Richard Drake

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. pmc Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease
    Richard R Drake
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Proteomics 72:907-17. 2009
  2. pmc Challenges to developing proteomic-based breast cancer diagnostics
    Richard R Drake
    Cancer Biology and Infectious Disease Research Center, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    OMICS 15:251-9. 2011
  3. pmc In-depth proteomic analyses of direct expressed prostatic secretions
    Richard R Drake
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23517, USA
    J Proteome Res 9:2109-16. 2010
  4. ncbi Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers
    Richard R Drake
    Eastern Virginia Medical School, Center for Biomedical Proteomics, Department of Microbiology and Molecular Cell Biology, Norfolk, VA 23507, USA
    Expert Rev Mol Diagn 5:93-100. 2005
  5. ncbi Proteomics for biodefense applications: progress and opportunities
    Richard R Drake
    Scientific Center for Biodefense, Center for Biomedical Proteomics, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Expert Rev Proteomics 2:203-13. 2005
  6. ncbi Differential capture of serum proteins for expression profiling and biomarker discovery in pre- and posttreatment head and neck cancer samples
    Gary L Freed
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, 700 W Olney Road, Norfolk, VA 23507, U S A
    Laryngoscope 118:61-8. 2008
  7. ncbi Identification of reproducible low mass SELDI protein profiles specific to cisplatin resistance in human ovarian cancer cells
    Richard A Britten
    Department of Radiation Oncology, 600 Gresham Drive, Norfolk, VA 23507, USA
    Oncol Rep 14:1323-30. 2005
  8. doi The identification of serum biomarkers of high-let radiation exposure and biological sequelae
    Richard A Britten
    Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Health Phys 98:196-203. 2010
  9. doi Proteomic expression profiling and identification of serum proteins using immobilized trypsin beads with MALDI-TOF/TOF
    Izabela D Karbassi
    George L Wright, Jr Center for Biomedical Proteomics, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Proteome Res 8:4182-92. 2009
  10. doi Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue
    Lisa H Cazares
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Clin Cancer Res 15:5541-51. 2009

