D B Warheit

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Nano Lett 7:2399-406. 2007
  2. ncbi request reprint Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles
    Joyce S Tsuji
    Exponent, Bellevue, Washington 98007, USA
    Toxicol Sci 89:42-50. 2006
  3. ncbi request reprint Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 95:270-80. 2007
  4. ncbi request reprint Characterization and reclassification of titanium dioxide-related pulmonary lesions
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    J Occup Environ Med 48:1308-13. 2006
  5. ncbi request reprint Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicology 230:90-104. 2007
  6. doi request reprint Embracing a weight-of-evidence approach for establishing NOAELs for nanoparticle inhalation toxicity studies
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Pathol 41:387-94. 2013
  7. doi request reprint Rationale of genotoxicity testing of nanomaterials: regulatory requirements and appropriateness of available OECD test guidelines
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Nanotoxicology 4:409-13. 2010
  8. ncbi request reprint Biodegradability of para-aramid respirable-sized fiber-shaped particulates (RFP) in human lung cells
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 89:296-303. 2006
  9. ncbi request reprint Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 91:227-36. 2006
  10. ncbi request reprint Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop
    David B Warheit
    DuPont, Haskell Laboratory, Newark, Delaware 19714 0050, USA
    Inhal Toxicol 19:631-43. 2007

Detail Information

Publications41

  1. ncbi request reprint Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Nano Lett 7:2399-406. 2007
    ....
  2. ncbi request reprint Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles
    Joyce S Tsuji
    Exponent, Bellevue, Washington 98007, USA
    Toxicol Sci 89:42-50. 2006
    ..These recent toxicity and exposure data, combined with therapeutic and other related literature, are beginning to shape risk assessments that will be used to regulate the use of nanomaterials in consumer products...
  3. ncbi request reprint Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 95:270-80. 2007
    ..The results demonstrate that the pulmonary toxicities of alpha-quartz particles appear to correlate better with surface activity than particle size and surface area...
  4. ncbi request reprint Characterization and reclassification of titanium dioxide-related pulmonary lesions
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    J Occup Environ Med 48:1308-13. 2006
    ....
  5. ncbi request reprint Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicology 230:90-104. 2007
    ..Thus, the lung toxicity of anatase/rutile uf-3 should not be viewed as representative for all ultrafine-TiO(2) particle-types...
  6. doi request reprint Embracing a weight-of-evidence approach for establishing NOAELs for nanoparticle inhalation toxicity studies
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Pathol 41:387-94. 2013
    ..g., normal macrophage phagocytic responses-minimal inflammation) to long-term particulate inhalation exposures...
  7. doi request reprint Rationale of genotoxicity testing of nanomaterials: regulatory requirements and appropriateness of available OECD test guidelines
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Nanotoxicology 4:409-13. 2010
    ..Accordingly, it seems reasonable to conclude that any specific regulatory testing requirements for nanoparticles would be premature at this time...
  8. ncbi request reprint Biodegradability of para-aramid respirable-sized fiber-shaped particulates (RFP) in human lung cells
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 89:296-303. 2006
    ....
  9. ncbi request reprint Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 91:227-36. 2006
    ..Furthermore, these findings run counter to the postulation that surface area is a major factor associated with the pulmonary toxicity of nanoscale particle types...
  10. ncbi request reprint Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop
    David B Warheit
    DuPont, Haskell Laboratory, Newark, Delaware 19714 0050, USA
    Inhal Toxicol 19:631-43. 2007
    ..However, it has become clear that these topics should be the subjects of separate workshops and they are not further addressed in this report...
  11. ncbi request reprint Pulmonary toxicity screening studies in male rats with M5 respirable fibers and particulates
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Inhal Toxicol 19:951-63. 2007
    ..Thus, based on the results of this study, we would expect that inhaled M5 respirable fibers have a low risk potential for producing adverse pulmonary effects...
  12. ncbi request reprint How meaningful are the results of nanotoxicity studies in the absence of adequate material characterization?
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
    Toxicol Sci 101:183-5. 2008
  13. doi request reprint Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
    Pharmacol Ther 120:35-42. 2008
    ....
