DIANE DUFFY

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. doi Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, VA 23507, USA
    Hum Reprod Update 21:652-70. 2015
  2. pmc Mammalian oocytes are targets for prostaglandin E2 (PGE2) action
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Reprod Biol Endocrinol 8:131. 2010
  3. pmc Comparative maturation of cynomolgus monkey oocytes in vivo and in vitro
    Hang Yin
    The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynaecology Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Reprod Biol Endocrinol 4:14. 2006
  4. pmc Maturation and fertilization of nonhuman primate oocytes are compromised by oral administration of a cyclooxygenase-2 inhibitor
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Fertil Steril 95:1256-60. 2011
  5. pmc Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, VA 23507, United States
    Mol Cell Endocrinol 333:119-26. 2011
  6. ncbi Follicular administration of a cyclooxygenase inhibitor can prevent oocyte release without alteration of normal luteal function in rhesus monkeys
    Diane M Duffy
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Hum Reprod 17:2825-31. 2002
  7. ncbi An ovulatory gonadotropin stimulus increases cytosolic phospholipase A2 expression and activity in granulosa cells of primate periovulatory follicles
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, Virginia 23507, USA
    J Clin Endocrinol Metab 90:5858-65. 2005
  8. ncbi Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, VA 23507, USA
    Hum Reprod 20:1485-92. 2005
  9. ncbi Prostaglandin dehydrogenase and prostaglandin levels in periovulatory follicles: implications for control of primate ovulation by prostaglandin E2
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Clin Endocrinol Metab 90:1021-7. 2005
  10. ncbi Growth differentiation factor-9 is expressed by the primate follicle throughout the periovulatory interval
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Biol Reprod 69:725-32. 2003

