Research Topics
Genomes and Genes | Yue ZouSummaryAffiliation: East Tennessee State University Country: USA Publications
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Publications
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responsesYue Zou
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
J Cell Physiol 208:267-73. 2006....- Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nucleaseYue Zou
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 42:12654-61. 2003..We therefore propose that these effects relate to the initial step of damage recognition of DNA structural distortion. The structure-function relationships in the recognition of the DNA lesions, based on our results, have been discussed... - DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repairYue Zou
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 43:4196-205. 2004..Our results suggest that Y92 may function differently with these two types of adducts, while the Y95 residue plays an unique role in stabilizing the interaction of UvrB with DNA damage, most likely by a hydrophobic stacking... - Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiationXiaoming Wu
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Cancer Res 66:2997-3005. 2006.... - Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain BYiyong Liu
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
J Biol Chem 280:32775-83. 2005.... - Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group ASteven M Shell
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
J Biol Chem 284:24213-22. 2009..Taken together, our results suggest that the ATR-XPA interaction mediated by the helix-turn-helix motif of XPA plays an important role in DNA-damage responses to promote cell survival and genomic stability after UV irradiation... - Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branchesZhengguan Yang
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 45:15921-30. 2006..Since ds-ssDNA junctions are common intermediates in many DNA metabolic pathways, the additional potential role of XPA in cellular processes is discussed... - Cooperative interaction of human XPA stabilizes and enhances specific binding of XPA to DNA damageYu Liu
Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 44:7361-8. 2005..We hypothesized that the concentration-dependent formation of different types of XPA-damaged DNA complex may play a role in cellular regulation of XPA activity... - XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phaseZhengke Li
Department of Biochemistry and Molecular Biology, East Tennessee State University, JH Quillen College of Medicine, Johnson City, Tennessee, United States of America
PLoS ONE 6:e28326. 2011..In contrast, the nuclear import of XPA in G(1) or G(2) phase appears to be largely independent of DNA damage and p53... - Interactions of human replication protein A with single-stranded DNA adductsYiyong Liu
Department of Biochemistry and Molecular Biology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Biochem J 385:519-26. 2005..For RPA interaction with short damaged ssDNA, we propose that, on RPA binding, the modified base of ssDNA is looped out from the surface of the protein, permitting proper contacts of RPA with the remaining unmodified bases... - Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin AYiyong Liu
East Tennessee State University, James H Quillen College of Medicine, Department of Biochemistry and Molecular Biology, Johnson City, TN 37614, USA
FASEB J 22:603-11. 2008..We propose that the uncharacteristic localization of XPA to or near DSBs inhibits DSB repair, thereby contributing to the premature aging phenotypes observed in progeria arising from genetic defects in prelamin A maturation... - Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular rulerLifeng Cai
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 46:8226-33. 2007..On the basis of these geometric constraints, a global structure model for the binding of the major RPA DBDs to ssDNA was proposed... 
Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nucleaseZhengguan Yang
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37604, USA
Chem Res Toxicol 18:1339-46. 2005..Our result suggests that G[8,5-Me]T intrastrand cross-link is more resistant to excision repair in comparison with the T[6,4]T and AAF adducts and thus will likely persist longer in E. coli cells...- Thermodynamic characterization of the interaction of mutant UvrB protein with damaged DNAHuaxian Ma
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 43:4206-11. 2004..5 ion pairs were involved in formation of the UvrB-DNA complex. Together, these results suggested that hydrophobic interactions are the main driving forces for the recognition of DNA damage by UvrB protein... - Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damageXiaoming Wu
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Biochem J 391:473-80. 2005..Our results suggest that hyperphosphorylated RPA is preferentially localized to DSB repair and the DNA damage checkpoint complexes in response to DNA damage... - DNA damage responses in progeroid syndromes arise from defective maturation of prelamin AYiyong Liu
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
J Cell Sci 119:4644-9. 2006..Since DNA damage accumulation is an important contributor to the symptoms of HGPS, our results call into question the possibility of treatment of HGPS with FTIs alone... - Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cellsXiaoming Wu
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Oncogene 24:4728-35. 2005..Taken together, our results suggest that 9-1-1 and RPA complexes collaboratively function in DNA damage responses, and that the RPA may serve as a regulator for the activity of 9-1-1 complex in the cellular checkpoint network... - Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNASteven M Shell
Department of Biochemistry and Molecular Biology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 44:971-8. 2005..In addition, two lysines, K183 and K259, are positioned outside the putative ssDNA binding cleft. We propose that the protection of these lysines could result from the RPA interdomain structural reorganization induced by ssDNA binding... - Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin APhillip R Musich
Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
Aging (Albany NY) 1:28-37. 2009.... - Dimerization of human XPA and formation of XPA2-RPA protein complexZheng guan Yang
Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Biochemistry 41:13012-20. 2002..Taken together, our data suggest that the dimerization of XPA may play an important role in the DNA damage recognition of nucleotide excision repair... 
DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndromePhillip R Musich
Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
Biochem Soc Trans 39:1764-9. 2011....- Replication factor C1, the large subunit of replication factor C, is proteolytically truncated in Hutchinson-Gilford progeria syndromeHui Tang
Department of Biochemistry and Molecular Biology, JH Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Aging Cell 11:363-5. 2012..Furthermore, this unique truncated form of RFC1 may serve as a potential marker for HGPS... - A quantitative analysis of secondary RNA structure using domination based parameters on treesTeresa Haynes
Mathematics and Statistics Department, East Tennessee State University, Box 70663, Johnson City, TN, USA
BMC Bioinformatics 7:108. 2006.... - Replication-mediated disassociation of replication protein A-XPA complex upon DNA damage: implications for RPA handing offGaofeng Jiang
Faculty of Preventive Medicine, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei 430065, People s Republic of China
Cell Biol Int 36:713-20. 2012..The biological significances of RPA-XPA complex disruption in relation with checkpoint activation, DSB repair and RPA hyperphosphorylation are discussed... - Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequenceVipin Jain
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
Nucleic Acids Res 40:3939-51. 2012..The present results provide valuable conformational insight into the sequence-dependent UvrABC incisions of the bulky aminofluorene DNA adducts... - Spectroscopic and theoretical insights into sequence effects of aminofluorene-induced conformational heterogeneity and nucleotide excision repairSrinivasa Rao Meneni
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, Rhode Island 02881, USA
Biochemistry 46:11263-78. 2007..The results indicate a novel structure-function relationship, which provides insights into how bulky DNA adducts are accommodated by UvrABC proteins... - Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteinsQian Ruan
Chemistry Department, New York University, 31 Washington Place, New York, New York 10003 5180, USA
Biochemistry 46:7006-15. 2007..The local weakening of base pairing interactions constitutes a recognition element of the UvrABC nucleotide excision repair apparatus... - Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterflyMasanobu Kawanishi
Environmental Genetics Laboratory, Frontier Science Innovation Center, Osaka Prefecture University, 1 2 Gakuen cho, Sakai, Osaka 599 8570, Japan
Chem Res Toxicol 20:694-700. 2007..More mutations were induced in the plasmid propagated in NER-deficient cells than that in wild-type human cells. These results indicate the involvement of the NER system in the repair of N2-ADPR-dG in both E. coli and human cells... - Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nucleaseChunang Gu
Environmental Toxicology Graduate Program, University of California, Riverside, California 92521 0403, USA
Biochemistry 45:10739-46. 2006..Taken together, the results from this study suggest that oxidative intrastrand lesions might be substrates for NER enzymes in vivo... - Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guaninesAgnieszka Kowalczyk
Chemistry Department and Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA
Biochemistry 41:3109-18. 2002..e., the efficiency of incision was 2-carbon >> 3-carbon > 4-carbon... - Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repairIrina G Minko
Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555, USA
Proc Natl Acad Sci U S A 99:1905-9. 2002.... - Redox-dependent formation of disulfide bonds in human replication protein ALijie Men
Department of Chemistry 027, University of California, Riverside, CA 92521 0403, USA
Rapid Commun Mass Spectrom 21:2743-9. 2007..Moreover, the other 11 cysteines in this protein remained intact. The results demonstrated that the formation of disulfide bonds at the zinc-finger site was responsible for the redox regulation of the DNA-binding activity of RPA... - Conformation-specific recognition of carcinogen-DNA adduct in escherichia coli nucleotide excision repairSrinivasarao Meneni
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, Rhode Island 02881, USA
Chem Res Toxicol 20:6-10. 2007....
Research Grants
- Checkpoint Signaling and Repair of UV Damage to Human DNAYue Zou; Fiscal Year: 2009....
- Checkpoint Signaling and Repair of UV Damage to Human DNAYue Zou; Fiscal Year: 2007..abstract_text> ..
- RECOGNITION AND REPAIR OF UV DAMAGE TO HUMAN DNAYue Zou; Fiscal Year: 2004....
- Checkpoint Signaling and Repair of UV Damage to Human DNAYue Zou; Fiscal Year: 2010....