Diane L Nabb

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint In vitro metabolism of 8-2 fluorotelomer alcohol: interspecies comparisons and metabolic pathway refinement
    Diane L Nabb
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 100:333-44. 2007
  2. doi request reprint Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Metab Dispos 39:1288-93. 2011
  3. doi request reprint Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Lett 181:81-6. 2008
  4. doi request reprint Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicology 255:177-86. 2009
  5. doi request reprint Cryopreserved hepatocytes from rainbow trout (Oncorhynchus mykiss): a validation study to support their application in bioaccumulation assessment
    Robert T Mingoia
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
    Environ Sci Technol 44:3052-8. 2010
  6. doi request reprint Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Toxicol Chem 28:481-8. 2009
  7. ncbi request reprint Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Sci Technol 41:3269-76. 2007
  8. doi request reprint Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Aquat Toxicol 89:11-7. 2008
  9. doi request reprint Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats
    William J Fasano
    EI DuPont de Nemours and Co, Inc, Newark, DE 19714 0050, USA
    Chem Biol Interact 180:281-95. 2009
  10. doi request reprint Absorption, distribution, metabolism, and excretion of [1-¹⁴C]-perfluorohexanoate ([¹⁴C]-PFHx) in rats and mice
    Shawn A Gannon
    DuPont Haskell Global Centers for Health and Environmental Sciences, Elkton Rd, Newark, DE 19714 0050, USA
    Toxicology 283:55-62. 2011

Detail Information

Publications15

  1. ncbi request reprint In vitro metabolism of 8-2 fluorotelomer alcohol: interspecies comparisons and metabolic pathway refinement
    Diane L Nabb
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 100:333-44. 2007
    ..These results suggest that human exposure to 8-2 FTOH is not expected to be a significant source of PFOA or any other perfluorocarboxylic acids...
  2. doi request reprint Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Metab Dispos 39:1288-93. 2011
    ..Because saturation of the GST-mediated reactions was not reached at the highest possible PFP concentration, GSH S-conjugation may become a much more important pathway at higher PFP concentrations (relative to the K(m) for TFPA)...
  3. doi request reprint Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Lett 181:81-6. 2008
    ..9 +/- 25.1 and 29.3 +/- 19.2 microM in male and female rat hepatocytes, respectively. When serum albumin was added to the incubations, PFO hepatic uptake rates were reduced, but were proportional to the unbound fractions of PFO...
  4. doi request reprint Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicology 255:177-86. 2009
    ....
  5. doi request reprint Cryopreserved hepatocytes from rainbow trout (Oncorhynchus mykiss): a validation study to support their application in bioaccumulation assessment
    Robert T Mingoia
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
    Environ Sci Technol 44:3052-8. 2010
    ....
  6. doi request reprint Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Toxicol Chem 28:481-8. 2009
    ..3 to 22.4% of those from trout hepatocytes, which explained, to a large extent, the differences in their CL(H) and bioconcentration factor prediction...
  7. ncbi request reprint Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Sci Technol 41:3269-76. 2007
    ..This study demonstrates a framework for future bioaccumulation assessment of xenobiotics using combined information of the physical-chemical properties of the compounds and the biotransformation potentials of the compounds in fish...
  8. doi request reprint Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Aquat Toxicol 89:11-7. 2008
    ....
  9. doi request reprint Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats
    William J Fasano
    EI DuPont de Nemours and Co, Inc, Newark, DE 19714 0050, USA
    Chem Biol Interact 180:281-95. 2009
    ....
  10. doi request reprint Absorption, distribution, metabolism, and excretion of [1-¹⁴C]-perfluorohexanoate ([¹⁴C]-PFHx) in rats and mice
    Shawn A Gannon
    DuPont Haskell Global Centers for Health and Environmental Sciences, Elkton Rd, Newark, DE 19714 0050, USA
    Toxicology 283:55-62. 2011
    ..25, 1, and 24 h) after dosing to investigate the tissue clearance kinetics of PFHx following a single dose at 2 or 100 mg/kg. In all tissues except skin, PFHx was not quantifiable 24 h after dosing in both sexes of the two species...
  11. ncbi request reprint Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening
    Robert T Mingoia
    DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, Delaware 19714, USA
    Toxicol In Vitro 21:165-73. 2007
    ....
  12. ncbi request reprint In vitro studies in microsomes from rat and human liver, kidney, and intestine suggest that perfluorooctanoic acid is not a substrate for microsomal UDP-glucuronosyltransferases
    Raymond A Kemper
    Discovery Toxicology Group, Haskell Laboratory for Health and Environmental Sciences, E I duPont de Nemours and Company, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:281-7. 2005
    ..These data suggest that PFOA is not a substrate for human or rodent microsomal UDPGTs...
  13. ncbi request reprint Comparative metabolism of geranyl nitrile and citronellyl nitrile in mouse, rat, and human hepatocytes
    Raymond A Kemper
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Drug Metab Dispos 34:1019-29. 2006
    ..No evidence for either phase I or phase II metabolism of the conjugated nitrile moiety was obtained. Thus, the presumed metabolic basis for differences in genotoxicity remains elusive...
  14. ncbi request reprint Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat
    Diane L Nabb
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Aquat Toxicol 80:52-9. 2006
    ..7-fold lower in rainbow trout, respectively). Our results suggest that the relative importance of CYP1A enzymes (among CYP subfamilies) in the biotransformation of xenobiotics in rainbow trout is likely much greater than that in mammals...
  15. doi request reprint Two-day inhalation toxicity study of methyl iodide in the rat
    Matthew W Himmelstein
    E I Du Pont de Nemours and Company, Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Inhal Toxicol 21:480-7. 2009
    ..These results indicate that following inhalation exposure, MeI is rapidly metabolized in blood and tissue of rats, resulting in methylation products and release of inorganic iodide...