Yue Zou

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. pmc Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
    Yue Zou
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Cell Physiol 208:267-73. 2006
  2. pmc Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease
    Yue Zou
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 42:12654-61. 2003
  3. pmc DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair
    Yue Zou
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 43:4196-205. 2004
  4. pmc Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation
    Xiaoming Wu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Cancer Res 66:2997-3005. 2006
  5. pmc Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B
    Yiyong Liu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 280:32775-83. 2005
  6. pmc Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A
    Steven M Shell
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 284:24213-22. 2009
  7. pmc Cooperative interaction of human XPA stabilizes and enhances specific binding of XPA to DNA damage
    Yu Liu
    Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 44:7361-8. 2005
  8. pmc Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches
    Zhengguan Yang
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 45:15921-30. 2006
  9. pmc XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase
    Zhengke Li
    Department of Biochemistry and Molecular Biology, East Tennessee State University, JH Quillen College of Medicine, Johnson City, Tennessee, United States of America
    PLoS ONE 6:e28326. 2011
  10. pmc Interactions of human replication protein A with single-stranded DNA adducts
    Yiyong Liu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem J 385:519-26. 2005

Collaborators

  • Ying Xu
  • Yu Liu
  • Yan Wang
  • Meng Yang Zhu
  • Jia Zhang
  • Hui Wang
  • Hui Tang
  • Gaofeng Jiang
  • Teresa Haynes
  • Michael Sinensky
  • R Stephen Lloyd
  • Ji Liu
  • Nicholas Geacintov
  • Masahiko Watanabe
  • Isao Kuraoka
  • Takashi Sugimura
  • Phillip R Musich
  • Steven M Shell
  • Zhengguan Yang
  • Zhengke Li
  • Xiaoming Wu
  • Bongsup P Cho
  • Marina Roginskaya
  • Vipin Jain
  • Moises A Serrano
  • M Paul Chiarelli
  • Lijie Men
  • Qian Ruan
  • Mamuka Kvaratskhelia
  • Masanobu Kawanishi
  • Srinivasa Rao Meneni
  • Srinivasarao Meneni
  • Lifeng Cai
  • Chunang Gu
  • Laureen C Colis
  • Ashis K Basu
  • Bennett Van Houten
  • Thomas M Harris
  • Constance M Harris
  • Huaxian Ma
  • Zheng guan Yang
  • Irina G Minko
  • Agnieszka Kowalczyk
  • Brian M Cartwright
  • Benjamin Hilton
  • Satyakam Patnaik
  • Zhiping Dong
  • Chris Brosey
  • Nikolozi Shkriabai
  • Walter J Chazin
  • Brijesh Malkani
  • Lan Gao
  • Takeji Takamura-Enya
  • Keiji Wakabayashi
  • Kiyoji Tanaka
  • Jian Ren
  • Shantu Amin
  • Jiri Sponer
  • Alexander Kolbanovskiy
  • Youxing Qu
  • Tongming Liu
  • Yukari Totsuka
  • Takashi Yagi
  • Yasuko Matsumoto
  • Wang Lee
  • Kazuki Matsukawa
  • Milan Skorvaga
  • Joshua Lader
  • Petr Jurecka
  • Qibin Zhang
  • Sonja Hess
  • J Russ Carmical
  • Leslie Y Mao

