DuPont Haskell Laboratory for Health and Environmental Sciences

Summary

Organization: DuPont Haskell Laboratory for Health and Environmental Sciences
Country: USA

Top Publications

  1. doi Characterization of synthetic copolymers by interaction polymer chromatography: Separation by microstructure
    Yefim Brun
    DuPont, Central Research and Development, Wilmington, DE 19880, USA
    J Sep Sci 33:3501-10. 2010
  2. ncbi Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 95:270-80. 2007
  3. ncbi Theory of structure-based carbon nanotube separations by ion-exchange chromatography of DNA/CNT hybrids
    Steven Raymond Lustig
    DuPont, Central Research and Development, Experimental Station, Route 141, Wilmington, Delaware 19880 0356, USA
    J Phys Chem B 109:2559-66. 2005
  4. ncbi Functional analysis of the split Synechocystis DnaE intein in plant tissues by biolistic particle bombardment
    Jianjun Yang
    Central Research and Development, E I DuPont de Nemours and Co, Experimental Station, Wilmington, DE 19880, USA
    Transgenic Res 15:583-93. 2006
  5. ncbi Method development for the determination of residual fluorotelomer raw materials and perflurooctanoate in fluorotelomer-based products by gas chromatography and liquid chromatography mass spectrometry
    Barbara S Larsen
    DuPont Corporate Center for Analytical Sciences, Central Research and Development, Experimental Station, Wilmington, DE 19880, USA
    J Chromatogr A 1110:117-24. 2006
  6. ncbi Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgE
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE, USA
    Regul Toxicol Pharmacol 44:136-43. 2006
  7. ncbi Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments
    Charles N McEwen
    DuPont Corporate Center for Analytical Sciences, Wilmington, Delaware 19880, USA
    Anal Chem 77:7826-31. 2005
  8. ncbi Matrix effect-free analytical methods for determination of perfluorinated carboxylic acids in environmental matrixes
    Charles R Powley
    DuPont Haskell Laboratories, P O Box 50, Newark, Delaware 19714 0050, USA
    Anal Chem 77:6353-8. 2005
  9. ncbi Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 88:514-24. 2005
  10. ncbi Comparative effectiveness of different insecticides for organic management of blueberry maggot (Diptera: Tephritidae)
    James D Barry
    Blueberry and Cranberry Research and Extension Center, Rutgers University, 125A Lake Oswego Road, Chatsworth, NJ 08019, USA
    J Econ Entomol 98:1236-41. 2005

Detail Information

Publications62

  1. doi Characterization of synthetic copolymers by interaction polymer chromatography: Separation by microstructure
    Yefim Brun
    DuPont, Central Research and Development, Wilmington, DE 19880, USA
    J Sep Sci 33:3501-10. 2010
    ..These findings provide theoretical and experimental bases for separation of statistical and block copolymers by chemical composition and microstructure of polymer chains...
  2. ncbi Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Toxicol Sci 95:270-80. 2007
    ..The results demonstrate that the pulmonary toxicities of alpha-quartz particles appear to correlate better with surface activity than particle size and surface area...
  3. ncbi Theory of structure-based carbon nanotube separations by ion-exchange chromatography of DNA/CNT hybrids
    Steven Raymond Lustig
    DuPont, Central Research and Development, Experimental Station, Route 141, Wilmington, Delaware 19880 0356, USA
    J Phys Chem B 109:2559-66. 2005
    ..The model correctly predicts hybrids with metallic nanotubes are weaker binding than hybrids with semiconducting nanotubes and larger diameter nanotubes are eluted at later times...
  4. ncbi Functional analysis of the split Synechocystis DnaE intein in plant tissues by biolistic particle bombardment
    Jianjun Yang
    Central Research and Development, E I DuPont de Nemours and Co, Experimental Station, Wilmington, DE 19880, USA
    Transgenic Res 15:583-93. 2006
    ..It also demonstrated that when up to 45 amino acid residues were removed from the C-terminus of the Int-n fragment, the Int-n fragment was still able to function in the protein trans-splicing process...
  5. ncbi Method development for the determination of residual fluorotelomer raw materials and perflurooctanoate in fluorotelomer-based products by gas chromatography and liquid chromatography mass spectrometry
    Barbara S Larsen
    DuPont Corporate Center for Analytical Sciences, Central Research and Development, Experimental Station, Wilmington, DE 19880, USA
    J Chromatogr A 1110:117-24. 2006
    ..The methods were applied to fluorotelomer-based raw materials and fluorotelomer-based surfactants and polymeric products and represent methods useful for the determination of higher carbon chain length homologs as well...
