Stephen I Deutsch

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. ncbi request reprint NMDA receptors on the surface of cancer cells: target for chemotherapy?
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, United States Electronic address
    Biomed Pharmacother 68:493-6. 2014
  2. ncbi request reprint Clinical outcomes of mild isolated cerebral ventriculomegaly in the presence of other neurodevelopmental risk factors
    John D Ball
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 710, Norfolk, VA 23507 1912 USA
    J Ultrasound Med 32:1933-8. 2013
  3. pmc Targeting alpha-7 nicotinic neurotransmission in schizophrenia: a novel agonist strategy
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, United States Department of Psychiatry, Georgetown University School of Medicine, United States
    Schizophr Res 148:138-44. 2013
  4. doi request reprint Pharmacotherapeutic implications of the association between genomic instability at chromosome 15q13.3 and autism spectrum disorders
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1912, USA
    Clin Neuropharmacol 34:203-5. 2011
  5. doi request reprint D-cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old mice
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk Virginia, USA
    Brain Res 1439:96-107. 2012
  6. ncbi request reprint Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801's antiseizure potency in the genetically inbred Balb/c mouse
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
    Epilepsy Behav 21:352-5. 2011
  7. doi request reprint D-Cycloserine improves the impaired sociability of the Balb/c mouse
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
    Brain Res Bull 84:8-11. 2011
  8. ncbi request reprint Does subtle disturbance of neuronal migration contribute to schizophrenia and other neurodevelopmental disorders? Potential genetic mechanisms with possible treatment implications
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
    Eur Neuropsychopharmacol 20:281-7. 2010
  9. ncbi request reprint Cholinergic abnormalities in autism: is there a rationale for selective nicotinic agonist interventions?
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
    Clin Neuropharmacol 33:114-20. 2010
  10. ncbi request reprint Regulation of intermittent oscillatory activity of pyramidal cell neurons by GABA inhibitory interneurons is impaired in schizophrenia: rationale for pharmacotherapeutic GABAergic interventions
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1912, USA
    Isr J Psychiatry Relat Sci 47:17-26. 2010

Collaborators

  • Barbara L Schwartz
  • Nina R Schooler
  • Serina A Neumann
  • Jessica A Burket
  • Luis F Jacome
  • Amy L Herndon
  • Andrew D Benson
  • Amy H Tang
  • John D Ball
  • William R Cannon
  • John Mastropaolo
  • Richard B Rosse
  • Elionora Katz
  • Jessica Burket
  • Janelle L Mason
  • Alfred Z Abuhamad
  • Erin E Winebarger
  • Elionora U Katz

