Research Topics
Genomes and Genes | Franck J BarratSummaryAffiliation: Dynavax Technologies Country: USA Publications
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Detail Information
Publications
IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequencesOmar Duramad
Dynavax Technologies, 717 Potter St, Ste 100, Berkeley, CA 94710, USA
Blood 102:4487-92. 2003..The 3 distinct classes of ISS differed with respect to induction of PDC maturation and T-cell priming capacity. IL-10 regulated PDC activation but did not inhibit the subsequent T-cell-priming ability of PDCs already activated by ISS...- Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammationOmar Duramad
Dynavax Technologies, Berkeley, CA 94710, USA
J Immunol 174:5193-200. 2005..IRS can also inhibit a complex pathological response to ISS, as shown by protection from death after massive systemic inflammation induced by a CpG-containing oligodeoxynucleotides... 
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activationCristiana Guiducci
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
J Exp Med 203:1999-2008. 2006..This establishes that the primary determinant of TLR9 signaling is not valency but endosomal location and demonstrates a strict compartmentalization of the biological response to TLR9 activation in PDCs...- In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokinesFranck J Barrat
DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
J Exp Med 195:603-16. 2002..Generating homogeneous populations of IL-10-producing T cells in vitro will thus facilitate the use of regulatory T cells in immunotherapy... - Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusFranck J Barrat
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
J Exp Med 202:1131-9. 2005..These inhibitors of TLR signaling thus represent novel therapeutic agents with potential for the treatment of lupus... - TLR recognition of self nucleic acids hampers glucocorticoid activity in lupusCristiana Guiducci
Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
Nature 465:937-41. 2010..These findings unveil a new role for self nucleic acid recognition by TLRs and indicate that inhibitors of TLR7 and 9 signalling could prove to be effective corticosteroid-sparing drugs... - Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptomsFranck J Barrat
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
Eur J Immunol 37:3582-6. 2007..These data demonstrate that in addition to its ability to block IFN-alpha, IRS 954 can reduce symptoms in a lupus model and thus represents a promising therapeutic agent for the treatment of SLE... - Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9Cristiana Guiducci
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
J Exp Med 207:2931-42. 2010..These data suggest that inhibitors of TLR7 and TLR9 signaling have potential therapeutic application for the treatment of interface dermatitis... 
Development of TLR inhibitors for the treatment of autoimmune diseasesFranck J Barrat
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
Immunol Rev 223:271-83. 2008..We describe novel inhibitors of these receptors and provide evidence to support their use as novel therapeutic agents for autoimmunity...- PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activationCristiana Guiducci
Dynavax Technologies Corporation, Berkeley, CA 94710, USA
J Exp Med 205:315-22. 2008..Thus, PI3K selectively controls type I IFN production by regulating IRF-7 nuclear translocation in human pDCs and could serve as a novel target to inhibit pathogenic type I IFN in autoimmune diseases... - Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonistsHolger Kanzler
Dynavax Technologies, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
Nat Med 13:552-9. 2007..As recognition grows of the role of inappropriate Toll-like receptor stimulation in inflammation and autoimmunity, significant efforts have begun to develop antagonists to Toll-like receptors as well... - Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8Dipyaman Ganguly
Department of Immunology, The University of Texas M D Anderson Cancer Center, TX 77030, USA
J Exp Med 206:1983-94. 2009..Our results demonstrate that the cationic antimicrobial peptide LL37 converts self-RNA into a trigger of TLR7 and TLR8 in human DCs, and provide new insights into the mechanism that drives the auto-inflammatory responses in psoriasis... - In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokinesFranck J Barrat
Division of Immunoregulation, The National Institute for Medical Research (NIMR, The Ridgeway, Mill Hill, NW7 1AA, London, UK
Immunol Lett 85:135-9. 2003 - Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infectionsJudith N Mandl
Graduate Program in Population Biology, Ecology and Evolution, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
Nat Med 14:1077-87. 2008..Such a vicious cycle of continuous virus replication and immunopathology is absent in natural sooty mangabey hosts... - Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patientsEmmanuel Xystrakis
Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma at King s College London, Strand, London, United Kingdom
J Clin Invest 116:146-55. 2006..This strongly suggests that vitamin D3 could potentially increase the therapeutic response to glucocorticoids in SR patients... - IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsPedro L Vieira
Division of Immunoregulation, The National Institute for Medical Research, London, United Kingdom
J Immunol 172:5986-93. 2004..These data show that Foxp3 expression is not a prerequisite for IL-10-T(Reg) activity in vitro or in vivo, and suggest that IL-10-T(Reg) and naturally occurring CD4(+)CD25(+) T(Reg) may have distinct origins... - Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to virusesKun Yang
Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
Immunity 23:465-78. 2005..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans... - Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosisMichael F Denny
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Blood 110:2907-15. 2007..SLE is characterized by an imbalance between endothelial cell damage and repair triggered by type I IFNs, which might promote accelerated atherosclerosis... - Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunityCheng Lung Ku
Laboratory of Human Genetics of Infectious Diseases, U550, Institut National de la Sante et de la Recherche Medicale, 75015 Paris, France
J Exp Med 204:2407-22. 2007..Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria... - Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyLionel Apetoh
Institut Gustave Roussy IGR, 39 rue Camille Desmoulins, F 94805 Villejuif, France
Nat Med 13:1050-9. 2007..These results delineate a clinically relevant immunoadjuvant pathway triggered by tumor cell death...