Patrick T Flaherty

Summary

Affiliation: Duquesne University
Country: USA

Publications

  1. doi request reprint Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway
    Patrick T Flaherty
    Division of Medicinal Chemistry, School of Pharmacy, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, USA
    Bioorg Med Chem Lett 20:2892-6. 2010
  2. doi request reprint Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway
    Patrick T Flaherty
    Division of Medicinal Chemistry, School of Pharmacy, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, United States
    Bioorg Med Chem 18:8054-60. 2010
  3. doi request reprint Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25
    Prashi Jain
    Department of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, 600 Forbes Hall, Pittsburgh, PA 15282, USA
    Bioorg Med Chem 19:359-73. 2011

Collaborators

  • Prashi Jain
  • Yoan Ferandin
  • Jeffry D Madura
  • Ishveen Chopra
  • Gwenyth Bleasdell
  • Laurent Meijer
  • Josh Lipay
  • Shuyan Yi

Detail Information

Publications3

  1. doi request reprint Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway
    Patrick T Flaherty
    Division of Medicinal Chemistry, School of Pharmacy, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, USA
    Bioorg Med Chem Lett 20:2892-6. 2010
    ..Analysis of the EGF-induced MEK5 signaling cascade in cultured HEK cells has identified compounds that can inhibit MEK5 phosphorylation of ERK5; observed biological activity is dependent on chemical variation...
  2. doi request reprint Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway
    Patrick T Flaherty
    Division of Medicinal Chemistry, School of Pharmacy, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, United States
    Bioorg Med Chem 18:8054-60. 2010
    ..Subsequent analysis of selected compounds in a high-throughput multiple kinase scan and the NCI 60-cell-line screen is presented...
  3. doi request reprint Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25
    Prashi Jain
    Department of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, 600 Forbes Hall, Pittsburgh, PA 15282, USA
    Bioorg Med Chem 19:359-73. 2011
    ..The design, synthesis, and testing of a series of 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles is presented...