Research Topics
| G S LadicsSummaryAffiliation: DuPont Haskell Laboratory for Health and Environmental Sciences Country: USA Publications
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Detail Information
Publications
Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for the elucidation of potential identities to known allergensGregory S Ladics
Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE 19880, USA
Mol Nutr Food Res 51:985-98. 2007..It is recommended that the conventional FASTA analysis be conducted to compare identities of proteins to allergens...
Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendationsGregory S Ladics
Pioneer Hi Bred International Inc, DuPont Agricultural Biotechnology, P O Box 80353, Wilmington, DE 19880, USA
Regul Toxicol Pharmacol 60:46-53. 2011..Recommendations for conducting bioinformatic analysis on novel food proteins for potential cross-reactivity to known allergens are also put forth...- Assessment of three human FcepsilonRI-transfected RBL cell-lines for identifying IgE induced degranulation utilizing peanut-allergic patient sera and peanut protein extractG S Ladics
DuPont Company, Building 353 334, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA
Regul Toxicol Pharmacol 51:288-94. 2008..The assay's utility in safety assessment, predictive value and reproducibility for evaluating the cross-reactivity of proteins with allergens needs further investigation with additional proteins and well-characterized sera... - Use of SRBC antibody responses for immunotoxicity testingGregory S Ladics
DuPont Co, E400 4402, Rt 141 and Henry Clay Road, Wilmington, DE 19880 0400, USA
Methods 41:9-19. 2007..In this manuscript, background information, as well as the pros and cons of each of these assays are discussed and detailed methods on conducting each assay are provided... - Current codex guidelines for assessment of potential protein allergenicityG S Ladics
DuPont Experimental Station, Building 353, Wilmington, DE 19880, USA
Food Chem Toxicol 46:S20-3. 2008..Additional approaches may be considered (e.g., animal models; targeted sera screening) as the science evolves; however, such approaches have not been thoroughly evaluated or validated for predicting protein allergenicity... - Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgEGregory S Ladics
Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE, USA
Regul Toxicol Pharmacol 44:136-43. 2006..Cry1F is heat labile, rapidly hydrolyzed in an in vitro pepsin resistance assay, not glycosylated and not from an allergenic source. Taken together, these data indicate a lack of allergenic concern for Cry1F... - Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studiesGregory S Ladics
The DuPont Company, Haskell Laboratory, Newark, Delaware 19714, USA
Toxicol Sci 88:24-9. 2005..The group agreed to consider the HESI ACSA Life Stages Task Force recommendations as a next step to address some of the issues and challenges raised during this session... - Subchronic toxicity of a fluoroalkylethanol mixture in ratsGregory S Ladics
DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Drug Chem Toxicol 28:135-58. 2005..Both plasma and urine fluoride levels were elevated in a dose-dependent manner. Under the conditions of the study, the no-observed adverse effect level for this mixture was 25 mg kg(-1) day(-1) for subchronic toxicity... - Identifying food proteins with allergenic potential: evolution of approaches to safety assessment and research to provide additional toolsGregory S Ladics
DuPont Co, DuPont Crop Genetics, Wilmington, DE 19880 USA
Regul Toxicol Pharmacol 54:S2-6. 2009..More recently US EPA has partnered with the National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health to support research in areas of mutual interest with respect to food allergy... - Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified cropsG S Ladics
DuPont Company, Route 141 and Henry Clary Road, Wilmington, DE 19880, USA
Regul Toxicol Pharmacol 56:212-24. 2010..In particular, more extensive validation testing with additional allergenic and non-allergenic material should be performed before using them in the safety assessment of genetically modified crops... - Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified cropsGregory S Ladics
The DuPont Co, Haskell Laboratory, Newark, Delaware 19714, USA
Toxicol Sci 73:8-16. 2003..However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods... - Evaluation of the reproductive and developmental toxicity of a fluoroalkylethanol mixtureEve Mylchreest
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Drug Chem Toxicol 28:159-75. 2005..No functional reproductive or developmental effects were observed at dose levels that did not adversely affect adult animals... - Acute, subchronic, and mutagenicity studies with norbornene fluoroalcoholMichael P DeLorme
E I duPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Drug Chem Toxicol 28:379-95. 2005..Based on the above findings, NBFOH demonstrates the potential to produce allergic contact dermatitis, and subchronic inhalation studies indicate a no-observed-adverse-effect-level (NOAEL) of 410 mg/m(3)... - Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogensJohn C O'Connor
DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Newark, Delaware 19714, USA
Toxicol Sci 69:92-108. 2002.... - Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulatorsJohn C O'Connor
DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Newark, Delaware 19714, USA
Toxicol Sci 69:79-91. 2002.... - 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in ratsGregory S Ladics
TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
Drug Chem Toxicol 31:189-216. 2008..The no-observed-adverse-effect level was 5 mg/kg... - Subchronic inhalation toxicity of the chlorinated propane 1,1,1,3,3,3-hexachloropropane (HCC-230fa)J R Bamberger
E. I. DuPont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
Toxicol Sci 62:155-65. 2001..Exposure to HCC-230fa did not significantly alter the primary humoral immune response to sheep red blood cell (SRBC). Under the conditions of this study, the no-observed-adverse-effect level (NOAEL) was considered to be 2.5 ppm... - Commentary on hormetic dose-response relationships in immunology: occurrence, quantitative features of the dose response, mechanistic foundations, and clinical implicationsGregory S Ladics
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Crit Rev Toxicol 35:303-4. 2005 - What's so special about the developing immune system?Leigh Ann Burns-Naas
Drug Safety Research and Development, Pfizer Global Research and Development, California, USA
Int J Toxicol 27:223-54. 2008..The overall objective of this review is to provide a 'snapshot' of the current state-of-the-science of DIT. Despite significant progress, DIT is still evolving and it is our hope that this review will advance the science... - Stability of a set of allergens and non-allergens in simulated gastric fluidRod A Herman
Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA
Int J Food Sci Nutr 58:125-41. 2007..While digestibility estimates were reproducible and robust, results for the proteins evaluated in this study did not support a significant association between stability in simulated gastric fluid and allergenicity... - A proposed testing framework for developmental immunotoxicology (DIT)Michael P Holsapple
ILSI Health Science and Environmental Sciences Institute, Washington, DC 20005, USA
Toxicol Sci 83:18-24. 2005.... 
Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment processRobert W Luebke
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 94:22-7. 2006..To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development...