decision making in the setting of an ICU...
  57. ncbi request reprint A 53-year-old man with fever, clubbing, hemoptysis, and rapid onset of respiratory failure
    Sajive Aleyas
    Thomas Jefferson University Hospital, Department of Pulmonary and Critical Care Medicine, Philadelphia, PA, USA
    Chest 131:1974-7. 2007
  58. ncbi request reprint Management of sepsis during the early "golden hours"
    Murugan Raghavan
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Emerg Med 31:185-99. 2006
    ..In this article we review the multi-modality approach to early diagnosis and intervention in the therapy of patients with severe sepsis and septic shock...
  59. doi request reprint Brain natriuretic peptide measurement in pulmonary medicine
    Daniel Salerno
    Tulane University Health Sciences Center, Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, 1430 Tulane Avenue, Office 204, New Orleans, LA 70112, USA
    Respir Med 105:1770-5. 2011
    ..The present paper reviews the role of natriuretic peptides for diagnosis, risk stratification and prognosis of several pulmonary disorders...
  60. ncbi request reprint Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:2667-74. 2008
    ..However, the hematocrit that should be maintained in any particular patient because the risks of further transfusion of RBC outweigh the benefits remains unclear...
  61. ncbi request reprint Management of patients with metastatic malignancy in the intensive care unit
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 23:479-82. 2006
    ..Intensivists, who are charged with making the best use of limited resources, should ultimately be the individuals who determine the appropriateness of admitting such patients to the intensive care unit...
  62. doi request reprint The efficacy and dosage effect of corticosteroids for the prevention of atrial fibrillation after cardiac surgery: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Crit Care 24:458-63. 2009
    ..Corticosteroids down-regulate activation of the proinflammatory response (including C-reactive protein) after cardiopulmonary bypass and have been suggested to reduce the risk of postoperative AF...
  63. ncbi request reprint Sublingual capnometry: a non-invasive measure of microcirculatory dysfunction and tissue hypoxia
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Physiol Meas 27:R37-47. 2006
    ..This paper reviews the technology and application of sublingual PCO(2) monitoring...
  64. ncbi request reprint An 18-year-old woman with fever, diffuse pulmonary opacities, and rapid onset of respiratory failure: idiopathic acute eosinophilic pneumonia
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University Hospital, 1015 Chestnut St, Suite M 100, Philadelphia, PA 19107, USA
    Chest 130:1938-41. 2006
  65. pmc Gastric versus post-pyloric feeding: a systematic review
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 7:R46-51. 2003
    ..Our objective was to evaluate the impact of gastric versus post-pyloric feeding on the incidence of pneumonia, caloric intake, intensive care unit (ICU) length of stay (LOS), and mortality in critically ill and injured ICU patients...
  66. doi request reprint The immune response to surgery and trauma: Implications for treatment
    Paul E Marik
    Divisions of General Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Trauma Acute Care Surg 73:801-8. 2012
    ..Recent data, however, suggests that his paradigm may not be correct...
  67. ncbi request reprint Recurrent episodes of dermatomyositis-associated pneumonitis masquerading as hypersensitivity pneumonitis
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Mt Sinai J Med 73:895-7. 2006
    ..Further work-up showed clinical and serologic evidence of dermatomyositis-associated pneumonitis. The patient was treated with oral prednisone and azathioprine. The subject of dermatomyositis-associated pneumonitis is discussed...
  68. ncbi request reprint Regional carbon dioxide monitoring to assess the adequacy of tissue perfusion
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 11:245-51. 2005
    ..Regional carbon dioxide monitoring appears to be ideally suited to monitoring the adequacy of resuscitation. This review provides an update on this evolving technology...
  69. ncbi request reprint A 64-year-old male with fever and persistent lung infiltrate
    Tajender S Vasu
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia PA 19107, USA
    Respir Care 54:1263-5. 2009
    ..He had substantial clinical and radiological improvement after the discontinuation of decitabine and a course of corticosteroids...
  70. doi request reprint Hypertensive disorders of pregnancy
    Paul E Marik
    Pulmonary and Critical Care, Thomas Jefferson University, Philadelphia, PA, USA
    Postgrad Med 121:69-76. 2009
    ....
  71. ncbi request reprint Current diagnosis and management of hypertensive emergency
    Andrew R Haas
    Division of Critical Care, Pulmonary, Allergy and Immunologic Disease, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Semin Dial 19:502-12. 2006
    ..In contrast, with hypertensive urgency, blood pressure control can be achieved with the use of oral medications within 24-48 hours. This paper reviews the management of hypertensive emergencies...
  72. pmc The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Walnut Street, Philadelphia, Pennsylvania 19107, USA
    Crit Care 10:176. 2006
    ..In those patients in whom the diagnosis of adrenal insufficiency may be important, this diagnosis may best be made based on the free cortisol level or the total cortisol level stratified by serum albumin...
  73. ncbi request reprint Management of the critically ill geriatric patient
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 34:S176-82. 2006
    ..To review the effect of an aging society on the utilization of critical care services and the physiology of aging as it applies to critical illness and prognosis and management issues in the intensive care unit (ICU)...
