J A Houmard

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. ncbi request reprint Effect of the volume and intensity of exercise training on insulin sensitivity
    Joseph A Houmard
    Department of Exercise and Sports Science, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol 96:101-6. 2004
  2. ncbi request reprint Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects
    Joseph A Houmard
    Department of Exercise and Sport Science, and the Human Performance Laboratory and Diabetes Obesity Center, East Carolina University, Greenville, North Carolina 27858, USA
    Diabetes 51:2959-63. 2002
  3. ncbi request reprint Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging
    J A Houmard
    Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    J Appl Physiol 85:1337-41. 1998
  4. ncbi request reprint Impact of hyperinsulinemia on myosin heavy chain gene regulation
    J A Houmard
    Human Performance Laboratory, Department of Exercise and Sport Science and School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    J Appl Physiol 86:1828-32. 1999
  5. ncbi request reprint Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle
    J A Houmard
    Human Performance Laboratory and Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol 277:E1055-60. 1999
  6. ncbi request reprint Association between muscle fiber composition and blood pressure levels during exercise in men
    J A Houmard
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Hypertens 13:586-92. 2000
  7. ncbi request reprint Leptin is related to body fat content in male distance runners
    M S Hickey
    Department of Exercise and Sport Science, School of Health and Human Performance, East Carolina University Greenville, North Carolina 27858, USA
    Am J Physiol 271:E938-40. 1996
  8. ncbi request reprint Plasma cholesteryl ester transfer protein activity is not linked to insulin sensitivity
    P S MacLean
    Department of Biochemistry and Surgery, School of Medicine and the Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Metabolism 50:783-8. 2001
  9. ncbi request reprint Diabetic groups as defined by ADA and NDDG criteria have a similar aerobic capacity, blood pressure and body composition. American Diabetes Association and National Diabetes Data Group
    R C Hickner
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Diabetologia 44:26-32. 2001
  10. doi request reprint Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise
    Jason R Berggren
    Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Am J Physiol Endocrinol Metab 294:E726-32. 2008

Detail Information

Publications59

  1. ncbi request reprint Effect of the volume and intensity of exercise training on insulin sensitivity
    Joseph A Houmard
    Department of Exercise and Sports Science, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol 96:101-6. 2004
    ..Total exercise duration should thus be considered when designing training programs with the intent of improving insulin action...
  2. ncbi request reprint Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects
    Joseph A Houmard
    Department of Exercise and Sport Science, and the Human Performance Laboratory and Diabetes Obesity Center, East Carolina University, Greenville, North Carolina 27858, USA
    Diabetes 51:2959-63. 2002
    ..These data suggest that a reduction in intramuscular LCACoA content may be responsible, at least in part, for the enhanced insulin action observed with weight loss in obese individuals...
  3. ncbi request reprint Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging
    J A Houmard
    Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    J Appl Physiol 85:1337-41. 1998
    ..No changes in fiber type were evident with age in either muscle. These data suggest a reduction in oxidative enzyme activity in human skeletal muscle with the aging process; this relationship may be muscle-group specific...
  4. ncbi request reprint Impact of hyperinsulinemia on myosin heavy chain gene regulation
    J A Houmard
    Human Performance Laboratory, Department of Exercise and Sport Science and School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    J Appl Physiol 86:1828-32. 1999
    ..In contrast, type IIX MHC mRNA increased (P < 0.05) with hyperinsulinemia compared with the fasted condition. These data indicate that hyperinsulinemia rapidly increases type IIx MHC mRNA in human skeletal muscle...
  5. ncbi request reprint Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle
    J A Houmard
    Human Performance Laboratory and Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol 277:E1055-60. 1999
    ..3 +/- 0.1-fold). There was no change in fasting PI 3-kinase activity. These data suggest that an enhancement of insulin signal transduction in skeletal muscle may contribute to the improvement in insulin action with exercise...
  6. ncbi request reprint Association between muscle fiber composition and blood pressure levels during exercise in men
    J A Houmard
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Hypertens 13:586-92. 2000
    ..These data suggest that muscle morphology is related to the blood pressure level during exercise and provides insight into factors that may predispose individuals toward the development of hypertension and cardiovascular disease...
