Zhi Q Yao

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. pmc Immune exhaustion and immune senescence: two distinct pathways for HBV vaccine failure during HCV and/or HIV infection
    Zhi Q Yao
    Department of Veterans Affairs, Hepatitis HCV HBV HIV Program, James H Quillen VA Medical Center, Johnson City, TN 37614, USA
    Arch Immunol Ther Exp (Warsz) 61:193-201. 2013
  2. doi request reprint Differential regulation of T and B lymphocytes by PD-1 and SOCS-1 signaling in hepatitis C virus-associated non-Hodgkin's lymphoma
    Zhi Q Yao
    Medical Service, James H Quillen VA Medical Center, Johnson City, TN, 37684, USA
    Immunol Invest 40:243-64. 2011
  3. pmc Impaired hepatitis B vaccine responses during chronic hepatitis C infection: involvement of the PD-1 pathway in regulating CD4(+) T cell responses
    Jonathan P Moorman
    Medical Service, Department of Veterans Affairs, James H Quillen VA Medical Center, Johnson City, TN 37614, USA
    Vaccine 29:3169-76. 2011
  4. doi request reprint Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
    Ying Zhang
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 186:3093-103. 2011
  5. pmc Programmed death-1 affects suppressor of cytokine signaling-1 expression in T cells during hepatitis C infection
    Ashley D Frazier
    Medical Service, Department of Veterans Affairs, James H Quillen Veterans Administration Medical Center, Mountain Home, Tennessee, USA
    Viral Immunol 23:487-95. 2010
  6. pmc PD-1 modulates regulatory T cells and suppresses T-cell responses in HCV-associated lymphoma
    Lei Ni
    Division of Infectious Diseases, Department of Internal Medicine, East Tennessee State University College of Medicine, Box 70622, Johnson City, TN 37614, USA
    Immunol Cell Biol 89:535-9. 2011
  7. pmc PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection
    Cheng J Ma
    Division of Infectious Diseases, Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Immunology 132:421-31. 2011
  8. pmc Differential regulation of interleukin-12 (IL-12)/IL-23 by Tim-3 drives T(H)17 cell development during hepatitis C virus infection
    Jia M Wang
    Hepatitis HCV HIV Program, James H Quillen VA Medical Center, Department of Veterans Affairs, Johnson City, Tennessee, USA
    J Virol 87:4372-83. 2013
  9. pmc HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway
    Xiao J Ji
    Department of Internal Medicine, Division of Infectious Diseases, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Eur J Immunol 43:458-67. 2013
  10. pmc KLRG1 negatively regulates natural killer cell functions through the Akt pathway in individuals with chronic hepatitis C virus infection
    Jia M Wang
    Department of Internal Medicine, Division of Infectious Diseases, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
    J Virol 87:11626-36. 2013

Collaborators

  • Ying Zhang
  • Jonathan Moorman
  • Deling Yin
  • Toshiro Niki
  • Guangyu Li
  • Jia M Wang
  • Xiao Y Wu
  • Cheng J Ma
  • Lei Shi
  • Lei Ni
  • Ruo S Ying
  • Xiao J Ji
  • Yong Q Cheng
  • Penny Thayer
  • Chun L Zhang
  • Antwan N Atia
  • Ashley D Frazier
  • Ellis King
  • Shu M Lin
  • Jeddidiah W D Griffin
  • Jun P Ren
  • Ashley M Smith
  • Kevin P High
  • Ke S Wang
  • Pamela Greer
  • Mitsumi Hirashima
  • Xin Y Chen
  • C L Zhang
  • Uday Kumaraguru
  • Thomas Borthwick
  • Subhadra Nandakumar
  • Agnes Hamati
  • Christopher Trabue

