P J Rice

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. ncbi request reprint cAMP and in vitro inotropic actions of secretin and VIP in rat papillary muscle
    P J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City 37614, USA
    Peptides 20:519-22. 1999
  2. ncbi request reprint Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans
    Peter J Rice
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Building 119 Room 1 29, Dogwood Lane, Johnson City, TN 37614 1708, USA
    J Leukoc Biol 72:140-6. 2002
  3. ncbi request reprint Pharmacokinetics of fungal (1-3)-beta-D-glucans following intravenous administration in rats
    Peter J Rice
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Int Immunopharmacol 4:1209-15. 2004
  4. ncbi request reprint Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
    Peter J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 314:1079-86. 2005
  5. ncbi request reprint Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production. Winner of the Best Paper Award from the Gold Medal Forum
    Elizabeth P Lowe
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0575, USA
    Am Surg 68:508-17; discussion 517-8. 2002
  6. pmc Normal human fibroblasts express pattern recognition receptors for fungal (1-->3)-beta-D-glucans
    P Kougias
    Departments of Surgery, James H. Quillen College of Medicine, Johnson City, Tennessee 37614, USA
    Infect Immun 69:3933-8. 2001
  7. doi request reprint Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies
    Michael F Wempe
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614 1708, USA
    J Cosmet Dermatol 8:63-73. 2009
  8. ncbi request reprint Anterior pituitary cells express pattern recognition receptors for fungal glucans: implications for neuroendocrine immune involvement in response to fungal infections
    Kevin F Breuel
    Department of Obstetrics and Gynecology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroimmunomodulation 11:1-9. 2004
  9. doi request reprint Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching
    Elizabeth L Adams
    Department of Surgery, PO Box 70575, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 325:115-23. 2008
  10. ncbi request reprint At low serum glucan concentrations there is an inverse correlation between serum glucan and serum cytokine levels in ICU patients with infections
    J Andres Gonzalez
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson, TN 37614, USA
    Int Immunopharmacol 4:1107-15. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint cAMP and in vitro inotropic actions of secretin and VIP in rat papillary muscle
    P J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City 37614, USA
    Peptides 20:519-22. 1999
    ..These results are consistent with reports that secretin and VIP stimulate cardiac adenylyl cyclase in the rat, but suggest that cAMP tissue levels cannot totally explain the positive inotropic responses to secretin and VIP...
  2. ncbi request reprint Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans
    Peter J Rice
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Building 119 Room 1 29, Dogwood Lane, Johnson City, TN 37614 1708, USA
    J Leukoc Biol 72:140-6. 2002
    ..Polymer charge has a dramatic effect on the affinity of glucans with macrophage scavenger receptors. However, it is also clear that human monocyte scavenger receptors recognize the basic glucan structure independent of charge...
  3. ncbi request reprint Pharmacokinetics of fungal (1-3)-beta-D-glucans following intravenous administration in rats
    Peter J Rice
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Int Immunopharmacol 4:1209-15. 2004
    ..Since plasma levels at steady state are inversely related to clearance, these differences suggest that pharmacokinetics could favor higher blood levels of glucans with certain physicochemical properties...
  4. ncbi request reprint Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
    Peter J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 314:1079-86. 2005
    ..The glucans are bound by GI epithelial and GALT cells, and they modulate the expression of pattern recognition receptors in the GALT, increase IL-12 expression, and induce protection against infectious challenge...
  5. ncbi request reprint Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production. Winner of the Best Paper Award from the Gold Medal Forum
    Elizabeth P Lowe
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0575, USA
    Am Surg 68:508-17; discussion 517-8. 2002
    ..These results provide new insights into the mechanisms by which the host recognizes and responds to fungal cell wall products and suggests that the response to glucans may not be confined to leukocytes...
  6. pmc Normal human fibroblasts express pattern recognition receptors for fungal (1-->3)-beta-D-glucans
    P Kougias
    Departments of Surgery, James H. Quillen College of Medicine, Johnson City, Tennessee 37614, USA
    Infect Immun 69:3933-8. 2001
    ..These results provide new insights into the mechanisms by which the host recognizes and responds to fungal (1-->3)-beta-D-glucans and suggests that the response to glucans may not be confined to cells of the immune system...
  7. doi request reprint Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies
    Michael F Wempe
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614 1708, USA
    J Cosmet Dermatol 8:63-73. 2009
    ..The aim of this study was to investigate inherent in vitro permeability, metabolism, and cytotoxicity of idebenone - an active used to protect skin as an anti-aging agent - and compare it to idebenone linoleate...
  8. ncbi request reprint Anterior pituitary cells express pattern recognition receptors for fungal glucans: implications for neuroendocrine immune involvement in response to fungal infections
    Kevin F Breuel
    Department of Obstetrics and Gynecology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroimmunomodulation 11:1-9. 2004
    ..Recent evidence confirms the existence of glucan-specific receptors on cells outside the immune system. We hypothesized that glucans may directly interact with pituitary cells as an early signaling event in fungal infections...
  9. doi request reprint Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching
    Elizabeth L Adams
    Department of Surgery, PO Box 70575, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 325:115-23. 2008
    ....
  10. ncbi request reprint At low serum glucan concentrations there is an inverse correlation between serum glucan and serum cytokine levels in ICU patients with infections
    J Andres Gonzalez
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson, TN 37614, USA
    Int Immunopharmacol 4:1107-15. 2004
    ..We conclude that circulating glucans may prevent cytokine upregulation in response to infection. This may represent an adaptive response to septic injury...
  11. ncbi request reprint Pharmacokinetics of moricizine in young patients
    P J Rice
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0577, USA
    J Clin Pharmacol 35:1016-9. 1995
    ..These results suggest that the pediatric pharmacokinetics of moricizine excretion are complex and may differ from those seen in adults...
  12. ncbi request reprint Papain: a novel urine adulterant
    David L Burrows
    Section of Toxicology, Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, 37614, USA
    J Anal Toxicol 29:275-95. 2005
    ..No adulterated specimens were rendered invalid based on the SAMHSA guidelines. Immediate FPIA analysis is suggested to minimize the interfering effects of papain with regards to primary drug screening...
  13. ncbi request reprint Pharmacokinetics of letrozole in male and female rats: influence of complexation with hydroxybutenyl-beta cyclodextrin
    Michael F Wempe
    Eastman Chemical Company, Kingsport, TN, USA
    J Pharm Pharmacol 59:795-802. 2007
    ..Thus, solubility limits both rate and extent of letrozole absorption in male rats, but limits only the rate of absorption in female rats...