Research Topics
Species | T P GavinSummaryAffiliation: East Carolina University Country: USA Publications
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Detail Information
Publications
Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulationTom D Brutsaert
Department of Physiology, School of Medicine, University of California, San Diego 92093 0623A, USA
BMC Physiol 2:8. 2002..Functional regions were visualized on muscle cross sections that were matched in series to slides processed through in situ hybridization with a VEGF165 probe. A greater upregulation in oxidative regions was hypothesized...
Angiogenic growth factor response to acute systemic exercise in human skeletal muscleTimothy P Gavin
Department of Exercise and Sport Science, East Carolina Univiversity, Greenville, NC 27858, USA
J Appl Physiol 96:19-24. 2004..Acta Physiol Scand 175: 201-209, 2002); and 3) VEGF protein is decreased immediately after exercise...- Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscleTimothy P Gavin
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
J Appl Physiol 92:1176-82. 2002..Therefore, these results provide evidence in adult rat tissue that the protective cardiovascular effects of moderate ethanol consumption may result in part through the increase of angiogenic growth factors... - Clothing fabric does not affect thermoregulation during exercise in moderate heatT P Gavin
Department of Kinesiology, Human Performance Laboratory, Indiana University, Bloomington, IN 47405, USA
Med Sci Sports Exerc 33:2124-30. 2001..We investigated whether temperature regulation is improved during exercise in moderate heat by the use of clothing constructed from fabric that was purported to promote sweat evaporation compared with traditional fabrics... - Effect of short-term exercise training on angiogenic growth factor gene responses in ratsT P Gavin
Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
J Appl Physiol 90:1219-26. 2001.... - Clothing and thermoregulation during exerciseTimothy P Gavin
Human Performance Laboratory, Departments of Exercise and Sport Science and Physiology, East Carolina University, Greenville, North Carolina 27858, USA
Sports Med 33:941-7. 2003..Future research should include conditions that more closely mimic outdoor conditions, where high work rates, large airflow and high relative humidity can significantly impact thermoregulation... - Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humansTimothy P Gavin
Department of Exercise and Sport Science, East Carolina University, 363 Ward Sports Medicine Bldg, Greenville, NC 27858, USA
J Appl Physiol 98:315-21. 2005..Although differences may exist in CD and capillary-to-fiber area ratio between lean and obese skeletal muscle, the present results provide evidence that VEGF and VEGF receptor expression are not different between lean and obese muscle... - Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exerciseT P Gavin
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
J Appl Physiol 88:1192-8. 2000..These findings suggest that NO is important in the regulation of the VEGF gene response to exercise through increases in VEGF transcription or by increases in the VEGF mRNA half-life... - Effect of captopril on skeletal muscle angiogenic growth factor responses to exerciseT P Gavin
Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
J Appl Physiol 88:1690-7. 2000..Captopril did reduce Flk-1 mRNA 30-40%, independently of exercise. This is partially consistent with the suggestion that captopril may inhibit capillary growth... - Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibitionT P Gavin
Department of Medicine, University of California San Diego, La Jolla, CA, USA
Acta Physiol Scand 175:201-9. 2002..These findings suggest that: (1) exercise alters Flt-1 and Flk-1 gene expression; and (2) NO is important in the regulation of the Flt-1 gene response to exercise... - Effect of prolonged, heavy exercise on pulmonary gas exchange in athletesS R Hopkins
Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Appl Physiol 85:1523-32. 1998..97, P < 0.005 at 60 min). These data are compatible with interstitial edema as a mechanism and suggest that lung size is an important determinant of the efficiency of gas exchange during exercise... - Acute resistance exercise increases skeletal muscle angiogenic growth factor expressionT P Gavin
Department of Exercise and Sport Science, Department of Pysiology, and Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
Acta Physiol (Oxf) 191:139-46. 2007..We hypothesized that acute resistance exercise also increases skeletal muscle angiogenic growth factor [VEGF and angiopoietin (Ang)] expression... - Pulmonary gas exchange during exercise in women: effects of exercise type and work incrementS R Hopkins
Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
J Appl Physiol 89:721-30. 2000..The Pa(O(2)) responses to R and C exercise in our 17 subjects do not differ significantly from those previously observed in men... - Evidence of O2 supply-dependent VO2 max in the exercise-trained human quadricepsR S Richardson
Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
J Appl Physiol 86:1048-53. 1999.... - Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young womenAndrea N Croley
Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
J Appl Physiol 99:1872-9. 2005.... - Ventilation's role in the decline in VO2max and SaO2 in acute hypoxic exerciseT P Gavin
Human Performance Laboratory, Department of Kinesiology, Indiana University, Bloomington 47405, USA
Med Sci Sports Exerc 30:195-9. 1998..However, the ventilatory response to hypoxic exercise is not dependent upon hypoxic ventilatory drive... 