  6. ncbi Lack of cross-reactivity between the Bacillus thuringiensis derived protein Cry1F in maize grain and dust mite Der p7 protein with human sera positive for Der p7-IgE
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE, USA
    Regul Toxicol Pharmacol 44:136-43. 2006
    ..Cry1F is heat labile, rapidly hydrolyzed in an in vitro pepsin resistance assay, not glycosylated and not from an allergenic source. Taken together, these data indicate a lack of allergenic concern for Cry1F...
  7. ncbi Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments
    Charles N McEwen
    DuPont Corporate Center for Analytical Sciences, Wilmington, Delaware 19880, USA
    Anal Chem 77:7826-31. 2005
    ..Accurate mass and mass-selected fragmentation are demonstrated as is the ability to obtain ions from biological tissue, currency, and other objects placed in the path of the hot nitrogen stream...
  8. ncbi Matrix effect-free analytical methods for determination of perfluorinated carboxylic acids in environmental matrixes
    Charles R Powley
    DuPont Haskell Laboratories, P O Box 50, Newark, Delaware 19714 0050, USA
    Anal Chem 77:6353-8. 2005
    ..The method utilizes an extraction solvent previously shown to release and recover aged residues of PFCAs. A confirmatory method using two precursor to product ions is also provided and demonstrated...
  9. ncbi Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity
    D B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Toxicol Sci 88:514-24. 2005
    ....
  10. ncbi Comparative effectiveness of different insecticides for organic management of blueberry maggot (Diptera: Tephritidae)
    James D Barry
    Blueberry and Cranberry Research and Extension Center, Rutgers University, 125A Lake Oswego Road, Chatsworth, NJ 08019, USA
    J Econ Entomol 98:1236-41. 2005
    ..Overall, the insecticides evaluated in these trials showed good ability to control blueberry maggot, suggesting that they can be incorporated in a blueberry maggot management program under organic standards...
  11. ncbi Adsorption of hydrophobin proteins at hydrophobic and hydrophilic interfaces
    Simon O Lumsdon
    DuPont Company, Experimental Station, Wilmington, DE 19880, USA
    Colloids Surf B Biointerfaces 44:172-8. 2005
    ..It is also capable of stabilizing aqueous dispersions of Kevlar nanopulp, reversing the wettability of hydrophobic films and stabilizing polyunsaturated fatty acid (PUFA) oil-in-water emulsions...
  12. ncbi In vitro studies in microsomes from rat and human liver, kidney, and intestine suggest that perfluorooctanoic acid is not a substrate for microsomal UDP-glucuronosyltransferases
    Raymond A Kemper
    Discovery Toxicology Group, Haskell Laboratory for Health and Environmental Sciences, E I duPont de Nemours and Company, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:281-7. 2005
    ..These data suggest that PFOA is not a substrate for human or rodent microsomal UDPGTs...
  13. ncbi Subcellular distribution and protein binding of perfluorooctanoic acid in rat liver and kidney
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 28:197-209. 2005
    ..Ligand blotting analysis revealed that multiple proteins from the liver cytosol, nuclei, and mitochondria fractions were capable of specific binding to PFOA...
  14. ncbi Determination of extractable perfluorooctanoic acid (PFOA) in water, sweat simulant, saliva simulant, and methanol from textile and carpet samples by LC/MS/MS
    Michael P Mawn
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19714, USA
    Analyst 130:670-8. 2005
    ..5 h pressurized fluid extraction (PFE) in methanol reveals that the 24 h wrist action shaker yields the highest results. The 2 h wrist action shaker results are similar to those of the 1.5 h PFE extraction...
  15. pmc Use of transposon promoter-probe vectors in the metabolic engineering of the obligate methanotroph Methylomonas sp. strain 16a for enhanced C40 carotenoid synthesis
    Pamela L Sharpe
    E I DuPont de Nemours Inc Experimental Station, E328 B49, Wilmington, DE 19880 0328, USA
    Appl Environ Microbiol 73:1721-8. 2007
    ....
