Research Topics
| Jae Sung YuSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteinsJae Sung Yu
Departments of Medicine, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
J Virol Methods 168:248-50. 2010..Thus, while MAbs 15H10 and 6D11 are indeed EBOV GP specific, MAb 17A3 is an alpha-2-macroglobulin MAb...
Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensorJae Sung Yu
Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, United States
J Virol Methods 137:219-28. 2006..Thus, polyclonal and monoclonal antibodies can be used in combination to identify and differentiate both human and non-human primate EBOV GPs...- Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expressionJae Sung Yu
Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Clin Vaccine Immunol 18:43-9. 2011..Thus, flow cytometry-based sorting can isolate recombinant mycobacteria enriched for higher insert expression... - Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sitesJae Sung Yu
Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Vaccine Immunol 14:886-93. 2007..However, rBCG could prime for a protein boost by HIV-1 envelope protein. Thus, rBCG can serve as a vector for induction of anti-HIV-1 consensus Env cellular responses at mucosal sites... - Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoproteinFeng Gao
Department of Medicine, Duke University Medical Center, 112 Research Park III, Research Dr, Box 3347, Durham, NC 27710, USA
J Virol 79:1154-63. 2005..Thus, the computer-generated "consensus" env genes are capable of expressing envelope glycoproteins that retain the structural, functional, and immunogenic properties of wild-type HIV-1 envelopes... - HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineagesM Anthony Moody
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
J Virol 86:7496-507. 2012..Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies... - H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccinationM Anthony Moody
Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 6:e25797. 2011..In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated with protection... - Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretionNatalie Taylor
Duke University School of Medicine, Human Vaccine Institute, Durham, NC, USA
Clin Vaccine Immunol 19:1416-25. 2012..smegmatis transposon mutants could be used as novel live attenuated vaccine strains to express foreign antigens, such as those of human immunodeficiency virus type 1 (HIV-1), and induce strong antigen-specific T cell responses... - Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatisJae-Sung Yu
Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Vaccine Immunol 13:1204-11. 2006..However, immunization with recombinant M. smegmatis expressing HIV-1 Env was able to prime for an HIV-1 Env protein boost for the induction of anti-HIV-1 antibody responses... - Comparison of multiple vaccine vectors in a single heterologous prime-boost trialBrice Barefoot
Duke Human Vaccine Institute, Duke University School of Medicine, DU Medical Center, 102 Research Drive, Durham, NC 27710, USA
Vaccine 26:6108-18. 2008..Comparative data such as those presented here are critical to efforts to generate protective vaccines for emerging infectious diseases as well as for biothreat agents... - Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individualElin S Gray
Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Virol 85:7719-29. 2011..Our data validate the use of differential sorting to isolate a MAb targeting a specific epitope in the envelope glycoprotein and provided insights into the mechanisms of autologous neutralization escape... - Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutatedHua Xin Liao
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
J Exp Med 208:2237-49. 2011..These data suggest that the majority of gp41-binding antibodies produced after acute HIV-1 infection are cross-reactive responses generated by stimulating memory B cells that have previously been activated by non-HIV-1 antigens... - In-frame overlapping genes: the challenges for regulating gene expressionJae Sung Yu
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
Mol Microbiol 63:1158-72. 2007..The more general implications of the results for expression of in-frame overlapping genes are discussed...