D B Hoover

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. doi request reprint Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Neuroscience 164:1170-9. 2009
  2. pmc PAC₁ receptors mediate positive chronotropic responses to PACAP-27 and VIP in isolated mouse atria
    Donald B Hoover
    Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Eur J Pharmacol 713:25-30. 2013
  3. pmc Differential activation of guinea pig intrinsic cardiac neurons by the PAC1 agonists maxadilan and pituitary adenylate cyclase-activating polypeptide 27 (PACAP27)
    Donald B Hoover
    Department of Pharmacology, East Tennessee State University, Johnson City, 37614, USA
    J Pharmacol Exp Ther 331:197-203. 2009
  4. ncbi request reprint Actions of tachykinins within the heart and their relevance to cardiovascular disease
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Jpn J Pharmacol 84:367-73. 2000
  5. ncbi request reprint Pharmacological characterization of the pressor response to tachykinins in isolated perfused rat kidney
    Y Chen
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City
    J Pharmacol Exp Ther 267:1176-80. 1993
  6. pmc Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75
    J L Hoard
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroscience 156:129-42. 2008
  7. ncbi request reprint Substance P modulates nicotinic responses of intracardiac neurons to acetylcholine in the guinea pig
    L Zhang
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1792-800. 2001
  8. ncbi request reprint Substance P evokes bradycardia by stimulation of postganglionic cholinergic neurons
    J D Tompkins
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Peptides 20:623-8. 1999
  9. ncbi request reprint Regional localization and abundance of calcitonin gene-related peptide receptors in guinea pig heart
    Y Chang
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614-0577, USA
    J Mol Cell Cardiol 33:745-54. 2001
  10. ncbi request reprint Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    J Pharmacol Exp Ther 282:1337-44. 1997

