Christie M Sayes

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells
    Christie M Sayes
    Department of Chemistry, Rice University, Houston, TX, USA
    Toxicol Sci 92:174-85. 2006
  2. ncbi request reprint Nano-C60 cytotoxicity is due to lipid peroxidation
    Christie M Sayes
    Department of Chemistry, 6100 Main St MS 60, Rice University, Houston, TX 77005, USA
    Biomaterials 26:7587-95. 2005
  3. doi request reprint Changing the dose metric for inhalation toxicity studies: short-term study in rats with engineered aerosolized amorphous silica nanoparticles
    Christie M Sayes
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
    Inhal Toxicol 22:348-54. 2010
  4. ncbi request reprint Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro
    Christie M Sayes
    Department of Chemistry, Rice University, 1900 Rice Blvd, MS 60, Houston, TX 77005, USA
    Toxicol Lett 161:135-42. 2006
  5. ncbi request reprint Bacterial cell association and antimicrobial activity of a C60 water suspension
    Delina Y Lyon
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Environ Toxicol Chem 24:2757-62. 2005
  6. doi request reprint Pulmonary exposures to Sepiolite nanoclay particulates in rats: resolution following multinucleate giant cell formation
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 192:286-93. 2010
  7. doi request reprint Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
    Pharmacol Ther 120:35-42. 2008
  8. ncbi request reprint Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 171:99-110. 2007
  9. ncbi request reprint Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicology 230:90-104. 2007
  10. ncbi request reprint Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 95:270-80. 2007

Detail Information

Publications15

  1. ncbi request reprint Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells
    Christie M Sayes
    Department of Chemistry, Rice University, Houston, TX, USA
    Toxicol Sci 92:174-85. 2006
    ..The result highlights the important role that ex vivo measures of RS production can play in developing screens for cytotoxicity...
  2. ncbi request reprint Nano-C60 cytotoxicity is due to lipid peroxidation
    Christie M Sayes
    Department of Chemistry, 6100 Main St MS 60, Rice University, Houston, TX 77005, USA
    Biomaterials 26:7587-95. 2005
    ..With the addition of an antioxidant, L-ascorbic acid, the oxidative damage and resultant toxicity of nano-C60 was completely prevented...
  3. doi request reprint Changing the dose metric for inhalation toxicity studies: short-term study in rats with engineered aerosolized amorphous silica nanoparticles
    Christie M Sayes
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
    Inhal Toxicol 22:348-54. 2010
    ..The expansion of the concept to subchronic studies is practical, due, in part, to the consistency of the nanoparticle generation method...
  4. ncbi request reprint Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro
    Christie M Sayes
    Department of Chemistry, Rice University, 1900 Rice Blvd, MS 60, Houston, TX 77005, USA
    Toxicol Lett 161:135-42. 2006
    ..e. the SWNTs in aqueous suspension precipitate out and selectively deposit on the membrane...
  5. ncbi request reprint Bacterial cell association and antimicrobial activity of a C60 water suspension
    Delina Y Lyon
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Environ Toxicol Chem 24:2757-62. 2005
    ..5 to 3.0 mg/L, respectively. Media with higher salt contents result in the nano-C60 particles aggregating and falling out of suspension; thus, higher salt solutions reduced or eliminated the antimicrobial properties of nano-C60...
  6. doi request reprint Pulmonary exposures to Sepiolite nanoclay particulates in rats: resolution following multinucleate giant cell formation
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 192:286-93. 2010
    ..However, it is noteworthy that no extrapulmonary target organ effects were observed in any of the particle-exposed groups at 3 months postexposure...
  7. doi request reprint Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
    Pharmacol Ther 120:35-42. 2008
    ....
  8. ncbi request reprint Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 171:99-110. 2007
    ..To summarize the findings, the results of most of the studies demonstrated low hazard potential in mammals or aquatic species following acute exposures to the ultrafine TiO(2) particle-types tested in this program...
  9. ncbi request reprint Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicology 230:90-104. 2007
    ..Thus, the lung toxicity of anatase/rutile uf-3 should not be viewed as representative for all ultrafine-TiO(2) particle-types...
  10. ncbi request reprint Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 95:270-80. 2007
    ..The results demonstrate that the pulmonary toxicities of alpha-quartz particles appear to correlate better with surface activity than particle size and surface area...
  11. ncbi request reprint Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 91:227-36. 2006
    ..Furthermore, these findings run counter to the postulation that surface area is a major factor associated with the pulmonary toxicity of nanoscale particle types...
  12. ncbi request reprint Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers
    William W Yu
    Department of Chemistry, Rice University, Houston, Texas 77005, USA
    J Am Chem Soc 129:2871-9. 2007
    ..In the particular case of semiconductor nanocrystals (e.g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions...
  13. ncbi request reprint Asymmetrical, water-soluble phthalocyanine dyes for covalent labeling of oligonucleotides
    Robert P Hammer
    Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803 1804, USA
    Bioconjug Chem 13:1244-52. 2002
    ..Both dyes were successfully conjugated to oligonucleotide primers, showing their potential for use in near-infrared-based DNA diagnostic applications...
  14. ncbi request reprint Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 97:163-80. 2007
    ..It seems clear that in vitro cellular systems will need to be further developed, standardized, and validated (relative to in vivo effects) in order to provide useful screening data on the relative toxicity of inhaled particle types...
  15. ncbi request reprint Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Nano Lett 7:2399-406. 2007
    ....