Edward Johnson

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. pmc The fox and the fat: an unexpected new treatment for brain tumors
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA
    Cell Cycle 11:3353. 2012
  2. pmc Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USA
    Clin Dev Immunol 2013:197807. 2013
  3. pmc The pur protein family: genetic and structural features in development and disease
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507 1696, USA
    J Cell Physiol 228:930-7. 2013
  4. pmc Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals
    Margaret J Wortman
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W, Olney Road, Norfolk, VA 23507, USA
    BMC Mol Biol 11:81. 2010
  5. ncbi request reprint Role of Pur alpha in targeting mRNA to sites of translation in hippocampal neuronal dendrites
    Edward M Johnson
    Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 83:929-43. 2006
  6. pmc Structural evaluation of new human polyomaviruses provides clues to pathobiology
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    Trends Microbiol 18:215-23. 2010
  7. doi request reprint Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex
    Longgui G Wang
    New York University Cancer Institute, New York, New York 10016, USA
    Cancer Res 68:2678-88. 2008
  8. pmc Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation
    Hong Liu
    Department of Pathology and the D H Ruttenberg Cancer Center, Box 1194, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 30:2417-26. 2002
  9. ncbi request reprint Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy
    David B Weinreb
    Department of Pathology, Mount Sinai School of Medicine, New York 10029, USA
    Int J Urol 13:439-41. 2006
  10. doi request reprint Induction of bicalutamide sensitivity in prostate cancer cells by an epigenetic Puralpha-mediated decrease in androgen receptor levels
    Xiaomei Liu
    New York University Cancer Institute and Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Prostate 70:179-89. 2010

Collaborators

Detail Information

Publications24

  1. pmc The fox and the fat: an unexpected new treatment for brain tumors
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA
    Cell Cycle 11:3353. 2012
    ..Comment on: Wilk A, et al. Cell Cycle 2012; 11:2660-71...
  2. pmc Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USA
    Clin Dev Immunol 2013:197807. 2013
    ..We shall describe how the NCCR sequence changes point to a model in which viral DNA replication drives NCCR recombination, allowing JCV adaptation to different cell types in its progression to neurovirulence...
  3. pmc The pur protein family: genetic and structural features in development and disease
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507 1696, USA
    J Cell Physiol 228:930-7. 2013
    ..Pur family members have been implicated in diseases as diverse as cancer, premature aging, and fragile-X mental retardation syndrome...
  4. pmc Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals
    Margaret J Wortman
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W, Olney Road, Norfolk, VA 23507, USA
    BMC Mol Biol 11:81. 2010
    ..The distinct but related roles of PurĪ± suggest a need for expression regulated differently depending on intracellular and external signals...
  5. ncbi request reprint Role of Pur alpha in targeting mRNA to sites of translation in hippocampal neuronal dendrites
    Edward M Johnson
    Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 83:929-43. 2006
    ..These results help define a mechanism by which Pur alpha targets specific mRNA molecules to sites of dendritic translation...
  6. pmc Structural evaluation of new human polyomaviruses provides clues to pathobiology
    Edward M Johnson
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    Trends Microbiol 18:215-23. 2010
    ..This review compares the structural features of the new and previously known polyomaviruses, with the aim of identifying approaches to molecular pathology...
  7. doi request reprint Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex
    Longgui G Wang
    New York University Cancer Institute, New York, New York 10016, USA
    Cancer Res 68:2678-88. 2008
    ..The success in restoring Pur alpha and the repressor complex function by pharmacologic intervention opens a promising new therapeutic approach for advanced PC...
  8. pmc Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation
    Hong Liu
    Department of Pathology and the D H Ruttenberg Cancer Center, Box 1194, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 30:2417-26. 2002
    ..PURG-A levels are low or undetectable in the normal tissue panel, but they are greatly elevated in all members of a tumor tissue panel. PURG-B is detected in several tumor panel members...
  9. ncbi request reprint Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy
    David B Weinreb
    Department of Pathology, Mount Sinai School of Medicine, New York 10029, USA
    Int J Urol 13:439-41. 2006
    ..We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN...
  10. doi request reprint Induction of bicalutamide sensitivity in prostate cancer cells by an epigenetic Puralpha-mediated decrease in androgen receptor levels
    Xiaomei Liu
    New York University Cancer Institute and Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Prostate 70:179-89. 2010
    ..Strategies to regain control of increased AR transcription may overcome resistance of AI-cells and improve treatment outcomes...
  11. ncbi request reprint Expression of p53 in virally infected tubular cells in renal transplant patients with polyomavirus nephropathy
    David B Weinreb
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Pathol 37:684-8. 2006
    ..These results provide the first evidence for intracellular actions of PV T antigen in the context of nonneoplastic diseases...
  12. ncbi request reprint Polyoma virus infection is a prominent risk factor for bladder carcinoma in immunocompetent individuals
    David B Weinreb
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Diagn Cytopathol 34:201-3. 2006
    ..The incidence of bladder carcinoma was sufficient to statistically establish temporality in a two-sided test, linking a prior diagnosis of PV infection to a subsequent diagnosis of bladder carcinoma (odds ratio = 3.419, P < 0.001)...
  13. ncbi request reprint Mechanism of DNA binding and localized strand separation by Pur alpha and comparison with Pur family member, Pur beta
    Margaret J Wortman
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1743:64-78. 2005
    ..Similarly, a C-terminal deletion of Pur alpha can bind supercoiled pMYC7 plasmid, but cannot bind the same linear duplex DNA segment. Therefore, access to linear DNA initially requires C-terminal sequences of Pur alpha...
  14. ncbi request reprint The Pur protein family: clues to function from recent studies on cancer and AIDS
    Edward M Johnson
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Anticancer Res 23:2093-100. 2003
    ....
  15. ncbi request reprint Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2
    Hong Liu
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 328:851-7. 2005
    ..Pur family member Purgamma colocalizes with Cdk2 to a specific DNA segment in this region...
  16. ncbi request reprint Internalization of exogenous human immunodeficiency virus-1 protein, Tat, by KG-1 oligodendroglioma cells followed by stimulation of DNA replication initiated at the JC virus origin
    Dianne C Daniel
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    DNA Cell Biol 23:858-67. 2004
    ..These results define a pathway by which a protein made by HIV-1 can directly affect the course of infection by another disease-causing virus...
  17. ncbi request reprint Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication
    Yayoi Kinoshita
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Microsc Res Tech 71:288-97. 2008
    ..Our data strongly suggest that MCM8 functions with other known replication proteins in processes which accompany DNA replication, especially initiation, and which are specifically adapted to suit higher eukaryotes...
  18. ncbi request reprint Site-specific loading of an MCM protein complex in a DNA replication initiation zone upstream of the c-MYC gene in the HeLa cell cycle
    Yayoi Kinoshita
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:35879-89. 2004
    ..Results indicate sequence-specific loading of MCM proteins onto DNA in late G(1) followed by a recruitment to multiple sites in chromatin subsequent to replication...
  19. pmc Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse
    Kamel Khalili
    Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Mol Cell Biol 23:6857-75. 2003
    ..Overall results are consistent with a role for Puralpha in developmentally timed DNA replication in specific cell types and also point to a newly emerging role in compartmentalized RNA transport and translation in neuronal dendrites...
  20. pmc Role of Puralpha in the modulation of homologous recombination-directed DNA repair by HIV-1 Tat
    Huichen Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Anticancer Res 28:1441-7. 2008
    ..Puralpha interacts with HIV-1 Tat, which regulates homologous recombination-directed DNA repair (HRR)...
  21. ncbi request reprint Evidence for the involvement of Puralpha in response to DNA replication stress
    Huichen Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    Cancer Biol Ther 6:596-602. 2007
    ..These results suggest a role for Puralpha as a caretaker protein that is involved in the repair of DSBs induced by stalled replication forks...
  22. pmc Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription
    Kyunghwan Kim
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    J Biol Chem 283:9113-26. 2008
    ..Therefore, these results reveal a previously unrecognized function of H1 as a transcriptional repressor as well as the underlying mechanism involving specific sets of factors in this repression process...
  23. pmc Puralpha as a cellular co-factor of Rev/RRE-mediated expression of HIV-1 intron-containing mRNA
    Rafal Kaminski
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 103:1231-45. 2008
    ..Our data indicate that the partnership of Puralpha with Rev is beneficial for Rev-mediated expression of the HIV-1 genome...
  24. ncbi request reprint Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter
    Thomas Prisinzano
    Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    J Med Chem 45:4371-4. 2002
    ..4-[2-[Bis(4-fluorophenyl)methoxy]ethyl-1-(2-naphthylmethyl)piperidine was found to possess subnanomolar affinity (K(i) = 0.7 nM) and good selectivity for the DAT (SERT/DAT = 323)...