Detail Information

Publications21

  1. ncbi request reprint NMDA receptors on the surface of cancer cells: target for chemotherapy?
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, United States Electronic address
    Biomed Pharmacother 68:493-6. 2014
    ....
  2. ncbi request reprint Clinical outcomes of mild isolated cerebral ventriculomegaly in the presence of other neurodevelopmental risk factors
    John D Ball
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 710, Norfolk, VA 23507 1912 USA
    J Ultrasound Med 32:1933-8. 2013
    ..The purpose of this study was to evaluate neuropsychological test data in school-aged children whose fetal sonograms revealed mild isolated cerebral ventriculomegaly without asymmetry of the lateral ventricles...
  3. pmc Targeting alpha-7 nicotinic neurotransmission in schizophrenia: a novel agonist strategy
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, United States Department of Psychiatry, Georgetown University School of Medicine, United States
    Schizophr Res 148:138-44. 2013
    ..Further study of α7 nAChR agonist/PAMs is warranted in larger studies that will have greater power. ..
  4. doi request reprint Pharmacotherapeutic implications of the association between genomic instability at chromosome 15q13.3 and autism spectrum disorders
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1912, USA
    Clin Neuropharmacol 34:203-5. 2011
    ....
  5. doi request reprint D-cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old mice
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk Virginia, USA
    Brain Res 1439:96-107. 2012
    ..The data suggest that targeting the NMDA receptor can have promising therapeutic effects on two prominent domains of psychopathology in ASDs: impaired sociability and spontaneous stereotypic behaviors...
  6. ncbi request reprint Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801's antiseizure potency in the genetically inbred Balb/c mouse
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
    Epilepsy Behav 21:352-5. 2011
    ..Thus, mGluR5 could serve as a target for strategies for adjuvant treatment of seizures exacerbated by stress...
  7. doi request reprint D-Cycloserine improves the impaired sociability of the Balb/c mouse
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
    Brain Res Bull 84:8-11. 2011
    ....
  8. ncbi request reprint Does subtle disturbance of neuronal migration contribute to schizophrenia and other neurodevelopmental disorders? Potential genetic mechanisms with possible treatment implications
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
    Eur Neuropsychopharmacol 20:281-7. 2010
    ..Importantly, in the fully-developed brain, there is a possibility that at least some of the consequences of these disturbed genetic pathways that adversely affect microtubule function may be "bypassed" or mitigated...
  9. ncbi request reprint Cholinergic abnormalities in autism: is there a rationale for selective nicotinic agonist interventions?
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
    Clin Neuropharmacol 33:114-20. 2010
    ....
  10. ncbi request reprint Regulation of intermittent oscillatory activity of pyramidal cell neurons by GABA inhibitory interneurons is impaired in schizophrenia: rationale for pharmacotherapeutic GABAergic interventions
    Stephen I Deutsch
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1912, USA
    Isr J Psychiatry Relat Sci 47:17-26. 2010
    ..A major research question is whether tonically-administered, selective GABAergic therapeutic interventions can mimic and correct disruptions of the intermittent oscillatory activity of assemblies of cortical pyramidal cell neurons...
  11. doi request reprint Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disorders
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
    Brain Res Bull 86:152-8. 2011
    ....
  12. doi request reprint D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Brain Res Bull 96:62-70. 2013
    ....
  13. doi request reprint D-Cycloserine enhances social exploration in the Balb/c mouse
    Luis F Jacome
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 710, Norfolk, VA 23507 1912, United States
    Brain Res Bull 85:141-4. 2011
    ..Further, the sociability deficit of the Balb/c mouse is not an epiphenomenon of increased generalized anxiety...
  14. doi request reprint D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain
    Luis F Jacome
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
    Brain Res Bull 84:12-6. 2011
    ..The data suggest that dimensions of the impaired sociability of the Balb/c mouse strain may be improved by targeted NMDA receptor agonist interventions...
  15. doi request reprint Locomotor activity of the genetically inbred Balb/c mouse strain is suppressed by a socially salient stimulus
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
    Brain Res Bull 83:255-6. 2010
    ..Reduced locomotor activity in the presence of a stimulus mouse is a sensitive behavioral outcome measure of impaired sociability...
  16. ncbi request reprint Balb/c mice treated with D-cycloserine arouse increased social interest in conspecifics
    Andrew D Benson
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, United States
    Brain Res Bull 99:95-9. 2013
    ..The results showed that B6 mice prefer D-cycloserine-treated Balb/c mice to vehicle-treated Balb/c mice, suggesting that treatment could have resulted in normalization of "emitted" social cues...
  17. doi request reprint Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders
    Luis F Jacome
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
    Autism Res 4:393-400. 2011
    ....
  18. doi request reprint MK-801, a noncompetitive NMDA receptor antagonist, elicits circling behavior in the genetically inbred Balb/c mouse strain
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
    Brain Res Bull 83:337-9. 2010
    ....
  19. doi request reprint NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 710, Norfolk, Virginia 23507 1912, United States
    Eur Neuropsychopharmacol 20:207-10. 2010
    ..Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100mg/kg, but was not able to elicit popping behavior at this dose...
  20. doi request reprint Genetically inbred Balb/C mice are more sensitive to an effect of flurazepam and more resistant to an effect of stress than a genetically outbred mouse strain
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Epilepsy Behav 16:415-7. 2009
    ....
  21. ncbi request reprint Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders
    Jessica A Burket
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
    Brain Res Bull 100:70-5. 2014
    ..Interestingly, there was no effect of rapamycin on stereotypic behaviors in this mouse model. ..