  16. ncbi Enrichment of single chirality carbon nanotubes
    Ming Zheng
    DuPont Central Research and Development, Wilmington, Delaware 19880, USA
    J Am Chem Soc 129:6084-5. 2007
  17. ncbi Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment
    Xing Han
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Environ Sci Technol 41:3269-76. 2007
    ..This study demonstrates a framework for future bioaccumulation assessment of xenobiotics using combined information of the physical-chemical properties of the compounds and the biotransformation potentials of the compounds in fish...
  18. pmc Stacking multiple transgenes at a selected genomic site via repeated recombinase-mediated DNA cassette exchanges
    Zhongsen Li
    DuPont Agricultural Biotechnology, Experimental Station E353, Wilmington, Delaware 19880, USA
    Plant Physiol 154:622-31. 2010
    ..Phenotypic analyses indicated that all the transgenes expressed expected phenotypes...
  19. doi Assessing health risks of inhaled nanomaterials: development of pulmonary bioassay hazard studies
    David B Warheit
    DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, Delaware 19714 0050, USA
    Anal Bioanal Chem 398:607-12. 2010
    ..In the final section, two studies are described which demonstrate that particle size is not the most significant particulate factor in producing exposure-related pulmonary effects...
  20. doi Association genetics in crop improvement
    J Antoni Rafalski
    DuPont Agricultural Biotechnology Group and Pioneer Hi Bred International, Wilmington, DE, USA
    Curr Opin Plant Biol 13:174-80. 2010
    ..Classical biparental mapping remains the method of choice for mapping the effects of alleles rare in germplasm collections, such as some disease resistance genes or alleles introgressed from exotic germplasm...
  21. pmc Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment
    E Maria Donner
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Mutagenesis 25:49-55. 2010
    ....
  22. doi Spectral separation of gaseous fluorocarbon mixtures and measurement of diffusion constants by 19F gas phase DOSY NMR
    Alexander A Marchione
    DuPont Central Research and Development, Experimental Station, Wilmington, DE 19803, USA
    J Magn Reson 201:34-8. 2009
    ..25 to 1.34 atm and temperatures from 20 to 122 degrees C. Under all conditions there was agreement within 20% of experimental self-diffusion constant D and values calculated by the semiempirical Fuller method...
  23. doi The Nexus between ecological risk assessment and natural resource damage assessment under CERCLA: introduction to a Society of Environmental Toxicology and ChemistryTechnical Workshop
    Ralph G Stahl
    DuPont Company, Wilmington, DE, USA
    Integr Environ Assess Manag 5:496-9. 2009
    ..These points are explained in greater detail in the series of papers published herein...
  24. pmc Site-specific integration of transgenes in soybean via recombinase-mediated DNA cassette exchange
    Zhongsen Li
    DuPont Pioneer Crop Genetics, Experimental Station, Wilmington, Delaware 19880, USA
    Plant Physiol 151:1087-95. 2009
    ..The introduced donor genes expressed normally and segregated according to Mendelian laws...
  25. doi New and selective ryanodine receptor activators for insect control
    George P Lahm
    DuPont Crop Protection, Stine Haskell Research Center, 1090 Elkton Road, Newark, DE 19711, USA
    Bioorg Med Chem 17:4127-33. 2009
    ..The high levels of mammalian safety are attributed to a strong selectivity for insect over mammalian receptors...
  26. doi Identifying food proteins with allergenic potential: evolution of approaches to safety assessment and research to provide additional tools
    Gregory S Ladics
    DuPont Co, DuPont Crop Genetics, Wilmington, DE 19880 USA
    Regul Toxicol Pharmacol 54:S2-6. 2009
    ..More recently US EPA has partnered with the National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health to support research in areas of mutual interest with respect to food allergy...
  27. ncbi Investigation of the biodegradation potential of a fluoroacrylate polymer product in aerobic soils
    Mark H Russell
    E I DuPont de Nemours and Co, Inc, Wilmington, Delaware, USA
    Environ Sci Technol 42:800-7. 2008
    ....
  28. ncbi Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements
    Sujata K Bhatia
    Biochemical Sciences and Engineering, Central Research and Development, DuPont Experimental Station, Wilmington, DE 19880, USA
    Cell Biol Toxicol 24:315-9. 2008
    ..An equation relating the visual cytotoxicity score and the percent viable cells was derived. The results of this study are significant for the design and interpretation of in vitro cytotoxicity studies of novel biomaterials...
  29. ncbi Retrospective cohort mortality study of workers in a polymer production plant including a reference population of regional workers
    Robin C Leonard
    DuPont Epidemiology Program, DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA
    Ann Epidemiol 18:15-22. 2008
    ..S. polymer manufacturing facility, the study objective was to investigate ischemic heart disease (IHD) mortality as well as a broad range of mortality causes for an occupational cohort at the facility...
