Terri Lois Young

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population
    Tammy Yanovitch
    Duke University Center for Human Genetics, 595 La Salle Street, Durham, NC 27710, USA
    Mol Vis 15:1028-35. 2009
  2. pmc An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error
    Diana Abbott
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 18:720-9. 2012
  3. pmc Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes
    Khanh Nhat Tran-Viet
    Duke Center for Human Genetics, 905 S LaSalle Street, 27705, Durham, North Carolina 27710, USA
    Mol Vis 19:759-66. 2013
  4. pmc Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota
    Sudha Nallasamy
    Division of Ophthalmology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Vis 13:229-36. 2007
  5. pmc Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility
    Khanh Nhat Tran-Viet
    The Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 18:937-44. 2012
  6. pmc Whole genome expression profiling of normal human fetal and adult ocular tissues
    Terri L Young
    Center for Human Genetics, Duke University, Durham, NC 27710, USA Electronic address
    Exp Eye Res 116:265-78. 2013
  7. pmc Molecular genetics of human myopia: an update
    Terri L Young
    Department of Ophthalmology and Pediatrics, The Duke Eye Center and the Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Optom Vis Sci 86:E8-E22. 2009
  8. ncbi request reprint Complex trait genetics of refractive error
    Terri L Young
    Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA
    Arch Ophthalmol 125:38-48. 2007
  9. pmc An international collaborative family-based whole-genome linkage scan for high-grade myopia
    Yi Ju Li
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 50:3116-27. 2009
  10. pmc The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome
    Tammy Yanovitch
    Duke University Eye Center, Durham, North Carolina 27710, USA
    J AAPOS 14:472-7. 2010

Research Grants

  1. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2005
  2. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2005
  3. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2006
  4. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2005
  5. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2009
  6. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2007
  7. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2003
  8. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2010
  9. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2007
  10. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2004

