Neel K Krishna

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. pmc Identification of structural domains involved in astrovirus capsid biology
    Neel K Krishna
    Department of Pediatrics and the Center for Pediatric Research, Norfolk, VA 23510, USA
    Viral Immunol 18:17-26. 2005
  2. pmc Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway
    Rheba S Bonaparte
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    J Virol 82:817-27. 2008
  3. ncbi request reprint Human astrovirus coat protein: a novel C1 inhibitor
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Adv Exp Med Biol 632:237-51. 2008
  4. doi request reprint Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 47:792-8. 2010
  5. ncbi request reprint Analysis of RNA packaging in wild-type and mosaic protein capsids of flock house virus using recombinant baculovirus vectors
    Neel K Krishna
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Virology 305:10-24. 2003
  6. pmc Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses
    Liang Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:6370-5. 2002
  7. pmc Large-scale, pH-dependent, quaternary structure changes in an RNA virus capsid are reversible in the absence of subunit autoproteolysis
    Derek J Taylor
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:9972-80. 2002
  8. pmc Capsid protein synthesis from replicating RNA directs specific packaging of the genome of a multipartite, positive-strand RNA virus
    P Arno Venter
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:6239-48. 2005

Collaborators

  • John Johnson
  • Pamela S Hair
  • Anette Schneemann
  • Kenji M Cunnion
  • Rheba S Bonaparte
  • P Arno Venter
  • Derek J Taylor
  • Liang Tang
  • Gerard J Arlaud
  • Jenny Q Gronemus
  • Nicole M Thielens
  • Veena P Salvi
  • Nenoo Rawal
  • Katrina B Crawford
  • Deepa Banthia
  • Dawn M Marshall
  • Chan Shing Lin
  • Mary A Canady
  • Mark Yeager

Detail Information

Publications8

  1. pmc Identification of structural domains involved in astrovirus capsid biology
    Neel K Krishna
    Department of Pediatrics and the Center for Pediatric Research, Norfolk, VA 23510, USA
    Viral Immunol 18:17-26. 2005
    ..Information derived from these structural predictions will serve as an important tool in designing experiments to understand astrovirus biology...
  2. pmc Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway
    Rheba S Bonaparte
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    J Virol 82:817-27. 2008
    ..Although diverse mechanisms of inhibition of complement activation have been described for many enveloped animal viruses, this is the first report of a nonenveloped icosahedral virus CP inhibiting classical pathway activation at C1...
  3. ncbi request reprint Human astrovirus coat protein: a novel C1 inhibitor
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Adv Exp Med Biol 632:237-51. 2008
    ..Additionally, the properties of this compound are elucidated highlighting its potential as an anti-complement therapeutic for the many diseases associated with inappropriate complement activation...
  4. doi request reprint Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 47:792-8. 2010
    ..These findings suggest CP inhibits C1 and MBL activation via a novel mechanism of interference with the normal interaction of the recognition molecule with its cognate serine proteases...
  5. ncbi request reprint Analysis of RNA packaging in wild-type and mosaic protein capsids of flock house virus using recombinant baculovirus vectors
    Neel K Krishna
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Virology 305:10-24. 2003
    ..We have further utilized this system to show that two coat protein deletion mutants with distinct RNA packaging defects form mosaic virus capsids but do not complement each other to rescue specific packaging of FHV RNAs...
  6. pmc Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses
    Liang Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:6370-5. 2002
    ..The structural similarities between fish nodaviruses and members of the tombusvirus and calicivirus groups provide significant new data for understanding the evolution of the nodavirus family...
  7. pmc Large-scale, pH-dependent, quaternary structure changes in an RNA virus capsid are reversible in the absence of subunit autoproteolysis
    Derek J Taylor
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:9972-80. 2002
    ..Here, we identify the relationship between cleavage and the conformational change and propose a pH-dependent helix-coil transition that may be responsible for the structural rearrangement in N omega V...
  8. pmc Capsid protein synthesis from replicating RNA directs specific packaging of the genome of a multipartite, positive-strand RNA virus
    P Arno Venter
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:6239-48. 2005
    ..Spatial coordination of RNA and capsid protein synthesis may be key to specific genome packaging and assembly in other RNA viruses...