  30. ncbi Comparison of conventional FASTA identity searches with the 80 amino acid sliding window FASTA search for the elucidation of potential identities to known allergens
    Gregory S Ladics
    Dupont Pioneer Crop Genetics Regulatory Science and Registration, Wilmington, DE 19880, USA
    Mol Nutr Food Res 51:985-98. 2007
    ..It is recommended that the conventional FASTA analysis be conducted to compare identities of proteins to allergens...
  31. ncbi Nanoscale self-assembly of multiblock copolymer chains into rods
    Yves Termonia
    Building 304, Room C219, Central Research and Development, Experimental Station, E I du Pont de Nemours, Inc, Wilmington, Delaware 19880 0304, USA
    Biomacromolecules 5:2404-7. 2004
    ..The model suggests that rodlike structures should be available in similarly designed synthetic polymers. This route would be distinct from existing routes that employ rigid monomers, e.g. aramids...
  32. ncbi Developmental toxicity study of dimethylpiperidone
    Susan M Munley
    Haskell Laboratory for Health and Environmental Sciences, E I duPont de Nemours and Company, Inc, 1090 Elkton Road, Newark, DE 19714, USA
    Drug Chem Toxicol 27:1-14. 2004
    ..There were no compound-related effects in either dams or fetuses at 52 mg/m3. It was, therefore, concluded that DMPD was not selectively toxic to the rat conceptus...
  33. ncbi Industrial wastewater bioreactors: sources of novel microorganisms for biotechnology
    M G Bramucci
    DuPont Central Research and Development, Wilmington, DE 19880 0328, USA
    Trends Biotechnol 18:501-5. 2000
    ..The microorganisms in these bioreactors compete for different carbon sources and constantly have to evolve new metabolic capabilities for survival. Thus, industrial bioreactors should be a rich source of novel biocatalysts...
  34. ncbi Chronic toxicity and oncogenicity bioassay in rats with the chloro-s-triazine herbicide cyanazine
    M S Bogdanffy
    DuPont Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
    J Toxicol Environ Health A 60:567-86. 2000
    ..Research into the mechanism of action suggests these mammary tumors are mediated through a prolactin mechanism that is thought to be of low relevance to humans...
  35. pmc Acquired thermotolerance and expression of the HSP100/ClpB genes of lima bean
    S J Keeler
    Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19717, USA
    Plant Physiol 123:1121-32. 2000
    ....
  36. ncbi Evaluation of a Tier I screening battery for detecting endocrine-active compounds (EACs) using the positive controls testosterone, coumestrol, progesterone, and RU486
    J C O'Connor
    DuPont Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
    Toxicol Sci 54:338-54. 2000
    ..These data demonstrate that the described Tier I battery is useful for identifying EACs and they extend the compounds evaluated to 16...
  37. ncbi Computational modeling of the baroreflex arc: nucleus tractus solitarius
    R F Rogers
    Central Research and Development, E I du Pont de Nemours and Co, Inc, Wilmington, DE 19880 0328, USA
    Brain Res Bull 51:139-50. 2000
    ..Our results demonstrate that modeling can be a useful tool in analysis of (and examination of underlying mechanisms for) NTS behavior on many levels...
  38. ncbi Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization
    K S Bentley
    DuPont Agricultural Products, Wilmington, DE 19880 0038, USA
    Mutat Res 464:41-51. 2000
    ..Nearly equimolar threshold concentrations were determined for benomyl- and carbendazim-induced non-disjunction...
  39. ncbi A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity
    M S Bogdanffy
    Haskell Laboratory for Toxicology and Industrial Medicine, E I du Pont de Nemours and Co, Inc, Newark, Delaware 19714, USA
    Toxicol Sci 51:19-35. 1999
    ..After the application of appropriate uncertainty factors, an ambient air value of 0.4 to 1.0 ppm was derived. The biologically based approach supports a workplace standard of 10 ppm...
  40. ncbi Effect of ebselen on IL-1-induced alterations in cartilage metabolism
    M A Pratta
    Inflammatory Diseases Research, DuPont Merck Pharmaceutical Company, Wilmington, DE 19880 0400, USA
    Inflamm Res 47:115-21. 1998
    ..To evaluate the effect of the antioxidant-like anti-inflammatory agent, ebselen, on cartilage proteoglycan degradation and to determine whether its cartilage protectant activity is related to its antioxidant activity...