Detail Information

Publications35

  1. pmc Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
    Yue Zou
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Cell Physiol 208:267-73. 2006
    ....
  2. pmc Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease
    Yue Zou
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 42:12654-61. 2003
    ..We therefore propose that these effects relate to the initial step of damage recognition of DNA structural distortion. The structure-function relationships in the recognition of the DNA lesions, based on our results, have been discussed...
  3. pmc DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair
    Yue Zou
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 43:4196-205. 2004
    ..Our results suggest that Y92 may function differently with these two types of adducts, while the Y95 residue plays an unique role in stabilizing the interaction of UvrB with DNA damage, most likely by a hydrophobic stacking...
  4. pmc Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation
    Xiaoming Wu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Cancer Res 66:2997-3005. 2006
    ....
  5. pmc Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B
    Yiyong Liu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 280:32775-83. 2005
    ....
  6. pmc Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A
    Steven M Shell
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 284:24213-22. 2009
    ..Taken together, our results suggest that the ATR-XPA interaction mediated by the helix-turn-helix motif of XPA plays an important role in DNA-damage responses to promote cell survival and genomic stability after UV irradiation...
  7. pmc Cooperative interaction of human XPA stabilizes and enhances specific binding of XPA to DNA damage
    Yu Liu
    Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 44:7361-8. 2005
    ..We hypothesized that the concentration-dependent formation of different types of XPA-damaged DNA complex may play a role in cellular regulation of XPA activity...
  8. pmc Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches
    Zhengguan Yang
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 45:15921-30. 2006
    ..Since ds-ssDNA junctions are common intermediates in many DNA metabolic pathways, the additional potential role of XPA in cellular processes is discussed...
  9. pmc XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase
    Zhengke Li
    Department of Biochemistry and Molecular Biology, East Tennessee State University, JH Quillen College of Medicine, Johnson City, Tennessee, United States of America
    PLoS ONE 6:e28326. 2011
    ..In contrast, the nuclear import of XPA in G(1) or G(2) phase appears to be largely independent of DNA damage and p53...
  10. pmc Interactions of human replication protein A with single-stranded DNA adducts
    Yiyong Liu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem J 385:519-26. 2005
    ..For RPA interaction with short damaged ssDNA, we propose that, on RPA binding, the modified base of ssDNA is looped out from the surface of the protein, permitting proper contacts of RPA with the remaining unmodified bases...
  11. pmc Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A
    Yiyong Liu
    East Tennessee State University, James H Quillen College of Medicine, Department of Biochemistry and Molecular Biology, Johnson City, TN 37614, USA
    FASEB J 22:603-11. 2008
    ..We propose that the uncharacteristic localization of XPA to or near DSBs inhibits DSB repair, thereby contributing to the premature aging phenotypes observed in progeria arising from genetic defects in prelamin A maturation...
  12. pmc Thermodynamic characterization of the interaction of mutant UvrB protein with damaged DNA
    Huaxian Ma
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 43:4206-11. 2004
    ..5 ion pairs were involved in formation of the UvrB-DNA complex. Together, these results suggested that hydrophobic interactions are the main driving forces for the recognition of DNA damage by UvrB protein...
  13. ncbi request reprint Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease
    Zhengguan Yang
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37604, USA
    Chem Res Toxicol 18:1339-46. 2005
    ..Our result suggests that G[8,5-Me]T intrastrand cross-link is more resistant to excision repair in comparison with the T[6,4]T and AAF adducts and thus will likely persist longer in E. coli cells...
  14. pmc Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular ruler
    Lifeng Cai
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 46:8226-33. 2007
    ..On the basis of these geometric constraints, a global structure model for the binding of the major RPA DBDs to ssDNA was proposed...
  15. pmc Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage
    Xiaoming Wu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem J 391:473-80. 2005
    ..Our results suggest that hyperphosphorylated RPA is preferentially localized to DSB repair and the DNA damage checkpoint complexes in response to DNA damage...
  16. pmc DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
    Yiyong Liu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Cell Sci 119:4644-9. 2006
    ..Since DNA damage accumulation is an important contributor to the symptoms of HGPS, our results call into question the possibility of treatment of HGPS with FTIs alone...
  17. pmc Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
    Xiaoming Wu
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Oncogene 24:4728-35. 2005
    ..Taken together, our results suggest that 9-1-1 and RPA complexes collaboratively function in DNA damage responses, and that the RPA may serve as a regulator for the activity of 9-1-1 complex in the cellular checkpoint network...
  18. pmc Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A
    Phillip R Musich
    Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
    Aging (Albany NY) 1:28-37. 2009
    ....
  19. pmc Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA
