Research Topics
| Richard M KostrzewaSummaryAffiliation: East Tennessee State University Country: USA Publications
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Detail Information
Publications
Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panaceaRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Neurotox Res 12:275-90. 2007..BoNT's pharmaceutical potential is boundless...- Pharmacological models of ADHDR M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
J Neural Transm 115:287-98. 2008..This paper describes the various pharmacological models of ADHD and attempts to ascribe a neuronal phenotype with specific brain regions that may be associated with ADHD... - Dopamine D2 agonist priming in intact and dopamine-lesioned ratsRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Neurotox Res 6:457-62. 2004.... - The blood-brain barrier for catecholamines - revisitedRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Neurotox Res 11:261-71. 2007..Regardless, the BBB forms at earlier times in forebrain vs hindbrain regions... 
Dopamine receptor supersensitivity: development, mechanisms, presentation, and clinical applicabilityRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Neurotox Res 14:121-8. 2008..The physiological consequence of RSS are multiple...- II Neurotoxicity Society Meeting. Mechanisms for neurodegenerative disordersRichard M Kostrzewa
East Tennessee State University, Department of Pharmacology, James H Quillen College of Medicine, PO Box 70577, Johnson City, TN 37614-0577, USA
IDrugs 8:469-71. 2005 - Stereotypic progressions in psychotic behaviorRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
Neurotox Res 19:243-52. 2011..This therapeutic potential broadens the realm of approaches toward treating psychiatric disorders... - Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatmentRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Neurotox Res 11:41-50. 2007..This series of findings implicates the 5-HT neuronal phenotype in TD, and promotes 5-HT(2) receptor antagonists, more specifically 5-HT(2C) receptor antagonists, as a rational treatment approach for TD in humans... - Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced vertical jumping in rats that were quinpirole primed during postnatal ontogenyRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
Neurotox Res 21:231-5. 2012..This finding indicates that an ontogenetic 6-OHDA lesion enhances quinpirole-induced vertical jumping in rats and that dopaminergic innervation may normally exert a suppressive effect on vertical jumping... - Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a reviewRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Neurotox Res 5:375-83. 2003..The objective of this paper is to invite added research into the newly discovered (or postulated) novel mechanisms; and to stimulate discovery of additional mechanisms attending neurodegeneration and neuroprotection... - Dopamine receptor supersensitivity: an outcome and index of neurotoxicityRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 1708, U S A
Neurotox Res 5:111-8. 2003..Long-lived agonist-induced behavioral abnormality, with or without anatomic evidence of a neuronal lesion, is one of the products of DA D(1) receptor supersensitization -- itself an index of neurotoxicity... - Peculiarities of L: -DOPA treatment of Parkinson's diseaseR M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
Amino Acids 28:157-64. 2005.... - The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpiroleStephanie K Thacker
Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
Eur J Neurosci 24:2075-83. 2006..These results show that olanzapine eliminates D2 receptor priming and cognitive impairment and also alleviates decreases in neurotrophins and acetylcholinergic markers produced by D2 priming in the hippocampus... - Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expressionRussell W Brown
Department of Psychology, East Tennessee State University, 100 C R Drive, P O Box 70649, Johnson City, TN 37614, USA
Eur J Neurosci 19:1634-42. 2004..Nicotine alleviates both cognitive and skilled reaching impairments caused by increases in D(2) sensitivity, but the mechanism through which nicotine is acting is currently unknown... - Schizophrenia and substance abuse comorbidity: nicotine addiction and the neonatal quinpirole modelRussell W Brown
Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
Dev Neurosci 34:140-51. 2012..Across these studies, we have reported several behavioral, neurochemical, and genetic consistencies with the disease, and present a hypothesis for what we believe to be the basis of psychostimulant addiction in schizophrenia... - Evolution of neurotoxins: from research modalities to clinical realitiesRichard M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Curr Protoc Neurosci . 2009..This unit reviews the early discovery of neurotoxins, describes categories of neurotoxins, and finally characterizes their usefulness--first as research tools, and eventually as clinical therapeutic agents... - Ontogenetic quinpirole treatments produce spatial memory deficits and enhance skilled reaching in adult ratsRussell W Brown
Department of Psychology, East Tennessee State University, Johnson City, USA
Pharmacol Biochem Behav 72:591-600. 2002..The behavioral changes produced by ontogenetic quinpirole treatment are consistent with dopaminergic hyperfunction, and possible mechanisms are discussed... - Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cellsXingshun Xu
Department of Pharmacology, and Cecile Cox Quillen Laboratory of Geriatric Research, James H Quillen College of Medicine, East Tennessee State University, James H Quillen Veterans Affairs Medical Center, Johnson City, Tennessee, USA
J Neurochem 103:2004-14. 2007.... - Histamine H3 receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in an absence of change in microdialysate dopamine levelsPrzemysław Nowak
Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
Eur J Pharmacol 552:46-54. 2006..On the basis of the present study, we believe that histaminergic systems may augment dyskinesias induced by dopamine receptor agonists, independent of direct actions on dopaminergic neurons... - Effect of prenatal lead exposure on nigrostriatal neurotransmission and hydroxyl radical formation in rat neostriatum: dopaminergic-nitrergic interactionPrzemysław Nowak
Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
Toxicology 246:83-9. 2008..On the basis of the current study we conclude that maternal Pb(2+) exposure distorts the dopaminergic-nitrergic interaction in the nigrostriatal pathway, but without involvement of reactive oxygen species (ROS)... - Histamine H(3) receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa derived extracellular dopamine in dopamine-denervated rat striatumPrzemyslaw Nowak
Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
Neurotox Res 13:231-40. 2008..Consequently, the histaminergic system represents a viable target for modulating the effectiveness of L-DOPA therapy in Parkinson's disease... - Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivityRyszard Brus
Department of Pharmacology, Medical University of Silesia, 41-808 Zabrze, Poland
Neurotox Res 6:317-25. 2004..These findings implicate 5-HT neurochemistry as potentially important therapeutic targets for treating human hyperactivity and possibly childhood ADHD... - Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapineGrzegorz Kuballa
Department of Pharmacology, Medical University of Silesia, Jordana 38, PL 41-808 Zabrze, Poland
Pharmacol Rep 57:161-9. 2005..The results of the study indicate that nafadotride, the dopamine D3 receptor antagonist, has a behavioral and biochemical profile of action different from that of haloperidol but partially similar to that of clozapine... - Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivityPrzemyslaw Nowak
Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
Neurotox Res 11:131-44. 2007.... - DSP-4 prevents dopamine receptor priming by quinpirolePrzemysław Nowak
Department of Pharmacology, Medical University of Silesia, H Jordana 38 St, 41 808 Zabrze, Poland
Pharmacol Biochem Behav 84:3-7. 2006..The findings are supportive of a modulatory role of noradrenergic fibers on dopamine receptor priming (supersensitization) in rat brain... - Maternal lead exposure produces long-term enhancement of dopaminergic reactivity in rat offspringGrazyna Szczerbak
Department of Pharmacology, Medical University of Silesia, 41 808, Zabrze, Poland
Neurochem Res 32:1791-8. 2007.... - [Molecular mechanisms of levodopa action in animal models of Parkinson's disease]Przemysław Nowak
Katedra i Zakład Farmakologii w Zabrzu, Slaska Akademia Medyczna w Katowicach, Poland
Neurol Neurochir Pol 40:517-25. 2006.... - Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned ratsRyszard Brus
Department of Pharmacology, Medical University of Silesia, 41-808 Zabrze, Poland
Neurotox Res 5:329-38. 2003..These findings demonstrate that D2 receptors are not primed by ontogenetic quinpirole treatments of neonatally 6-OHDA-lesioned rats, although D2 agonist treatments do at least partially prime D1 receptors in the 6-OHDA-lesioned rats... - Prenatal cadmium and ethanol increase amphetamine-evoked dopamine release in rat striatumPrzemysław Nowak
Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
Neurotoxicol Teratol 28:563-72. 2006.... - Ontogenetic noradrenergic lesion alters histaminergic activity in adult ratsPrzemyslaw Nowak
Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
Neurotox Res 13:79-83. 2008.... - Gene-environment interplay in schizopsychotic disordersTomas Palomo
, Hospital Universitario 12 de Octubre, , 28041 Madrid, Spain
Neurotox Res 6:1-9. 2004..Results continue to unravel the interplay of genes and environment in the etiology of schizophrenia and other psychotic disorders... - Alternating extremely low frequency magnetic field increases turnover of dopamine and serotonin in rat frontal cortexAleksander Sieron
Clinic of Internal Diseases and Physical Medicine, Medical University of Silesia, Bytom, Poland
Bioelectromagnetics 25:426-30. 2004.... - The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolismIrmgard Paris
Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, Casilla 70000, Santiago 7, Chile
Neurotox Res 13:221-30. 2008..This cell line is a suitable in vitro model for studies of dopamine metabolism, since under proliferating conditions the cells express all the pertinent markers... - Gene-environment interplay in neurogenesis and neurodegenerationTomas Palomo
Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
Neurotox Res 6:415-34. 2004..In studies attributing the influence of genetic alteration on behavioral phenotypy, it is essential to carefully control environmental influences... - Nitric oxide modulates the amphetamine effect on [3H]glucose uptake in the brain of rats prenatally exposed to leadPrzemysław Nowak
Department of Pharmacology, Medical University of Silesia, H Jordana 38, PL 41 808 Zabrze, Poland
Pharmacol Rep 59:601-5. 2007..Similar effect was observed in lead-intoxicated rats (striatum, frontal cortex and hippocampus). These results indicate that NO modulates AMPH-induced [3H]glucose uptake in the brain of rats prenatally exposed to lead... - Neurotoxins and neurotoxic species implicated in neurodegenerationJuan Segura Aguilar
Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago, Chile
Neurotox Res 6:615-30. 2004..Neurotoxins represent tools to help elucidate intra- and extra-cellular processes involved in neuronal necrosis and apoptosis, so that drugs can be developed towards targets that interrupt the processes leading towards neuronal death... - Comorbidity implications in brain disease: neuronal substrates of symptom profilesTomas Palomo
Psychiatry Service, 12 de Octubre, University Hospital, Madrid 28041, Spain
Neurotox Res 12:1-15. 2007.... - Trimetazidine increases [3H]glucose uptake in rat brainPrzemysław Nowak
Department of Pharmacology, Medical University of Silesia, H Jordana 38, PL 41 808 Zabrze, Poland
Pharmacol Rep 58:559-61. 2006..Therefore, central effects need to be taken into consideration as possibly adding to known beneficial cardiac effects of trimetazidine... - Neurotoxins and neurotoxicity mechanisms. An overviewJuan Segura-Aguilar
Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago, Chile
Neurotox Res 10:263-87. 2006..Highlights on discoveries in the areas noted, and on selective neurotoxins, are included, mainly from the past 2 to 3 years...