T P Gavin

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. pmc Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation
    Tom D Brutsaert
    Department of Physiology, School of Medicine, University of California, San Diego 92093 0623A, USA
    BMC Physiol 2:8. 2002
  2. ncbi Angiogenic growth factor response to acute systemic exercise in human skeletal muscle
    Timothy P Gavin
    Department of Exercise and Sport Science, East Carolina Univiversity, Greenville, NC 27858, USA
    J Appl Physiol (1985) 96:19-24. 2004
  3. ncbi Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle
    Timothy P Gavin
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 92:1176-82. 2002
  4. ncbi Clothing fabric does not affect thermoregulation during exercise in moderate heat
    T P Gavin
    Department of Kinesiology, Human Performance Laboratory, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 33:2124-30. 2001
  5. ncbi Effect of short-term exercise training on angiogenic growth factor gene responses in rats
    T P Gavin
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 90:1219-26. 2001
  6. ncbi Clothing and thermoregulation during exercise
    Timothy P Gavin
    Human Performance Laboratory, Departments of Exercise and Sport Science and Physiology, East Carolina University, Greenville, North Carolina 27858, USA
    Sports Med 33:941-7. 2003
  7. ncbi Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans
    Timothy P Gavin
    Department of Exercise and Sport Science, East Carolina University, 363 Ward Sports Medicine Bldg, Greenville, NC 27858, USA
    J Appl Physiol (1985) 98:315-21. 2005
  8. ncbi Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise
    T P Gavin
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 88:1192-8. 2000
  9. ncbi Effect of captopril on skeletal muscle angiogenic growth factor responses to exercise
    T P Gavin
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 88:1690-7. 2000
  10. ncbi Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition
    T P Gavin
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Acta Physiol Scand 175:201-9. 2002

