Research Topics
| Stephen I DeutschSummaryAffiliation: Eastern Virginia Medical School Country: USA Publications
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Detail Information
Publications
Pharmacotherapeutic implications of the association between genomic instability at chromosome 15q13.3 and autism spectrum disordersStephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1912, USA
Clin Neuropharmacol 34:203-5. 2011....- D-cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old miceStephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk Virginia, USA
Brain Res 1439:96-107. 2012..The data suggest that targeting the NMDA receptor can have promising therapeutic effects on two prominent domains of psychopathology in ASDs: impaired sociability and spontaneous stereotypic behaviors... - Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801's antiseizure potency in the genetically inbred Balb/c mouseStephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
Epilepsy Behav 21:352-5. 2011..Thus, mGluR5 could serve as a target for strategies for adjuvant treatment of seizures exacerbated by stress... - D-Cycloserine improves the impaired sociability of the Balb/c mouseStephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
Brain Res Bull 84:8-11. 2011.... 
Regulation of intermittent oscillatory activity of pyramidal cell neurons by GABA inhibitory interneurons is impaired in schizophrenia: rationale for pharmacotherapeutic GABAergic interventionsStephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507 1912, USA
Isr J Psychiatry Relat Sci 47:17-26. 2010..A major research question is whether tonically-administered, selective GABAergic therapeutic interventions can mimic and correct disruptions of the intermittent oscillatory activity of assemblies of cortical pyramidal cell neurons...- Cholinergic abnormalities in autism: is there a rationale for selective nicotinic agonist interventions?Stephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
Clin Neuropharmacol 33:114-20. 2010.... - Does subtle disturbance of neuronal migration contribute to schizophrenia and other neurodevelopmental disorders? Potential genetic mechanisms with possible treatment implicationsStephen I Deutsch
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
Eur Neuropsychopharmacol 20:281-7. 2010..Importantly, in the fully-developed brain, there is a possibility that at least some of the consequences of these disturbed genetic pathways that adversely affect microtubule function may be "bypassed" or mitigated... - Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disordersJessica A Burket
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
Brain Res Bull 86:152-8. 2011.... - Locomotor activity of the genetically inbred Balb/c mouse strain is suppressed by a socially salient stimulusJessica A Burket
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
Brain Res Bull 83:255-6. 2010..Reduced locomotor activity in the presence of a stimulus mouse is a sensitive behavioral outcome measure of impaired sociability... - D-Cycloserine enhances social exploration in the Balb/c mouseLuis F Jacome
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 710, Norfolk, VA 23507 1912, United States
Brain Res Bull 85:141-4. 2011..Further, the sociability deficit of the Balb/c mouse is not an epiphenomenon of increased generalized anxiety... - D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strainLuis F Jacome
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
Brain Res Bull 84:12-6. 2011..The data suggest that dimensions of the impaired sociability of the Balb/c mouse strain may be improved by targeted NMDA receptor agonist interventions... - Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disordersLuis F Jacome
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, USA
Autism Res 4:393-400. 2011.... - MK-801, a noncompetitive NMDA receptor antagonist, elicits circling behavior in the genetically inbred Balb/c mouse strainJessica A Burket
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507 1912, United States
Brain Res Bull 83:337-9. 2010.... - NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in miceJessica A Burket
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 710, Norfolk, Virginia 23507 1912, United States
Eur Neuropsychopharmacol 20:207-10. 2010..Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100mg/kg, but was not able to elicit popping behavior at this dose... - Genetically inbred Balb/C mice are more sensitive to an effect of flurazepam and more resistant to an effect of stress than a genetically outbred mouse strainJessica A Burket
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Epilepsy Behav 16:415-7. 2009....