Gerald L Kennedy
Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
- Toxicity of hexamethylenediamineGerald L Kennedy
Haskell Laboratory, DuPont Company, Newark, Delaware 19714, USA
Drug Chem Toxicol 28:15-33. 2005..The chemical is not particularly toxic to fish and aquatic invertebrates but is quite toxic to algae. HMDA is rapidly absorbed and metabolized by the rat with little tissue storage...
- Review of the toxicology of three alkyl diaminesGerald L Kennedy
DuPont Company Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Drug Chem Toxicol 30:145-57. 2007..The main effects of this series of diamines appear related to their irritant properties, and attention needs to be paid to their delayed hypersensitivity potential...
- Health and ecological effects of adiponitrileGerald L Kennedy
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711, USA
Drug Chem Toxicol 27:123-31. 2004..ADN is rapidly absorbed and excreted by mammals, and is metabolized to some extent although unchanged ADN is readily detected in urine, and does not bioaccumulate...
- The toxicology of perfluorooctanoateGerald L Kennedy
DuPont, Newark, Delaware, USA
Crit Rev Toxicol 34:351-84. 2004..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects...
- Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO)Scott E Loveless
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, United States
Toxicology 220:203-17. 2006..Based on these results, and for the endpoints evaluated in this study, the toxicological database developed primarily from testing linear/branched APFO is applicable to linear APFO...
- 90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in ratsGregory S Ladics
TRP Toxicology Program, DuPont Haskell Laboratory, Newark, Delaware, USA
Drug Chem Toxicol 31:189-216. 2008..The no-observed-adverse-effect level was 5 mg/kg...
- Perfluorooctanoate: Placental and lactational transport pharmacokinetics in ratsPaul M Hinderliter
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
Toxicology 211:139-48. 2005..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure...
- Renal elimination of perfluorocarboxylates (PFCAs)Xing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
Chem Res Toxicol 25:35-46. 2012....
- Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the ratWilliam J Fasano
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Sci 91:341-55. 2006..1%) and feces (< 0.2%) was minor, and radioactivity concentrations in most tissues were below the limit of detection. Systemic availability of 8-2 FTOH following dermal exposure was negligible...
- Inhalation toxicity of 1,3-propanediol in the ratRobert S Scott
DuPont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Inhal Toxicol 17:487-93. 2005..1,3-Propanediol does not appear to pose a significant hazard via inhalation of either the vapor or a vapor/aerosol mixture...
- Developmental toxicity study of dimethylpiperidoneSusan M Munley
Haskell Laboratory for Health and Environmental Sciences, E I duPont de Nemours and Company, Inc, 1090 Elkton Road, Newark, DE 19714, USA
Drug Chem Toxicol 27:1-14. 2004..There were no compound-related effects in either dams or fetuses at 52 mg/m3. It was, therefore, concluded that DMPD was not selectively toxic to the rat conceptus...
- Four week feeding toxicity study with phenylphosphinic acid in ratsE Maria Donner
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
Drug Chem Toxicol 26:125-33. 2003..Parameters measured were clinical signs, growth, neurobehavior, ophthalmology, and clinical and anatomical pathology. Phenylphosphinic acid is very low in toxicity following 31 days of feeding to the rat...
- Toxicity of adipic acidGerald L Kennedy
Haskell Laboratory, DuPont Company, 1090 Elkton Road, Newark, DE 19714, USA
Drug Chem Toxicol 25:191-202. 2002..Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine. Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests...
- Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearanceDavid B Warheit
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA
Toxicology 192:189-210. 2003..Histopathology revealed no adverse lower pulmonary or upper respiratory effects. In summary, the no-observed-effect level (NOEL) for inhaled Nylon RFP was 57f/cm3 (20mg/m3), the highest concentration tested...
- Reproductive and repeated dose toxicity of cyclododecatriene (CDDT) in rats following oral (gavage) treatmentLinda A Malley
E I Du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, 1090 Elkton Road, Newark, DE 19714, USA
Drug Chem Toxicol 25:149-70. 2002..The NOEL in pups was 100 mg/kg/day, based on decreased body weights of pups in the 300 mg/kg/day group during lactation...
- The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the ratJohn L Butenhoff
3M Medical Department, Corporate Toxicology, 3M Center 220 2E 02, Saint Paul, MN 55133, USA
Toxicology 196:95-116. 2004....
- 13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male ratsRoger G Perkins
3M Medical Department, Corporate Toxicology, St Paul, MN 55144, USA
Drug Chem Toxicol 27:361-78. 2004..1, 41, 70, and 138 microg/mL in the 1, 10, 30 and 100 ppm dose groups. The study no effect level was 1 ppm (0.06 microg/mg) with doses of 10 ppm (0.64 microg/mg) and higher producing adaptive and reversible liver changes...
- Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of actionMelvin E Andersen
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 102:3-14. 2008..This report summarizes the discourse that occurred during the symposium...