Basma El Yacoubi

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. pmc A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification
    Basma El Yacoubi
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA
    EMBO J 30:882-93. 2011
  2. pmc Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate
    VALERIE DE CRECY-LAGARD
    Department of Microbiology and Department of Microbiology and Cell Science, University of Florida, P O Box 110700, Gainesville, Florida 32611 0700, United States
    ACS Chem Biol 7:1807-16. 2012
  3. pmc Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I
    Gabriella Phillips
    Department of Microbiology, University of Florida, Gainesville, FL 32611 0700, USA
    J Bacteriol 190:7876-84. 2008
  4. pmc Functional promiscuity of the COG0720 family
    Gabriela Phillips
    Department of Microbiology and Cell Science, University of Florida, Gainesville, 32611, United States
    ACS Chem Biol 7:197-209. 2012
  5. pmc The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA
    Basma El Yacoubi
    Department of Microbiology, University of Florida, Gainesville, FL 32611 0700, USA
    Nucleic Acids Res 37:2894-909. 2009
  6. ncbi request reprint Integrative data-mining tools to link gene and function
    Basma El Yacoubi
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 1101:43-66. 2014
  7. doi request reprint Biosynthesis and function of posttranscriptional modifications of transfer RNAs
    Basma El Yacoubi
    Department of Microbiology, University of Florida, Gainesville, Florida 32611 0700, USA
    Annu Rev Genet 46:69-95. 2012
  8. pmc Towards a systems approach in the genetic analysis of archaea: Accelerating mutant construction and phenotypic analysis in Haloferax volcanii
    Ian K Blaby
    Department of Microbiology and Cell Science, University of Florida, Gainesville, 32611 0700, USA
    Archaea 2010:426239. 2010
  9. pmc Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations
    VALERIE DE CRECY-LAGARD
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA
    BMC Genomics 8:245. 2007
  10. ncbi request reprint Discovery of a new prokaryotic type I GTP cyclohydrolase family
    Basma El Yacoubi
    Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 281:37586-93. 2006

Collaborators

Detail Information

Publications11

  1. pmc A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification
    Basma El Yacoubi
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA
    EMBO J 30:882-93. 2011
    ..We also showed that YaeZ, a YgjD paralog, is required for YgjD function in vivo in bacteria. This work lays the foundation for understanding the pleiotropic role of this universal protein family...
  2. pmc Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate
    VALERIE DE CRECY-LAGARD
    Department of Microbiology and Department of Microbiology and Cell Science, University of Florida, P O Box 110700, Gainesville, Florida 32611 0700, United States
    ACS Chem Biol 7:1807-16. 2012
    ..The discovery of these missing genes solves a long-standing mystery and provides novel examples of convergent evolutions where proteins of dissimilar architectures perform the same biochemical function...
  3. pmc Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I
    Gabriella Phillips
    Department of Microbiology, University of Florida, Gainesville, FL 32611 0700, USA
    J Bacteriol 190:7876-84. 2008
    ..These results link the production of a tRNA-modified base to primary metabolism and further clarify the biosynthetic pathway for these complex modified nucleosides...
  4. pmc Functional promiscuity of the COG0720 family
    Gabriela Phillips
    Department of Microbiology and Cell Science, University of Florida, Gainesville, 32611, United States
    ACS Chem Biol 7:197-209. 2012
    ..This study reveals an expanded versatility of the COG0720 family members and illustrates that for certain protein families extensive comparative genomic analysis beyond homology is required to correctly predict function...
  5. pmc The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA
    Basma El Yacoubi
    Department of Microbiology, University of Florida, Gainesville, FL 32611 0700, USA
    Nucleic Acids Res 37:2894-909. 2009
    ..This work lays the foundation for elucidating the function of a protein family found in every sequenced genome to date and understanding the role of t(6)A in vivo...
  6. ncbi request reprint Integrative data-mining tools to link gene and function
    Basma El Yacoubi
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 1101:43-66. 2014
    ..The main focus is on phylogenetic distribution and physical clustering tools, but other tools such as pathway reconstruction, gene fusions, and analysis of high-throughput experimental data are also surveyed. ..
  7. doi request reprint Biosynthesis and function of posttranscriptional modifications of transfer RNAs
    Basma El Yacoubi
    Department of Microbiology, University of Florida, Gainesville, Florida 32611 0700, USA
    Annu Rev Genet 46:69-95. 2012
    ....
  8. pmc Towards a systems approach in the genetic analysis of archaea: Accelerating mutant construction and phenotypic analysis in Haloferax volcanii
    Ian K Blaby
    Department of Microbiology and Cell Science, University of Florida, Gainesville, 32611 0700, USA
    Archaea 2010:426239. 2010
    ..We conclude that these high-throughput methods are suitable for a rapid investigation of an H. volcanii mutant library and suggest that they should form the basis of a larger genome-wide experiment...
  9. pmc Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations
    VALERIE DE CRECY-LAGARD
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA
    BMC Genomics 8:245. 2007
    ..This study reports the results of the analysis and integrates them with new and existing experimental data...
  10. ncbi request reprint Discovery of a new prokaryotic type I GTP cyclohydrolase family
    Basma El Yacoubi
    Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 281:37586-93. 2006
    ..This new GCYH-I family is found in approximately 20% of sequenced bacteria and is prevalent in Archaea, but the family is to this date absent in Eukarya...
  11. pmc A Gateway platform for functional genomics in Haloferax volcanii: deletion of three tRNA modification genes
    Basma El Yacoubi
    Department of Microbiology and Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA
    Archaea 2:211-9. 2009
    ..Preliminary phenotypic analysis of the deletion mutants was conducted, and confirmed all three predictions...