William J Fasano

Summary

Affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Publications

  1. ncbi request reprint Rapid integrity assessment of rat and human epidermal membranes for in vitro dermal regulatory testing: correlation of electrical resistance with tritiated water permeability
    W J Fasano
    The DuPont Company, Haskell Laboratory for Health and Environmental Sciences, PO Box 50 Elkton Road, Newark, DE 19714, USA
    Toxicol In Vitro 16:731-40. 2002
  2. ncbi request reprint Penetration of ammonium perfluorooctanoate through rat and human skin in vitro
    W J Fasano
    DuPont Haskell Laboratory, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:79-90. 2005
  3. ncbi request reprint Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 91:341-55. 2006
  4. doi request reprint Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats
    William J Fasano
    EI DuPont de Nemours and Co, Inc, Newark, DE 19714 0050, USA
    Chem Biol Interact 180:281-95. 2009
  5. ncbi request reprint In vitro metabolism of 8-2 fluorotelomer alcohol: interspecies comparisons and metabolic pathway refinement
    Diane L Nabb
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 100:333-44. 2007
  6. doi request reprint Dermal penetration of propylene glycols: measured absorption across human abdominal skin in vitro and comparison with a QSAR model
    William J Fasano
    E I Du Pont de Nemours and Company, DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
    Toxicol In Vitro 25:1664-70. 2011
  7. ncbi request reprint The in vitro permeability coefficient and short-term absorption rates for vinyl toluene using human cadaver skin mounted in a static diffusion cell model
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Drug Chem Toxicol 29:39-55. 2006
  8. doi request reprint In vitro dermal absorption rate testing of certain chemicals of interest to the Occupational Safety and Health Administration: summary and evaluation of USEPA's mandated testing
    William J Fasano
    The DuPont Company, Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Regul Toxicol Pharmacol 51:181-94. 2008
  9. ncbi request reprint The Tinsley LCR Databridge Model 6401 and electrical impedance measurements to evaluate skin integrity in vitro
    W J Fasano
    The DuPont Company, Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Elkton Road, Newark, DE 19714 0050, USA
    Toxicol In Vitro 18:725-9. 2004

Detail Information

Publications9

  1. ncbi request reprint Rapid integrity assessment of rat and human epidermal membranes for in vitro dermal regulatory testing: correlation of electrical resistance with tritiated water permeability
    W J Fasano
    The DuPont Company, Haskell Laboratory for Health and Environmental Sciences, PO Box 50 Elkton Road, Newark, DE 19714, USA
    Toxicol In Vitro 16:731-40. 2002
    ..The use of electrical resistance provides a rapid and reliable method for evaluating the integrity of rat and human epidermal membranes for in vitro dermal kinetic testing...
  2. ncbi request reprint Penetration of ammonium perfluorooctanoate through rat and human skin in vitro
    W J Fasano
    DuPont Haskell Laboratory, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:79-90. 2005
    ..048+/-0.01%) had penetrated through human skin. Thus, under infinite dose and occlusive conditions, the steady-state penetration of APFO from a 20% solution was approximately 34-fold faster through rat skin than human skin...
  3. ncbi request reprint Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 91:341-55. 2006
    ..1%) and feces (< 0.2%) was minor, and radioactivity concentrations in most tissues were below the limit of detection. Systemic availability of 8-2 FTOH following dermal exposure was negligible...
  4. doi request reprint Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats
    William J Fasano
    EI DuPont de Nemours and Co, Inc, Newark, DE 19714 0050, USA
    Chem Biol Interact 180:281-95. 2009
    ....
  5. ncbi request reprint In vitro metabolism of 8-2 fluorotelomer alcohol: interspecies comparisons and metabolic pathway refinement
    Diane L Nabb
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 100:333-44. 2007
    ..These results suggest that human exposure to 8-2 FTOH is not expected to be a significant source of PFOA or any other perfluorocarboxylic acids...
  6. doi request reprint Dermal penetration of propylene glycols: measured absorption across human abdominal skin in vitro and comparison with a QSAR model
    William J Fasano
    E I Du Pont de Nemours and Company, DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA
    Toxicol In Vitro 25:1664-70. 2011
    ..39%/h) for DPG. However, the extrapolation for MPG may be further overestimated due to possible residence in the stratum corneum under infinite conditions of exposure that would not be applicable to a finite loading dose...
  7. ncbi request reprint The in vitro permeability coefficient and short-term absorption rates for vinyl toluene using human cadaver skin mounted in a static diffusion cell model
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Drug Chem Toxicol 29:39-55. 2006
    ....
  8. doi request reprint In vitro dermal absorption rate testing of certain chemicals of interest to the Occupational Safety and Health Administration: summary and evaluation of USEPA's mandated testing
    William J Fasano
    The DuPont Company, Haskell Global Centers for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Regul Toxicol Pharmacol 51:181-94. 2008
    ..When available, in vitro dermal flux measurements should be combined with toxicity information in order to improve the utility of chemical skin notations...
  9. ncbi request reprint The Tinsley LCR Databridge Model 6401 and electrical impedance measurements to evaluate skin integrity in vitro
    W J Fasano
    The DuPont Company, Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Elkton Road, Newark, DE 19714 0050, USA
    Toxicol In Vitro 18:725-9. 2004
    ..The results confirm that the operator-selected settings on the Tinsley LCR Databridge Model 6401 affect the impedance measurement and the dynamic range of values observed for dermatomed human skin in vitro...