  14. doi request reprint Pulmonary exposures to Sepiolite nanoclay particulates in rats: resolution following multinucleate giant cell formation
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 192:286-93. 2010
    ..However, it is noteworthy that no extrapulmonary target organ effects were observed in any of the particle-exposed groups at 3 months postexposure...
  15. doi request reprint Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures?
    D B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
    Environ Sci Technol 43:7939-45. 2009
    ..To summarize, the comparisons of in vivo and in vitro toxicity measurements following nano or fine ZnO particle exposures demonstrated little convergence and few differences in potency...
  16. doi request reprint Assessing health risks of inhaled nanomaterials: development of pulmonary bioassay hazard studies
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, Delaware 19714 0050, USA
    Anal Bioanal Chem 398:607-12. 2010
    ..In the final section, two studies are described which demonstrate that particle size is not the most significant particulate factor in producing exposure-related pulmonary effects...
  17. ncbi request reprint Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 88:514-24. 2005
    ....
  18. ncbi request reprint Biodegradability of inhaled p-aramid respirable fiber-shaped particulates (RFP): mechanisms of RFP shortening and evidence of reversibility of pulmonary lesions
    D B Warheit
    DuPont Haskell Laboratory, P O Box 50, Elkton Road, Newark, DE, USA
    Toxicol Lett 127:259-67. 2002
    ..These results demonstrate that lung fluids coat and catalyze the p-aramid RFP as a prelude for shortening and describe a likely mechanism for the biodegradability of inhaled p-aramid RFP in the lungs of exposed animals...
  19. ncbi request reprint p-Aramid RFP do not induce chromosomal aberrations in a standardized in vitro genotoxicity assay using human lymphocytes
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19711, USA
    Inhal Toxicol 13:1079-91. 2001
    ..In addition, we conclude that the utility of these tests for evaluating the genotoxicity of fibrous or particulate materials is questionable...
  20. ncbi request reprint Inhaled amorphous silica particulates: what do we know about their toxicological profiles?
    D B Warheit
    DuPont Haskell Laboratory, Newark, DE 19714 0050, USA
    J Environ Pathol Toxicol Oncol 20:133-41. 2001
    ....
  21. ncbi request reprint Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 171:99-110. 2007
    ..To summarize the findings, the results of most of the studies demonstrated low hazard potential in mammals or aquatic species following acute exposures to the ultrafine TiO(2) particle-types tested in this program...
  22. ncbi request reprint Biodegradability of inhaled p-aramid respirable fibre-shaped particulates: representative of other synthetic organic fibre-types?
    D B Warheit
    DuPont Haskell Laboratory, Newark, DE 19714 0050, USA
    Int Arch Occup Environ Health 73:S75-8. 2000
    ..To investigate the mechanisms of RFP biodegradation, we have hypothesized that lung fluids activate p-aramid RFP following deposition, and the RFP are then vulnerable to enzymatic attack in the lungs...
  23. ncbi request reprint Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 77:117-25. 2004
    ..Thus, the physiological relevance of these findings should ultimately be determined by conducting an inhalation toxicity study...
  24. pmc Lung proliferative and clearance responses to inhaled para-aramid RFP in exposed hamsters and rats: comparisons with chrysotile asbestos fibers
    D B Warheit
    DuPont Haskell Laboratory, Newark, DE 19714, USA
    Environ Health Perspect 105:1219-22. 1997
    ..In contrast, exposures to chrysotile asbestos fibers in rats resulted in a selective pulmonary retention of long chrysotile fibers...
  25. ncbi request reprint Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearance
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA
    Toxicology 192:189-210. 2003
    ..Histopathology revealed no adverse lower pulmonary or upper respiratory effects. In summary, the no-observed-effect level (NOEL) for inhaled Nylon RFP was 57f/cm3 (20mg/m3), the highest concentration tested...
  26. ncbi request reprint Pulmonary toxicity studies in rats with triethoxyoctylsilane (OTES)-coated, pigment-grade titanium dioxide particles: bridging studies to predict inhalation hazard
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Exp Lung Res 29:593-606. 2003
    ..The authors conclude that the OTES hydrophobic coating on the pigment-grade TiO(2) particle does not cause significant pulmonary toxicity...