Collaborators

Detail Information

Publications20

  1. pmc Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population
    Tammy Yanovitch
    Duke University Center for Human Genetics, 595 La Salle Street, Durham, NC 27710, USA
    Mol Vis 15:1028-35. 2009
    ..We examined whether these genes were associated with myopia in a Caucasian family dataset biased towards high myopia...
  2. pmc An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error
    Diana Abbott
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 18:720-9. 2012
    ..To investigate quantitative trait loci linked to refractive error, we performed a genome-wide quantitative trait linkage analysis using single nucleotide polymorphism markers and family data from five international sites...
  3. pmc Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes
    Khanh Nhat Tran-Viet
    Duke Center for Human Genetics, 905 S LaSalle Street, 27705, Durham, North Carolina 27710, USA
    Mol Vis 19:759-66. 2013
    ..A three-generation Caucasian family variably diagnosed with either syndrome was screened for sequence variants in the COL2A1 and VCAN genes...
  4. pmc Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota
    Sudha Nallasamy
    Division of Ophthalmology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Vis 13:229-36. 2007
    ..1, 7p15.3, 15q12-13, 3q26, 4q12, 8p23, 4q22-q27, 1p36, and Xq23-q25. Here, we demonstrate evidence of linkage for AD non-syndromic high-grade myopia in a large Hutterite family to a locus on chromosome 10q21.1...
  5. pmc Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility
    Khanh Nhat Tran-Viet
    The Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 18:937-44. 2012
    ..Herein we focused on investigating the role for ZNF644 variants in high-grade myopia in a United States (US) cohort...
  6. pmc Whole genome expression profiling of normal human fetal and adult ocular tissues
    Terri L Young
    Center for Human Genetics, Duke University, Durham, NC 27710, USA Electronic address
    Exp Eye Res 116:265-78. 2013
    ..In all tissues, development, cell death/growth, cancer functions, and signaling canonical pathways were enriched. There was also a general trend of down-regulation of collagen genes in adult tissues. ..
  7. pmc Molecular genetics of human myopia: an update
    Terri L Young
    Department of Ophthalmology and Pediatrics, The Duke Eye Center and the Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Optom Vis Sci 86:E8-E22. 2009
    ..In general, myopia susceptibility genes are unknown with few association studies performed, and without confirmation in other research laboratories or testing of separate patient cohorts...
  8. ncbi request reprint Complex trait genetics of refractive error
    Terri L Young
    Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA
    Arch Ophthalmol 125:38-48. 2007
    ..This review explores the genetic mechanisms associated with nonsyndromic refractive error development known to date...
  9. pmc An international collaborative family-based whole-genome linkage scan for high-grade myopia
    Yi Ju Li
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 50:3116-27. 2009
    ..In this study, whole-genome linkage scans were performed for high-grade myopia, using single nucleotide polymorphisms (SNPs) in 254 families from five independent sites...
  10. pmc The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome
    Tammy Yanovitch
    Duke University Eye Center, Durham, North Carolina 27710, USA
    J AAPOS 14:472-7. 2010
    ..The purpose of this study is to determine the sensitivity, specificity, and positive and negative predictive values of photoscreening in detecting treatable ocular conditions in children with DS...
  11. pmc Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort
    Ravikanth Metlapally
    Center for Human GeneticsDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 51:4476-9. 2010
    ..This study was conducted to determine whether IGF-1 polymorphisms are associated with myopia in a large, international dataset of Caucasian high-grade myopia pedigrees...
  12. pmc Myopia genetics: a review of current research and emerging trends
    Dana M Hornbeak
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Ophthalmol 20:356-62. 2009
    ..Ample epidemiologic and molecular genetic studies support heritability of the nonsyndromic forms of this condition...
  13. ncbi request reprint Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies
    Ravikanth Metlapally
    Duke University Eye Center, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 50:1552-8. 2009
    ..Genomic DNA from five pedigrees (with high myopia and either protanopia or deuteranopia) that mapped to Xq28 were screened for TEX28 copy number variations (CNVs) and sequence variants...
  14. ncbi request reprint Norrie disease gene sequence variants in an ethnically diverse population with retinopathy of prematurity
    Kelly A Hutcheson
    Department of Ophthalmology, Children s National Medical Center, Washington, DC, USA
    Mol Vis 11:501-8. 2005
    ..African Americans, for example, are less likely to develop severe degrees of ROP. We screened a large cohort of ethnically diverse patients for mutations in the entire NDP...
  15. pmc Dissecting the genetics of human high myopia: a molecular biologic approach
    Terri L Young
    Department of Ophthalmology, University of Pennsylvania, and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Trans Am Ophthalmol Soc 102:423-45. 2004
    ..The purpose of this proposal is to describe the results of positional candidate gene screening of selected genes within the autosomal dominant high-grade myopia-2 locus (MYP2) on chromosome 18p11.31...
  16. ncbi request reprint X-linked high myopia associated with cone dysfunction
    Terri L Young
    Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, USA
    Arch Ophthalmol 122:897-908. 2004
    ..We studied a second family from Minnesota with a similar X-linked phenotype, also of Danish descent. All affected males had protanopia instead of deuteranopia...
  17. pmc Comparative analyses of seven algorithms for copy number variant identification from single nucleotide polymorphism arrays
    Andrew E Dellinger
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Nucleic Acids Res 38:e105. 2010
    ..QuantiSNP outperformed other methods based on ROC curve residuals over most datasets. Nexus Rank and SNPRank have low specificity and high power. Nexus Rank calls oversized CNVs. PennCNV detects one of the fewest numbers of CNVs...
  18. pmc Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia
    Ravikanth Metlapally
    Duke University Eye Center, Durham, NC, USA
    Mol Vis 14:387-93. 2008
    ....
  19. pmc Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome
    Shawn M Ronan
    Duke University Eye Center, Durham, NC 27710, USA
    Arch Ophthalmol 127:1511-9. 2009
    ..11-q13.2, with associated COL2A1 gene mutations. Wagner syndrome maps to chromosome 5q13-q14 and is associated with mutations in CSPG2 encoding versican, a proteoglycan present in human vitreous...

Research Grants12

  1. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2005
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  2. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2005
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  3. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2006
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  4. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2005
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  5. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2009
    ..This effort may lead to effective therapies for these potentially blinding disorders. ..
  6. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2007
    ..This effort may lead to effective therapies for these potentially blinding disorders. ..
  7. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2003
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  8. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2010
    ..This effort may lead to effective therapies to treat or potentially prevent this common eye condition. ..
  9. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2007
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  10. The Molecular Genetics of High Myopia
    Terri Young; Fiscal Year: 2004
    ..This effort will contribute to our long-term goal to devise diagnostic and therapeutic strategies for the severe forms of this potentially blinding eye disease, which presently has no effective treatment. ..
  11. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2009
    ..This effort may lead to effective therapies for these potentially blinding disorders. ..