Elena V Galkina
Affiliation: Eastern Virginia Medical School
Taghavie Moghadam P, Waseem T, Hattler J, Glenn L, Dobrian A, Kaplan M, et al
. STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice. J Immunol. 2017;199:3453-3465 pubmed publisher
Taghavie Moghadam P, Gjurich B, Jabeen R, Krishnamurthy P, Kaplan M, Dobrian A, et al
. STAT4 deficiency reduces the development of atherosclerosis in mice. Atherosclerosis. 2015;243:169-78 pubmed publisher
..Thus, this study identifies for the first time a pro-atherogenic role of STAT4 that is at least partially independent of Th1 cell-derived IFNÎ³, and primarily involving the modulation of MÎ¦ responses. ..
Gjurich B, Taghavie Moghadam P, Galkina E. Flow Cytometric Analysis of Immune Cells Within Murine Aorta. Methods Mol Biol. 2015;1339:161-75 pubmed publisher
..The method involves the harvesting and enzymatic digestion of the aorta, extracellular and intracellular protein staining, and a subsequent flow cytometric analysis. ..
Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol. 2009;27:165-97 pubmed publisher
..Regulatory T cells and B1 cells secreting natural antibodies are atheroprotective. This review summarizes our current understanding of inflammatory and immune mechanisms in atherosclerosis. ..
Butcher M, Filipowicz A, Waseem T, McGary C, Crow K, Magilnick N, et al
. Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFN?+ Th1/Tregs. Circ Res. 2016;119:1190-1203 pubmed publisher
..Atherosclerosis drives Treg plasticity, resulting in the accumulation of dysfunctional IFN?+ Th1/Tregs that may permit further arterial inflammation and atherogenesis. ..
Galkina E, Butcher M, Keller S, Goff M, Bruce A, Pei H, et al
. Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol. 2012;32:247-56 pubmed publisher
..These results demonstrate that defective insulin signaling is involved in accelerated atherosclerosis in Insr(+/-)Irs1(+/-)Apoe(-/-) mice by promoting vascular dysfunction and inflammation. ..
Butcher M, Wu C, Waseem T, Galkina E. CXCR6 regulates the recruitment of pro-inflammatory IL-17A-producing T cells into atherosclerotic aortas. Int Immunol. 2016;28:255-61 pubmed publisher
..Altogether these results demonstrate an important role of CXCR6 in the regulation of pathological Th17 and IL-17A(+)TCRÎ³Î´(+) T-cell recruitment into atherosclerotic lesions. ..
Butcher M, Waseem T, Galkina E. Smooth Muscle Cell-Derived Interleukin-17C Plays an Atherogenic Role via the Recruitment of Proinflammatory Interleukin-17A+ T Cells to the Aorta. Arterioscler Thromb Vasc Biol. 2016;36:1496-506 pubmed publisher
..Smooth muscle cell-derived IL-17C plays a proatherogenic role by supporting the recruitment of Th17 cells to atherosclerotic lesions. ..