Xing Han

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint Binding of perfluorooctanoic acid to rat and human plasma proteins
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, Newark, Delaware 19714, USA
    Chem Res Toxicol 16:775-81. 2003
  2. doi request reprint Renal elimination of perfluorocarboxylates (PFCAs)
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
    Chem Res Toxicol 25:35-46. 2012
  3. doi request reprint Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Metab Dispos 39:1288-93. 2011
  4. doi request reprint Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats
    Ching Hui Yang
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Lett 190:163-71. 2009
  5. doi request reprint Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Lett 181:81-6. 2008
  6. doi request reprint Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Aquat Toxicol 89:11-7. 2008
  7. ncbi request reprint Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Sci Technol 41:3269-76. 2007
  8. ncbi request reprint Subcellular distribution and protein binding of perfluorooctanoic acid in rat liver and kidney
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:197-209. 2005
  9. ncbi request reprint Binding of perfluorooctanoic acid to rat liver-form and kidney-form alpha2u-globulins
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 27:341-60. 2004
  10. ncbi request reprint Sequence analysis and membrane partitioning energies of alpha-helical antimicrobial peptides
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, Newark, DE 19714, USA
    Bioinformatics 20:970-3. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Binding of perfluorooctanoic acid to rat and human plasma proteins
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, Newark, Delaware 19714, USA
    Chem Res Toxicol 16:775-81. 2003
    ..3-0.4 mM and 6-9, respectively. On the basis of these binding parameters and the estimated plasma concentration of serum albumin, greater than 90% of PFOA would be bound to serum albumin in both rat and human blood...
  2. doi request reprint Renal elimination of perfluorocarboxylates (PFCAs)
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
    Chem Res Toxicol 25:35-46. 2012
    ....
  3. doi request reprint Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Metab Dispos 39:1288-93. 2011
    ..Because saturation of the GST-mediated reactions was not reached at the highest possible PFP concentration, GSH S-conjugation may become a much more important pathway at higher PFP concentrations (relative to the K(m) for TFPA)...
  4. doi request reprint Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats
    Ching Hui Yang
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Lett 190:163-71. 2009
    ..Due to the sex-dependent expression of Oatp1a1 in rat kidney, Oatp1a1-mediated tubular reabsorption is suggested to be the mechanism for the sex-dependent renal elimination of PFO in rats...
  5. doi request reprint Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Lett 181:81-6. 2008
    ..9 +/- 25.1 and 29.3 +/- 19.2 microM in male and female rat hepatocytes, respectively. When serum albumin was added to the incubations, PFO hepatic uptake rates were reduced, but were proportional to the unbound fractions of PFO...
  6. doi request reprint Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Aquat Toxicol 89:11-7. 2008
    ....
  7. ncbi request reprint Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Sci Technol 41:3269-76. 2007
    ..This study demonstrates a framework for future bioaccumulation assessment of xenobiotics using combined information of the physical-chemical properties of the compounds and the biotransformation potentials of the compounds in fish...
  8. ncbi request reprint Subcellular distribution and protein binding of perfluorooctanoic acid in rat liver and kidney
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:197-209. 2005
    ..Ligand blotting analysis revealed that multiple proteins from the liver cytosol, nuclei, and mitochondria fractions were capable of specific binding to PFOA...
  9. ncbi request reprint Binding of perfluorooctanoic acid to rat liver-form and kidney-form alpha2u-globulins
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 27:341-60. 2004
    ....
  10. ncbi request reprint Sequence analysis and membrane partitioning energies of alpha-helical antimicrobial peptides
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, Newark, DE 19714, USA
    Bioinformatics 20:970-3. 2004
    ..We hypothesize that this (N-terminal oblique alpha-helix)-central bend-(C-terminus) could be a common structural motif of membrane-disruptive peptides...
  11. doi request reprint Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Toxicol Chem 28:481-8. 2009
    ..3 to 22.4% of those from trout hepatocytes, which explained, to a large extent, the differences in their CL(H) and bioconcentration factor prediction...
  12. doi request reprint Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates
    Ching Hui Yang
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 117:294-302. 2010
    ..Our results suggest that OAT4 and URAT1 are key transporters in renal reabsorption of PFCs in humans and, as a result, may contribute significantly to the long half-life of PFO in humans...
  13. doi request reprint Cryopreserved hepatocytes from rainbow trout (Oncorhynchus mykiss): a validation study to support their application in bioaccumulation assessment
    Robert T Mingoia
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
    Environ Sci Technol 44:3052-8. 2010
    ....
  14. doi request reprint Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities
    Xing Han
    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicology 255:177-86. 2009
    ....
  15. ncbi request reprint Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat
    Diane L Nabb
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Aquat Toxicol 80:52-9. 2006
    ..7-fold lower in rainbow trout, respectively). Our results suggest that the relative importance of CYP1A enzymes (among CYP subfamilies) in the biotransformation of xenobiotics in rainbow trout is likely much greater than that in mammals...
  16. ncbi request reprint Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening
    Robert T Mingoia
    DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, Delaware 19714, USA
    Toxicol In Vitro 21:165-73. 2007
    ....
  17. pmc Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion
    Yinling Li
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 800736, Charlottesville, VA 22908 0736, USA
    J Virol 79:12065-76. 2005
    ..These results underline the functional importance of the kink in the fusion peptide and suggest a structural role for the N-terminal glycine ridge in viral membrane fusion...
  18. ncbi request reprint Thermodynamics of fusion peptide-membrane interactions
    Yinling Li
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, P O Box 800736, Charlottesville, Virginia 22908 0736, USA
    Biochemistry 42:7245-51. 2003
    ....