  74. ncbi request reprint Should age limit admission to the intensive care unit?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 24:63-6. 2007
    ..This suggests that age alone should not be used in making intensive care unit triage decisions...
  75. ncbi request reprint Methicillin-resistant Staphylococcus aureus pneumonia after thoracic surgery: successful treatment with linezolid after failed vancomycin therapy
    Daniel Salerno
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 83:1888-91. 2007
    ..All 3 patients were cured with linezolid...
  76. ncbi request reprint Mechanisms and clinical consequences of critical illness associated adrenal insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 13:363-9. 2007
    ..The review summarizes our current understanding of the causes and consequences of adrenal insufficiency in critically ill patients...
  77. ncbi request reprint Maximizing efficacy from parenteral nutrition in critical care: appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA, 19107, USA
    Curr Gastroenterol Rep 9:345-53. 2007
    ..A lipid emulsion containing fish oil, olive oil, or both should replace soybean-containing emulsions. Supplemental glutamine, 0.2 g/kg/d to 0.5 g/kg/d, has been shown to reduce the risk of infection and to improve glycemic control...
  78. ncbi request reprint Should family members be present during cardiopulmonary resuscitation? A review of the literature
    C Dana Critchell
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Thomas Jefferson University, 834 Walnut Street, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 24:311-7. 2007
    ..In this article, we review the current status of family-witnessed resuscitation and provide recommendations on the development of hospital policies for family-witnessed resuscitation...
  79. doi request reprint What is the best way to feed patients with pancreatitis?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 15:131-8. 2009
    ..Recent data, however, suggest that this approach may be associated with increased morbidity and mortality. This paper reviews evolving concepts in the nutritional management of patients with acute pancreatitis...
  80. ncbi request reprint Airway pressure-release ventilation in pregnant patients with acute respiratory distress syndrome: a novel strategy
    Amyn Hirani
    Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Respir Care 54:1405-8. 2009
    ..APRV is consistent with lung-protective strategies that aim to limit lung injury associated with mechanical ventilation. APRV utilization in obstetrical patients has not previously been reported...
  81. ncbi request reprint Fungal infections in solid organ transplantation
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Expert Opin Pharmacother 7:297-305. 2006
    ..This article will review the risk factors, clinical presentation and treatment of invasive fungal infections in solid organ transplant patients, and evaluate the role of prophylactic therapy in this group of patients...
  82. doi request reprint Prolonged and profound therapeutic hypothermia for the treatment of "brain death" after a suicidal intoxication. Challenging conventional wisdoms
    Paul E Marik
    EVMS Internal Medicine, Norfolk, VA 2350, USA
    Am J Emerg Med 28:258.e1-4. 2010
    ..Inappropriately labeling such patients as "brain dead" will result in the failure to institute therapeutic hypothermia and other advanced neuroprotective interventions in patients who could be salvaged with a good neurologic outcome...
  83. doi request reprint Thrombolytic therapy in a patient with suspected pulmonary embolism despite a negative computed tomography pulmonary angiogram
    Urvashi Vaid
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Respir Care 56:336-8. 2011
    ..Autopsy confirmed the diagnosis of multiple pulmonary emboli and unexpectedly discovered a patent foramen ovale that explained paradoxical embolism to the brain...
  84. ncbi request reprint Multiple venous thromboses in a young man with sarcoidosis: is there a relation between sarcoidosis and venous thrombosis?
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, e Thomas Jefferson University, Philadelphia, PA, USA
    South Med J 99:998-9. 2006
    ..Lymph node tissue culture and special stains were negative for mycobacterial or fungal infection. This is an unusual case of multiple deep venous thromboses and sarcoidosis. The subject of sarcoidosis and venous thrombosis is discussed...
  85. doi request reprint Acute lung injury following blood transfusion: expanding the definition
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:3080-4. 2008
    ..The objectives of this review are to summarize current knowledge of TRALI with an emphasis on issues pertinent to the intensivist and to define the newly recognized "Delayed TRALI syndrome."..
  86. ncbi request reprint The hazards of blood transfusion
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Br J Hosp Med (Lond) 70:12-5. 2009
    ..This article reviews the major complications associated with blood transfusion...
  87. ncbi request reprint Role of CD8 lymphocytes and neutrophilic alveolitis in Pneumocystis jiroveci pneumonia
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, USA
    Scand J Infect Dis 39:612-4. 2007
    ..These findings are consistent with data from animal studies...
  88. ncbi request reprint Propofol: an immunomodulating agent
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Pharmacotherapy 25:28S-33S. 2005
    ..The antiinflammatory and antioxidant properties of propofol may have beneficial effects in patients with sepsis and systemic inflammatory response syndrome...
  89. pmc The optimal endpoint of resuscitation in trauma patients
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 7:19-20. 2003
  90. pmc Pulmonary blastomycosis masquerading as metastatic disease in the lung: a case report
    Bobbak Vahid
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    MedGenMed 8:31. 2006
    ..To our knowledge, this is the first case of a PET-positive pulmonary blastomycosis lesion mimicking pulmonary malignancy reported in the literature...