  7. ncbi request reprint Leptin is related to body fat content in male distance runners
    M S Hickey
    Department of Exercise and Sport Science, School of Health and Human Performance, East Carolina University Greenville, North Carolina 27858, USA
    Am J Physiol 271:E938-40. 1996
    ..Furthermore, the data suggest that, in trained individuals with low leptin concentrations, acute exhaustive exercise has no immediate effect on circulating leptin concentration...
  8. ncbi request reprint Plasma cholesteryl ester transfer protein activity is not linked to insulin sensitivity
    P S MacLean
    Department of Biochemistry and Surgery, School of Medicine and the Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Metabolism 50:783-8. 2001
    ..These data suggest that the elevated CETP activity found in obese patients is less associated with hyperinsulinemia and the accompanying insulin resistance, but rather is more related to some other metabolic complication of obesity...
  9. ncbi request reprint Diabetic groups as defined by ADA and NDDG criteria have a similar aerobic capacity, blood pressure and body composition. American Diabetes Association and National Diabetes Data Group
    R C Hickner
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Diabetologia 44:26-32. 2001
    ..The ADA and NDDG groups, however, might not have identical risks for cardiovascular disease because of differences between total:HDL cholesterol ratios, circulating HDL cholesterol and triglyceride concentrations...
  10. doi request reprint Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise
    Jason R Berggren
    Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Am J Physiol Endocrinol Metab 294:E726-32. 2008
    ..These data indicate that a defect in the ability to oxidize lipid in skeletal muscle is evident with obesity, which is corrected with exercise training but persists after weight loss...
  11. ncbi request reprint Effect of weight loss on muscle lipid content in morbidly obese subjects
    Robert E Gray
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 284:E726-32. 2003
    ..This reduction in intramuscular triglyceride may contribute to enhanced insulin action seen with weight loss...
  12. pmc A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals
    K E Boyle
    Human Performance Laboratory, East Carolina University, Greenville, North Carolina 27858, USA
    J Clin Endocrinol Metab 96:775-81. 2011
    ..In lean individuals, increasing dietary lipid can elicit an increase in whole body lipid oxidation; however, with obesity the capacity to respond to changes in substrate availability appears to be compromised...
  13. ncbi request reprint Insulin activation of phosphatidylinositol 3-kinase in human skeletal muscle in vivo
    M S Hickey
    Human Performance Laboratory and Department of Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858 4353, USA
    J Appl Physiol 83:718-22. 1997
    ....
  14. pmc Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation
    Sudip Bajpeyi
    Department of Exercise and Sports Science, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol 106:1079-85. 2009
    ....
  15. doi request reprint Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans
    K E Boyle
    The Human Performance Laboratory, East Carolina University, Greenville, NC, USA
    Int J Obes (Lond) 36:1025-31. 2012
    ..The purpose of this study was to determine if this metabolic inflexibility with obesity is retained in mitochondria of human skeletal muscle cells raised in culture (HSkMC) and to identify potential mechanisms involved...
  16. pmc Mechanism for improved insulin sensitivity after gastric bypass surgery
    Benjamin T Bikman
    The Metabolic Institute for the Study of Diabetes and Obesity, East Carolina University, 6N98 600 Moye Boulevard, Greenville, North Carolina 27834, USA
    J Clin Endocrinol Metab 93:4656-63. 2008
    ..Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity...
  17. pmc Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment
    Benjamin T Bikman
    The Metabolic Institute for the Study of Diabetes and Obesity, East Carolina University, Greenville, North Carolina 27834, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1692-9. 2010
    ..These findings suggest an important role for regular exercise in addition to offering a potential mechanism of action for oral AMPK-activating agents, such as thiazolidinediones and metformin...
  18. ncbi request reprint Primary cell cultures in the study of human muscle metabolism
    Jason R Berggren
    Human Performance Laboratory and Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    Exerc Sport Sci Rev 35:56-61. 2007
    ..The purpose of the current paper is to provide evidence indicating the efficacy of primary human skeletal muscle cell cultures as a tool to study substrate regulation and control in human tissue...