Research Grants

Collaborators

Detail Information

Publications26

  1. doi request reprint Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Neuroscience 164:1170-9. 2009
    ..The putative role of multiple neurotransmitters in controlling intrinsic cardiac neurons and mediating efferent signaling to the heart indicates the possibility of novel therapeutic targets for arrhythmia prevention...
  2. pmc PAC₁ receptors mediate positive chronotropic responses to PACAP-27 and VIP in isolated mouse atria
    Donald B Hoover
    Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Eur J Pharmacol 713:25-30. 2013
    ..We conclude that all three VIP/PACAP family receptors are expressed by mouse cardiac tissue, but only PAC₁ receptors mediate positive chronotropic responses to PACAP-27 and VIP...
  3. pmc Differential activation of guinea pig intrinsic cardiac neurons by the PAC1 agonists maxadilan and pituitary adenylate cyclase-activating polypeptide 27 (PACAP27)
    Donald B Hoover
    Department of Pharmacology, East Tennessee State University, Johnson City, 37614, USA
    J Pharmacol Exp Ther 331:197-203. 2009
    ..They also suggest that maxadilan and PACAP27 differ in activating PAC1 receptors on cardiac neurons and/or stimulating downstream signaling mechanisms...
  4. ncbi request reprint Actions of tachykinins within the heart and their relevance to cardiovascular disease
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Jpn J Pharmacol 84:367-73. 2000
    ..It is proposed that these ganglion stimulant and vascular actions are manifest by endogenous tachykinins during myocardial ischemia...
  5. ncbi request reprint Pharmacological characterization of the pressor response to tachykinins in isolated perfused rat kidney
    Y Chen
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City
    J Pharmacol Exp Ther 267:1176-80. 1993
    ..3 nmol, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)..
  6. pmc Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75
    J L Hoard
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroscience 156:129-42. 2008
    ..They also suggest that neurotrophins and local NE synthesis might have important effects on neurons of the mouse ICG...
  7. ncbi request reprint Substance P modulates nicotinic responses of intracardiac neurons to acetylcholine in the guinea pig
    L Zhang
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1792-800. 2001
    ..These findings support the conclusion that SP could function as a neuromodulator and neurotransmitter in intracardiac ganglia of the guinea pig...
  8. ncbi request reprint Substance P evokes bradycardia by stimulation of postganglionic cholinergic neurons
    J D Tompkins
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Peptides 20:623-8. 1999
    ..These results suggest that SP can evoke bradycardia in vivo through stimulation of postganglionic cholinergic neurons...
  9. ncbi request reprint Regional localization and abundance of calcitonin gene-related peptide receptors in guinea pig heart
    Y Chang
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614-0577, USA
    J Mol Cell Cardiol 33:745-54. 2001
    ....
  10. ncbi request reprint Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts
    D B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    J Pharmacol Exp Ther 282:1337-44. 1997
    ..Furthermore, they provide evidence that the M3 receptor subtype mediates the vasoconstrictor effect of acetylcholine on resistance vessels in rat heart...
  11. ncbi request reprint NK(3) receptors in the feline nucleus tractus solitarius are not involved with the muscle pressor response
    B Fry
    Department of Physiology, College of Medicine, East Tennessee State University, Johnson City 37614-0576, USA
    Neuropeptides 35:154-61. 2001
    ..We conclude that NK(3) receptors in the NTS are not involved with the regulation of cardiovascular function during activation of the muscle pressor response...
  12. ncbi request reprint Tachykinin agonists modulate cholinergic neurotransmission at guinea-pig intracardiac Ganglia
    Lili Zhang
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 1708, USA
    J Pharmacol Sci 99:228-38. 2005
    ..Inhibition of neurotransmission by SP is most likely explained by the known blocking action of this peptide at ganglionic nicotine receptors...
  13. ncbi request reprint Distinct regional distributions of NK1 and NK3 neurokinin receptor immunoreactivity in rat brainstem gustatory centers
    Theresa A Harrison
    Department of Anatomy and Cell Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res Bull 63:7-17. 2004
    ..These findings suggest that distinct tachykinin ligand/neurokinin receptor combinations may be important in local processing of information within brainstem gustatory centers...
  14. ncbi request reprint Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters
    Donald B Hoover
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Cardiovasc Res 62:112-21. 2004
    ..This study maps cholinergic innervation of guinea pig heart using a new antibody to the human high-affinity choline transporter (CHT), which is present only in cholinergic nerves...
  15. doi request reprint Capsaicin-evoked bradycardia in anesthetized guinea pigs is mediated by endogenous tachykinins
    John C Hancock
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Regul Pept 147:19-24. 2008
    ..This effect appears to be truncated by the positive chronotropic action of CGRP that is also released from cardiac afferents by capsaicin...
  16. doi request reprint Development of cardiac parasympathetic neurons, glial cells, and regional cholinergic innervation of the mouse heart
    S P Fregoso
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroscience 221:28-36. 2012
    ....
  17. ncbi request reprint Increased ganglionic responses to substance P in hypertensive rats due to upregulation of NK(1) receptors
    R V Schoborg
    Department of Microbiology, James H Quillen College of Medicine, Johnson City, Tennessee 37614, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1685-94. 2000
    ..RT-PCR showed increased abundance of NK(1) receptor mRNA in SHRs as well. These observations suggest that the greater ganglionic stimulation caused by SP in SHRs is due to upregulation of NK(1) receptors...
  18. ncbi request reprint Regional cardiac ganglia projections in the guinea pig heart studied by postmortem DiI tracing
    Theresa A Harrison
    Department of Anatomy and Cell Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Anat Rec A Discov Mol Cell Evol Biol 285:758-70. 2005
    ..Also, tracing with DiI has provided evidence for collateral nerve projections that could be the substrate for novel intracardiac regulatory circuits...
  19. ncbi request reprint Phenotypic properties of adult mouse intrinsic cardiac neurons maintained in culture
    Jennifer L Hoard
    Department of Physiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 1708, USA
    Am J Physiol Cell Physiol 293:C1875-83. 2007
    ..Accordingly, these cultures provide a viable model for evaluating the physiology, pharmacology, and trophic factor sensitivity of adult mouse cardiac parasympathetic neurons...
  20. ncbi request reprint Expression of c-fos-like immunoreactivity in the feline brainstem in response to isometric muscle contraction and baroreceptor reflex changes in arterial pressure
    C A Williams
    Department of Physiology, The James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0576, USA
    Brain Res 852:424-35. 2000
    ..These results indicate that the exercise pressor reflex and baroreflex activate similar, but not completely identical, sites in the brainstem...
  21. doi request reprint Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice
    Abigail M Mabe
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Cardiovasc Res 82:93-9. 2009
    ..This study used nrtn knockout (KO) and wild-type (WT) mice to determine the effect of nrtn deletion on cardiac cholinergic innervation and function in the adult heart...
  22. pmc Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium
    Donald B Hoover
    Department of Pharmacology, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States
    Auton Neurosci 141:38-45. 2008
    ..These findings suggest that ventricular sensory information is transferred to the central nervous system by relatively small populations of vagal and spinal afferent neurons and that spinal afferents use a variety of neurotransmitters...
  23. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide: localization and differential influence on isolated hearts from rats and guinea pigs
    Yingzi Chang
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University Johnson City, TN 37614, USA
    Regul Pept 129:139-46. 2005
    ..A direct positive chronotropic influence of endogenous PACAP is unlikely since atrial muscle lacks PACAP-immunoreactive nerve fibers...
  24. ncbi request reprint Presence and co-localization of vasoactive intestinal polypeptide with neuronal nitric oxide synthase in cells and nerve fibers within guinea pig intrinsic cardiac ganglia and cardiac tissue
    Rodney L Parsons
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Tissue Res 323:197-209. 2006
    ..These extrinsic VIP-IR fibers are also immunoreactive for nNOS and therefore most likely are a component of the afferent fibers derived from the vagal sensory ganglia...
  25. ncbi request reprint Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failure
    Tatsuo Katori
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions Baltimore, MD, USA
    Circ Res 96:234-43. 2005
    ..This mechanism is suppressed in heart failure, so that afterload reduction accounts for CGRP-enhanced function in this setting...
  26. pmc Neurally released pituitary adenylate cyclase-activating polypeptide enhances guinea pig intrinsic cardiac neurone excitability
    John D Tompkins
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Physiol 582:87-93. 2007
    ..We hypothesize that in vivo PACAP released during preganglionic firing may modulate neurotransmission within the intrinsic cardiac ganglia...

Research Grants7

  1. NONCLASSICAL TRANSMITTERS AND CARDIAC GANGLIA
    Donald Hoover; Fiscal Year: 1999
    ..This line of investigation could ultimately establish sensory neuron peptide receptors as targets for therapy of specific cardiac arrhythmias and coronary vasospasm. ..
  2. Role of Nonclassical Transmitters in Cardiac Ganglia
    Donald Hoover; Fiscal Year: 2004
    ..abstract_text> ..