Detail Information

Publications17

  1. pmc Immune exhaustion and immune senescence: two distinct pathways for HBV vaccine failure during HCV and/or HIV infection
    Zhi Q Yao
    Department of Veterans Affairs, Hepatitis HCV HBV HIV Program, James H Quillen VA Medical Center, Johnson City, TN 37614, USA
    Arch Immunol Ther Exp (Warsz) 61:193-201. 2013
    ..We raise the possibility that blocking these negative signaling pathways might improve success rates of immunizations in the setting of chronic viral infection...
  2. doi request reprint Differential regulation of T and B lymphocytes by PD-1 and SOCS-1 signaling in hepatitis C virus-associated non-Hodgkin's lymphoma
    Zhi Q Yao
    Medical Service, James H Quillen VA Medical Center, Johnson City, TN, 37684, USA
    Immunol Invest 40:243-64. 2011
    ..Importantly, blocking PD-1 also restored the impaired T cell functions observed in the setting of HCV-NHL. These results support a coordinated mechanism by which HCV might cause immune dysregulation that is associated to HCV-NHL...
  3. pmc Impaired hepatitis B vaccine responses during chronic hepatitis C infection: involvement of the PD-1 pathway in regulating CD4(+) T cell responses
    Jonathan P Moorman
    Medical Service, Department of Veterans Affairs, James H Quillen VA Medical Center, Johnson City, TN 37614, USA
    Vaccine 29:3169-76. 2011
    ....
  4. doi request reprint Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
    Ying Zhang
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 186:3093-103. 2011
    ....
  5. pmc Programmed death-1 affects suppressor of cytokine signaling-1 expression in T cells during hepatitis C infection
    Ashley D Frazier
    Medical Service, Department of Veterans Affairs, James H Quillen Veterans Administration Medical Center, Mountain Home, Tennessee, USA
    Viral Immunol 23:487-95. 2010
    ....
  6. pmc PD-1 modulates regulatory T cells and suppresses T-cell responses in HCV-associated lymphoma
    Lei Ni
    Division of Infectious Diseases, Department of Internal Medicine, East Tennessee State University College of Medicine, Box 70622, Johnson City, TN 37614, USA
    Immunol Cell Biol 89:535-9. 2011
    ..This study suggests that the PD-1 pathway is involved in regulating T(R) cells that suppress T-cell functions in the setting of HCV-associated B-cell lymphoma...
  7. pmc PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection
    Cheng J Ma
    Division of Infectious Diseases, Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Immunology 132:421-31. 2011
    ..These results suggest that the PD-1 inhibitory pathway may negatively regulate IL-12 expression by limiting STAT-1 phosphorylation in M/Mφ during chronic HCV infection...
  8. pmc Differential regulation of interleukin-12 (IL-12)/IL-23 by Tim-3 drives T(H)17 cell development during hepatitis C virus infection
    Jia M Wang
    Hepatitis HCV HIV Program, James H Quillen VA Medical Center, Department of Veterans Affairs, Johnson City, Tennessee, USA
    J Virol 87:4372-83. 2013
    ..Our findings suggest that Tim-3-mediated differential regulation of IL-12/IL-23 drives T(H)17 cell development, a milieu favoring viral persistence and autoimmune phenomenon during HCV infection...
  9. pmc HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway
    Xiao J Ji
    Department of Internal Medicine, Division of Infectious Diseases, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Eur J Immunol 43:458-67. 2013
    ....
  10. pmc KLRG1 negatively regulates natural killer cell functions through the Akt pathway in individuals with chronic hepatitis C virus infection
    Jia M Wang
    Department of Internal Medicine, Division of Infectious Diseases, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
    J Virol 87:11626-36. 2013
    ..Taken together, these results indicate that KLRG1 negatively regulates NK cell numbers and functions via the Akt pathway, thus providing a novel marker and therapeutic target for HCV infection. ..
  11. pmc Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection
    Jonathan P Moorman
    Department of Veterans Affairs, James H Quillen Veterans Affairs Medical Center, Johnson City, TN 37614, USA
    J Immunol 189:755-66. 2012
    ..Taken together, the Tim-3 pathway appears to control Treg and Teff balance through altering cell proliferation and apoptosis during HCV infection...
  12. pmc Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes
    Ying Zhang
    Medical Service, Department of Veterans Affairs, James H Quillen Veterans Administration Medical Center, Johnson City, Tennessee, USA
    J Leukoc Biol 91:189-96. 2012
    ..These results suggest that Tim-3 has a role as a regulator of pro- and anti-inflammatory innate immune responses...
  13. doi request reprint KLRG1 Impairs CD4+ T Cell Responses via p16ink4a and p27kip1 Pathways: Role in Hepatitis B Vaccine Failure in Individuals with Hepatitis C Virus Infection
    Lei Shi
    Division of Infectious Diseases, Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614
    J Immunol 192:649-57. 2014
    ....
  14. pmc Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: role in hepatitis B vaccine failure during hepatitis C infection
    Jia M Wang
    Department of Internal Medicine, Division of Infectious Diseases, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States
    Vaccine 31:2238-45. 2013
    ....
  15. pmc Abnormal B-cell activation associated with TALL-1 over-expression and SOCS-1 suppression during chronic hepatitis C virus infection
    Jonathan Moorman
    Medical Service, James H Quillen VAMC, Johnson City, TN, USA
    Immunology 128:227-35. 2009
    ....
  16. ncbi request reprint Hepatitis C: the complications of immune dysfunction
    Ellis King
    East Tennessee State University, Department of Internal Medicine, James H Quillen College of Medicine, Box 70622, Johnson City, TN 37614, USA
    Expert Rev Clin Immunol 3:145-57. 2007
    ..Novel treatments that target these areas of dysregulation offer hope for improved therapy for the diseases associated with immunodysregulation by HCV...
  17. ncbi request reprint T cell dysfunction by hepatitis C virus core protein involves PD-1/PDL-1 signaling
    Zhi Q Yao
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Viral Immunol 20:276-87. 2007
    ..This upregulation of the PD-1 and PDL-1 pathway in humans represents a novel and perhaps common mechanism by which a virus usurps host machinery to facilitate persistence...