Richard M Kostrzewa

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. ncbi request reprint Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 12:275-90. 2007
  2. ncbi request reprint Pharmacological models of ADHD
    R M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Neural Transm 115:287-98. 2008
  3. ncbi request reprint Dopamine D2 agonist priming in intact and dopamine-lesioned rats
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 6:457-62. 2004
  4. ncbi request reprint The blood-brain barrier for catecholamines - revisited
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 11:261-71. 2007
  5. doi request reprint Dopamine receptor supersensitivity: development, mechanisms, presentation, and clinical applicability
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 14:121-8. 2008
  6. ncbi request reprint II Neurotoxicity Society Meeting. Mechanisms for neurodegenerative disorders
    Richard M Kostrzewa
    East Tennessee State University, Department of Pharmacology, James H Quillen College of Medicine, PO Box 70577, Johnson City, TN 37614 0577, USA
    IDrugs 8:469-71. 2005
  7. doi request reprint Stereotypic progressions in psychotic behavior
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Neurotox Res 19:243-52. 2011
  8. ncbi request reprint Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 11:41-50. 2007
  9. doi request reprint Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced vertical jumping in rats that were quinpirole primed during postnatal ontogeny
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
    Neurotox Res 21:231-5. 2012
  10. ncbi request reprint Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 5:375-83. 2003

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 12:275-90. 2007
    ..BoNT's pharmaceutical potential is boundless...
  2. ncbi request reprint Pharmacological models of ADHD
    R M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Neural Transm 115:287-98. 2008
    ..This paper describes the various pharmacological models of ADHD and attempts to ascribe a neuronal phenotype with specific brain regions that may be associated with ADHD...
  3. ncbi request reprint Dopamine D2 agonist priming in intact and dopamine-lesioned rats
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 6:457-62. 2004
    ....
  4. ncbi request reprint The blood-brain barrier for catecholamines - revisited
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 11:261-71. 2007
    ..Regardless, the BBB forms at earlier times in forebrain vs hindbrain regions...
  5. doi request reprint Dopamine receptor supersensitivity: development, mechanisms, presentation, and clinical applicability
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 14:121-8. 2008
    ..The physiological consequence of RSS are multiple...
  6. ncbi request reprint II Neurotoxicity Society Meeting. Mechanisms for neurodegenerative disorders
    Richard M Kostrzewa
    East Tennessee State University, Department of Pharmacology, James H Quillen College of Medicine, PO Box 70577, Johnson City, TN 37614 0577, USA
    IDrugs 8:469-71. 2005
  7. doi request reprint Stereotypic progressions in psychotic behavior
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Neurotox Res 19:243-52. 2011
    ..This therapeutic potential broadens the realm of approaches toward treating psychiatric disorders...
  8. ncbi request reprint Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 11:41-50. 2007
    ..This series of findings implicates the 5-HT neuronal phenotype in TD, and promotes 5-HT(2) receptor antagonists, more specifically 5-HT(2C) receptor antagonists, as a rational treatment approach for TD in humans...
  9. doi request reprint Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced vertical jumping in rats that were quinpirole primed during postnatal ontogeny
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
    Neurotox Res 21:231-5. 2012
    ..This finding indicates that an ontogenetic 6-OHDA lesion enhances quinpirole-induced vertical jumping in rats and that dopaminergic innervation may normally exert a suppressive effect on vertical jumping...
  10. ncbi request reprint Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 5:375-83. 2003
    ..The objective of this paper is to invite added research into the newly discovered (or postulated) novel mechanisms; and to stimulate discovery of additional mechanisms attending neurodegeneration and neuroprotection...
  11. ncbi request reprint Dopamine receptor supersensitivity: an outcome and index of neurotoxicity
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 1708, U S A
    Neurotox Res 5:111-8. 2003
    ..Long-lived agonist-induced behavioral abnormality, with or without anatomic evidence of a neuronal lesion, is one of the products of DA D(1) receptor supersensitization -- itself an index of neurotoxicity...
  12. ncbi request reprint Peculiarities of L: -DOPA treatment of Parkinson's disease
    R M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Amino Acids 28:157-64. 2005
    ....