  27. ncbi request reprint Biodegradability of inhaled para-aramid respirable-sized fiber-shaped particulates: mechanistic in vivo and in vitro studies
    D B Warheit
    DuPont Haskell Laboratory, Newark, Delaware 19714-0050, USA
    Toxicol Appl Pharmacol 174:78-88. 2001
    ..This process could play a significant role in facilitating the transverse cleavage or shortening of inhaled p-aramid RFP in the lungs of exposed rats and hamsters...
  28. ncbi request reprint Man-made respirable-sized organic fibers: what do we know about their toxicological profiles?
    D B Warheit
    DuPont Haskell Laboratory, Newark, Delaware 19714 0050, USA
    Ind Health 39:119-25. 2001
    ..The results of these studies provide clues regarding the mechanism(s) of p-aramid RFP shortening in the lungs of exposed animals, and may be relevant for humans...
  29. ncbi request reprint Initiating the risk assessment process for inhaled particulate materials: development of short term inhalation bioassays
    D B Warheit
    Du Pont Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
    J Expo Anal Environ Epidemiol 7:313-25. 1997
    ....
  30. doi request reprint A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA david b warheit usa dupont com
    Inhal Toxicol 21:61-7. 2009
    ..Embodied in a Nanorisk framework process, implementation of a base set of toxicity tests for evaluating the health and environmental hazards related to nanoparticle exposures is discussed...
  31. ncbi request reprint Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 97:163-80. 2007
    ..It seems clear that in vitro cellular systems will need to be further developed, standardized, and validated (relative to in vivo effects) in order to provide useful screening data on the relative toxicity of inhaled particle types...
  32. ncbi request reprint Interspecies comparisons of lung responses to inhaled particles and gases
    D B Warheit
    Department of Acute and Developmental Toxicology, E I duPont de Nemours and Company, Inc, Newark, Delaware
    Crit Rev Toxicol 20:1-29. 1989
    ..Chronic ozone exposure in rats and monkeys causes epithelial injury at the level of the terminal bronchiole and proximal alveolar regions of the lung.(ABSTRACT TRUNCATED AT 400 WORDS)..
  33. ncbi request reprint Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells
    Christie M Sayes
    Department of Chemistry, Rice University, Houston, TX, USA
    Toxicol Sci 92:174-85. 2006
    ..The result highlights the important role that ex vivo measures of RS production can play in developing screens for cytotoxicity...
  34. ncbi request reprint 4-week inhalation toxicity study with a mixture of dichloroethylene and perfluorobutylethylene in rats
    Linda Angevine Malley
    DuPont Haskell Laboratory, 1090 Elkton Road, PO Box 50, Newark, DE 19714, USA
    Inhal Toxicol 14:773-87. 2002
    ..Under the conditions of the study, the no-observed-effect level (NOEL) was 400 ppm in males and females based on clinical signs of toxicity during exposure to 2000 or 8000 ppm...
  35. ncbi request reprint Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats
    Donna D Zhang
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Exp Lung Res 28:641-70. 2002
    ....
  36. ncbi request reprint Assessing the role of neutrophil apoptosis in the resolution of particle-induced pulmonary inflammation
    Andrea J Wiethoff
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Inhal Toxicol 15:1231-46. 2003
    ..The findings suggest that the coordination between the resolution of inflammation and inflammatory cell apoptosis in the lung is dependent on the particle-type and that other factors, such as particle cytotoxicity, may also be important...
  37. ncbi request reprint Safe handling of nanotechnology
    Andrew D Maynard
    Woodrow Wilson International Center for Scholars, USA
    Nature 444:267-9. 2006
  38. ncbi request reprint Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles
    Edilberto Bermudez
    CIIT Centers for Health Research, PO Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 70:86-97. 2002
    ..Rats also were unique in the development of progressive fibroproliferative lesions and alveolar epithelial metaplasia in response to 90 days of exposure to a high concentration of p-TiO(2) particles...
  39. ncbi request reprint Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
    Edilberto Bermudez
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 77:347-57. 2004
    ..These differences can be explained both by pulmonary respy response and by particle dosimetry differences among these rodent species...
  40. ncbi request reprint Testing of fibrous particles: short-term assays and strategies
    David Bernstein
    Geneva, Switzerland
    Inhal Toxicol 17:497-537. 2005