Affiliation: Eastern Virginia Medical School
Trau H, Davis J, Duffy D. Angiogenesis in the primate ovulatory follicle is stimulated by luteinizing hormone via prostaglandin E2. Biol Reprod. 2015;92:15 pubmed publisher
..While PTGER1 and PTGER2 likely promote the formation of new capillaries, each PGE2 receptor may mediate aspects of PGE2's actions and, therefore, LH's ability to regulate angiogenesis in the primate ovulatory follicle. ..
Kim S, Markosyan N, Pepe G, Duffy D. Estrogen promotes luteolysis by redistributing prostaglandin F2Î± receptors within primate luteal cells. Reproduction. 2015;149:453-64 pubmed publisher
..Estrogen receptor-mediated relocation of PTGFRs within luteal cells may be a necessary step in the initiation of luteolysis in primates. ..
Duffy D. Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway. Hum Reprod Update. 2015;21:652-70 pubmed publisher
..Therapies which target PGE2 may also impact disorders of the uterus and could also have benefits for women's health in addition to contraception. ..
Trau H, BrÃ¤nnstrÃ¶m M, Curry T, Duffy D. Prostaglandin E2 and vascular endothelial growth factor A mediate angiogenesis of human ovarian follicular endothelial cells. Hum Reprod. 2016;31:436-44 pubmed publisher
..This research was supported by grant funding from the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (HD071875 to D.M.D., T.E.C., M.B.). The authors have no conflicts of interest to disclose. ..
Kim S, Duffy D. Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal. Biol Reprod. 2016;95:33 pubmed publisher
..Understanding the role of each PTGER in ovulation may point to previously unappreciated opportunities to both promote and prevent fertility. ..
Duffy D. Growth differentiation factor-9 is expressed by the primate follicle throughout the periovulatory interval. Biol Reprod. 2003;69:725-32 pubmed
..However, GDF-9 expression and action differ between rodent and primate follicles, suggesting a possible regulatory role for GDF-9 that is unique to the primate follicle. ..
Duffy D, Seachord C, Dozier B. Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle. Hum Reprod. 2005;20:1485-92 pubmed publisher
Duffy D. Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins. Mol Cell Endocrinol. 2011;333:119-26 pubmed publisher
..Increased, then decreased PGDH activity may delay accumulation of prostaglandins in the follicle until late in the periovulatory interval, contributing to timely ovulation in primates. ..