Anca Dana Dobrian

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. pmc Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice
    A D Dobrian
    Dept of Physiological Sciences, Eastern Virginia Medical School, Norfolk, USA
    Am J Physiol Endocrinol Metab 300:E410-21. 2011
  2. pmc A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School Norfolk, VA, USA
    Front Endocrinol (Lausanne) 3:108. 2012
  3. doi ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Kidney Int 81:722-4. 2012
  4. pmc Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Biochem Biophys Res Commun 403:485-90. 2010
  5. pmc Functional and pathological roles of the 12- and 15-lipoxygenases
    Anca D Dobrian
    Eastern Virginia Medical School, Department of Physiological Sciences, Lewis Hall, Room 2027, 700 W Olney Road, Norfolk, VA 23507, United States
    Prog Lipid Res 50:115-31. 2011
  6. ncbi The complex role of PPARgamma in renal dysfunction in obesity: managing a Janus-faced receptor
    Anca Dana Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Road, Lewis Hall, Room 2027, Norfolk, VA 23507, USA
    Vascul Pharmacol 45:36-45. 2006
  7. ncbi Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Rd, Norfolk, VA 23507, USA
    Hypertension 43:48-56. 2004
  8. ncbi Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Rd, Norfolk, VA 23507, USA
    Am J Physiol Renal Physiol 285:F619-28. 2003
  9. ncbi Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension
    A D Dobrian
    Eastern Virginia Medical School, Department of Physiological Sciences, Norfolk 23507, USA
    Hypertension 38:361-6. 2001
  10. ncbi Oxidative stress in a rat model of obesity-induced hypertension
    A D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
    Hypertension 37:554-60. 2001

Detail Information

Publications12

  1. pmc Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice
    A D Dobrian
    Dept of Physiological Sciences, Eastern Virginia Medical School, Norfolk, USA
    Am J Physiol Endocrinol Metab 300:E410-21. 2011
    ..2-fold), IL-12(p35) (5-fold, P < 0.01), and IP-10 (2-fold). Collectively, the results indicate that sitagliptin has anti-inflammatory effects in adipose tissue and in pancreatic islets that accompany the insulinotropic effect...
  2. pmc A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School Norfolk, VA, USA
    Front Endocrinol (Lausanne) 3:108. 2012
    ....
  3. doi ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Kidney Int 81:722-4. 2012
    ....
  4. pmc Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Biochem Biophys Res Commun 403:485-90. 2010
    ..Our finding is identifying selective expression of ALOX15a in human om but not sc fat. This is a study showing a major inflammatory gene exclusively expressed in visceral fat in humans...
  5. pmc Functional and pathological roles of the 12- and 15-lipoxygenases
    Anca D Dobrian
    Eastern Virginia Medical School, Department of Physiological Sciences, Lewis Hall, Room 2027, 700 W Olney Road, Norfolk, VA 23507, United States
    Prog Lipid Res 50:115-31. 2011
    ..Selective inhibitors of the different lipoxygenase isoforms are an active area of investigation, and will be both an important research tool and a promising therapeutic target for treating a wide spectrum of human diseases...
  6. ncbi The complex role of PPARgamma in renal dysfunction in obesity: managing a Janus-faced receptor
    Anca Dana Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Road, Lewis Hall, Room 2027, Norfolk, VA 23507, USA
    Vascul Pharmacol 45:36-45. 2006
    ..The focus of this review is to present and critically discuss the recent findings on the roles of PPARgamma in the kidney in direct relation to renal function and renal injury in obesity and obesity-initiated diabetes...
  7. ncbi Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Rd, Norfolk, VA 23507, USA
    Hypertension 43:48-56. 2004
    ..Collectively, the results show that pioglitazone treatment prevented hypertension and renal oxidative stress both by reducing free-radical production and by increasing nitric oxide production/availability...
  8. ncbi Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Rd, Norfolk, VA 23507, USA
    Am J Physiol Renal Physiol 285:F619-28. 2003
    ..Also, the OP rats on high salt displayed adipocyte hypertrophy and increased leptin production...
  9. ncbi Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension
    A D Dobrian
    Eastern Virginia Medical School, Department of Physiological Sciences, Norfolk 23507, USA
    Hypertension 38:361-6. 2001
    ..This status in the oxidative balance seems to affect BP in the renal hypertensive rats...
  10. ncbi Oxidative stress in a rat model of obesity-induced hypertension
    A D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
    Hypertension 37:554-60. 2001
    ..44+/-0.02 in OR rats), suggesting a possible shift toward superoxide production by the enzyme. Collectively, the data show a decreased NO bioavailability in OP animals that is due in part to the increased oxidative stress...
  11. ncbi Development of hypertension in a rat model of diet-induced obesity
    A D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501 1980, USA
    Hypertension 35:1009-15. 2000
    ....
  12. ncbi Src tyrosine kinases and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries
    J P Wesselman
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, USA
    Hypertension 37:955-60. 2001
    ..The results suggest that pressure-induced c-fos expression in intact cannulated rat mesenteric small arteries may be mediated, at least in part, by src tyrosine kinases and ERK...