John C Sutherland

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. doi request reprint Dichrometer errors resulting from large signals or improper modulator phasing
    John C Sutherland
    Physics Department, East Carolina University, Greenville, NC 27858 4353, USA
    Chirality 24:706-17. 2012
  2. ncbi request reprint Repair dependent radiation survival: a stochastic model with Euler gamma function solutions
    John C Sutherland
    Physics Department, East Carolina University, Greenville, NC 27858, USA
    Phys Med Biol 51:4883-901. 2006
  3. ncbi request reprint Biological effects of polychromatic light
    John C Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY, USA
    Photochem Photobiol 76:164-70. 2002
  4. ncbi request reprint Repair of cyclobutyl pyrimidine dimers in human skin: variability among normal humans in nucleotide excision and in photorepair
    Betsy M Sutherland
    Biology Department, Building 463, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Photodermatol Photoimmunol Photomed 18:109-16. 2002
  5. ncbi request reprint DNA damage quantitation by alkaline gel electrophoresis
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY, USA
    Methods Mol Biol 314:251-73. 2006
  6. ncbi request reprint Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Mutat Res 531:93-107. 2003
  7. ncbi request reprint Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Radiat Res 43:S149-52. 2002
  8. ncbi request reprint Evaluation of number average length analysis in quantifying double strand breaks in genomic DNAs
    Betsy M Sutherland
    Department of Biology, Brookhaven National Laboratory, Building 463, 50 Bell Avenue, Upton, New York 11973 5000, USA
    Biochemistry 42:3375-84. 2003
  9. pmc Quantifying double-strand breaks and clustered damages in DNA by single-molecule laser fluorescence sizing
    Elena M Filippova
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Biophys J 84:1281-90. 2003
  10. ncbi request reprint Clustered DNA damages induced by x rays in human cells
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Radiat Res 157:611-6. 2002

Collaborators

Detail Information

Publications10

  1. doi request reprint Dichrometer errors resulting from large signals or improper modulator phasing
    John C Sutherland
    Physics Department, East Carolina University, Greenville, NC 27858 4353, USA
    Chirality 24:706-17. 2012
    ..Modulator phase can also impact the values of total absorbance recorded simultaneously with linear dichroism and total fluorescence...
  2. ncbi request reprint Repair dependent radiation survival: a stochastic model with Euler gamma function solutions
    John C Sutherland
    Physics Department, East Carolina University, Greenville, NC 27858, USA
    Phys Med Biol 51:4883-901. 2006
    ..The survival of cells exposed to photodynamic therapy is analysed assuming that lethal damages cannot be repaired, but more than one may be required for inactivation...
  3. ncbi request reprint Biological effects of polychromatic light
    John C Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY, USA
    Photochem Photobiol 76:164-70. 2002
    ....
  4. ncbi request reprint Repair of cyclobutyl pyrimidine dimers in human skin: variability among normal humans in nucleotide excision and in photorepair
    Betsy M Sutherland
    Biology Department, Building 463, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Photodermatol Photoimmunol Photomed 18:109-16. 2002
    ..We met a similar problem of dimer induction by a PRL source. We designed and validated a PRL source of sufficient intensity to catalyse PR, but that did not induce CPD, and used it to measure photorepair in human skin...
  5. ncbi request reprint DNA damage quantitation by alkaline gel electrophoresis
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY, USA
    Methods Mol Biol 314:251-73. 2006
    ....
  6. ncbi request reprint Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Mutat Res 531:93-107. 2003
    ..This review presents the theoretical basis, biochemical requirements and practical aspects of this approach, and shows examples of their applications in identification and quantitation of complex clustered damages...
  7. ncbi request reprint Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Radiat Res 43:S149-52. 2002
    ..Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation...
  8. ncbi request reprint Evaluation of number average length analysis in quantifying double strand breaks in genomic DNAs
    Betsy M Sutherland
    Department of Biology, Brookhaven National Laboratory, Building 463, 50 Bell Avenue, Upton, New York 11973 5000, USA
    Biochemistry 42:3375-84. 2003
    ..The use of this approach in quantifying DNA damages is illustrated for double strand breaks and damage clusters (e.g., OxyPurine clusters recognized by Escherichia coli Fpg protein) induced in T7 DNA by ionizing radiation...
  9. pmc Quantifying double-strand breaks and clustered damages in DNA by single-molecule laser fluorescence sizing
    Elena M Filippova
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Biophys J 84:1281-90. 2003
    ..For a given size range of DNA molecules, single-molecule sizing is as or more sensitive than gel electrophoresis, and requires several orders-of-magnitude less DNA to determine damage levels...
  10. ncbi request reprint Clustered DNA damages induced by x rays in human cells
    Betsy M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Radiat Res 157:611-6. 2002
    ..Non-DSB clustered damages comprise about 70% of the complex lesions produced in cells. The relative levels of specific cluster classes depend on the environment of the DNA...