  19. ncbi request reprint Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running
    R C Hickner
    Human Performance Laboratory, Department of Exercise and Sports Science, East Carolina University, Greenville, North Carolina 27858, USA
    J Appl Physiol 90:1334-41. 2001
    ..56, P < 0.05). These data suggest that FM/FFM is a major determinant of losses in muscle strength after downhill running...
  20. ncbi request reprint Effect of intense training on plasma leptin in male and female swimmers
    R C Noland
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA
    Med Sci Sports Exerc 33:227-31. 2001
    ..These data suggest that leptin may not be useful in monitoring relative training stress in athletes...
  21. ncbi request reprint Weight loss and exercise: implications for muscle lipid metabolism and insulin action
    Jason R Berggren
    Department of Exercise and Sport Science, Human Performance Laboratory, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Med Sci Sports Exerc 36:1191-5. 2004
    ..The mechanism(s) by which exercise enhances insulin action remains to be determined...
  22. ncbi request reprint Muscle fiber type is associated with obesity and weight loss
    Charles J Tanner
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 282:E1191-6. 2002
    ..72, P < 0.005) between the percentage of excess weight loss and the percentage of type I fibers in morbidly obese patients. These findings indicate that there is a relationship between muscle fiber type and obesity...
  23. ncbi request reprint Fat as an endocrine organ: influence of exercise
    Jason R Berggren
    Human Performance Laboratory and Department of Exercise and Sport Science, 363 Ward Sports Medicine Bldg, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol 99:757-64. 2005
    ..This review explores the role of adipocytokines in insulin action and examines the effect of exercise training on adipocytokine content...
  24. ncbi request reprint Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training
    Ronald N Cortright
    The Human Performance Laboratory, Department of Excercise and Sport Science, College of Health and Human Performance, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Obesity (Silver Spring) 14:1201-10. 2006
    ..CW. In lean CW, endurance exercise training (EET) elevates the oxidative capacity of skeletal muscle. Therefore, we determined whether EET would elevate skeletal muscle FAO similarly in AAW and CW with a lower lipid oxidative capacity...
  25. pmc Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals
    Leslie A Consitt
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, USA
    Diabetes 59:1407-15. 2010
    ....
  26. pmc Intramuscular lipid oxidation and obesity
    Joseph A Houmard
    Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1111-6. 2008
    ..In terms of intervention, weight loss does not seem to correct the defect in FAO with obesity. This review will provide evidence supporting a reduction in muscle FAO with obesity...
  27. pmc Intramuscular lipid metabolism, insulin action, and obesity
    Leslie A Consitt
    Department of Exercise and Sport Science and Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    IUBMB Life 61:47-55. 2009
    ..In this review, we will briefly summarize the defects in skeletal muscle lipid metabolism associated with obesity, and discuss the proposed mechanisms by which these defects may contribute to insulin resistance...
  28. ncbi request reprint Glucose uptake in muscle cell cultures from endurance-trained men
    Jason R Berggren
    Human Performance Laboratory, Department of Exercise and Sport Science, and Diabetes Obesity Center, East Carolina University, Greenville, NC 27858, USA
    Med Sci Sports Exerc 37:579-84. 2005
    ..To examine noninsulin- (basal) and insulin-mediated glucose uptake in human skeletal muscle cells from endurance-trained and sedentary individuals...
  29. ncbi request reprint Plasma leptin and exercise: recent findings
    Matthew W Hulver
    Department of Physiology, East Carolina University, Greenville, North Carolina, USA
    Sports Med 33:473-82. 2003
    ....
  30. ncbi request reprint Adiponectin is not altered with exercise training despite enhanced insulin action
    Matthew W Hulver
    Department of Physiology, East Carolina University, Greenville North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 283:E861-5. 2002
    ..These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity...
  31. ncbi request reprint Skeletal muscle lipid metabolism with obesity
    Matthew W Hulver
    Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 284:E741-7. 2003
    ....
