Research Topics
Species | John YorkSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Regulation of nuclear processes by inositol polyphosphatesJohn D York
Departments of Pharmacology and Cancer Biology and of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
Biochim Biophys Acta 1761:552-9. 2006....- Inositol diphosphate signaling regulates telomere lengthSally J York
Departments of Pharmacology, Cancer Biology, and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:4264-9. 2005..Our data provide in vivo evidence of a regulatory link between inositol polyphosphate signaling and the checkpoint kinase family and describe a third nuclear process modulated by phospholipase C activation... - Signal transduction. Unexpected mediators of protein phosphorylationJohn D York
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Science 306:2053-5. 2004 - Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiaeAndrew M Seeds
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:27654-61. 2005..Our work provides a revised genetic map of IP metabolism in yeast and evidence for dosage compensation between IPs and PP-IPs downstream of I(1,4,5)P3 in the regulation of nucleocytoplasmic processes... 
Inositol phosphate synthesis and the nuclear processes they affectJessica P Monserrate
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Cell Biol 22:365-73. 2010..The purpose of this review is to cover the latest data gathered regarding only the nuclear roles of the various inositol phosphates while simultaneously providing a step-by-step tour of IP synthesis in eukaryotes...
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesYoung Sam Lee
Howard Hughes Medical Institute, Faculty of Arts and Sciences Center for Systems Biology, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Science 316:109-12. 2007..These observations reveal regulation of a cyclin-CDK complex by a metabolite and suggest that a complex metabolic network mediates signaling of phosphate availability...- A conserved family of enzymes that phosphorylate inositol hexakisphosphateSashidhar Mulugu
Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
Science 316:106-9. 2007..Alterations in kinase activity led to defects in cell growth, morphology, and interactions with ARP complex members. The functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6... - The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosisChristopher D Kontos
Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
Mol Cell Biol 22:1704-13. 2002..These findings are the first biochemical demonstration of a signal transduction pathway and corresponding cellular function for Tie1, and the antiapoptotic effect of Tie1 is consistent with the results of previous genetic studies... - A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1Rina Plattner
Department of Pharmacology and Cancer Biology Duke University Medical Center Durham, NC 27710, USA
Nat Cell Biol 5:309-19. 2003..After activation, c-Abl phosphorylates PLC-gamma1 and negatively modulates its function in vivo. These findings uncover a newly discovered functional interdependence between non-receptor Tyr kinase and lipid signalling pathways... - A molecular basis for inositol polyphosphate synthesis in Drosophila melanogasterAndrew M Seeds
Department of Pharmacology, Howard Hughes Medical Institute, Duke University Medical Center, DUMC 3813, Durham, North Carolina 27710, USA
J Biol Chem 279:47222-32. 2004.... - APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2Robert DeKroon
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Circ Res 99:829-36. 2006.... - Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinasesJames C Otto
Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 104:15653-8. 2007..The essential roles for IPKs in organism development and cellular adaptation are consistent with our hypothesis that such an IP code may be relevant to signaling pathways... - Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolismBryan D Spiegelberg
Department of Pharmacology and Cancer Biology and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
J Biol Chem 280:5400-5. 2005.... - Biochemical analysis of inositol phosphate kinasesJames C Otto
Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
Methods Enzymol 434:171-85. 2007..This chapter summarizes experimental techniques for the biochemical characterization of the key inositol phosphate kinases IPKs necessary for producing the diverse array of IP species... - Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biologyAndrew M Seeds
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, P.O. Box 3813, Durham, NC 27710, USA
Adv Enzyme Regul 47:10-25. 2007 - Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinasesJill Stevenson-Paulik
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:42711-8. 2002.... - Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methodsJill Stevenson-Paulik
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Methods 39:112-21. 2006..Here, we describe updated methods for rapid analysis of IP metabolism in normal and genetically manipulated Saccharomyces cerevisiae, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, and Homo sapiens... - A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cellsMakoto Fujii
Departments of Pharmacology and Cancer Biology and of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:1156-64. 2005..The ability to modulate the intracellular inositol polyphosphate levels by altering IPK2 and IPK1 expression in rat cells will provide powerful tools to study the roles of I(1,3,4,5,6)P5 and IP6 in cell signaling... - An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger productionJoshua P Frederick
Department of Pharmacology, Howard Hughes Medical Institute, Duke University, Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 102:8454-9. 2005..Our data demonstrate that Ipk2 plays a major role in the synthesis of inositol polyphosphate messengers derived from inositol 1,4,5-trisphosphate and uncovers a role for their production in embryogenesis and normal development... - A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cellsAnn M Winter-Vann
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 102:4336-41. 2005..These findings provide a compelling rationale for development of Icmt inhibitors as another approach to anticancer drug development... - Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesPeter C Fridy
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina, 27710, USA
J Biol Chem 282:30754-62. 2007.... - A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfationJoshua P Frederick
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 105:11605-12. 2008.... - Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cellsJames C Otto
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA
Methods Mol Biol 645:47-60. 2010..It provides a mechanism by which the metabolism of a variety of InsPs can be upregulated, enabling the evaluation of the effects of these InsPs on cellular functions... - IP7 guards the CDK gateJohn D York
Nat Chem Biol 4:16-7. 2008 - Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cellsJames G Alb
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
Mol Biol Cell 13:739-54. 2002..We suggest that PITP beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals than that indicated by in vitro systems that show PITP dependence...
Research Grants
- The Biology of Inositol Polyphosphate SignalingJohn D York; Fiscal Year: 2010..Understanding these essential enzymes will provide significant insights into human cell biology and improve public health through basic science research. ..
- The Biology of Inositol Polyphosphate SignalingJohn York; Fiscal Year: 2009..Understanding these essential enzymes will provide significant insights into human cell biology and improve public health through basic science research. ..
- Biological Oscilloscopes Spatio-Temporal MetabolomicsJohn York; Fiscal Year: 2006..abstract_text> ..
- Signal Transduction within the Nucleus Gordon ConferenceJohn York; Fiscal Year: 2007..We anticipate that this will be an outstanding and unique meeting that offers the opportunity of cross-fertilization among outstanding investigators. The requested funds will be invaluable to the support of this conference. ..
- The Role of Inositol Signaling in Human DiseaseJohn York; Fiscal Year: 2005....
- The Biology of Inositol Polyphosphate SignalingJohn York; Fiscal Year: 2009..Understanding these essential enzymes will provide significant insights into human cell biology and improve public health through basic science research. ..