  13. ncbi request reprint The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpirole
    Stephanie K Thacker
    Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
    Eur J Neurosci 24:2075-83. 2006
    ..These results show that olanzapine eliminates D2 receptor priming and cognitive impairment and also alleviates decreases in neurotrophins and acetylcholinergic markers produced by D2 priming in the hippocampus...
  14. ncbi request reprint Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression
    Russell W Brown
    Department of Psychology, East Tennessee State University, 100 C R Drive, P O Box 70649, Johnson City, TN 37614, USA
    Eur J Neurosci 19:1634-42. 2004
    ..Nicotine alleviates both cognitive and skilled reaching impairments caused by increases in D(2) sensitivity, but the mechanism through which nicotine is acting is currently unknown...
  15. ncbi request reprint Schizophrenia and substance abuse comorbidity: nicotine addiction and the neonatal quinpirole model
    Russell W Brown
    Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
    Dev Neurosci 34:140-51. 2012
    ..Across these studies, we have reported several behavioral, neurochemical, and genetic consistencies with the disease, and present a hypothesis for what we believe to be the basis of psychostimulant addiction in schizophrenia...
  16. doi request reprint Evolution of neurotoxins: from research modalities to clinical realities
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
    Curr Protoc Neurosci . 2009
    ..This unit reviews the early discovery of neurotoxins, describes categories of neurotoxins, and finally characterizes their usefulness--first as research tools, and eventually as clinical therapeutic agents...
  17. ncbi request reprint Ontogenetic quinpirole treatments produce spatial memory deficits and enhance skilled reaching in adult rats
    Russell W Brown
    Department of Psychology, East Tennessee State University, Johnson City, USA
    Pharmacol Biochem Behav 72:591-600. 2002
    ..The behavioral changes produced by ontogenetic quinpirole treatment are consistent with dopaminergic hyperfunction, and possible mechanisms are discussed...
  18. ncbi request reprint Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells
    Xingshun Xu
    Department of Pharmacology, and Cecile Cox Quillen Laboratory of Geriatric Research, James H Quillen College of Medicine, East Tennessee State University, James H Quillen Veterans Affairs Medical Center, Johnson City, Tennessee, USA
    J Neurochem 103:2004-14. 2007
    ....
  19. ncbi request reprint Histamine H3 receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in an absence of change in microdialysate dopamine levels
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
    Eur J Pharmacol 552:46-54. 2006
    ..On the basis of the present study, we believe that histaminergic systems may augment dyskinesias induced by dopamine receptor agonists, independent of direct actions on dopaminergic neurons...
  20. doi request reprint Effect of prenatal lead exposure on nigrostriatal neurotransmission and hydroxyl radical formation in rat neostriatum: dopaminergic-nitrergic interaction
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
    Toxicology 246:83-9. 2008
    ..On the basis of the current study we conclude that maternal Pb(2+) exposure distorts the dopaminergic-nitrergic interaction in the nigrostriatal pathway, but without involvement of reactive oxygen species (ROS)...
  21. ncbi request reprint Histamine H(3) receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa derived extracellular dopamine in dopamine-denervated rat striatum
    Przemyslaw Nowak
    Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
    Neurotox Res 13:231-40. 2008
    ..Consequently, the histaminergic system represents a viable target for modulating the effectiveness of L-DOPA therapy in Parkinson's disease...
  22. ncbi request reprint Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity
    Ryszard Brus
    Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
    Neurotox Res 6:317-25. 2004
    ..These findings implicate 5-HT neurochemistry as potentially important therapeutic targets for treating human hyperactivity and possibly childhood ADHD...
  23. ncbi request reprint Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine
    Grzegorz Kuballa
    Department of Pharmacology, Medical University of Silesia, Jordana 38, PL 41 808 Zabrze, Poland
    Pharmacol Rep 57:161-9. 2005
    ..The results of the study indicate that nafadotride, the dopamine D3 receptor antagonist, has a behavioral and biochemical profile of action different from that of haloperidol but partially similar to that of clozapine...
  24. ncbi request reprint Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity
    Przemyslaw Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
    Neurotox Res 11:131-44. 2007
    ....
  25. ncbi request reprint DSP-4 prevents dopamine receptor priming by quinpirole
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38 St, 41 808 Zabrze, Poland
    Pharmacol Biochem Behav 84:3-7. 2006
    ..The findings are supportive of a modulatory role of noradrenergic fibers on dopamine receptor priming (supersensitization) in rat brain...