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease
    Richard R Drake
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Proteomics 72:907-17. 2009
    ..Continued characterization of the prostate specific protein components of EPS urine combined with optimization of clinical collection procedures should facilitate discovery of new biomarkers for prostate cancer...
  2. pmc Challenges to developing proteomic-based breast cancer diagnostics
    Richard R Drake
    Cancer Biology and Infectious Disease Research Center, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    OMICS 15:251-9. 2011
    ..Based on these limitations, research strategies emphasizing identification of glycoprotein biomarkers in blood and MALDI mass spectrometry imaging of tissues are described...
  3. pmc In-depth proteomic analyses of direct expressed prostatic secretions
    Richard R Drake
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23517, USA
    J Proteome Res 9:2109-16. 2010
    ..To further streamline this process, the entire data set was deposited to the Tranche repository for use by other researchers...
  4. ncbi Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers
    Richard R Drake
    Eastern Virginia Medical School, Center for Biomedical Proteomics, Department of Microbiology and Molecular Cell Biology, Norfolk, VA 23507, USA
    Expert Rev Mol Diagn 5:93-100. 2005
    ..Issues related to assay reproducibility, management of large data sets and future improvements in clinical proteomics are also addressed...
  5. ncbi Proteomics for biodefense applications: progress and opportunities
    Richard R Drake
    Scientific Center for Biodefense, Center for Biomedical Proteomics, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Expert Rev Proteomics 2:203-13. 2005
    ..A translational proteomic research paradigm illustrating this approach using influenza virus as an example is discussed...
  6. ncbi Differential capture of serum proteins for expression profiling and biomarker discovery in pre- and posttreatment head and neck cancer samples
    Gary L Freed
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, 700 W Olney Road, Norfolk, VA 23507, U S A
    Laryngoscope 118:61-8. 2008
    ..We have previously demonstrated that protein expression profiling of serum can identify multiple protein biomarker events that can serve as molecular fingerprints for the assessment of HNSCC disease state and prognosis...
  7. ncbi Identification of reproducible low mass SELDI protein profiles specific to cisplatin resistance in human ovarian cancer cells
    Richard A Britten
    Department of Radiation Oncology, 600 Gresham Drive, Norfolk, VA 23507, USA
    Oncol Rep 14:1323-30. 2005
    ..These data suggest that SELDI-based proteomic profiling may be useful in monitoring the emergence of cisplatin-resistant tumor cell clones...
  8. doi The identification of serum biomarkers of high-let radiation exposure and biological sequelae
    Richard A Britten
    Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Health Phys 98:196-203. 2010
    ....
  9. doi Proteomic expression profiling and identification of serum proteins using immobilized trypsin beads with MALDI-TOF/TOF
    Izabela D Karbassi
    George L Wright, Jr Center for Biomedical Proteomics, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Proteome Res 8:4182-92. 2009
    ..A proof-of-concept pilot experiment using pooled human serum samples demonstrating reproducibility is presented, along with the sequence determination of selected tryptic peptides of serum proteins...
  10. doi Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue
    Lisa H Cazares
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Clin Cancer Res 15:5541-51. 2009
    ..Direct profiling of proteins from tissue using matrix-assisted laser desorption/ionization imaging mass spectrometry has the potential to supplement morphology with underlying molecular detail...
  11. ncbi Serum biomarkers to differentiate benign and malignant mammographic lesions
    Susanna Shin
    Department of Surgery, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Am Coll Surg 204:1065-71; discussion 1071-3. 2007
    ..Our objective was to determine if serum protein-expression profiles could be used to differentiate between benign and malignant mammographic lesions...
  12. ncbi Proteomic approach to breast cancer
    Christine Laronga
    Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Cancer Control 14:360-8. 2007
    ..Proteomics is a rapidly developing field that can explore the heterogeneity of breast cancer and supplement the wealth of information gained from genomics...
  13. doi Serum proteomic biomarker discovery reflective of stage and obesity in breast cancer patients
    Nicholas P Schaub
    Division of Surgical Oncology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Am Coll Surg 208:970-8; discussion 978-80. 2009
    ..The goals of this study were to use proteomic mass spectrometry approaches for profiling, fractionation, and identification of serum proteins from breast cancer patients for discovery of new biomarkers of stage and nodal status...
  14. doi Characterization of a Staphylococcus aureus USA300 protein signature using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Sarah R Boggs
    Division of Infectious Diseases, Children s Hospital of the King s Daughters, Norfolk, VA 23510, USA
    J Med Microbiol 61:640-4. 2012
    ..19 and negative likelihood ratio of 0.15. The three-peak intensity MALDI-TOF model designed and tested in the current study can be used to rapidly identify USA300 family S. aureus isolates with reasonable sensitivity and specificity...
  15. pmc Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids
    Krista Y White
    Department of Microbiology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Proteome Res 8:620-30. 2009
    ..The glycans identified in these studies will allow for more defined targeting of prostate disease-specific changes for PAP, PSA and other secreted prostatic glycoproteins...
  16. ncbi Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers
    Richard R Drake
    Center for Biomedical Proteomics, Virginia Prostate Center, and Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, 23507, USA
    Mol Cell Proteomics 5:1957-67. 2006
    ..Our example workflow incorporates the necessity of early validation in biomarker discovery using an immunoaffinity-based targeted analytical approach that integrates well with upstream discovery technologies...
  17. ncbi SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma
    E Ellen Schwegler
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA
    Hepatology 41:634-42. 2005
    ..In conclusion, SELDI-TOF MS serum profiling is able to distinguish HCC from liver disease before cirrhosis as well as cirrhosis, especially in patients with HCV infection compared with other etiologies...
  18. ncbi Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancer
    Stephen Becker
    Department of Surgery, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 610, Norfolk, VA 23507, USA
    Ann Surg Oncol 11:907-14. 2004
    ..Our objective was to distinguish women with BRCA-1 mutations who developed breast cancer (BRCA-1 Ca) from those who did not (Carrier), normal volunteers (NL), and women with sporadic breast cancer (SBC), using SELDI-TOF...
  19. pmc SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers
    Christine Laronga
    Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia and the Virginia Prostate Center, Norfolk, VA, USA
    Dis Markers 19:229-38. 2003
    ..These initial results indicate the utility of protein profiling approaches for developing new diagnostic and prognostic assays for breast cancers...
  20. pmc Precision enhancement of MALDI-TOF MS using high resolution peak detection and label-free alignment
    Maureen B Tracy
    William and Mary Research Institute, College of William and Mary, Williamsburg, VA, USA
    Proteomics 8:1530-8. 2008
    ..We show that the CV for m/z is 0.01% (100 ppm) for 12 out of the 13 peaks that were observed in all datasets between 2995 and 9297 Da...
  21. ncbi Resampling and deconvolution of linear time-of-flight records for enhanced protein profiling
    Dariya I Malyarenko
    Departments of Physics and Applied Science, College of William and Mary, Williamsburg, VA 23187 8795, USA
    Rapid Commun Mass Spectrom 20:1670-8. 2006
    ..This approach is particularly appropriate for automated data analysis and peak detection in dense TOF spectra...
  22. ncbi Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma
    Lajos Pusztai
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 100:1814-22. 2004
    ..The authors also compared the plasma profiles of patients with cancer with the plasma profiles of healthy women to identify breast carcinoma-associated protein markers...

Research Grants7

  1. ENGINEERED THYMIDINE KINASES FOR CANCER GENE THERAPY
    Richard Drake; Fiscal Year: 2002
    ..abstract_text> ..
  2. Proteomic Profiling for Influenza Vaccination/Infection
    Richard Drake; Fiscal Year: 2006
    ..These studies could lead to the development of crucial new paradigms for detection, diagnosis and vaccination strategies necessary to increase our national biodefense preparedness against viral pathogens. ..
  3. Glycan Biomarkers of Prostate Cancer in Prostatic Fluids
    Richard R Drake; Fiscal Year: 2010
    ..Identification of these molecular markers will improve prostate cancer detection and risk stratification prior to biopsy and prostatectomy procedures. ..