Research Topics
| D B WarheitSummaryAffiliation: DuPont Haskell Laboratory for Health and Environmental Sciences Country: USA Publications
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Detail Information
Publications
Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profilesChristie M Sayes
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Nano Lett 7:2399-406. 2007....- Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticlesJoyce S Tsuji
Exponent, Bellevue, Washington 98007, USA
Toxicol Sci 89:42-50. 2006..These recent toxicity and exposure data, combined with therapeutic and other related literature, are beginning to shape risk assessments that will be used to regulate the use of nanomaterials in consumer products... - Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristicsDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Toxicol Sci 95:270-80. 2007..The results demonstrate that the pulmonary toxicities of alpha-quartz particles appear to correlate better with surface activity than particle size and surface area... - Characterization and reclassification of titanium dioxide-related pulmonary lesionsDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
J Occup Environ Med 48:1308-13. 2006.... - Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface propertiesDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
Toxicology 230:90-104. 2007..Thus, the lung toxicity of anatase/rutile uf-3 should not be viewed as representative for all ultrafine-TiO(2) particle-types... 
Embracing a weight-of-evidence approach for establishing NOAELs for nanoparticle inhalation toxicity studiesDavid B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Pathol 41:387-94. 2013..g., normal macrophage phagocytic responses-minimal inflammation) to long-term particulate inhalation exposures...- Biodegradability of para-aramid respirable-sized fiber-shaped particulates (RFP) in human lung cellsD B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Toxicol Sci 89:296-303. 2006.... - Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface areaDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Toxicol Sci 91:227-36. 2006..Furthermore, these findings run counter to the postulation that surface area is a major factor associated with the pulmonary toxicity of nanoscale particle types... - Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshopDavid B Warheit
DuPont, Haskell Laboratory, Newark, Delaware 19714 0050, USA
Inhal Toxicol 19:631-43. 2007..However, it has become clear that these topics should be the subjects of separate workshops and they are not further addressed in this report... - Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk managementDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
Toxicol Lett 171:99-110. 2007..To summarize the findings, the results of most of the studies demonstrated low hazard potential in mammals or aquatic species following acute exposures to the ultrafine TiO(2) particle-types tested in this program... - Pulmonary toxicity screening studies in male rats with M5 respirable fibers and particulatesDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Inhal Toxicol 19:951-63. 2007..Thus, based on the results of this study, we would expect that inhaled M5 respirable fibers have a low risk potential for producing adverse pulmonary effects... - How meaningful are the results of nanotoxicity studies in the absence of adequate material characterization?David B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
Toxicol Sci 101:183-5. 2008 - Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risksDavid B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
Pharmacol Ther 120:35-42. 2008.... - Pulmonary exposures to Sepiolite nanoclay particulates in rats: resolution following multinucleate giant cell formationDavid B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714 0050, USA
Toxicol Lett 192:286-93. 2010..However, it is noteworthy that no extrapulmonary target organ effects were observed in any of the particle-exposed groups at 3 months postexposure... - Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures?D B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
Environ Sci Technol 43:7939-45. 2009..To summarize, the comparisons of in vivo and in vitro toxicity measurements following nano or fine ZnO particle exposures demonstrated little convergence and few differences in potency... - Assessing health risks of inhaled nanomaterials: development of pulmonary bioassay hazard studiesDavid B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, Delaware 19714 0050, USA
Anal Bioanal Chem 398:607-12. 2010..In the final section, two studies are described which demonstrate that particle size is not the most significant particulate factor in producing exposure-related pulmonary effects... - Rationale of genotoxicity testing of nanomaterials: regulatory requirements and appropriateness of available OECD test guidelinesDavid B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Nanotoxicology 4:409-13. 2010..Accordingly, it seems reasonable to conclude that any specific regulatory testing requirements for nanoparticles would be premature at this time... - Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicityD B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
Toxicol Sci 88:514-24. 2005.... - Biodegradability of inhaled p-aramid respirable fiber-shaped particulates (RFP): mechanisms of RFP shortening and evidence of reversibility of pulmonary lesionsD B Warheit
DuPont Haskell Laboratory, P O Box 50, Elkton Road, Newark, DE, USA
Toxicol Lett 127:259-67. 2002..These results demonstrate that lung fluids coat and catalyze the p-aramid RFP as a prelude for shortening and describe a likely mechanism for the biodegradability of inhaled p-aramid RFP in the lungs of exposed animals... - p-Aramid RFP do not induce chromosomal aberrations in a standardized in vitro genotoxicity assay using human lymphocytesD B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19711, USA
Inhal Toxicol 13:1079-91. 2001..In addition, we conclude that the utility of these tests for evaluating the genotoxicity of fibrous or particulate materials is questionable... - Inhaled amorphous silica particulates: what do we know about their toxicological profiles?D B Warheit
DuPont Haskell Laboratory, Newark, DE 19714 0050, USA
J Environ Pathol Toxicol Oncol 20:133-41. 2001.... - Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in ratsD B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Sci 77:117-25. 2004..Thus, the physiological relevance of these findings should ultimately be determined by conducting an inhalation toxicity study... - Biodegradability of inhaled p-aramid respirable fibre-shaped particulates: representative of other synthetic organic fibre-types?D B Warheit
DuPont Haskell Laboratory, Newark, DE 19714 0050, USA
Int Arch Occup Environ Health 73:S75-8. 2000..To investigate the mechanisms of RFP biodegradation, we have hypothesized that lung fluids activate p-aramid RFP following deposition, and the RFP are then vulnerable to enzymatic attack in the lungs... - Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearanceDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA
Toxicology 192:189-210. 2003..Histopathology revealed no adverse lower pulmonary or upper respiratory effects. In summary, the no-observed-effect level (NOEL) for inhaled Nylon RFP was 57f/cm3 (20mg/m3), the highest concentration tested... - Pulmonary toxicity studies in rats with triethoxyoctylsilane (OTES)-coated, pigment-grade titanium dioxide particles: bridging studies to predict inhalation hazardD B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Exp Lung Res 29:593-606. 2003..The authors conclude that the OTES hydrophobic coating on the pigment-grade TiO(2) particle does not cause significant pulmonary toxicity... 
