Rehana K Leak

Summary

Affiliation: Duquesne University
Country: USA

Publications

  1. pmc Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo
    Jessica M Posimo
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e58596. 2013
  2. pmc Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates
    Rehana K Leak
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
    Cell Tissue Res 350:401-7. 2012
  3. pmc Innervation of ventricular and periventricular brain compartments
    Rehana K Leak
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
    Brain Res 1463:51-62. 2012
  4. pmc Assaying multiple biochemical variables from the same tissue sample
    Rehana K Leak
    Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, 3501 Fifth Ave, 7026 BST3, University of Pittsburgh, Pittsburgh, PA, United States
    J Neurosci Methods 191:234-8. 2010
  5. pmc Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China, Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China, Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, China, and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania 15240
    J Neurosci 34:1903-15. 2014
  6. pmc Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism
    Rehana K Leak
    Department of Neurology, Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurochem 106:860-74. 2008
  7. pmc Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai Medical College, Shanghai 200032, China Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA
    Prog Neurobiol 114:58-83. 2014
  8. doi Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency
    Michael J Zigmond
    Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Parkinsonism Relat Disord 15:S42-5. 2009
  9. pmc Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
    Anthony K F Liou
    Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Neurobiol Dis 32:116-24. 2008
  10. ncbi Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells
    Eva Lin
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosci Res 86:108-17. 2008