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exerciseKevin A Zwetsloot
Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
J Physiol 586:6021-35. 2008....- Soleus, plantaris and gastrocnemius VEGF mRNA responses to hypoxia and exercise are preserved in aged compared with young female C57BL/6 miceT P Gavin
Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
Acta Physiol (Oxf) 188:113-21. 2006..We hypothesized that attenuated VEGF mRNA responses to hypoxia and exercise with advanced age would be greatest in oxidative vs. glycolytic muscles... - No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged menTimothy P Gavin
Department of Exercise and Sport Science, Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
J Physiol 585:231-9. 2007..In addition, muscular activity-associated increases in interstitial VEGF protein may play an important role in the maintenance of skeletal muscle capillarization across the life span... - Lower skeletal muscle capillarization and VEGF expression in aged vs. young menNicholas A Ryan
Department of Exercise and Sport Science, 363 Ward Sports Medicine Bldg, East Carolina University, Greenville, North Carolina 27858, USA
J Appl Physiol 100:178-85. 2006..There were no effects of exercise or age on muscle Flt-1 mRNA or protein or KDR protein. These results confirm that skeletal muscle capillarization and VEGF expression are lower in aged compared with young men... 
Basal and exercise-induced regulation of skeletal muscle capillarizationTimothy P Gavin
Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
Exerc Sport Sci Rev 37:86-92. 2009..Future work needs to increase the use of advanced molecular techniques to expand our knowledge of the regulation of basal and exercise-induced capillarization...- Duodenal-jejunal bypass surgery does not increase skeletal muscle insulin signal transduction or glucose disposal in Goto-Kakizaki type 2 diabetic ratsTimothy P Gavin
Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
Obes Surg 21:231-7. 2011..It was hypothesized that DJB would increase skeletal muscle insulin signal transduction and glucose disposal in GK rats... - A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individualsK E Boyle
Human Performance Laboratory, East Carolina University, Greenville, North Carolina 27858, USA
J Clin Endocrinol Metab 96:775-81. 2011..In lean individuals, increasing dietary lipid can elicit an increase in whole body lipid oxidation; however, with obesity the capacity to respond to changes in substrate availability appears to be compromised... - Circulating plasma VEGF response to exercise in sedentary and endurance-trained menRaymond M Kraus
Department of Exercise and Sport Medicine, East Carolina University, Greenville, NC 27858, USA
J Appl Physiol 96:1445-50. 2004..In conclusion, exercise can increase plasma VEGF in both ET athletes and Sed men; however, there is considerable variation in the individual time of the peak VEGF response... - Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exerciseI Mark Olfert
Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
Growth Factors 24:253-9. 2006.... - Reduced mechanical efficiency in chronic obstructive pulmonary disease but normal peak VO2 with small muscle mass exerciseRussell S Richardson
Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
Am J Respir Crit Care Med 169:89-96. 2004.... - Affective and self-efficacy responses to acute aerobic exercise in sedentary older and younger adultsBrian C Focht
Division of Health Behavior and Health Promotion, The Ohio State University, Columbus, OH 43210, USA
J Aging Phys Act 15:123-38. 2007..The relationship between these acute responses and physical activity behavior across the life span warrants future inquiry... - Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscleAnne A Wooldridge
Department of Pharmacology, Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 283:11850-9. 2008..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity...