G S Ladics

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for the elucidation of potential identities to known allergens
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE 19880, USA
    Mol Nutr Food Res 51:985-98. 2007
  2. doi request reprint Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations
    Gregory S Ladics
    Pioneer Hi Bred International Inc, DuPont Agricultural Biotechnology, P O Box 80353, Wilmington, DE 19880, USA
    Regul Toxicol Pharmacol 60:46-53. 2011
  3. doi request reprint Assessment of three human FcepsilonRI-transfected RBL cell-lines for identifying IgE induced degranulation utilizing peanut-allergic patient sera and peanut protein extract
    G S Ladics
    DuPont Company, Building 353 334, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA
    Regul Toxicol Pharmacol 51:288-94. 2008
  4. ncbi request reprint Use of SRBC antibody responses for immunotoxicity testing
    Gregory S Ladics
    DuPont Co, E400 4402, Rt 141 and Henry Clay Road, Wilmington, DE 19880 0400, USA
    Methods 41:9-19. 2007
  5. doi request reprint Current codex guidelines for assessment of potential protein allergenicity
    G S Ladics
    DuPont Experimental Station, Building 353, Wilmington, DE 19880, USA
    Food Chem Toxicol 46:S20-3. 2008
  6. ncbi request reprint Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgE
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE, USA
    Regul Toxicol Pharmacol 44:136-43. 2006
  7. ncbi request reprint Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies
    Gregory S Ladics
    The DuPont Company, Haskell Laboratory, Newark, Delaware 19714, USA
    Toxicol Sci 88:24-9. 2005
  8. ncbi request reprint Subchronic toxicity of a fluoroalkylethanol mixture in rats
    Gregory S Ladics
    DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:135-58. 2005
  9. doi request reprint Identifying food proteins with allergenic potential: evolution of approaches to safety assessment and research to provide additional tools
    Gregory S Ladics
    DuPont Co, DuPont Crop Genetics, Wilmington, DE 19880 USA
    Regul Toxicol Pharmacol 54:S2-6. 2009
  10. doi request reprint Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops
    G S Ladics
    DuPont Company, Route 141 and Henry Clary Road, Wilmington, DE 19880, USA
    Regul Toxicol Pharmacol 56:212-24. 2010

