Mark D Mannie

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. ncbi request reprint Tolerogenic vaccines for Multiple sclerosis
    Mark D Mannie
    Department of Microbiology and Immunology Brody School of Medicine East Carolina University Greenville, NC USA
    Hum Vaccin Immunother 9:1032-8. 2013
  2. ncbi request reprint A fusion protein consisting of IL-16 and the encephalitogenic peptide of myelin basic protein constitutes an antigen-specific tolerogenic vaccine that inhibits experimental autoimmune encephalomyelitis
    Mark D Mannie
    Department of Microbiology and Immunology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 179:1458-65. 2007
  3. ncbi request reprint IL-2/neuroantigen fusion proteins as antigen-specific tolerogens in experimental autoimmune encephalomyelitis (EAE): correlation of T cell-mediated antigen presentation and tolerance induction
    Mark D Mannie
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27834, USA
    J Immunol 178:2835-43. 2007
  4. ncbi request reprint Cytokine-neuroantigen fusion proteins: new tools for modulation of myelin basic protein (MBP)-specific T cell responses in experimental autoimmune encephalomyelitis
    Mark D Mannie
    The Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27834, USA
    J Immunol Methods 319:118-32. 2007
  5. pmc A GMCSF-neuroantigen fusion protein is a potent tolerogen in experimental autoimmune encephalomyelitis (EAE) that is associated with efficient targeting of neuroantigen to APC
    J Lori Blanchfield
    The Department of Microbiology and Immunology, East Carolina University, Brody School of Medicine, Greenville, North Carolina, USA
    J Leukoc Biol 87:509-21. 2010
  6. ncbi request reprint MHC class II biosynthesis by activated rat CD4+ T cells: development of repression in vitro and modulation by APC-derived signals
    Mark D Mannie
    Department of Microbiology and Immunology, Brody Medical Sciences Building, East Carolina University School of Medicine, Greenville, NC 27834, USA
    Cell Immunol 230:33-43. 2004
  7. pmc Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T-cell priming, and peptide association with MHC class II
    Kristina E Rehm
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
    Immunology 128:381-92. 2009
  8. pmc Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
    Derek J Abbott
    The Department of Microbiology and Immunology, East Carolina University, Greenville, NC, USA
    BMC Immunol 12:72. 2011
  9. doi request reprint Experimental autoimmune encephalomyelitis in Lewis rats: IFN-beta acts as a tolerogenic adjuvant for induction of neuroantigen-dependent tolerance
    Mark D Mannie
    Department of Microbiology and Immunology, East Carolina University, Brody School of Medicine, Greenville, NC 27834, USA
    J Immunol 182:5331-41. 2009
  10. ncbi request reprint Acquisition of functional MHC class II/peptide complexes by T cells during thymic development and CNS-directed pathogenesis
    Mindi R Walker
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27858 4354, USA
    Cell Immunol 218:13-25. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Tolerogenic vaccines for Multiple sclerosis
    Mark D Mannie
    Department of Microbiology and Immunology Brody School of Medicine East Carolina University Greenville, NC USA
    Hum Vaccin Immunother 9:1032-8. 2013
    ..The purpose here is to provide a snapshot of the current concepts and future prospects of tolerogenic vaccination for Multiple Sclerosis, along with the central challenges to clinical application. ..
  2. ncbi request reprint A fusion protein consisting of IL-16 and the encephalitogenic peptide of myelin basic protein constitutes an antigen-specific tolerogenic vaccine that inhibits experimental autoimmune encephalomyelitis
    Mark D Mannie
    Department of Microbiology and Immunology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 179:1458-65. 2007
    ..These data identify IL-16 as an optimal cytokine partner for the generation of tolerogenic vaccines and indicate that such vaccines may serve as Ag-specific tolerogens for the treatment of autoimmune disease...
