Saame Raza Shaikh

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. pmc Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, 600 Moye Blvd, Greenville, NC 28590, USA
    Prostaglandins Leukot Essent Fatty Acids 88:21-5. 2013
  2. pmc N-3 fatty acids and membrane microdomains: from model membranes to lymphocyte function
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University 600, Moye Blvd, Greenville, NC 27834, USA
    Prostaglandins Leukot Essent Fatty Acids 87:205-8. 2012
  3. pmc Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Nutr Biochem 23:101-5. 2012
  4. pmc n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology and East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    Mol Aspects Med 33:46-54. 2012
  5. doi request reprint Docosahexaenoic acid modifies the clustering and size of lipid rafts and the lateral organization and surface expression of MHC class I of EL4 cells
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Nutr 139:1632-9. 2009
  6. pmc Oleic- and docosahexaenoic acid-containing phosphatidylethanolamines differentially phase separate from sphingomyelin
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
    Biochim Biophys Acta 1788:2421-6. 2009
  7. doi request reprint Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 28590, USA
    Prostaglandins Leukot Essent Fatty Acids 82:159-64. 2010
  8. pmc Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Lipid Res 53:674-85. 2012
  9. pmc Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids
    Heather Teague
    Department of Biochemistry and Molecular Biology, East Carolina University, Greenville, NC, USA
    Immunology 139:386-94. 2013
  10. pmc Fish oil disrupts MHC class II lateral organization on the B-cell side of the immunological synapse independent of B-T cell adhesion
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, Brody School of Medicine and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834
    J Nutr Biochem 24:1810-6. 2013

Collaborators

Detail Information

Publications17

  1. pmc Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, 600 Moye Blvd, Greenville, NC 28590, USA
    Prostaglandins Leukot Essent Fatty Acids 88:21-5. 2013
    ..Finally, we conclude by postulating future experiments that will augment our understanding of DHA-dependent membrane organization in health and disease...
  2. pmc N-3 fatty acids and membrane microdomains: from model membranes to lymphocyte function
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University 600, Moye Blvd, Greenville, NC 27834, USA
    Prostaglandins Leukot Essent Fatty Acids 87:205-8. 2012
    ..The work raises the intriguing possibility of testing the model at the human level to target health and disease...
  3. pmc Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Nutr Biochem 23:101-5. 2012
    ..Overall, elucidating the complex mechanisms by which n-3 PUFA acyl chains reorganize membrane architecture will enhance the translation of these fatty acids into the clinic for treating several diseases...
  4. pmc n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology and East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    Mol Aspects Med 33:46-54. 2012
    ..We conclude by proposing new functional and mechanistic questions in this area of research that will aid in the development of fish oil as adjuvant therapy for treating unresolved chronic inflammation...
  5. doi request reprint Docosahexaenoic acid modifies the clustering and size of lipid rafts and the lateral organization and surface expression of MHC class I of EL4 cells
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Nutr 139:1632-9. 2009
    ..Our study supports the notion that rafts are an important target of DHA's mode of action...
  6. pmc Oleic- and docosahexaenoic acid-containing phosphatidylethanolamines differentially phase separate from sphingomyelin
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
    Biochim Biophys Acta 1788:2421-6. 2009
    ....
  7. doi request reprint Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function
    Saame Raza Shaikh
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 28590, USA
    Prostaglandins Leukot Essent Fatty Acids 82:159-64. 2010
    ....
  8. pmc Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Lipid Res 53:674-85. 2012
    ..Altogether, our studies with B cells support an emerging model that FO increases raft size and membrane order accompanied by functional changes; furthermore, the results highlight differences in EPA and DHA bioactivity...
  9. pmc Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids
    Heather Teague
    Department of Biochemistry and Molecular Biology, East Carolina University, Greenville, NC, USA
    Immunology 139:386-94. 2013
    ..The results also show that DC microdomain clustering and microviscosity were not changed by the n-3 LCPUFA intervention used in this study...
  10. pmc Fish oil disrupts MHC class II lateral organization on the B-cell side of the immunological synapse independent of B-T cell adhesion
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, Brody School of Medicine and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834
    J Nutr Biochem 24:1810-6. 2013
    ..Furthermore, the data establish MHC class II lateral organization on the B-cell side of the immunological synapse as a novel molecular target of fish oil. ..
  11. pmc Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Nutr 141:1041-8. 2011
    ..The ex vivo data, which confirm previous studies with EL4 cells, provide evidence that (n-3) PUFA consumed through the diet disrupt B cell lipid raft clustering...
  12. pmc DHA-fluorescent probe is sensitive to membrane order and reveals molecular adaptation of DHA in ordered lipid microdomains
    Heather Teague
    Department of Biochemistry and Molecular Biology, East Carolina Diabetes and Obesity Institute, East Carolina University, NC 27834, USA
    J Nutr Biochem 24:188-95. 2013
    ..Mechanistically, this explains how DHA acyl chains can increase order upon formation of lipid microdomains in vivo...
  13. pmc Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids
    Ethan J Anderson
    Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC 27834, USA
    Biochem J 441:359-66. 2012
    ....
  14. pmc n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, 600 Moye Blvd, Brody 5S 18, Greenville, NC 27834, USA
    J Lipid Res 51:1284-97. 2010
    ..The study highlights that high-fat n-3 PUFA diets can promote pro-inflammatory responses, at least from one cell type...
  15. ncbi request reprint Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injury
    David A Brown
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, NC, USA Electronic address
    Pharmacol Ther 140:258-66. 2013
    ..Finally, we point to areas where future study is needed to expand and improve our understanding of mitochondrial pathophysiology during cardiac ischemia/reperfusion. ..
  16. pmc n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity
    Heather Teague
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC
    J Lipid Res 54:3130-8. 2013
    ..Altogether, the data show n-3 PUFAs enhance B cell-mediated immunity in vivo, which has implications for immunocompromised populations, such as the obese. ..
  17. ncbi request reprint Increasing levels of cardiolipin differentially influence packing of phospholipids found in the mitochondrial inner membrane
    Tonya N Zeczycki
    Department of Biochemistry and Molecular Biology, East Carolina Heart Institute Building, Brody School of Medicine, East Carolina University, 115 Heart Drive, Greenville, NC 27834, United States East Carolina Diabetes and Obesity Institute, East Carolina Heart Institute Building, Brody School of Medicine, East Carolina University, 115 Heart Drive, Greenville, NC 27834, United States
    Biochem Biophys Res Commun 450:366-71. 2014
    ..This has implications for mitochondrial protein activity in response to changing CL levels in microdomains of varying composition. ..