John York

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Regulation of nuclear processes by inositol polyphosphates
    John D York
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    Biochim Biophys Acta 1761:552-9. 2006
  2. ncbi request reprint Inositol diphosphate signaling regulates telomere length
    Sally J York
    Departments of Pharmacology, Cancer Biology, and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:4264-9. 2005
  3. ncbi request reprint Signal transduction. Unexpected mediators of protein phosphorylation
    John D York
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Science 306:2053-5. 2004
  4. ncbi request reprint Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae
    Andrew M Seeds
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27654-61. 2005
  5. doi request reprint Inositol phosphate synthesis and the nuclear processes they affect
    Jessica P Monserrate
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Cell Biol 22:365-73. 2010
  6. pmc Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates
    Young Sam Lee
    Howard Hughes Medical Institute, Faculty of Arts and Sciences Center for Systems Biology, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 316:109-12. 2007
  7. ncbi request reprint A conserved family of enzymes that phosphorylate inositol hexakisphosphate
    Sashidhar Mulugu
    Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Science 316:106-9. 2007
  8. pmc The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis
    Christopher D Kontos
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 22:1704-13. 2002
  9. ncbi request reprint A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1
    Rina Plattner
    Department of Pharmacology and Cancer Biology Duke University Medical Center Durham, NC 27710, USA
    Nat Cell Biol 5:309-19. 2003
  10. ncbi request reprint A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster
    Andrew M Seeds
    Department of Pharmacology, Howard Hughes Medical Institute, Duke University Medical Center, DUMC 3813, Durham, North Carolina 27710, USA
    J Biol Chem 279:47222-32. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Regulation of nuclear processes by inositol polyphosphates
    John D York
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    Biochim Biophys Acta 1761:552-9. 2006
    ....
  2. ncbi request reprint Inositol diphosphate signaling regulates telomere length
    Sally J York
    Departments of Pharmacology, Cancer Biology, and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:4264-9. 2005
    ..Our data provide in vivo evidence of a regulatory link between inositol polyphosphate signaling and the checkpoint kinase family and describe a third nuclear process modulated by phospholipase C activation...
  3. ncbi request reprint Signal transduction. Unexpected mediators of protein phosphorylation
    John D York
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Science 306:2053-5. 2004
  4. ncbi request reprint Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae
    Andrew M Seeds
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27654-61. 2005
    ..Our work provides a revised genetic map of IP metabolism in yeast and evidence for dosage compensation between IPs and PP-IPs downstream of I(1,4,5)P3 in the regulation of nucleocytoplasmic processes...
  5. doi request reprint Inositol phosphate synthesis and the nuclear processes they affect
    Jessica P Monserrate
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Cell Biol 22:365-73. 2010
    ..The purpose of this review is to cover the latest data gathered regarding only the nuclear roles of the various inositol phosphates while simultaneously providing a step-by-step tour of IP synthesis in eukaryotes...
  6. pmc Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates
    Young Sam Lee
    Howard Hughes Medical Institute, Faculty of Arts and Sciences Center for Systems Biology, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 316:109-12. 2007
    ..These observations reveal regulation of a cyclin-CDK complex by a metabolite and suggest that a complex metabolic network mediates signaling of phosphate availability...
  7. ncbi request reprint A conserved family of enzymes that phosphorylate inositol hexakisphosphate
    Sashidhar Mulugu
    Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Science 316:106-9. 2007
    ..Alterations in kinase activity led to defects in cell growth, morphology, and interactions with ARP complex members. The functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6...
  8. pmc The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis
    Christopher D Kontos
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 22:1704-13. 2002
    ..These findings are the first biochemical demonstration of a signal transduction pathway and corresponding cellular function for Tie1, and the antiapoptotic effect of Tie1 is consistent with the results of previous genetic studies...
  9. ncbi request reprint A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1
    Rina Plattner
    Department of Pharmacology and Cancer Biology Duke University Medical Center Durham, NC 27710, USA
    Nat Cell Biol 5:309-19. 2003
    ..After activation, c-Abl phosphorylates PLC-gamma1 and negatively modulates its function in vivo. These findings uncover a newly discovered functional interdependence between non-receptor Tyr kinase and lipid signalling pathways...
  10. ncbi request reprint A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster
    Andrew M Seeds
    Department of Pharmacology, Howard Hughes Medical Institute, Duke University Medical Center, DUMC 3813, Durham, North Carolina 27710, USA