    Steven M Shell
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 44:971-8. 2005
    ..In addition, two lysines, K183 and K259, are positioned outside the putative ssDNA binding cleft. We propose that the protection of these lysines could result from the RPA interdomain structural reorganization induced by ssDNA binding...
  20. pmc Dimerization of human XPA and formation of XPA2-RPA protein complex
    Zheng guan Yang
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Biochemistry 41:13012-20. 2002
    ..Taken together, our data suggest that the dimerization of XPA may play an important role in the DNA damage recognition of nucleotide excision repair...
  21. doi request reprint DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome
    Phillip R Musich
    Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
    Biochem Soc Trans 39:1764-9. 2011
    ....
  22. pmc Effects of DSP4 on the Noradrenergic Phenotypes and Its Potential Molecular Mechanisms in SH-SY5Y Cells
    Yan Wang
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37604, USA
    Neurotox Res 25:193-207. 2014
    ..These action mechanisms of DSP4 may account for its degenerative consequence after systematic administration for animal models. ..
  23. pmc UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner
    Zhengke Li
    Department of Biomedical Sciences, East Tennessee State University, J H Quillen College of Medicine, Johnson City, Tennessee, USA
    PLoS ONE 8:e68297. 2013
    ..In addition, these findings reveal a potential new therapeutic target for the sensitization of cancer cells to chemotherapy. ..
  24. pmc Replication factor C1, the large subunit of replication factor C, is proteolytically truncated in Hutchinson-Gilford progeria syndrome
    Hui Tang
    Department of Biochemistry and Molecular Biology, JH Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Aging Cell 11:363-5. 2012
    ..Furthermore, this unique truncated form of RFC1 may serve as a potential marker for HGPS...
  25. pmc A quantitative analysis of secondary RNA structure using domination based parameters on trees
    Teresa Haynes
    Mathematics and Statistics Department, East Tennessee State University, Box 70663, Johnson City, TN, USA
    BMC Bioinformatics 7:108. 2006
    ....
  26. doi request reprint Replication-mediated disassociation of replication protein A-XPA complex upon DNA damage: implications for RPA handing off
    Gaofeng Jiang
    Faculty of Preventive Medicine, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei 430065, People s Republic of China
    Cell Biol Int 36:713-20. 2012
    ..The biological significances of RPA-XPA complex disruption in relation with checkpoint activation, DSB repair and RPA hyperphosphorylation are discussed...
  27. pmc Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequence
    Vipin Jain
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Nucleic Acids Res 40:3939-51. 2012
    ..The present results provide valuable conformational insight into the sequence-dependent UvrABC incisions of the bulky aminofluorene DNA adducts...
  28. ncbi request reprint Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines
    Agnieszka Kowalczyk
    Chemistry Department and Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biochemistry 41:3109-18. 2002
    ..e., the efficiency of incision was 2-carbon >> 3-carbon > 4-carbon...
  29. ncbi request reprint Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins
    Qian Ruan
    Chemistry Department, New York University, 31 Washington Place, New York, New York 10003 5180, USA
    Biochemistry 46:7006-15. 2007
    ..The local weakening of base pairing interactions constitutes a recognition element of the UvrABC nucleotide excision repair apparatus...
  30. pmc Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nuclease
    Chunang Gu
    Environmental Toxicology Graduate Program, University of California, Riverside, California 92521 0403, USA
    Biochemistry 45:10739-46. 2006
    ..Taken together, the results from this study suggest that oxidative intrastrand lesions might be substrates for NER enzymes in vivo...
  31. ncbi request reprint Spectroscopic and theoretical insights into sequence effects of aminofluorene-induced conformational heterogeneity and nucleotide excision repair
    Srinivasa Rao Meneni
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, Rhode Island 02881, USA
    Biochemistry 46:11263-78. 2007
    ..The results indicate a novel structure-function relationship, which provides insights into how bulky DNA adducts are accommodated by UvrABC proteins...
  32. ncbi request reprint Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly
    Masanobu Kawanishi
    Environmental Genetics Laboratory, Frontier Science Innovation Center, Osaka Prefecture University, 1 2 Gakuen cho, Sakai, Osaka 599 8570, Japan
    Chem Res Toxicol 20:694-700. 2007
    ..More mutations were induced in the plasmid propagated in NER-deficient cells than that in wild-type human cells. These results indicate the involvement of the NER system in the repair of N2-ADPR-dG in both E. coli and human cells...
  33. pmc Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair
    Irina G Minko
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 99:1905-9. 2002
    ....
  34. ncbi request reprint Conformation-specific recognition of carcinogen-DNA adduct in escherichia coli nucleotide excision repair
    Srinivasarao Meneni
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, Rhode Island 02881, USA
    Chem Res Toxicol 20:6-10. 2007
    ....
  35. ncbi request reprint Redox-dependent formation of disulfide bonds in human replication protein A
    Lijie Men
    Department of Chemistry 027, University of California, Riverside, CA 92521 0403, USA
    Rapid Commun Mass Spectrom 21:2743-9. 2007
    ..Moreover, the other 11 cysteines in this protein remained intact. The results demonstrated that the formation of disulfide bonds at the zinc-finger site was responsible for the redox regulation of the DNA-binding activity of RPA...

Research Grants10