Neel K Krishna

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. ncbi request reprint Human astrovirus coat protein: a novel C1 inhibitor
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Adv Exp Med Biol 632:237-51. 2008
  2. doi request reprint Role of molecular diagnostics in the management of infectious disease emergencies
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Med Clin North Am 96:1067-78. 2012
  3. doi request reprint Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein
    Jenny Q Gronemus
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    Mol Immunol 48:305-13. 2010
  4. pmc Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, USA
    J Transl Med 10:35. 2012
  5. pmc Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    J Transl Med 12:181. 2014
  6. pmc A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility
    Clifford T Mauriello
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 53:132-9. 2013
  7. doi request reprint Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 47:792-8. 2010
  8. pmc Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway
    Rheba S Bonaparte
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    J Virol 82:817-27. 2008
  9. pmc Identification of structural domains involved in astrovirus capsid biology
    Neel K Krishna
    Department of Pediatrics and the Center for Pediatric Research, Norfolk, VA 23510, USA
    Viral Immunol 18:17-26. 2005

Research Grants

Collaborators

  • Pamela S Hair
  • Nicole M Thielens
  • Gerard J Arlaud
  • Julia A Sharp
  • Nenoo Rawal
  • Kenji M Cunnion
  • Clifford T Mauriello
  • Tushar A Shah
  • Jenny Q Gronemus
  • Rheba S Bonaparte
  • Michael P Stolz
  • William Thomas Bass
  • Amandeep Sandhu
  • Frank A Lattanzio
  • Haree K Pallera
  • Jon L Woltmann
  • Pieter van der Pol
  • Shizhi Qian
  • Cees van Kooten
  • Julius O Nyalwidhe
  • Katrina B Crawford
  • Dawn M Marshall
  • Deepa Banthia

Detail Information

Publications9

  1. ncbi request reprint Human astrovirus coat protein: a novel C1 inhibitor
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Adv Exp Med Biol 632:237-51. 2008
    ..Additionally, the properties of this compound are elucidated highlighting its potential as an anti-complement therapeutic for the many diseases associated with inappropriate complement activation...
  2. doi request reprint Role of molecular diagnostics in the management of infectious disease emergencies
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Med Clin North Am 96:1067-78. 2012
    ..An added advantage of rapid diagnostic tests often not emphasized is the capability to rule out certain diagnoses for which unnecessary antimicrobial therapy may otherwise be instituted and/or continued...
  3. doi request reprint Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein
    Jenny Q Gronemus
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    Mol Immunol 48:305-13. 2010
    ....
  4. pmc Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, USA
    J Transl Med 10:35. 2012
    ..Diabetic patients are at increased risk for bacterial infections; these studies provide new insight into the role of the host defense complement system in controlling bacterial pathogens in hyperglycemic environments...
  5. pmc Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    J Transl Med 12:181. 2014
    ..Our goal was to measure the independent effect of temperature on complement activation, and more specifically, examine the relationship between clinical hypothermia temperatures (31-33°C), and complement activation...
  6. pmc A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility
    Clifford T Mauriello
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 53:132-9. 2013
    ....
  7. doi request reprint Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 47:792-8. 2010
    ..These findings suggest CP inhibits C1 and MBL activation via a novel mechanism of interference with the normal interaction of the recognition molecule with its cognate serine proteases...
  8. pmc Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway
    Rheba S Bonaparte
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    J Virol 82:817-27. 2008
    ..Although diverse mechanisms of inhibition of complement activation have been described for many enveloped animal viruses, this is the first report of a nonenveloped icosahedral virus CP inhibiting classical pathway activation at C1...
  9. pmc Identification of structural domains involved in astrovirus capsid biology
    Neel K Krishna
    Department of Pediatrics and the Center for Pediatric Research, Norfolk, VA 23510, USA
    Viral Immunol 18:17-26. 2005
    ..Information derived from these structural predictions will serve as an important tool in designing experiments to understand astrovirus biology...

Research Grants1

  1. Molecular analysis of astrovirus capsid assembly
    NEEL KRISHNA; Fiscal Year: 2005
    ..In the long term, we expect that this work will add not only to the understanding of astrovirus particle biology, but also lead to the development of therapeutic drugs or vaccines to combat viral gastroenteritis in humans. ..