Ethan J Anderson

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. pmc Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
    Kelsey H Fisher-Wellman
    Department of Kinesiology, East Carolina University, Greenville, NC 27834, USA
    J Physiol 591:3471-86. 2013
  2. pmc Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart
    Ethan J Anderson
    Department of Cardiovascular Sciences and East Carolina Heart Institute, East Carolina University, Greenville, North Carolina 27835, USA
    J Am Coll Cardiol 54:1891-8. 2009
  3. pmc Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways
    Ethan J Anderson
    Dept of Pharmacology and Toxicology, Brody School of Medicine, East Carolina Univ, Greenville, NC 27834, USA
    Am J Physiol Heart Circ Physiol 300:H118-24. 2011
  4. pmc Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids
    Ethan J Anderson
    Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC 27834, USA
    Biochem J 441:359-66. 2012
  5. pmc Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
    Ethan J Anderson
    Metabolic Institute for the Study of Diabetes and Obesity, East Carolina University, Greenville, North Carolina 27834, USA
    J Clin Invest 119:573-81. 2009
  6. pmc Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes
    Hyo Bum Kwak
    Department of Kinesiology, East Carolina University, Greenville, NC 27834, USA
    Free Radic Biol Med 52:198-207. 2012
  7. doi request reprint Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment
    Justin D La Favor
    Department of Kinesiology, East Carolina University, Greenville, North Carolina
    Am J Physiol Regul Integr Comp Physiol 305:R423-34. 2013
  8. pmc Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women
    Daniel A Kane
    The Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Am J Physiol Endocrinol Metab 300:E528-35. 2011
  9. doi request reprint Short-term exercise preserves myocardial glutathione and decreases arrhythmias after thiol oxidation and ischemia in isolated rat hearts
    Chad R Frasier
    Dept of Physiology, Brody School of Medicine, East Carolina Univ, Greenville, NC 27834, USA
    J Appl Physiol (1985) 111:1751-9. 2011
  10. doi request reprint Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium
    Jitka A I Virag
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina and
    Am J Physiol Heart Circ Physiol 305:H477-83. 2013

Collaborators

Detail Information

Publications16

  1. pmc Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
    Kelsey H Fisher-Wellman
    Department of Kinesiology, East Carolina University, Greenville, NC 27834, USA
    J Physiol 591:3471-86. 2013
    ..Furthermore, upregulation of thioredoxin reductase-2 plays a critical role in preserving the mitochondrial redox status in the heart and skeletal muscle with exercise...
  2. pmc Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart
    Ethan J Anderson
    Department of Cardiovascular Sciences and East Carolina Heart Institute, East Carolina University, Greenville, North Carolina 27835, USA
    J Am Coll Cardiol 54:1891-8. 2009
    ..The aim of this study was to determine the impact of diabetes on oxidant balance and mitochondrial metabolism of carbohydrate- and lipid-based substrates in myocardium of type 2 diabetic patients...
  3. pmc Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways
    Ethan J Anderson
    Dept of Pharmacology and Toxicology, Brody School of Medicine, East Carolina Univ, Greenville, NC 27834, USA
    Am J Physiol Heart Circ Physiol 300:H118-24. 2011
    ..In addition, they lend further support to the notion that mitochondria represent a viable target for future therapies directed at ameliorating heart failure and other comorbidities that come with diabetes...
  4. pmc Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids
    Ethan J Anderson
    Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC 27834, USA
    Biochem J 441:359-66. 2012
    ....
  5. pmc Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
    Ethan J Anderson
    Metabolic Institute for the Study of Diabetes and Obesity, East Carolina University, Greenville, North Carolina 27834, USA
    J Clin Invest 119:573-81. 2009
    ....
  6. pmc Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes
    Hyo Bum Kwak
    Department of Kinesiology, East Carolina University, Greenville, NC 27834, USA
    Free Radic Biol Med 52:198-207. 2012
    ....
  7. doi request reprint Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment
    Justin D La Favor
    Department of Kinesiology, East Carolina University, Greenville, North Carolina
    Am J Physiol Regul Integr Comp Physiol 305:R423-34. 2013
    ..Furthermore, exercise training may be a practical means of preventing diet-induced ED and CAD development. ..
  8. pmc Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women
    Daniel A Kane
    The Human Performance Laboratory, East Carolina University, Greenville, NC 27858, USA
    Am J Physiol Endocrinol Metab 300:E528-35. 2011
    ..01). The results suggest that 1) P4 increases mE(H2O2) with or without E2; 2) P4 alone inhibits Jo(2) but not when E2 is present; and 3) P4 is related to the mE(H2O2) previously linked to skeletal muscle insulin resistance...
  9. doi request reprint Short-term exercise preserves myocardial glutathione and decreases arrhythmias after thiol oxidation and ischemia in isolated rat hearts
    Chad R Frasier
    Dept of Physiology, Brody School of Medicine, East Carolina Univ, Greenville, NC 27834, USA
    J Appl Physiol (1985) 111:1751-9. 2011
    ....
  10. doi request reprint Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium
    Jitka A I Virag
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina and
    Am J Physiol Heart Circ Physiol 305:H477-83. 2013
    ..Understanding the mechanisms connecting cardiac events, mitochondrial function, and mPer2 could lead to preventative and therapeutic strategies for at risk populations...
  11. doi request reprint Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, Western pattern diet
    Justin D La Favor
    East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Sex Med 10:694-703. 2013
    ..La Favor JD, Anderson EJ, Hickner RC, and Wingard CJ. Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, Western pattern diet. J Sex Med 2013;10:694-703...
  12. pmc Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle
    Christopher G R Perry
    East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA
    Biochem J 437:215-22. 2011
    ....
  13. pmc Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats
    Daniel A Kane
    East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    Free Radic Biol Med 49:1082-7. 2010
    ..These findings suggest that therapeutic concentrations of metformin normalize mitochondrial H(2)O(2) emission by blocking reverse electron flow without affecting forward electron flow or respiratory O(2) flux in skeletal muscle...
  14. doi request reprint The impact of race and postoperative atrial fibrillation on operative mortality after elective coronary artery bypass grafting
    Jimmy T Efird
    Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Eur J Cardiothorac Surg 45:e20-5. 2014
    ..However, the influence of race and POAF on operative mortality has not been examined. The objective of this study was to determine the influence of race and POAF on operative mortality after CABG...
  15. pmc Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization
    David A Brown
    Department of Physiology, Brody School of Medicine, Brody School of Medicine East Carolina University, Greenville, NC 27834, USA
    J Mol Cell Cardiol 48:673-9. 2010
    ..Targeting the mitochondrial benzodiazepine receptor can prevent electrical and mechanical dysfunction in both models of oxidative stress...
  16. doi request reprint A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids
    Carlyle Rogers
    Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC 27834, USA
    Free Radic Biol Med 67:330-41. 2014
    ....