Affiliation: Duke University Medical Center
Jin Y, Zhu M, Guo Y, Foreman D, Feng F, Duan G, et al
. Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function. Cell Signal. 2019;57:102-109 pubmed publisher
..Our data suggest that PM2.5, mainly water-soluble fraction of PM2.5, could affect mast cell activation through enhancing FcεRI-mediated signaling. ..
Zhu M, Foreman D, O Brien S, Jin Y, Zhang W. Phospholipase D in TCR-Mediated Signaling and T Cell Activation. J Immunol. 2018;200:2165-2173 pubmed publisher
..In addition, it impaired TCR downregulation and the secondary T cell response. Together, our results suggested that PLD1 plays an important role in T cell activation. ..
O Brien S, Zhu M, Zhang W. The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. J Immunol. 2015;195:695-705 pubmed publisher
..Our data indicated that the LAT-PLCÎ³1 interaction is important for controlling IL-6 production by T cells and demonstrated a critical role of IL-6 in the development of this lymphoproliferative syndrome. ..
Zhu M, Zou J, Li T, O Brien S, Zhang Y, Ogden S, et al
. Differential Roles of Phospholipase D Proteins in FcÎµRI-Mediated Signaling and Mast Cell Function. J Immunol. 2015;195:4492-502 pubmed publisher
..Together, our results suggested that PLD1 and PLD2, two proteins that catalyze the same enzymatic reaction, regulate different steps in mast cell degranulation. ..