Research Grants25

  1. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2004
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  2. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2005
    ..Results will help elucidate pathways of activation of HIV-1 and JCV in the brain and will help target particular molecular interactions for therapy. ..
  3. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2005
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  4. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2006
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  5. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2006
    ..Results will help elucidate pathways of activation of HIV-1 and JCV in the brain and will help target particular molecular interactions for therapy. ..
  6. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2005
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  7. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2007
    ..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..
  8. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2009
    ..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..
  9. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward M Johnson; Fiscal Year: 2010
    ..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..
  10. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2004
    ..Results will help elucidate pathways of activation of HIV-1 and JCV in the brain and will help target particular molecular interactions for therapy. ..
  11. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2003
    ..Results will help elucidate pathways of activation of HIV-1 and JCV in the brain and will help target particular molecular interactions for therapy. ..
  12. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2003
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  13. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 1999
    ..Results will help us understand how DNA replication initiates and how this replication is aberrant at specific origins in lung cancer. ..
  14. PROTEINS MEDIATING INTERACTION OF HIV 1 AND JCV IN CNS
    Edward Johnson; Fiscal Year: 1999
    ..Results will provide information about the interaction of HIV-1 and JCV in human glial cells and will help illuminate a potential target for HIV-1 therapy. ..
  15. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2000
    ..Results will help us understand how DNA replication initiates and how this replication is aberrant at specific origins in lung cancer. ..
  16. PROTEINS MEDIATING INTERACTION OF HIV 1 AND JCV IN CNS
    Edward Johnson; Fiscal Year: 2000
    ..Results will provide information about the interaction of HIV-1 and JCV in human glial cells and will help illuminate a potential target for HIV-1 therapy. ..
  17. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2001
    ..Results will help us understand how DNA replication initiates and how this replication is aberrant at specific origins in lung cancer. ..
  18. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward Johnson; Fiscal Year: 2002
    ..Results will help elucidate pathways of activation of HIV-1 and JCV in the brain and will help target particular molecular interactions for therapy. ..
  19. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2002
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  20. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward M Johnson; Fiscal Year: 2011
    ..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..