Research Topics
| Gerald L KennedySummaryAffiliation: DuPont Haskell Laboratory for Health and Environmental Sciences Country: USA Publications
| Collaborators
|
Detail Information
Publications
Toxicity of hexamethylenediamineGerald L Kennedy
Haskell Laboratory, DuPont Company, Newark, Delaware 19714, USA
Drug Chem Toxicol 28:15-33. 2005..The chemical is not particularly toxic to fish and aquatic invertebrates but is quite toxic to algae. HMDA is rapidly absorbed and metabolized by the rat with little tissue storage...- Review of the toxicology of three alkyl diaminesGerald L Kennedy
DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Drug Chem Toxicol 30:145-57. 2007..The main effects of this series of diamines appear related to their irritant properties, and attention needs to be paid to their delayed hypersensitivity potential... - Health and ecological effects of adiponitrileGerald L Kennedy
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711, USA
Drug Chem Toxicol 27:123-31. 2004..ADN is rapidly absorbed and excreted by mammals, and is metabolized to some extent although unchanged ADN is readily detected in urine, and does not bioaccumulate... - The toxicology of perfluorooctanoateGerald L Kennedy
DuPont, Newark, Delaware, USA
Crit Rev Toxicol 34:351-84. 2004..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects... - Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO)Scott E Loveless
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, United States
Toxicology 220:203-17. 2006..Based on these results, and for the endpoints evaluated in this study, the toxicological database developed primarily from testing linear/branched APFO is applicable to linear APFO... - 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in ratsGregory S Ladics
TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
Drug Chem Toxicol 31:189-216. 2008..The no-observed-adverse-effect level was 5 mg/kg... - Perfluorooctanoate: Placental and lactational transport pharmacokinetics in ratsPaul M Hinderliter
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
Toxicology 211:139-48. 2005..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure... 
Renal elimination of perfluorocarboxylates (PFCAs)Xing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
Chem Res Toxicol 25:35-46. 2012....- Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the ratWilliam J Fasano
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Sci 91:341-55. 2006..1%) and feces (< 0.2%) was minor, and radioactivity concentrations in most tissues were below the limit of detection. Systemic availability of 8-2 FTOH following dermal exposure was negligible... - Inhalation toxicity of 1,3-propanediol in the ratRobert S Scott
DuPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Inhal Toxicol 17:487-93. 2005..1,3-Propanediol does not appear to pose a significant hazard via inhalation of either the vapor or a vapor/aerosol mixture... - Developmental toxicity study of dimethylpiperidoneSusan M Munley
Haskell Laboratory for Health and Environmental Sciences, E I duPont de Nemours and Company, Inc, 1090 Elkton Road, Newark, DE 19714, USA
Drug Chem Toxicol 27:1-14. 2004..There were no compound-related effects in either dams or fetuses at 52 mg/m3. It was, therefore, concluded that DMPD was not selectively toxic to the rat conceptus... - Four week feeding toxicity study with phenylphosphinic acid in ratsE Maria Donner
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Drug Chem Toxicol 26:125-33. 2003..Parameters measured were clinical signs, growth, neurobehavior, ophthalmology, and clinical and anatomical pathology. Phenylphosphinic acid is very low in toxicity following 31 days of feeding to the rat... - Toxicity of adipic acidGerald L Kennedy
Haskell Laboratory, DuPont Company, 1090 Elkton Road, Newark, DE 19714, USA
Drug Chem Toxicol 25:191-202. 2002..Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine. Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests... - Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearanceDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA
Toxicology 192:189-210. 2003..Histopathology revealed no adverse lower pulmonary or upper respiratory effects. In summary, the no-observed-effect level (NOEL) for inhaled Nylon RFP was 57f/cm3 (20mg/m3), the highest concentration tested... - Reproductive and repeated dose toxicity of cyclododecatriene (CDDT) in rats following oral (gavage) treatmentLinda A Malley
E I Du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, 1090 Elkton Road, Newark, DE 19714, USA
Drug Chem Toxicol 25:149-70. 2002..The NOEL in pups was 100 mg/kg/day, based on decreased body weights of pups in the 300 mg/kg/day group during lactation... - The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the ratJohn L Butenhoff
3M Medical Department, Corporate Toxicology, 3M Center 220 2E 02, Saint Paul, MN 55133, USA
Toxicology 196:95-116. 2004.... - 13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male ratsRoger G Perkins
3M Medical Department, Corporate Toxicology, St Paul, MN 55144, USA
Drug Chem Toxicol 27:361-78. 2004..1, 41, 70, and 138 microg/mL in the 1, 10, 30 and 100 ppm dose groups. The study no effect level was 1 ppm (0.06 microg/mg) with doses of 10 ppm (0.64 microg/mg) and higher producing adaptive and reversible liver changes... - Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of actionMelvin E Andersen
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 102:3-14. 2008..This report summarizes the discourse that occurred during the symposium...