Collaborators

Detail Information

Publications26

  1. pmc Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo
    Jessica M Posimo
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e58596. 2013
    ....
  2. pmc Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates
    Rehana K Leak
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
    Cell Tissue Res 350:401-7. 2012
    ..Furthermore, low overall physical activity predicts greater loss of dopaminergic phenotype in MPTP-treated primates. These data have implications for the maintenance of active lifestyles in both healthy and neurodegenerative conditions...
  3. pmc Innervation of ventricular and periventricular brain compartments
    Rehana K Leak
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
    Brain Res 1463:51-62. 2012
    ..These observations support the view that ventricular CSF is a significant channel for volume transmission and identifies those brain regions most likely to be involved in this process...
  4. pmc Assaying multiple biochemical variables from the same tissue sample
    Rehana K Leak
    Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, 3501 Fifth Ave, 7026 BST3, University of Pittsburgh, Pittsburgh, PA, United States
    J Neurosci Methods 191:234-8. 2010
    ..The general principles reported here are likely to apply to other brain regions, facilitate multiple comparisons of variables, increase efficiency, and decrease costs...
  5. pmc Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China, Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China, Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, China, and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania 15240
    J Neurosci 34:1903-15. 2014
    ..Further investigation of n-3 PUFA neuroprotective mechanisms may accelerate the development of stroke therapies. ..
  6. pmc Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism
    Rehana K Leak
    Department of Neurology, Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurochem 106:860-74. 2008
    ..Our data complement such observations, revealing that dopaminergic cells are also able to use endogenous CuZnSOD in self-defensive adaptations to chronic stress, and that they can even do so in the face of extensive GSH loss...
  7. pmc Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai Medical College, Shanghai 200032, China Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA
    Prog Neurobiol 114:58-83. 2014
    ..In this review, we focus on the experimental evidence of preconditioning in the brain and systematically survey the models used to develop paradigms for neuroprotection, and then discuss the clinical potential of brain preconditioning. ..
  8. doi Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency
    Michael J Zigmond
    Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Parkinsonism Relat Disord 15:S42-5. 2009
    ....
  9. pmc Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
    Anthony K F Liou
    Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Neurobiol Dis 32:116-24. 2008
    ..Collectively, our results indicated that cells expressing LRRK2 mutants suffer a loss of protection normally derived from wild-type LRRK2, making them more vulnerable to oxidative stress...
  10. ncbi Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells
    Eva Lin
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosci Res 86:108-17. 2008
    ....
  11. pmc Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Shanghai, China
    J Neurochem 123:125-37. 2012
    ..This is the first demonstration that LPS pre-conditioning initiates multiple signaling pathways leading to mitochondrial biogenesis in neurons and that these dynamic changes contribute to ischemic tolerance...
  12. pmc HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity
    Rehana K Leak
    Department of Neurology, S507 Biomedical Science Tower, University of Pittsburgh, Pittsburgh PA 15213, USA
    CNS Neurol Disord Drug Targets 12:325-37. 2013
    ..Exogenous enhancement of HSP27 by rational drug design may lead to future therapies against a host of injuries, including but not limited to a harmful breach in brain vasculature...
  13. doi Astrocyte plasticity revealed by adaptations to severe proteotoxic stress
    Amanda M Titler
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, USA
    Cell Tissue Res 352:427-43. 2013
    ..Such plasticity may permit astrocytes under severe stress to better support neurons and help explain the protracted nature of neurodegeneration...
  14. pmc Microglia/macrophage polarization dynamics in white matter after traumatic brain injury
    Guohua Wang
    1 State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China 2 Department of Neurology, Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 3 Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, China
    J Cereb Blood Flow Metab 33:1864-74. 2013
    ..The M1 phenotypic shift may propel WMI progression and represents a rational target for TBI treatment. ..
  15. ncbi Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine
    Ajay S Unnithan
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
    Neurochem Int 61:356-68. 2012
    ....
  16. ncbi Activation of the extracellular signal-regulated kinases 1 and 2 by glial cell line-derived neurotrophic factor and its relation to neuroprotection in a mouse model of Parkinson's disease
    Niklas Lindgren
    Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci Res 86:2039-49. 2008
    ..5 microg. Thus, our results suggest that the ability of GDNF to protect dopamine neurons cannot be explained solely in terms of its influence on ERK1/2 and that the role of other signaling pathways should be explored...
  17. pmc Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China
    Prog Neurobiol 100:30-47. 2013
    ..Following this background, we expand our discussion to the neuroprotective effects of phase II enzymes and the potential application of Nrf2 inducers to the treatment of neurological diseases...
  18. doi Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Stroke 43:3063-70. 2012
    ..A comprehensive characterization of microglia/macrophage polarization after ischemia may advance our knowledge of poststroke damage/recovery...
  19. ncbi Delivery of neurotherapeutics across the blood brain barrier in stroke
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Curr Pharm Des 18:3704-20. 2012
    ..Continuing modifications and improvements of CPPs are expected to enhance both their feasibility in clinical stroke management and their specificity towards particular cell types...
  20. pmc Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia
    Peiying Li
    From the Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA P L, L M, J C, X H Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China P L, L M, J C, X H Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Taian, Shandong, China G Z, B L S Affiliated Hospital of Taishan Medical College, Taian, Shandong, China G Z, B L S Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA R K L and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA J C, X H
    Stroke 44:3509-15. 2013
    ..However, the effect of Tregs on systemic inflammatory responses and immune status has not been fully characterized...
  21. pmc Drug-induced hypothermia in stroke models: does it always protect?
    Meijuan Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15213, USA
    CNS Neurol Disord Drug Targets 12:371-80. 2013
    ..This article provides guidance for future clinical trials and animal studies on pharmacological cooling in the setting of acute stroke...
  22. pmc The dynamics of the mitochondrial organelle as a potential therapeutic target
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University Shanghai Medical College, Shanghai, China
    J Cereb Blood Flow Metab 33:22-32. 2013
    ..An overview of the system as it is currently understood is presented, and current assessment strategies and their limitations are discussed...
  23. ncbi Effect of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning
    Rehana K Leak
    Department of Neurology and Pittsburgh Institute of Neurodegenerative Disease, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 99:1151-63. 2006
    ....
  24. ncbi N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress
    Ajay S Unnithan
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Neurosci Lett 560:71-6. 2014
    ..The present study supports the notion that N-acetyl cysteine can robustly protect against severe, unremitting oxidative stress in a glutathione-dependent manner. ..
  25. pmc Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3
    Loreto A Egaña
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurosci 29:4592-604. 2009
    ..Collectively, our data identify a novel interaction between DAT and synaptogyrin-3 and suggest a physical and functional link between DAT and the vesicular DA system...
  26. pmc Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury
    Feng Zhang
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Stroke 43:1390-7. 2012
    ..We hypothesize that chemically induced HO-1 upregulation with the novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imidazoline), a robust inducer of Phase 2 genes, protects neurons against ischemic injury...