  32. ncbi request reprint Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men
    Charles J Tanner
    Human Performance Laboratory, Diabetes Obesity Center, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 282:E147-53. 2002
    ..1 vs. 1.4 +/- 0.2-fold stimulation with insulin) with training. These data suggest that insulin action is enhanced with short-term exercise training via an adaptation distal to PI 3-kinase in middle-aged, insulin-resistant individuals...
  33. ncbi request reprint Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle
    Kim Jong-Yeon
    Department of Biochemistry, Diabetes Obesity Center, East Carolina University, Greenville, NC 27858, USA
    Metabolism 51:460-4. 2002
    ..In contrast, carnitine-mediated transport (COT) does not appear to contribute to an enhancement in MCFA oxidation with exercise training...
  34. ncbi request reprint Effects of exercise training on plasma androgens in men
    J A Houmard
    Human Performance Laboratory, East Carolina University, Greenville, North Carolina
    Horm Metab Res 26:297-300. 1994
    ..05) increase in insulin sensitivity, plasma HDL cholesterol, and a decrease in plasma triglyceride and adiposity. Exercise training thus appears to reduce CAD risk irrespective of androgen concentration in men...
  35. ncbi request reprint A comparison of methods for estimating the lactate threshold
    James C McGehee
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    J Strength Cond Res 19:553-8. 2005
    ..These findings suggest that the 30-minute time-trial method should be considered by coaches and distance runners/triathletes as a method for estimating both the running velocity and heart rate at the lactate threshold...
  36. ncbi request reprint Do the mitochondria of obese individuals respond to exercise training?
    Joseph A Houmard
    J Appl Physiol 103:6-7. 2007
  37. pmc Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:962-8. 2007
    ..Our objective was to determine if GL is related to hsCRP and other measures of CVD risk in a population of sedentary, overweight, dyslipidemic middle-aged women and men enrolled in an exercise intervention trial (STRRIDE)...
  38. pmc Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise)
    Johanna L Johnson
    Department of Medicine, Division of Cardiology, Duke University Medical Center and Duke Center for Living, Durham, North Carolina, USA
    Am J Cardiol 100:1759-66. 2007
    ..A higher amount of vigorous exercise had greater and more widespread benefits. Finally, there was an indication that moderate-intensity may be better than vigorous-intensity exercise for improving MS...
  39. ncbi request reprint Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
    ..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins...
  40. pmc Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:577-83. 2008
    ..In contradiction to our hypothesis, despite significant alterations in body composition, exercise training produced limited cytokine responses...
  41. ncbi request reprint Proteome analysis of skeletal muscle from obese and morbidly obese women
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Diabetes 54:1283-8. 2005
    ..In summary, proteome analysis of muscle has helped us better describe the molecular etiology of obesity-related disease...
  42. ncbi request reprint Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ....
  43. ncbi request reprint Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells
    Deborah M Muoio
    Department of Medicine and Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes 51:901-9. 2002
    ..These results demonstrate a role for hPPAR-alpha in regulating muscle lipid homeostasis...
  44. ncbi request reprint Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study
    Johanna L Johnson
    Divisions of Cardiology, Duke Center for Living, Duke University Medical Center, 1300 Morreene Road, DUMC Box 3022 Durham, NC 27710, USA
    Atherosclerosis 176:371-7. 2004
    ..Within this homogenous population, there were distinct differences between gender and racial groups. Blacks and women had less atherogenic profiles than whites and men, which was not evident from the standard lipid panel...
  45. ncbi request reprint Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount
    Cris A Slentz
    Division of Cardiology, Duke Univ Medical Center, Durham, NC 27710, USA
    J Appl Physiol 103:432-42. 2007
    ..Moderate-intensity but not vigorous-intensity exercise resulted in sustained VLDL-triglyceride lowering. Thirty minutes per day of vigorous exercise, like jogging, has sustained beneficial effects on HDL metabolism...
  46. ncbi request reprint Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Appl Physiol 98:168-79. 2005
    ..These biochemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in prediabetic individuals...
  47. ncbi request reprint Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects
    Celia Pender
    Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California San Francisco, Box 1616, San Francisco, CA 94143, USA
    Metabolism 54:598-603. 2005
    ..These data therefore indicate that the insulin resistance associated with obesity is not maintained in cultured muscle cells and suggest that this insulin resistance is an acquired feature of obesity...