  3. ncbi request reprint IL-2/neuroantigen fusion proteins as antigen-specific tolerogens in experimental autoimmune encephalomyelitis (EAE): correlation of T cell-mediated antigen presentation and tolerance induction
    Mark D Mannie
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27834, USA
    J Immunol 178:2835-43. 2007
    ..The activities of IL2NAg revealed a potential relationship between NAg targeting to activated T cells, T cell-mediated Ag presentation, and tolerance induction...
  4. ncbi request reprint Cytokine-neuroantigen fusion proteins: new tools for modulation of myelin basic protein (MBP)-specific T cell responses in experimental autoimmune encephalomyelitis
    Mark D Mannie
    The Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27834, USA
    J Immunol Methods 319:118-32. 2007
    ..Cytokine/antigen fusion proteins may represent a novel tool for antigen-specific immune modulation in autoimmune disease...
  5. pmc A GMCSF-neuroantigen fusion protein is a potent tolerogen in experimental autoimmune encephalomyelitis (EAE) that is associated with efficient targeting of neuroantigen to APC
    J Lori Blanchfield
    The Department of Microbiology and Immunology, East Carolina University, Brody School of Medicine, Greenville, North Carolina, USA
    J Leukoc Biol 87:509-21. 2010
    ..Covalent GMCSF-NAg linkage was required for prevention and treatment of EAE. In conclusion, GMCSF-NAg was highly effective for targeting NAg to myeloid APC and was a potent, antigen-specific tolerogen in EAE...
  6. ncbi request reprint MHC class II biosynthesis by activated rat CD4+ T cells: development of repression in vitro and modulation by APC-derived signals
    Mark D Mannie
    Department of Microbiology and Immunology, Brody Medical Sciences Building, East Carolina University School of Medicine, Greenville, NC 27834, USA
    Cell Immunol 230:33-43. 2004
    ..These data indicate that most naive rat CD4(+) T cells exhibit activation-dependent synthesis of MHCII whereas continuously propagated T cells require an APC-derived signal to support MHCII synthesis...
  7. pmc Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T-cell priming, and peptide association with MHC class II
    Kristina E Rehm
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
    Immunology 128:381-92. 2009
    ..These data indicate that VACV evades the host immune response by impairing critical functions of the APC...
  8. pmc Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
    Derek J Abbott
    The Department of Microbiology and Immunology, East Carolina University, Greenville, NC, USA
    BMC Immunol 12:72. 2011
    ....
  9. doi request reprint Experimental autoimmune encephalomyelitis in Lewis rats: IFN-beta acts as a tolerogenic adjuvant for induction of neuroantigen-dependent tolerance
    Mark D Mannie
    Department of Microbiology and Immunology, East Carolina University, Brody School of Medicine, Greenville, NC 27834, USA
    J Immunol 182:5331-41. 2009
    ..The novel finding that IFN-beta acts as a tolerogenic adjuvant as well as a tolerogenic fusion partner may have significance for development of tolerogenic vaccines...
  10. ncbi request reprint Acquisition of functional MHC class II/peptide complexes by T cells during thymic development and CNS-directed pathogenesis
    Mindi R Walker
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27858 4354, USA
    Cell Immunol 218:13-25. 2002
    ..Overall, this study indicates that immature and mature T cells in rats and mice acquire functional MHCII in vivo during thymic development and pathogenic inflammation...
  11. ncbi request reprint Activation-dependent phases of T cells distinguished by use of optical tweezers and near infrared Raman spectroscopy
    Mark D Mannie
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27834, USA
    J Immunol Methods 297:53-60. 2005
    ..These findings indicate that near-infrared Raman spectroscopy can be used as a noninvasive technique to reveal the activation status of single living T cells...
  12. ncbi request reprint IL-4 responsive CD4+ T cells specific for myelin basic protein: IL-2 confers a prolonged postactivation refractory phase
    Mark D Mannie
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA
    Immunol Cell Biol 81:8-19. 2003
    ..The coupling of dominant growth factor activity with prolonged postactivation refractoriness may be associated with the requisite role of IL-2 in homeostatic self-tolerance...