Research Topics
Species | Jason D MarshallSummaryAffiliation: Dynavax Technologies Country: USA Publications
| Collaborators
|
Detail Information
Publications
Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functionsJason D Marshall
Dynavax Technologies Corporation, Berkeley, California, USA
J Leukoc Biol 73:781-92. 2003....- Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule, synthetic TLR7 ligandJason D Marshall
Dynavax Technologies Corporation, Berkeley, California, USA
J Leukoc Biol 82:497-508. 2007.... 
Induction of interferon-gamma from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid-dendritic-cell-produced interferon-alpha and tumour necrosis factor-alphaJason D Marshall
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
Immunology 117:38-46. 2006..These results illustrate an important function for type I interferon in innate immunity, which is not only to activate effectors like NK cells directly, but also to prime them for enhanced activation by other factors such as TNF-alpha...- Superior activity of the type C class of ISS in vitro and in vivo across multiple speciesJason D Marshall
Dynavax Technologies Corporation, Berkeley, California 94710, USA
DNA Cell Biol 24:63-72. 2005..In conclusion, we have shown CpG-C to exert several types of immune functions across multiple species, and this novel class is thus an attractive candidate for ISS-based therapeutic strategies... - Polymyxin B enhances ISS-mediated immune responses across multiple speciesJason D Marshall
Dynavax Technologies Corporation, Berkeley, CA, USA
Cell Immunol 229:93-105. 2004..These data illustrate the usefulness of formulating ISS with a cationic lipopeptide such as PMXB, which focuses and greatly amplifies the ISS-induced pathway of IFN-alpha-mediated responses... - A minimal human immunostimulatory CpG motif that potently induces IFN-gamma and IFN-alpha productionKaren Fearon
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
Eur J Immunol 33:2114-22. 2003..These results describe a novel technique for formulating active, but very short, ISS oligodeoxynucleotide that allows for the dissection and characterization of minimal immunostimulatory CpG motifs... - Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cellsJason D Marshall
Dynavax Technologies Corporation, 717 Potter Street, Suite 100, Berkeley, CA 94710, USA
Nucleic Acids Res 31:5122-33. 2003.... - IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequencesOmar Duramad
Dynavax Technologies, 717 Potter St, Ste 100, Berkeley, CA 94710, USA
Blood 102:4487-92. 2003..The 3 distinct classes of ISS differed with respect to induction of PDC maturation and T-cell priming capacity. IL-10 regulated PDC activation but did not inhibit the subsequent T-cell-priming ability of PDCs already activated by ISS... - Immunostimulatory DNA as a vaccine adjuvantDebbie Higgins
Preclinical Research, Dynavax Technologies, 2929 Seventh Street, Suite 100, Berkeley, CA 94710, USA
Expert Rev Vaccines 6:747-59. 2007..To date, clinical testing has largely affirmed the potency and safety of ISS-adjuvanted vaccines... - CpG oligodeoxynucleotide-induced immunity prevents growth of germinal center-derived B lymphoma cellsNicholas M Ponzio
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, NJ 07107, United States
Int Immunopharmacol 6:2057-68. 2006....