  48. ncbi request reprint Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount
    Cris A Slentz
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Appl Physiol 99:1613-8. 2005
    ..Importantly, a modest increase over the CDC/ACSM exercise recommendations resulted in significant decreases in visceral, subcutaneous, and total abdominal fat without changes in caloric intake...
  49. ncbi request reprint Introduction-preventing insulin resistance through exercise: a cellular approach
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, R M I T University, Bundoora, Victoria, Australia
    Med Sci Sports Exerc 36:1187-90. 2004
    ..The five papers comprising this symposium provide a state-of-the-art synopsis of the metabolic, cellular, and molecular mechanisms positively affected by exercise training in individuals who are insulin resistant...
  50. ncbi request reprint Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
    Matthew W Hulver
    Pennington Biomedical Research, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Cell Metab 2:251-61. 2005
    ..These results suggest that elevated expression of SCD1 in skeletal muscle contributes to abnormal lipid metabolism and progression of obesity...
  51. ncbi request reprint Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease
    Brian D Duscha
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Box 3022, Durham, NC 27710, USA
    Chest 128:2788-93. 2005
    ..Although increasing aerobic fitness by exercise training is advocated as part of a healthy lifestyle, studies examining the different effects of intensity and amount on peak consumption (V(O2)) remain sparse...
  52. pmc Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:888-95. 2008
    ..These findings have implications for the relative utility of ET for improving insulin action in middle-aged men and women, particularly in the setting of differences in HRT use...
  53. ncbi request reprint Glucose transporter expression in skeletal muscle of endurance-trained individuals
    Yoshinori Seki
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Med Sci Sports Exerc 38:1088-92. 2006
    ..Two recently identified glucose transporters, GLUT8 and GLUT12, are expressed in human skeletal muscle and may be involved in insulin-mediated sugar transport...
  54. ncbi request reprint GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
    Jung Jun Park
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Physiol Genomics 27:114-21. 2006
    ..Thus our data provide a possible regulatory pathway involved in the development of insulin resistance in the morbidly obese state, and improvement of insulin resistance with weight loss...
  55. ncbi request reprint Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study
    Cris A Slentz
    Divisions of Cardiology, Geriatric Medicine, and General Internal Medicine, Department of Medicine, Duke Center for Living, Center for Health Policy Research, Durham, NC 27710, USA
    Arch Intern Med 164:31-9. 2004
    ..Obesity is a major health problem due, in part, to physical inactivity. The amount of activity needed to prevent weight gain is unknown...
  56. ncbi request reprint Modest exercise prevents the progressive disease associated with physical inactivity
    Cris A Slentz
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Exerc Sport Sci Rev 35:18-23. 2007
    ..There seems to be a critical minimal level of physical activity required to maintain metabolic health. A modest amount of exercise seems to prevent metabolic deterioration...
  57. ncbi request reprint Minimal versus umbilical waist circumference measures as indicators of cardiovascular disease risk
    Leslie H Willis
    Division of Cardiology, Department of Medicine, Duke University Medical Center, P O Box 102903, Durham, NC 27710, USA
    Obesity (Silver Spring) 15:753-9. 2007
    ..We examined two WC locations to determine which was more highly correlated with CVD risk factors and metabolic syndrome (MS)...
  58. ncbi request reprint Response of high-sensitivity C-reactive protein to exercise training in an at-risk population
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 152:793-800. 2006
    ..Our objective was to determine if modulating fitness with exercise training imposes changes in high-sensitivity C-reactive protein in a mixed-sex population at risk for cardiovascular disease...
  59. ncbi request reprint Expression of genes regulating malonyl-CoA in human skeletal muscle
    Celia Pender
    Department of Medicine, Diabetes and Endocrine Research, Mount Zion Medical Center, University of California, San Francisco, California 94143 1616, USA
    J Cell Biochem 99:860-7. 2006
    ..No other genes showed signs of increased mRNA content with obesity, suggesting that there may be selective transcriptional regulation of malonyl-CoA metabolism in human obesity...