Lung proliferative and clearance responses to inhaled para-aramid RFP in exposed hamsters and rats: comparisons with chrysotile asbestos fibersD B Warheit
DuPont Haskell Laboratory, Newark, DE 19714, USA
Environ Health Perspect 105:1219-22. 1997..In contrast, exposures to chrysotile asbestos fibers in rats resulted in a selective pulmonary retention of long chrysotile fibers...- Biodegradability of inhaled para-aramid respirable-sized fiber-shaped particulates: mechanistic in vivo and in vitro studiesD B Warheit
DuPont Haskell Laboratory, Newark, Delaware 19714-0050, USA
Toxicol Appl Pharmacol 174:78-88. 2001..This process could play a significant role in facilitating the transverse cleavage or shortening of inhaled p-aramid RFP in the lungs of exposed rats and hamsters... - Man-made respirable-sized organic fibers: what do we know about their toxicological profiles?D B Warheit
DuPont Haskell Laboratory, Newark, Delaware 19714 0050, USA
Ind Health 39:119-25. 2001..The results of these studies provide clues regarding the mechanism(s) of p-aramid RFP shortening in the lungs of exposed animals, and may be relevant for humans... - Initiating the risk assessment process for inhaled particulate materials: development of short term inhalation bioassaysD B Warheit
Du Pont Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
J Expo Anal Environ Epidemiol 7:313-25. 1997.... - A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk managementDavid B Warheit
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA david b warheit usa dupont com
Inhal Toxicol 21:61-7. 2009..Embodied in a Nanorisk framework process, implementation of a base set of toxicity tests for evaluating the health and environmental hazards related to nanoparticle exposures is discussed... - Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profilesChristie M Sayes
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Sci 97:163-80. 2007..It seems clear that in vitro cellular systems will need to be further developed, standardized, and validated (relative to in vivo effects) in order to provide useful screening data on the relative toxicity of inhaled particle types... - Interspecies comparisons of lung responses to inhaled particles and gasesD B Warheit
Department of Acute and Developmental Toxicology, E I duPont de Nemours and Company, Inc, Newark, Delaware
Crit Rev Toxicol 20:1-29. 1989..Chronic ozone exposure in rats and monkeys causes epithelial injury at the level of the terminal bronchiole and proximal alveolar regions of the lung.(ABSTRACT TRUNCATED AT 400 WORDS).. - Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cellsChristie M Sayes
Department of Chemistry, Rice University, Houston, TX, USA
Toxicol Sci 92:174-85. 2006..The result highlights the important role that ex vivo measures of RS production can play in developing screens for cytotoxicity... - 4-week inhalation toxicity study with a mixture of dichloroethylene and perfluorobutylethylene in ratsLinda Angevine Malley
DuPont Haskell Laboratory, 1090 Elkton Road, PO Box 50, Newark, DE 19714, USA
Inhal Toxicol 14:773-87. 2002..Under the conditions of the study, the no-observed-effect level (NOEL) was 400 ppm in males and females based on clinical signs of toxicity during exposure to 2000 or 8000 ppm... - Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in ratsDonna D Zhang
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
Exp Lung Res 28:641-70. 2002.... - Assessing the role of neutrophil apoptosis in the resolution of particle-induced pulmonary inflammationAndrea J Wiethoff
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714-0050, USA
Inhal Toxicol 15:1231-46. 2003..The findings suggest that the coordination between the resolution of inflammation and inflammatory cell apoptosis in the lung is dependent on the particle-type and that other factors, such as particle cytotoxicity, may also be important... - Safe handling of nanotechnologyAndrew D Maynard
Woodrow Wilson International Center for Scholars, USA
Nature 444:267-9. 2006 - Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particlesEdilberto Bermudez
CIIT Centers for Health Research, PO Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Sci 70:86-97. 2002..Rats also were unique in the development of progressive fibroproliferative lesions and alveolar epithelial metaplasia in response to 90 days of exposure to a high concentration of p-TiO(2) particles... - Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particlesEdilberto Bermudez
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 77:347-57. 2004..These differences can be explained both by pulmonary respy response and by particle dosimetry differences among these rodent species... - Testing of fibrous particles: short-term assays and strategiesDavid Bernstein
Geneva, Switzerland
Inhal Toxicol 17:497-537. 2005