Research Topics
| Xing HanSummaryAffiliation: DuPont Haskell Laboratory for Health and Environmental Sciences Country: USA Publications
| Collaborators
|
Detail Information
Publications
Binding of perfluorooctanoic acid to rat and human plasma proteinsXing Han
DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, Newark, Delaware 19714, USA
Chem Res Toxicol 16:775-81. 2003..3-0.4 mM and 6-9, respectively. On the basis of these binding parameters and the estimated plasma concentration of serum albumin, greater than 90% of PFOA would be bound to serum albumin in both rat and human blood...
Renal elimination of perfluorocarboxylates (PFCAs)Xing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
Chem Res Toxicol 25:35-46. 2012....- Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathwaysXing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, DE 19714, USA
Drug Metab Dispos 39:1288-93. 2011..Because saturation of the GST-mediated reactions was not reached at the highest possible PFP concentration, GSH S-conjugation may become a much more important pathway at higher PFP concentrations (relative to the K(m) for TFPA)... - Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in ratsChing Hui Yang
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
Toxicol Lett 190:163-71. 2009..Due to the sex-dependent expression of Oatp1a1 in rat kidney, Oatp1a1-mediated tubular reabsorption is suggested to be the mechanism for the sex-dependent renal elimination of PFO in rats... - Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female ratsXing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
Toxicol Lett 181:81-6. 2008..9 +/- 25.1 and 29.3 +/- 19.2 microM in male and female rat hepatocytes, respectively. When serum albumin was added to the incubations, PFO hepatic uptake rates were reduced, but were proportional to the unbound fractions of PFO... - Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubationsXing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
Aquat Toxicol 89:11-7. 2008.... - Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessmentXing Han
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Environ Sci Technol 41:3269-76. 2007..This study demonstrates a framework for future bioaccumulation assessment of xenobiotics using combined information of the physical-chemical properties of the compounds and the biotransformation potentials of the compounds in fish... - Subcellular distribution and protein binding of perfluorooctanoic acid in rat liver and kidneyXing Han
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Drug Chem Toxicol 28:197-209. 2005..Ligand blotting analysis revealed that multiple proteins from the liver cytosol, nuclei, and mitochondria fractions were capable of specific binding to PFOA... - Binding of perfluorooctanoic acid to rat liver-form and kidney-form alpha2u-globulinsXing Han
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Drug Chem Toxicol 27:341-60. 2004.... - Sequence analysis and membrane partitioning energies of alpha-helical antimicrobial peptidesXing Han
DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, Newark, DE 19714, USA
Bioinformatics 20:970-3. 2004..We hypothesize that this (N-terminal oblique alpha-helix)-central bend-(C-terminus) could be a common structural motif of membrane-disruptive peptides... - Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessmentXing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
Environ Toxicol Chem 28:481-8. 2009..3 to 22.4% of those from trout hepatocytes, which explained, to a large extent, the differences in their CL(H) and bioconcentration factor prediction... - Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylatesChing Hui Yang
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Sci 117:294-302. 2010..Our results suggest that OAT4 and URAT1 are key transporters in renal reabsorption of PFCs in humans and, as a result, may contribute significantly to the long half-life of PFO in humans... - Cryopreserved hepatocytes from rainbow trout (Oncorhynchus mykiss): a validation study to support their application in bioaccumulation assessmentRobert T Mingoia
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
Environ Sci Technol 44:3052-8. 2010.... - Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activitiesXing Han
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA
Toxicology 255:177-86. 2009.... - Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and ratDiane L Nabb
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
Aquat Toxicol 80:52-9. 2006..7-fold lower in rainbow trout, respectively). Our results suggest that the relative importance of CYP1A enzymes (among CYP subfamilies) in the biotransformation of xenobiotics in rainbow trout is likely much greater than that in mammals... - Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screeningRobert T Mingoia
DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, 1090 Elkton Road, Newark, Delaware 19714, USA
Toxicol In Vitro 21:165-73. 2007.... 
Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusionYinling Li
Department of Molecular Physiology and Biological Physics, University of Virginia, P.O. Box 800736, Charlottesville, VA 22908-0736, USA
J Virol 79:12065-76. 2005..These results underline the functional importance of the kink in the fusion peptide and suggest a structural role for the N-terminal glycine ridge in viral membrane fusion...- Thermodynamics of fusion peptide-membrane interactionsYinling Li
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, P.O. Box 800736, Charlottesville, Virginia 22908-0736, USA
Biochemistry 42:7245-51. 2003....