J D York

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export
    J D York
    Department of Pharmacology, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Science 285:96-100. 1999
  2. ncbi request reprint A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control
    A R Odom
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Science 287:2026-9. 2000
  3. ncbi request reprint SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
    S Guo
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:12990-5. 1999
  4. pmc Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt
    C D Kontos
    Departments of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 18:4131-40. 1998
  5. ncbi request reprint Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate
    B D Spiegelberg
    Departments of Pharmacology and Cancer Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:13619-28. 1999
  6. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion
    D Raucher
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 100:221-8. 2000
  7. ncbi request reprint INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype
    L E Stolz
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:11852-61. 1998
  8. ncbi request reprint Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases
    E B Ives
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:36575-83. 2000
  9. pmc Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy
    M P Rivas
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Mol Biol Cell 10:2235-50. 1999
  10. pmc Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae
    L E Stolz
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 148:1715-29. 1998

Collaborators

  • W Chen
  • S R Wente
  • T Meyer
  • R Murphy
  • D Raucher
  • M P Sheetz
  • L E Stolz
  • S Guo
  • Y Tsujishita
  • A R Odom
  • E B Ives
  • B D Spiegelberg
  • M P Rivas
  • C D Kontos
  • J H Hurley
  • A Stahlberg
  • J Nichols
  • J P Xiong
  • V A Bankaitis
  • M C Sekar
  • S Kagiwada
  • K Hosaka
  • J J Smith
  • Z Xie
  • R F Gu
  • S M Lemrow
  • B G Kearns
  • K G Peters
  • M A Blanar
  • L Huang
  • M K Sekhon
  • J Longchamps
  • C V Huynh
  • J Thorner
  • T P Stauffer
  • W J Kuo
  • W P Yang

Detail Information

Publications11

  1. ncbi request reprint A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export
    J D York
    Department of Pharmacology, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Science 285:96-100. 1999
    ..The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export...
  2. ncbi request reprint A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control
    A R Odom
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Science 287:2026-9. 2000
    ..Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression...
  3. ncbi request reprint SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
    S Guo
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:12990-5. 1999
    ..Additionally, the tethering of PPIPase and 5-phosphatase activities indicate a novel mechanism by which concerted phosphoinositide hydrolysis participates in membrane trafficking...
  4. pmc Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt
    C D Kontos
    Departments of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 18:4131-40. 1998
    ....
  5. ncbi request reprint Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate
    B D Spiegelberg
    Departments of Pharmacology and Cancer Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:13619-28. 1999
    ..We propose that inhibition of human BPntase may account for lithium-induced nephrotoxicity, which may be overcome by supplementation of current therapeutic regimes with inhibitors of nucleotide biosynthesis, such as methionine...
  6. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion
    D Raucher
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 100:221-8. 2000
    ..Our study suggests that plasma membrane PIP2 controls dynamic membrane functions and cell shape by locally increasing and decreasing the adhesion between the actin-based cortical cytoskeleton and the plasma membrane...
  7. ncbi request reprint INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype
    L E Stolz
    Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:11852-61. 1998
    ..In addition, we define a novel role for a 5-phosphatase loss of function mutant that improves the growth of cells at colder temperatures without alteration of growth at normal temperatures, which may have useful commercial applications...
  8. ncbi request reprint Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases
    E B Ives
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:36575-83. 2000
    ..This includes two conserved motifs: E(i/l/m)KPKWL(t/y) and LXMTLRDV(t/g)(l/c)(f/y)I. Our data suggest that the mechanism for IP(6) production is conserved across species...
  9. pmc Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy
    M P Rivas
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Mol Biol Cell 10:2235-50. 1999
    ..Finally, we determine that CDP-choline pathway activity contributes to the inositol auxotrophy of sac1 strains in a novel manner that does not involve obvious defects in transcriptional expression of the INO1 gene...
  10. pmc Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae
    L E Stolz
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 148:1715-29. 1998
    ....
  11. ncbi request reprint Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase
    Y Tsujishita
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 105:379-89. 2001
    ..Based on the structure, a series of mutants are described that exhibit altered substrate specificity providing general determinants for substrate recognition...