Gerald L Kennedy

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint Toxicity of hexamethylenediamine
    Gerald L Kennedy
    Haskell Laboratory, DuPont Company, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:15-33. 2005
  2. ncbi request reprint Review of the toxicology of three alkyl diamines
    Gerald L Kennedy
    DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 30:145-57. 2007
  3. ncbi request reprint Health and ecological effects of adiponitrile
    Gerald L Kennedy
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711, USA
    Drug Chem Toxicol 27:123-31. 2004
  4. ncbi request reprint The toxicology of perfluorooctanoate
    Gerald L Kennedy
    DuPont, Newark, Delaware, USA
    Crit Rev Toxicol 34:351-84. 2004
  5. ncbi request reprint Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO)
    Scott E Loveless
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, United States
    Toxicology 220:203-17. 2006
  6. ncbi request reprint 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats
    Gregory S Ladics
    TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
    Drug Chem Toxicol 31:189-216. 2008
  7. ncbi request reprint Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats
    Paul M Hinderliter
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
    Toxicology 211:139-48. 2005
  8. doi request reprint Renal elimination of perfluorocarboxylates (PFCAs)
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
    Chem Res Toxicol 25:35-46. 2012
  9. ncbi request reprint Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 91:341-55. 2006
  10. ncbi request reprint Inhalation toxicity of 1,3-propanediol in the rat
    Robert S Scott
    DuPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Inhal Toxicol 17:487-93. 2005

Detail Information

Publications18

  1. ncbi request reprint Toxicity of hexamethylenediamine
    Gerald L Kennedy
    Haskell Laboratory, DuPont Company, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:15-33. 2005
    ..The chemical is not particularly toxic to fish and aquatic invertebrates but is quite toxic to algae. HMDA is rapidly absorbed and metabolized by the rat with little tissue storage...
  2. ncbi request reprint Review of the toxicology of three alkyl diamines
    Gerald L Kennedy
    DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 30:145-57. 2007
    ..The main effects of this series of diamines appear related to their irritant properties, and attention needs to be paid to their delayed hypersensitivity potential...
  3. ncbi request reprint Health and ecological effects of adiponitrile
    Gerald L Kennedy
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711, USA
    Drug Chem Toxicol 27:123-31. 2004
    ..ADN is rapidly absorbed and excreted by mammals, and is metabolized to some extent although unchanged ADN is readily detected in urine, and does not bioaccumulate...
  4. ncbi request reprint The toxicology of perfluorooctanoate
    Gerald L Kennedy
    DuPont, Newark, Delaware, USA
    Crit Rev Toxicol 34:351-84. 2004
    ..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects...
  5. ncbi request reprint Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO)
    Scott E Loveless
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, United States
    Toxicology 220:203-17. 2006
    ..Based on these results, and for the endpoints evaluated in this study, the toxicological database developed primarily from testing linear/branched APFO is applicable to linear APFO...
  6. ncbi request reprint 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats
    Gregory S Ladics
    TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
    Drug Chem Toxicol 31:189-216. 2008
    ..The no-observed-adverse-effect level was 5 mg/kg...
  7. ncbi request reprint Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats
    Paul M Hinderliter
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
    Toxicology 211:139-48. 2005
    ..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure...
  8. doi request reprint Renal elimination of perfluorocarboxylates (PFCAs)
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
    Chem Res Toxicol 25:35-46. 2012
    ....
  9. ncbi request reprint Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 91:341-55. 2006
    ..1%) and feces (< 0.2%) was minor, and radioactivity concentrations in most tissues were below the limit of detection. Systemic availability of 8-2 FTOH following dermal exposure was negligible...
  10. ncbi request reprint Inhalation toxicity of 1,3-propanediol in the rat
    Robert S Scott
    DuPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Inhal Toxicol 17:487-93. 2005
    ..1,3-Propanediol does not appear to pose a significant hazard via inhalation of either the vapor or a vapor/aerosol mixture...
  11. ncbi request reprint Developmental toxicity study of dimethylpiperidone
    Susan M Munley
    Haskell Laboratory for Health and Environmental Sciences, E I duPont de Nemours and Company, Inc, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Chem Toxicol 27:1-14. 2004
    ..There were no compound-related effects in either dams or fetuses at 52 mg/m3. It was, therefore, concluded that DMPD was not selectively toxic to the rat conceptus...
  12. ncbi request reprint Four week feeding toxicity study with phenylphosphinic acid in rats
    E Maria Donner
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Drug Chem Toxicol 26:125-33. 2003
    ..Parameters measured were clinical signs, growth, neurobehavior, ophthalmology, and clinical and anatomical pathology. Phenylphosphinic acid is very low in toxicity following 31 days of feeding to the rat...
  13. ncbi request reprint Toxicity of adipic acid
    Gerald L Kennedy
    Haskell Laboratory, DuPont Company, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Chem Toxicol 25:191-202. 2002
    ..Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine. Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests...
  14. ncbi request reprint Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearance
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA
    Toxicology 192:189-210. 2003
    ..Histopathology revealed no adverse lower pulmonary or upper respiratory effects. In summary, the no-observed-effect level (NOEL) for inhaled Nylon RFP was 57f/cm3 (20mg/m3), the highest concentration tested...
  15. ncbi request reprint Reproductive and repeated dose toxicity of cyclododecatriene (CDDT) in rats following oral (gavage) treatment
    Linda A Malley
    E I Du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Chem Toxicol 25:149-70. 2002
    ..The NOEL in pups was 100 mg/kg/day, based on decreased body weights of pups in the 300 mg/kg/day group during lactation...
  16. ncbi request reprint The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat
    John L Butenhoff
    3M Medical Department, Corporate Toxicology, 3M Center 220 2E 02, Saint Paul, MN 55133, USA
    Toxicology 196:95-116. 2004
    ....
  17. ncbi request reprint 13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats
    Roger G Perkins
    3M Medical Department, Corporate Toxicology, St Paul, MN 55144, USA
    Drug Chem Toxicol 27:361-78. 2004
    ..1, 41, 70, and 138 microg/mL in the 1, 10, 30 and 100 ppm dose groups. The study no effect level was 1 ppm (0.06 microg/mg) with doses of 10 ppm (0.64 microg/mg) and higher producing adaptive and reversible liver changes...
  18. ncbi request reprint Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action
    Melvin E Andersen
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:3-14. 2008
    ..This report summarizes the discourse that occurred during the symposium...