  41. ncbi Validation of cleaning procedures for highly potent drugs. I. Losoxantrone
    J A Shea
    DuPont Merck Pharmaceutical Company, Pharmaceutical R and D, Wilmington, Delaware 19880 0353, USA
    Pharm Dev Technol 1:69-75. 1996
    ..These results demonstrate the need to fully characterize the recovery of drugs from surfaces and swabs in order to properly validate cleaning procedures...
  42. pmc Lung proliferative and clearance responses to inhaled para-aramid RFP in exposed hamsters and rats: comparisons with chrysotile asbestos fibers
    D B Warheit
    DuPont Haskell Laboratory, Newark, DE 19714, USA
    Environ Health Perspect 105:1219-22. 1997
    ..In contrast, exposures to chrysotile asbestos fibers in rats resulted in a selective pulmonary retention of long chrysotile fibers...
  43. ncbi Initiating the risk assessment process for inhaled particulate materials: development of short term inhalation bioassays
    D B Warheit
    Du Pont Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714, USA
    J Expo Anal Environ Epidemiol 7:313-25. 1997
    ....
  44. ncbi Biological matrix-dependent pharmacokinetic and pharmacodynamic parameters of a novel platelet glycoprotein IIB/IIIA receptor antagonist, XU063, in beagle dogs
    R P Kapil
    Drug Metabolism and Pharmacokinetics Section, Stine Haskell Research Center, DuPont Merck Pharmaceutical Company, Newark, DE 19714, USA
    Thromb Res 86:221-32. 1997
    ..The pros and cons of various blood sample collection methods for the evaluation of PK/PD relationship of potential antiplatelet agents are presented...
  45. ncbi The cell adhesion domain in plasma vitronectin is cryptic
    D Seiffert
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 272:13705-10. 1997
    ..The data presented here indicate that such conformational changes in Vn are likely to occur in areas of tissue injury and thrombosis...
  46. ncbi Sensitivity and specificity of the test kit BAX for screening/E. coli O157:H7 in ground beef: independent laboratory study
    A M Hochberg
    Qualicon, Inc, Wilmington, DE 19810, USA
    J AOAC Int 83:1349-56. 2000
    ..The BAX system kit detected the target organism at levels approximately 10-fold lower than those that gave positive BAM results. This study validated product claims, and Performance Tested Method status was granted...
  47. ncbi Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk
    M S Bogdanffy
    Haskell Laboratory for Toxicology and Industrial Medicine, E I Du Pont de Nemours and Company, PO Box 50, Newark, DE 19714, USA
    Inhal Toxicol 13:377-96. 2001
    ..Proposing a reasonable mode of action is an important step in any risk assessment and is critical to the choice of dosimeter(s) to be used for interspecies dosimetry extrapolation...
  48. ncbi A structural account of substrate and inhibitor specificity differences between two naphthol reductases
    D I Liao
    Experimental Station, DuPont Central Research and Development, Wilmington, Delaware 19880, USA
    Biochemistry 40:8696-704. 2001
    ..Thus, the C-terminal residues of the two naphthol reductase are determinants of inhibitor and substrate specificities...
  49. ncbi Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis
    Matthew W Himmelstein
    E I Du Pont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, PO Box 50, 1090 Elkton Road, Newark, Delaware 19711, USA
    Toxicol Sci 79:28-37. 2004
    ..The combined analysis of lung tumor response across species using the PBTK-derived internal dose provides an improved alternative to default pharmacokinetic interspecies adjustments for application to human health risk assessment...
  50. ncbi Sequence analysis of plasmid pTS1 isolated from oral spirochetes
    Sarita Chauhan
    Department of Oral Biology, State University of New York, Buffalo, USA
    Plasmid 51:61-5. 2004
    ..Analysis of the four open reading frames identified on the plasmid suggests the presence of genes involved in replication and mobilization...
  51. ncbi Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearance
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE, USA
    Toxicology 192:189-210. 2003
    ..Histopathology revealed no adverse lower pulmonary or upper respiratory effects. In summary, the no-observed-effect level (NOEL) for inhaled Nylon RFP was 57f/cm3 (20mg/m3), the highest concentration tested...