    J Biol Chem 279:47222-32. 2004
    ....
  11. ncbi request reprint APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2
    Robert DeKroon
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 99:829-36. 2006
    ....
  12. pmc Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases
    James C Otto
    Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:15653-8. 2007
    ..The essential roles for IPKs in organism development and cellular adaptation are consistent with our hypothesis that such an IP code may be relevant to signaling pathways...
  13. ncbi request reprint Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism
    Bryan D Spiegelberg
    Department of Pharmacology and Cancer Biology and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 280:5400-5. 2005
    ....
  14. ncbi request reprint Biochemical analysis of inositol phosphate kinases
    James C Otto
    Howard Hughes Medical Institute, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Methods Enzymol 434:171-85. 2007
    ..This chapter summarizes experimental techniques for the biochemical characterization of the key inositol phosphate kinases IPKs necessary for producing the diverse array of IP species...
  15. pmc Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology
    Andrew M Seeds
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, P O Box 3813, Durham, NC 27710, USA
    Adv Enzyme Regul 47:10-25. 2007
  16. ncbi request reprint Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases
    Jill Stevenson-Paulik
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:42711-8. 2002
    ....
  17. ncbi request reprint Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods
    Jill Stevenson-Paulik
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Methods 39:112-21. 2006
    ..Here, we describe updated methods for rapid analysis of IP metabolism in normal and genetically manipulated Saccharomyces cerevisiae, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, and Homo sapiens...
  18. ncbi request reprint A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells
    Makoto Fujii
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:1156-64. 2005
    ..The ability to modulate the intracellular inositol polyphosphate levels by altering IPK2 and IPK1 expression in rat cells will provide powerful tools to study the roles of I(1,3,4,5,6)P5 and IP6 in cell signaling...
  19. pmc An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production
    Joshua P Frederick
    Department of Pharmacology, Howard Hughes Medical Institute, Duke University, Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:8454-9. 2005
    ..Our data demonstrate that Ipk2 plays a major role in the synthesis of inositol polyphosphate messengers derived from inositol 1,4,5-trisphosphate and uncovers a role for their production in embryogenesis and normal development...
  20. pmc A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
    Ann M Winter-Vann
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:4336-41. 2005
    ..These findings provide a compelling rationale for development of Icmt inhibitors as another approach to anticancer drug development...
  21. ncbi request reprint Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases
    Peter C Fridy
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    J Biol Chem 282:30754-62. 2007
    ....
  22. pmc A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation
    Joshua P Frederick
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:11605-12. 2008
    ....
  23. doi request reprint Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells
    James C Otto
    Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA
    Methods Mol Biol 645:47-60. 2010
    ..It provides a mechanism by which the metabolism of a variety of InsPs can be upregulated, enabling the evaluation of the effects of these InsPs on cellular functions...
  24. ncbi request reprint IP7 guards the CDK gate
    John D York
    Nat Chem Biol 4:16-7. 2008
  25. pmc Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells
    James G Alb
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Mol Biol Cell 13:739-54. 2002
    ..We suggest that PITP beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals than that indicated by in vitro systems that show PITP dependence...

Research Grants14

  1. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2001
    ....
  2. The Biology of Inositol Polyphosphate Signaling
    John D York; Fiscal Year: 2010
    ..Understanding these essential enzymes will provide significant insights into human cell biology and improve public health through basic science research. ..
  3. The Biology of Inositol Polyphosphate Signaling
    John York; Fiscal Year: 2009
    ..Understanding these essential enzymes will provide significant insights into human cell biology and improve public health through basic science research. ..
  4. Biological Oscilloscopes Spatio-Temporal Metabolomics
    John York; Fiscal Year: 2006
    ..abstract_text> ..
  5. Signal Transduction within the Nucleus Gordon Conference
    John York; Fiscal Year: 2007
    ..We anticipate that this will be an outstanding and unique meeting that offers the opportunity of cross-fertilization among outstanding investigators. The requested funds will be invaluable to the support of this conference. ..
  6. The Role of Inositol Signaling in Human Disease
    John York; Fiscal Year: 2005
    ....
  7. The Biology of Inositol Polyphosphate Signaling
    John York; Fiscal Year: 2009
    ..Understanding these essential enzymes will provide significant insights into human cell biology and improve public health through basic science research. ..