Research Topics
| Edward JohnsonSummaryAffiliation: Eastern Virginia Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
The pur protein family: genetic and structural features in development and diseaseEdward M Johnson
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507 1696, USA
J Cell Physiol 228:930-7. 2013..Pur family members have been implicated in diseases as diverse as cancer, premature aging, and fragile-X mental retardation syndrome...
Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signalsMargaret J Wortman
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W, Olney Road, Norfolk, VA 23507, USA
BMC Mol Biol 11:81. 2010..The distinct but related roles of PurĪ± suggest a need for expression regulated differently depending on intracellular and external signals...- Structural evaluation of new human polyomaviruses provides clues to pathobiologyEdward M Johnson
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
Trends Microbiol 18:215-23. 2010..This review compares the structural features of the new and previously known polyomaviruses, with the aim of identifying approaches to molecular pathology... 
Role of Pur alpha in targeting mRNA to sites of translation in hippocampal neuronal dendritesEdward M Johnson
Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
J Neurosci Res 83:929-43. 2006..These results help define a mechanism by which Pur alpha targets specific mRNA molecules to sites of dendritic translation...- Induction of bicalutamide sensitivity in prostate cancer cells by an epigenetic Puralpha-mediated decrease in androgen receptor levelsXiaomei Liu
New York University Cancer Institute and Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
Prostate 70:179-89. 2010..Strategies to regain control of increased AR transcription may overcome resistance of AI-cells and improve treatment outcomes... - Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complexLonggui G Wang
New York University Cancer Institute, New York, New York 10016, USA
Cancer Res 68:2678-88. 2008..The success in restoring Pur alpha and the repressor complex function by pharmacologic intervention opens a promising new therapeutic approach for advanced PC... - Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathyDavid B Weinreb
Department of Pathology, Mount Sinai School of Medicine, New York 10029, USA
Int J Urol 13:439-41. 2006..We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN... - Expression of p53 in virally infected tubular cells in renal transplant patients with polyomavirus nephropathyDavid B Weinreb
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
Hum Pathol 37:684-8. 2006..These results provide the first evidence for intracellular actions of PV T antigen in the context of nonneoplastic diseases... - Polyoma virus infection is a prominent risk factor for bladder carcinoma in immunocompetent individualsDavid B Weinreb
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
Diagn Cytopathol 34:201-3. 2006..The incidence of bladder carcinoma was sufficient to statistically establish temporality in a two-sided test, linking a prior diagnosis of PV infection to a subsequent diagnosis of bladder carcinoma (odds ratio = 3.419, P < 0.001)... - Mechanism of DNA binding and localized strand separation by Pur alpha and comparison with Pur family member, Pur betaMargaret J Wortman
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
Biochim Biophys Acta 1743:64-78. 2005..Similarly, a C-terminal deletion of Pur alpha can bind supercoiled pMYC7 plasmid, but cannot bind the same linear duplex DNA segment. Therefore, access to linear DNA initially requires C-terminal sequences of Pur alpha... - The Pur protein family: clues to function from recent studies on cancer and AIDSEdward M Johnson
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
Anticancer Res 23:2093-100. 2003.... - Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylationHong Liu
Department of Pathology and the D H Ruttenberg Cancer Center, Box 1194, Mount Sinai School of Medicine, New York, NY 10029, USA
Nucleic Acids Res 30:2417-26. 2002..PURG-A levels are low or undetectable in the normal tissue panel, but they are greatly elevated in all members of a tumor tissue panel. PURG-B is detected in several tumor panel members... - Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2Hong Liu
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
Biochem Biophys Res Commun 328:851-7. 2005..Pur family member Purgamma colocalizes with Cdk2 to a specific DNA segment in this region... - Internalization of exogenous human immunodeficiency virus-1 protein, Tat, by KG-1 oligodendroglioma cells followed by stimulation of DNA replication initiated at the JC virus originDianne C Daniel
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
DNA Cell Biol 23:858-67. 2004..These results define a pathway by which a protein made by HIV-1 can directly affect the course of infection by another disease-causing virus... - Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replicationYayoi Kinoshita
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
Microsc Res Tech 71:288-97. 2008..Our data strongly suggest that MCM8 functions with other known replication proteins in processes which accompany DNA replication, especially initiation, and which are specifically adapted to suit higher eukaryotes... - Site-specific loading of an MCM protein complex in a DNA replication initiation zone upstream of the c-MYC gene in the HeLa cell cycleYayoi Kinoshita
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 279:35879-89. 2004..Results indicate sequence-specific loading of MCM proteins onto DNA in late G(1) followed by a recruitment to multiple sites in chromatin subsequent to replication... - Evidence for the involvement of Puralpha in response to DNA replication stressHuichen Wang
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
Cancer Biol Ther 6:596-602. 2007..These results suggest a role for Puralpha as a caretaker protein that is involved in the repair of DSBs induced by stalled replication forks... - Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouseKamel Khalili
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Mol Cell Biol 23:6857-75. 2003..Overall results are consistent with a role for Puralpha in developmentally timed DNA replication in specific cell types and also point to a newly emerging role in compartmentalized RNA transport and translation in neuronal dendrites... - Role of Puralpha in the modulation of homologous recombination-directed DNA repair by HIV-1 TatHuichen Wang
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA 19122, USA
Anticancer Res 28:1441-7. 2008..Puralpha interacts with HIV-1 Tat, which regulates homologous recombination-directed DNA repair (HRR)... - Puralpha as a cellular co-factor of Rev/RRE-mediated expression of HIV-1 intron-containing mRNARafal Kaminski
Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
J Cell Biochem 103:1231-45. 2008..Our data indicate that the partnership of Puralpha with Rev is beneficial for Rev-mediated expression of the HIV-1 genome... - Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporterThomas Prisinzano
Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
J Med Chem 45:4371-4. 2002..4-[2-[Bis(4-fluorophenyl)methoxy]ethyl-1-(2-naphthylmethyl)piperidine was found to possess subnanomolar affinity (K(i) = 0.7 nM) and good selectivity for the DAT (SERT/DAT = 323)... - Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcriptionKyunghwan Kim
Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
J Biol Chem 283:9113-26. 2008..Therefore, these results reveal a previously unrecognized function of H1 as a transcriptional repressor as well as the underlying mechanism involving specific sets of factors in this repression process...
Research Grants
- CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCEREdward Johnson; Fiscal Year: 2006..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
- Proteins Mediating Interaction of HIV-1 and JCV in CNSEdward Johnson; Fiscal Year: 2006..Results will help elucidate pathways of activation of HIV-1 and JCV in the brain and will help target particular molecular interactions for therapy. ..
- Proteins Mediating Interaction of HIV-1 and JCV in CNSEdward M Johnson; Fiscal Year: 2010..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..
- PROTEINS MEDIATING INTERACTION OF HIV 1 AND JCV IN CNSEdward Johnson; Fiscal Year: 2000..Results will provide information about the interaction of HIV-1 and JCV in human glial cells and will help illuminate a potential target for HIV-1 therapy. ..
- CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCEREdward Johnson; Fiscal Year: 2001..Results will help us understand how DNA replication initiates and how this replication is aberrant at specific origins in lung cancer. ..
- Proteins Mediating Interaction of HIV-1 and JCV in CNSEdward M Johnson; Fiscal Year: 2011..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..