Research Grants

  1. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003

Detail Information

Publications19

  1. doi Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, VA 23507, USA
    Hum Reprod Update 21:652-70. 2015
    ..Elevated intrafollicular PGE2 is required for successful ovulation, so disruption of PGE2 synthesis, metabolism or transport may yield effective contraceptive strategies...
  2. pmc Mammalian oocytes are targets for prostaglandin E2 (PGE2) action
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Reprod Biol Endocrinol 8:131. 2010
    ..PGE2 actions on granulosa cells are essential for successful ovulation. The aim of the present study is to determine if PGE2 also acts directly at the oocyte to regulate periovulatory events...
  3. pmc Comparative maturation of cynomolgus monkey oocytes in vivo and in vitro
    Hang Yin
    The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynaecology Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Reprod Biol Endocrinol 4:14. 2006
    ....
  4. pmc Maturation and fertilization of nonhuman primate oocytes are compromised by oral administration of a cyclooxygenase-2 inhibitor
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Fertil Steril 95:1256-60. 2011
    ..To determine if oral administration of a cyclooxygenase-2 (COX2) inhibitor affects oocyte nuclear maturation and fertilization in nonhuman primates...
  5. pmc Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, VA 23507, United States
    Mol Cell Endocrinol 333:119-26. 2011
    ..Increased, then decreased PGDH activity may delay accumulation of prostaglandins in the follicle until late in the periovulatory interval, contributing to timely ovulation in primates...
  6. ncbi Follicular administration of a cyclooxygenase inhibitor can prevent oocyte release without alteration of normal luteal function in rhesus monkeys
    Diane M Duffy
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Hum Reprod 17:2825-31. 2002
    ..Prostaglandins (PG), produced by the follicle just before ovulation, appear to act locally to promote follicle rupture and oocyte release...
  7. ncbi An ovulatory gonadotropin stimulus increases cytosolic phospholipase A2 expression and activity in granulosa cells of primate periovulatory follicles
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, Virginia 23507, USA
    J Clin Endocrinol Metab 90:5858-65. 2005
    ..Arachidonic acid, the common precursor for PG synthesis, is cleaved from membrane phospholipids via the activity of phospholipase A2 (PLA2)...
  8. ncbi Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, VA 23507, USA
    Hum Reprod 20:1485-92. 2005
    ..Follicular PGE2 levels increase just before the expected time of ovulation, suggesting that the midcycle LH surge induces the expression of enzymes involved in PGE2 synthesis...
  9. ncbi Prostaglandin dehydrogenase and prostaglandin levels in periovulatory follicles: implications for control of primate ovulation by prostaglandin E2
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Clin Endocrinol Metab 90:1021-7. 2005
    ....
  10. ncbi Growth differentiation factor-9 is expressed by the primate follicle throughout the periovulatory interval
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Biol Reprod 69:725-32. 2003
    ..However, GDF-9 expression and action differ between rodent and primate follicles, suggesting a possible regulatory role for GDF-9 that is unique to the primate follicle...
  11. ncbi Luteinizing hormone acts directly at granulosa cells to stimulate periovulatory processes: modulation of luteinizing hormone effects by prostaglandins
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Endocrine 22:249-56. 2003
    ..e., MMPs/TIMPs and angiogenic factors, as well as steroidogenesis. LH-stimulated PGs may have a regulatory role to modulate some effects of the LH surge, such as MMP/TIMP expression...
  12. ncbi Adipose differentiation-related protein: a gonadotropin- and prostaglandin-regulated protein in primate periovulatory follicles
    Carrie L Seachord
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Biol Reprod 72:1305-14. 2005
    ..Because ADRP facilitates arachidonic acid uptake in non-ovarian cells, ADRP-associated lipid droplets may enhance arachidonic acid uptake by granulosa cells to provide a precursor for periovulatory prostaglandin production...
  13. pmc Two pathways for prostaglandin F2 alpha synthesis by the primate periovulatory follicle
    Brandy L Dozier
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Lewis Hall, Norfolk, Virginia 23507, USA
    Reproduction 136:53-63. 2008
    ..Both of these enzyme activities are present in periovulatory granulosa cells. These data support the concept that follicular PGF2 alpha can be synthesized via two pathways during the periovulatory interval...
  14. pmc Prostaglandin E2 acts via multiple receptors to regulate plasminogen-dependent proteolysis in the primate periovulatory follicle
    Nune Markosyan
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Endocrinology 150:435-44. 2009
    ..PGE2 also increases tPA and PAI-1 protein levels in granulosa cells, suggesting that elevated PGE2 late in the periovulatory interval acts to stimulate proteolysis and follicle rupture...
  15. ncbi Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium
    Rafael A Cabrera
    The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Fertil Steril 86:1088-96. 2006
    ..To determine whether hCG regulates the expression of prostaglandin (PG) synthesis enzymes and the production of PGs by normal monkey ovarian surface epithelium (OSE)...
  16. ncbi Primate granulosa cell response via prostaglandin E2 receptors increases late in the periovulatory interval
    Nune Markosyan
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1980, USA
    Biol Reprod 75:868-76. 2006
    ....
  17. ncbi Molecular control of ovulation and luteinization in the primate follicle
    Richard L Stouffer
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci 12:297-307. 2007
    ....
  18. doi Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception
    Kim E Hester
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Hum Reprod 25:360-7. 2010
    ..This study was conducted to determine if a 5-day course of oral administration of the COX-2 inhibitor meloxicam can prevent ovulation while maintaining normal menstrual cycles in non-human primates...
  19. ncbi Ca2+-activated, large conductance K+ channel in the ovary: identification, characterization, and functional involvement in steroidogenesis
    Lars Kunz
    Anatomical Institute, University of Munich, D 80802 Munich, Germany
    J Clin Endocrinol Metab 87:5566-74. 2002
    ..We conclude that BK(Ca) channel activity in GCs is mediated by components of the intraovarian signaling system, thereby interlinking a systemic hormonal and a local neuroendocrine system in control of steroidogenesis...

Research Grants1

  1. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..