  52. ncbi Examination of a reaction intermediate in the active site of riboflavin synthase
    Ya Jun Zheng
    DuPont Agricultural Products, Stine Haskell Research Center, 1094 Elkton Road, Post Office Box 30, Newark, DE 19714, USA
    Bioorg Chem 31:278-87. 2003
    ..The model of the trans intermediate complements the model of the two substrates in the active site and allows for a hypothetical mechanism of the roles of specific protein residues in catalysis to be proposed...
  53. ncbi Inhalation toxicity of methylglutaronitrile in rats
    D P Kelly
    E I Du Pont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Drug Chem Toxicol 26:99-115. 2003
    ..Based on the above findings of body weight depression at 200 mg/m3, the no-observed-adverse-effect level (NOAEL) for this study was considered to be 25 mg/m3...
  54. ncbi Differentiating between local cytotoxicity, mitogenesis, and genotoxicity in carcinogen risk assessments: the case of vinyl acetate
    Matthew S Bogdanffy
    DuPont Haskell Laboratory for Health and Environmental Sciences, E I Du Pont de Nemours and Company, P O Box 50, Newark, DE 19714, USA
    Toxicol Lett 140:83-98. 2003
    ..These mechanistic insights provide the scientific basis for a cancer classification that incorporates thresholds for cytotoxic and/or mitogenic cell proliferation secondary to intracellular acidification...
  55. ncbi Structure of glycerol dehydratase reactivase: a new type of molecular chaperone
    Der Ing Liao
    DuPont Central Research and Development, Experimental Station, Wilmington, DE 19880, USA
    Structure 11:109-19. 2003
    ..A hypothesis for the reactivation mechanism of reactivase is proposed based on these structural features...
  56. ncbi A comparison of crop and non-crop plants as sensitive indicator species for regulatory testing
    Robert A McKelvey
    DuPont Haskell Laboratory for Health and Environmental Sciences, PO Box 50, 1090 Elkton Rd, Newark, DE 19714 0050, USA
    Pest Manag Sci 58:1161-74. 2002
    ..This comparison indicates that crop species sensitivity to test substances is likely to be representative of non-crop herbaceous species response, regardless of chemical class, mode of action and magnitude or route of exposure...
  57. pmc Global gene expression profiles of the cyanobacterium Synechocystis sp. strain PCC 6803 in response to irradiation with UV-B and white light
    Lixuan Huang
    Central Research and Development, DuPont Company, Wilmington, Delaware 19880 0173, USA
    J Bacteriol 184:6845-58. 2002
    ..Overall, the gene expression profile analysis generated new insights into the integrated network of genes that adapts rapidly to different wavelengths and intensities of light...
  58. ncbi Rapid genetic mapping of ESTs using SNP pyrosequencing and indel analysis
    Ada Ching
    DuPont Crop Genetics, Molecular Genetics Group, 1, Innovation Way, Newark, DE 19711, USA
    Cell Mol Biol Lett 7:803-10. 2002
    ..These loci were successfully placed onto chromosomes 3, 7 and 9 respectively. This method is generally applicable to most plant species, which show sufficient sequence diversity in the 3'-UTR region of genes...
  59. ncbi Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators
    John C O'Connor
    DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Newark, Delaware 19714, USA
    Toxicol Sci 69:79-91. 2002
    ....
  60. pmc Biochemical and molecular characterization of a mutation that confers a decreased raffinosaccharide and phytic acid phenotype on soybean seeds
    William D Hitz
    DuPont Crop Genetics, P O Box 80402, Wilmington, DE 19880 0402, USA
    Plant Physiol 128:650-60. 2002
    ..That same decrease in myo-inositol 1-phosphate synthetic capacity leads to a decreased capacity for the synthesis of myo-inositol hexaphosphate (phytic acid) and a concomitant increase in inorganic phosphate...
  61. ncbi An enantioselective synthesis of insecticidal 4-alkynyloxazolines
    D Clark
    DuPont Crop Protection, Stine Haskell Research Center, PO Box 30, Bldg 300, Newark, DE 19714, USA
    Bioorg Med Chem 9:2857-62. 2001
    ..An efficient and enantioselective synthesis to these compounds has been developed which relies on a (-)-sparteine mediated hydroxymethylation of the lithium dianion of propargylic amides...
  62. ncbi Analysis of heart rate-based control of arterial blood pressure
    W C Rose
    Neural Computation Program, DuPont Central Research and Development, Wilmington, Delaware 19880 0328, USA
    Am J Physiol 271:H812-22. 1996
    ....