Jae Sung Yu

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteins
    Jae Sung Yu
    Departments of Medicine, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Virol Methods 168:248-50. 2010
  2. ncbi request reprint Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor
    Jae Sung Yu
    Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, United States
    J Virol Methods 137:219-28. 2006
  3. pmc Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression
    Jae Sung Yu
    Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Vaccine Immunol 18:43-9. 2011
  4. pmc Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis
    Jae Sung Yu
    Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Vaccine Immunol 13:1204-11. 2006
  5. pmc Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein
    Feng Gao
    Department of Medicine, Duke University Medical Center, 112 Research Park III, Research Dr, Box 3347, Durham, NC 27710, USA
    J Virol 79:1154-63. 2005
  6. pmc Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites
    Jae Sung Yu
    Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Vaccine Immunol 14:886-93. 2007
  7. pmc HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    J Virol 86:7496-507. 2012
  8. pmc H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25797. 2011
  9. pmc Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion
    Natalie Taylor
    Duke University School of Medicine, Human Vaccine Institute, Durham, NC, USA
    Clin Vaccine Immunol 19:1416-25. 2012
  10. pmc Comparison of multiple vaccine vectors in a single heterologous prime-boost trial
    Brice Barefoot
    Duke Human Vaccine Institute, Duke University School of Medicine, DU Medical Center, 102 Research Drive, Durham, NC 27710, USA
    Vaccine 26:6108-18. 2008

Collaborators

Detail Information

Publications13

  1. pmc Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteins
    Jae Sung Yu
    Departments of Medicine, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Virol Methods 168:248-50. 2010
    ..Thus, while MAbs 15H10 and 6D11 are indeed EBOV GP specific, MAb 17A3 is an alpha-2-macroglobulin MAb...
  2. ncbi request reprint Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor
    Jae Sung Yu
    Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, United States
    J Virol Methods 137:219-28. 2006
    ..Thus, polyclonal and monoclonal antibodies can be used in combination to identify and differentiate both human and non-human primate EBOV GPs...
  3. pmc Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression
    Jae Sung Yu
    Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Vaccine Immunol 18:43-9. 2011
    ..Thus, flow cytometry-based sorting can isolate recombinant mycobacteria enriched for higher insert expression...
  4. pmc Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis
    Jae Sung Yu
    Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Vaccine Immunol 13:1204-11. 2006
    ..However, immunization with recombinant M. smegmatis expressing HIV-1 Env was able to prime for an HIV-1 Env protein boost for the induction of anti-HIV-1 antibody responses...
  5. pmc Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein
    Feng Gao
    Department of Medicine, Duke University Medical Center, 112 Research Park III, Research Dr, Box 3347, Durham, NC 27710, USA
    J Virol 79:1154-63. 2005
    ..Thus, the computer-generated "consensus" env genes are capable of expressing envelope glycoproteins that retain the structural, functional, and immunogenic properties of wild-type HIV-1 envelopes...
  6. pmc Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites
    Jae Sung Yu
    Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Vaccine Immunol 14:886-93. 2007
    ..However, rBCG could prime for a protein boost by HIV-1 envelope protein. Thus, rBCG can serve as a vector for induction of anti-HIV-1 consensus Env cellular responses at mucosal sites...
  7. pmc HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    J Virol 86:7496-507. 2012
    ..Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies...
  8. pmc H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25797. 2011
    ..In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated with protection...
  9. pmc Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion
    Natalie Taylor
    Duke University School of Medicine, Human Vaccine Institute, Durham, NC, USA
    Clin Vaccine Immunol 19:1416-25. 2012
    ..smegmatis transposon mutants could be used as novel live attenuated vaccine strains to express foreign antigens, such as those of human immunodeficiency virus type 1 (HIV-1), and induce strong antigen-specific T cell responses...
  10. pmc Comparison of multiple vaccine vectors in a single heterologous prime-boost trial
    Brice Barefoot
    Duke Human Vaccine Institute, Duke University School of Medicine, DU Medical Center, 102 Research Drive, Durham, NC 27710, USA
    Vaccine 26:6108-18. 2008
    ..Comparative data such as those presented here are critical to efforts to generate protective vaccines for emerging infectious diseases as well as for biothreat agents...
  11. pmc Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual
    Elin S Gray
    Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Virol 85:7719-29. 2011
    ..Our data validate the use of differential sorting to isolate a MAb targeting a specific epitope in the envelope glycoprotein and provided insights into the mechanisms of autologous neutralization escape...
  12. pmc Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated
    Hua Xin Liao
    Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
    J Exp Med 208:2237-49. 2011
    ..These data suggest that the majority of gp41-binding antibodies produced after acute HIV-1 infection are cross-reactive responses generated by stimulating memory B cells that have previously been activated by non-HIV-1 antigens...
  13. ncbi request reprint In-frame overlapping genes: the challenges for regulating gene expression
    Jae Sung Yu
    Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Mol Microbiol 63:1158-72. 2007
    ..The more general implications of the results for expression of in-frame overlapping genes are discussed...