Detail Information

Publications22

  1. ncbi request reprint Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for the elucidation of potential identities to known allergens
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE 19880, USA
    Mol Nutr Food Res 51:985-98. 2007
    ..It is recommended that the conventional FASTA analysis be conducted to compare identities of proteins to allergens...
  2. doi request reprint Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations
    Gregory S Ladics
    Pioneer Hi Bred International Inc, DuPont Agricultural Biotechnology, P O Box 80353, Wilmington, DE 19880, USA
    Regul Toxicol Pharmacol 60:46-53. 2011
    ..Recommendations for conducting bioinformatic analysis on novel food proteins for potential cross-reactivity to known allergens are also put forth...
  3. doi request reprint Assessment of three human FcepsilonRI-transfected RBL cell-lines for identifying IgE induced degranulation utilizing peanut-allergic patient sera and peanut protein extract
    G S Ladics
    DuPont Company, Building 353 334, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA
    Regul Toxicol Pharmacol 51:288-94. 2008
    ..The assay's utility in safety assessment, predictive value and reproducibility for evaluating the cross-reactivity of proteins with allergens needs further investigation with additional proteins and well-characterized sera...
  4. ncbi request reprint Use of SRBC antibody responses for immunotoxicity testing
    Gregory S Ladics
    DuPont Co, E400 4402, Rt 141 and Henry Clay Road, Wilmington, DE 19880 0400, USA
    Methods 41:9-19. 2007
    ..In this manuscript, background information, as well as the pros and cons of each of these assays are discussed and detailed methods on conducting each assay are provided...
  5. doi request reprint Current codex guidelines for assessment of potential protein allergenicity
    G S Ladics
    DuPont Experimental Station, Building 353, Wilmington, DE 19880, USA
    Food Chem Toxicol 46:S20-3. 2008
    ..Additional approaches may be considered (e.g., animal models; targeted sera screening) as the science evolves; however, such approaches have not been thoroughly evaluated or validated for predicting protein allergenicity...
  6. ncbi request reprint Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgE
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE, USA
    Regul Toxicol Pharmacol 44:136-43. 2006
    ..Cry1F is heat labile, rapidly hydrolyzed in an in vitro pepsin resistance assay, not glycosylated and not from an allergenic source. Taken together, these data indicate a lack of allergenic concern for Cry1F...
  7. ncbi request reprint Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies
    Gregory S Ladics
    The DuPont Company, Haskell Laboratory, Newark, Delaware 19714, USA
    Toxicol Sci 88:24-9. 2005
    ..The group agreed to consider the HESI ACSA Life Stages Task Force recommendations as a next step to address some of the issues and challenges raised during this session...
  8. ncbi request reprint Subchronic toxicity of a fluoroalkylethanol mixture in rats
    Gregory S Ladics
    DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:135-58. 2005
    ..Both plasma and urine fluoride levels were elevated in a dose-dependent manner. Under the conditions of the study, the no-observed adverse effect level for this mixture was 25 mg kg(-1) day(-1) for subchronic toxicity...
  9. doi request reprint Identifying food proteins with allergenic potential: evolution of approaches to safety assessment and research to provide additional tools
    Gregory S Ladics
    DuPont Co, DuPont Crop Genetics, Wilmington, DE 19880 USA
    Regul Toxicol Pharmacol 54:S2-6. 2009
    ..More recently US EPA has partnered with the National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health to support research in areas of mutual interest with respect to food allergy...
  10. doi request reprint Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops
    G S Ladics
    DuPont Company, Route 141 and Henry Clary Road, Wilmington, DE 19880, USA
    Regul Toxicol Pharmacol 56:212-24. 2010
    ..In particular, more extensive validation testing with additional allergenic and non-allergenic material should be performed before using them in the safety assessment of genetically modified crops...
  11. ncbi request reprint Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified crops
    Gregory S Ladics
    The DuPont Co, Haskell Laboratory, Newark, Delaware 19714, USA
    Toxicol Sci 73:8-16. 2003
    ..However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods...
  12. ncbi request reprint Evaluation of the reproductive and developmental toxicity of a fluoroalkylethanol mixture
    Eve Mylchreest
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:159-75. 2005
    ..No functional reproductive or developmental effects were observed at dose levels that did not adversely affect adult animals...
  13. ncbi request reprint Acute, subchronic, and mutagenicity studies with norbornene fluoroalcohol
    Michael P DeLorme
    E I duPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Drug Chem Toxicol 28:379-95. 2005
    ..Based on the above findings, NBFOH demonstrates the potential to produce allergic contact dermatitis, and subchronic inhalation studies indicate a no-observed-adverse-effect-level (NOAEL) of 410 mg/m(3)...
  14. ncbi request reprint Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens
    John C O'Connor
    DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Newark, Delaware 19714, USA
    Toxicol Sci 69:92-108. 2002
    ....
  15. ncbi request reprint Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators
    John C O'Connor
    DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Newark, Delaware 19714, USA
    Toxicol Sci 69:79-91. 2002
    ....
  16. ncbi request reprint 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats
    Gregory S Ladics
    TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
    Drug Chem Toxicol 31:189-216. 2008
    ..The no-observed-adverse-effect level was 5 mg/kg...
  17. ncbi request reprint Subchronic inhalation toxicity of the chlorinated propane 1,1,1,3,3,3-hexachloropropane (HCC-230fa)
    J R Bamberger
    E. I. DuPont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
    Toxicol Sci 62:155-65. 2001
    ..Exposure to HCC-230fa did not significantly alter the primary humoral immune response to sheep red blood cell (SRBC). Under the conditions of this study, the no-observed-adverse-effect level (NOAEL) was considered to be 2.5 ppm...
  18. ncbi request reprint Commentary on hormetic dose-response relationships in immunology: occurrence, quantitative features of the dose response, mechanistic foundations, and clinical implications
    Gregory S Ladics
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Crit Rev Toxicol 35:303-4. 2005
  19. doi request reprint What's so special about the developing immune system?
    Leigh Ann Burns-Naas
    Drug Safety Research and Development, Pfizer Global Research and Development, California, USA
    Int J Toxicol 27:223-54. 2008
    ..The overall objective of this review is to provide a 'snapshot' of the current state-of-the-science of DIT. Despite significant progress, DIT is still evolving and it is our hope that this review will advance the science...
  20. ncbi request reprint Stability of a set of allergens and non-allergens in simulated gastric fluid
    Rod A Herman
    Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA
    Int J Food Sci Nutr 58:125-41. 2007
    ..While digestibility estimates were reproducible and robust, results for the proteins evaluated in this study did not support a significant association between stability in simulated gastric fluid and allergenicity...
  21. ncbi request reprint A proposed testing framework for developmental immunotoxicology (DIT)
    Michael P Holsapple
    ILSI Health Science and Environmental Sciences Institute, Washington, DC 20005, USA
    Toxicol Sci 83:18-24. 2005
    ....
  22. pmc Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process
    Robert W Luebke
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:22-7. 2006
    ..To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development...