  26. ncbi request reprint Maternal lead exposure produces long-term enhancement of dopaminergic reactivity in rat offspring
    Grazyna Szczerbak
    Department of Pharmacology, Medical University of Silesia, 41 808, Zabrze, Poland
    Neurochem Res 32:1791-8. 2007
    ....
  27. ncbi request reprint [Molecular mechanisms of levodopa action in animal models of Parkinson's disease]
    Przemysław Nowak
    Katedra i Zakład Farmakologii w Zabrzu, Slaska Akademia Medyczna w Katowicach, Poland
    Neurol Neurochir Pol 40:517-25. 2006
    ....
  28. ncbi request reprint Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats
    Ryszard Brus
    Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
    Neurotox Res 5:329-38. 2003
    ..These findings demonstrate that D2 receptors are not primed by ontogenetic quinpirole treatments of neonatally 6-OHDA-lesioned rats, although D2 agonist treatments do at least partially prime D1 receptors in the 6-OHDA-lesioned rats...
  29. ncbi request reprint Prenatal cadmium and ethanol increase amphetamine-evoked dopamine release in rat striatum
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
    Neurotoxicol Teratol 28:563-72. 2006
    ....
  30. ncbi request reprint Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats
    Przemyslaw Nowak
    Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
    Neurotox Res 13:79-83. 2008
    ....
  31. ncbi request reprint Gene-environment interplay in schizopsychotic disorders
    Tomas Palomo
    Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    Neurotox Res 6:1-9. 2004
    ..Results continue to unravel the interplay of genes and environment in the etiology of schizophrenia and other psychotic disorders...
  32. ncbi request reprint Alternating extremely low frequency magnetic field increases turnover of dopamine and serotonin in rat frontal cortex
    Aleksander Sieron
    Clinic of Internal Diseases and Physical Medicine, Medical University of Silesia, Bytom, Poland
    Bioelectromagnetics 25:426-30. 2004
    ....
  33. ncbi request reprint The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism
    Irmgard Paris
    Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, Casilla 70000, Santiago 7, Chile
    Neurotox Res 13:221-30. 2008
    ..This cell line is a suitable in vitro model for studies of dopamine metabolism, since under proliferating conditions the cells express all the pertinent markers...
  34. ncbi request reprint Gene-environment interplay in neurogenesis and neurodegeneration
    Tomas Palomo
    Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    Neurotox Res 6:415-34. 2004
    ..In studies attributing the influence of genetic alteration on behavioral phenotypy, it is essential to carefully control environmental influences...
  35. ncbi request reprint Nitric oxide modulates the amphetamine effect on [3H]glucose uptake in the brain of rats prenatally exposed to lead
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, PL 41 808 Zabrze, Poland
    Pharmacol Rep 59:601-5. 2007
    ..Similar effect was observed in lead-intoxicated rats (striatum, frontal cortex and hippocampus). These results indicate that NO modulates AMPH-induced [3H]glucose uptake in the brain of rats prenatally exposed to lead...
  36. ncbi request reprint Neurotoxins and neurotoxic species implicated in neurodegeneration
    Juan Segura Aguilar
    Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago, Chile
    Neurotox Res 6:615-30. 2004
    ..Neurotoxins represent tools to help elucidate intra- and extra-cellular processes involved in neuronal necrosis and apoptosis, so that drugs can be developed towards targets that interrupt the processes leading towards neuronal death...
  37. ncbi request reprint Comorbidity implications in brain disease: neuronal substrates of symptom profiles
    Tomas Palomo
    Psychiatry Service, 12 de Octubre, University Hospital, Madrid 28041, Spain
    Neurotox Res 12:1-15. 2007
    ....
  38. ncbi request reprint Trimetazidine increases [3H]glucose uptake in rat brain
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, PL 41 808 Zabrze, Poland
    Pharmacol Rep 58:559-61. 2006
    ..Therefore, central effects need to be taken into consideration as possibly adding to known beneficial cardiac effects of trimetazidine...
  39. ncbi request reprint Neurotoxins and neurotoxicity mechanisms. An overview
    Juan Segura-Aguilar
    Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago, Chile
    Neurotox Res 10:263-87. 2006
    ..Highlights on discoveries in the areas noted, and on selective neurotoxins, are included, mainly from the past 2 to 3 years...