Collaborators

Detail Information

Publications28

  1. pmc Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation
    Tom D Brutsaert
    Department of Physiology, School of Medicine, University of California, San Diego 92093 0623A, USA
    BMC Physiol 2:8. 2002
    ..Functional regions were visualized on muscle cross sections that were matched in series to slides processed through in situ hybridization with a VEGF165 probe. A greater upregulation in oxidative regions was hypothesized...
  2. ncbi Angiogenic growth factor response to acute systemic exercise in human skeletal muscle
    Timothy P Gavin
    Department of Exercise and Sport Science, East Carolina Univiversity, Greenville, NC 27858, USA
    J Appl Physiol (1985) 96:19-24. 2004
    ..Acta Physiol Scand 175: 201-209, 2002); and 3) VEGF protein is decreased immediately after exercise...
  3. ncbi Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle
    Timothy P Gavin
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 92:1176-82. 2002
    ..Therefore, these results provide evidence in adult rat tissue that the protective cardiovascular effects of moderate ethanol consumption may result in part through the increase of angiogenic growth factors...
  4. ncbi Clothing fabric does not affect thermoregulation during exercise in moderate heat
    T P Gavin
    Department of Kinesiology, Human Performance Laboratory, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 33:2124-30. 2001
    ..We investigated whether temperature regulation is improved during exercise in moderate heat by the use of clothing constructed from fabric that was purported to promote sweat evaporation compared with traditional fabrics...
  5. ncbi Effect of short-term exercise training on angiogenic growth factor gene responses in rats
    T P Gavin
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 90:1219-26. 2001
    ....
  6. ncbi Clothing and thermoregulation during exercise
    Timothy P Gavin
    Human Performance Laboratory, Departments of Exercise and Sport Science and Physiology, East Carolina University, Greenville, North Carolina 27858, USA
    Sports Med 33:941-7. 2003
    ..Future research should include conditions that more closely mimic outdoor conditions, where high work rates, large airflow and high relative humidity can significantly impact thermoregulation...
  7. ncbi Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans
    Timothy P Gavin
    Department of Exercise and Sport Science, East Carolina University, 363 Ward Sports Medicine Bldg, Greenville, NC 27858, USA
    J Appl Physiol (1985) 98:315-21. 2005
    ..Although differences may exist in CD and capillary-to-fiber area ratio between lean and obese skeletal muscle, the present results provide evidence that VEGF and VEGF receptor expression are not different between lean and obese muscle...
  8. ncbi Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise
    T P Gavin
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 88:1192-8. 2000
    ..These findings suggest that NO is important in the regulation of the VEGF gene response to exercise through increases in VEGF transcription or by increases in the VEGF mRNA half-life...
  9. ncbi Effect of captopril on skeletal muscle angiogenic growth factor responses to exercise
    T P Gavin
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 88:1690-7. 2000
    ..Captopril did reduce Flk-1 mRNA 30-40%, independently of exercise. This is partially consistent with the suggestion that captopril may inhibit capillary growth...
  10. ncbi Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition
    T P Gavin
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Acta Physiol Scand 175:201-9. 2002
    ..These findings suggest that: (1) exercise alters Flt-1 and Flk-1 gene expression; and (2) NO is important in the regulation of the Flt-1 gene response to exercise...
  11. ncbi Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes
    S R Hopkins
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Appl Physiol (1985) 85:1523-32. 1998
    ..97, P < 0.005 at 60 min). These data are compatible with interstitial edema as a mechanism and suggest that lung size is an important determinant of the efficiency of gas exchange during exercise...
  12. ncbi Acute resistance exercise increases skeletal muscle angiogenic growth factor expression
    T P Gavin
    Department of Exercise and Sport Science, Department of Pysiology, and Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Acta Physiol (Oxf) 191:139-46. 2007
    ..We hypothesized that acute resistance exercise also increases skeletal muscle angiogenic growth factor [VEGF and angiopoietin (Ang)] expression...
  13. ncbi Pulmonary gas exchange during exercise in women: effects of exercise type and work increment
    S R Hopkins
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Appl Physiol (1985) 89:721-30. 2000
    ..The Pa(O(2)) responses to R and C exercise in our 17 subjects do not differ significantly from those previously observed in men...
  14. ncbi Evidence of O2 supply-dependent VO2 max in the exercise-trained human quadriceps
    R S Richardson
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Appl Physiol (1985) 86:1048-53. 1999
    ....
  15. ncbi Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women
    Andrea N Croley
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol (1985) 99:1872-9. 2005
    ....
  16. ncbi Ventilation's role in the decline in VO2max and SaO2 in acute hypoxic exercise
    T P Gavin
    Human Performance Laboratory, Department of Kinesiology, Indiana University, Bloomington 47405, USA
    Med Sci Sports Exerc 30:195-9. 1998
    ..However, the ventilatory response to hypoxic exercise is not dependent upon hypoxic ventilatory drive...
  17. pmc AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
    Kevin A Zwetsloot
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    J Physiol 586:6021-35. 2008
    ....
  18. ncbi Soleus, plantaris and gastrocnemius VEGF mRNA responses to hypoxia and exercise are preserved in aged compared with young female C57BL/6 mice
    T P Gavin
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    Acta Physiol (Oxf) 188:113-21. 2006
    ..We hypothesized that attenuated VEGF mRNA responses to hypoxia and exercise with advanced age would be greatest in oxidative vs. glycolytic muscles...
  19. pmc No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men
    Timothy P Gavin
    Department of Exercise and Sport Science, Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    J Physiol 585:231-9. 2007
    ..In addition, muscular activity-associated increases in interstitial VEGF protein may play an important role in the maintenance of skeletal muscle capillarization across the life span...
  20. ncbi Lower skeletal muscle capillarization and VEGF expression in aged vs. young men
    Nicholas A Ryan
    Department of Exercise and Sport Science, 363 Ward Sports Medicine Bldg, East Carolina University, Greenville, North Carolina 27858, USA
    J Appl Physiol (1985) 100:178-85. 2006
    ..There were no effects of exercise or age on muscle Flt-1 mRNA or protein or KDR protein. These results confirm that skeletal muscle capillarization and VEGF expression are lower in aged compared with young men...
  21. pmc Basal and exercise-induced regulation of skeletal muscle capillarization
    Timothy P Gavin
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    Exerc Sport Sci Rev 37:86-92. 2009
    ..Future work needs to increase the use of advanced molecular techniques to expand our knowledge of the regulation of basal and exercise-induced capillarization...
  22. pmc Duodenal-jejunal bypass surgery does not increase skeletal muscle insulin signal transduction or glucose disposal in Goto-Kakizaki type 2 diabetic rats
    Timothy P Gavin
    Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Obes Surg 21:231-7. 2011
    ..It was hypothesized that DJB would increase skeletal muscle insulin signal transduction and glucose disposal in GK rats...
  23. pmc A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals
    K E Boyle
    Human Performance Laboratory, East Carolina University, Greenville, North Carolina 27858, USA
    J Clin Endocrinol Metab 96:775-81. 2011
    ..In lean individuals, increasing dietary lipid can elicit an increase in whole body lipid oxidation; however, with obesity the capacity to respond to changes in substrate availability appears to be compromised...
  24. ncbi Circulating plasma VEGF response to exercise in sedentary and endurance-trained men
    Raymond M Kraus
    Department of Exercise and Sport Medicine, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol (1985) 96:1445-50. 2004
    ..In conclusion, exercise can increase plasma VEGF in both ET athletes and Sed men; however, there is considerable variation in the individual time of the peak VEGF response...
  25. ncbi Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise
    I Mark Olfert
    Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Growth Factors 24:253-9. 2006
    ....
  26. ncbi Reduced mechanical efficiency in chronic obstructive pulmonary disease but normal peak VO2 with small muscle mass exercise
    Russell S Richardson
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
    Am J Respir Crit Care Med 169:89-96. 2004
    ....
  27. ncbi Affective and self-efficacy responses to acute aerobic exercise in sedentary older and younger adults
    Brian C Focht
    Division of Health Behavior and Health Promotion, The Ohio State University, Columbus, OH 43210, USA
    J Aging Phys Act 15:123-38. 2007
    ..The relationship between these acute responses and physical activity behavior across the life span warrants future inquiry...
  28. pmc Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle
    Anne A Wooldridge
    Department of Pharmacology, Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:11850-9. 2008
    ..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity...