Research Topics
Genomes and GenesSpecies | Yiping YangSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigenXiaopei Huang
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Eur J Immunol 34:1351-60. 2004..Further exploration of these mechanisms will have direct impact on the design of effective immunotherapy for autoimmune diseases, chronic infections and cancers...- Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 toleranceYiping Yang
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Immunol 5:508-15. 2004..These results demonstrate that virus provides TLR signals required for bypassing regulatory T cell-mediated tolerance and emphasize the importance of persistent TLR signals for immunotherapy in the setting of established tolerance... 
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in miceJiangao Zhu
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 119:2388-98. 2009....- A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infectionMichael Quigley
Department of Medicine, Duke University Medical Center, Durham, NC, USA
Blood 113:2256-64. 2009..These results identify a critical role for intrinsic TLR2-MyD88 signaling and PI3K-Akt pathway activation in CD8 T-cell clonal expansion and memory formation in vivo and could lead to the development of new vaccine approaches... - STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivoMichael Quigley
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 180:2158-64. 2008..These results identify a critical role for type I IFN-STAT1 signaling in multiple stages of CD8 T cell response in vivo and suggest that strategies to activate type I IFN-STAT1 signaling pathway may enhance vaccine potency... - Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNAJennifer Martinez
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 107:6442-7. 2010..Collectively, our data are unique in demonstrating that TLR8 is required for sensing poly(A)/T-rich DNA in pDCs, and that murine TLR8 is functional in the context of a viral infection... - Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infectionJennifer Martinez
Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS Pathog 6:e1000811. 2010.... - Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantationIan Horkheimer
Departments of Medicine, Duke University Medical Center, Durham, NC 2771, USA
Blood 113:5330-9. 2009..Collectively, these results may suggest effective immunotherapeutic strategies for treating cancer after stem cell transplantation... 
Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantationDavid A Rizzieri
Duke University Medical Center, Department of Medicine, Division of Cellular Therapy, Durham, North Carloina, 27705, USA
Biol Blood Marrow Transplant 16:1107-14. 2010..Future studies must assess whether the improved outcomes are the direct result of the high doses and improved NK cell function or other aspects of immune recovery...- A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivoJiangao Zhu
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Ther 16:1300-7. 2008.... - The development and function of memory regulatory T cells after acute viral infectionsAna M Sanchez
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 189:2805-14. 2012..Our work reveals a memory Treg population that develops after acute viral infections and may help in the design of effective strategies to circumvent excessive immunopathological effects... - Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantationTodd V Brennan
Department of Surgery, Duke University, Durham, NC 27710, USA
Blood 120:2899-908. 2012..These results identify a critical role for HS in promoting acute GVHD after allo-HSCT, and they suggest that modulation of HS release may have therapeutic potential for the control of clinical GVHD... - Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infectionPatricia Novy
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 186:2729-38. 2011..These results identify a critical role for intrinsic IL-21 signaling in CD8 T cell responses to an acute viral infection in vivo and may help design effective vaccine strategies... - Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathwaysJiangao Zhu
Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
J Virol 81:3170-80. 2007..Our results that suggest strategies to interfere with type I IFN pathway may improve the outcome of adenovirus-mediated gene therapy, whereas approaches to activate the type I IFN pathway may enhance vaccine potency... - Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirusJiangao Zhu
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 178:3505-10. 2007..The results may suggest potential strategies for improving adenovirus-mediated gene therapy in vivo and/or the design of effective vaccines for cancer and infectious diseases... - Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivoJennifer Martinez
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 180:1592-7. 2008..Our findings may help design effective strategies for the control of poxviral infections in vivo... - CD4 T cells are required for CD8 T cell survival during both primary and memory recall responsesPatricia Novy
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 179:8243-51. 2007..Our study indicates that CD4 T cells play a crucial role in multiple stages of CD8 T cell response to vaccinia virus infection and may help to design effective vaccine strategies... - NKG2D is required for NK cell activation and function in response to E1-deleted adenovirusJiangao Zhu
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 185:7480-6. 2010.... - NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cellsCarl Fortin
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 189:1843-9. 2012.... - Extent of stimulation controls the formation of memory CD8 T cellsMichael Quigley
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 179:5768-77. 2007..Collectively, our data suggest that the extent of stimulation controls CD8 memory formation via activation of Akt and may provide important insights into the design of effective vaccines... - The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulationXiaopei Huang
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Immunology 118:361-71. 2006..Furthermore, protective immunity against tumour cannot develop in the persisting antigen environment. These results suggest that removal of persisting antigen by other means might be a prerequisite for effective immunotherapy in cancer... - Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responsesXiaopei Huang
Duke University Medical Center, Department of Medicine, Durham, NC 27710, USA
Expert Opin Ther Targets 14:787-96. 2010..Recent advances also reveal a crucial role for TLRs in shaping adaptive immune responses, conferring a potential therapeutic value to their modulation in the treatment of diseases... - Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-betaXiaopei Huang
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 175:4283-91. 2005.... - Innate immune recognition of viruses and viral vectorsXiaopei Huang
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Hum Gene Ther 20:293-301. 2009..In this review we first discuss our current understanding of innate immune recognition of viruses in general, and then focus on the innate immune responses to viral vectors for gene therapy... - Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-betaJiangao Zhu
Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
Blood 109:619-25. 2007.... - Natural killer cell responses to viral infectionJoshua D Brandstadter
Molecular Cancer Biology Program, Duke University Medical Center, Durham, NC 27710, USA
J Innate Immun 3:274-9. 2011..We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells... - Targeting co-stimulatory pathways in gene therapyXiaopei Huang
Department of Medicine, Duke University Medical Center Durham, NC, USA
Front Microbiol 2:202. 2011..This review summarizes our current understanding of T cell co-stimulatory pathways, and strategies targeting these co-stimulatory pathways in gene therapy applications as well as potential future directions... - Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donorsDavid A Rizzieri
Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Invest 29:56-61. 2011..The primary objective of this pilot study was to evaluate the feasibility of administering IL-2 following a T-cell-depleted nonmyeloablative hematopoietic stem cell transplant... - The role of natural regulatory T cells in infectionAna M Sanchez
Department of Immunology, Duke University Medical Center, Box 103005, Durham, NC 27710, USA
Immunol Res 49:124-34. 2011..Finally, we discuss the ways in which the T(Reg) function can be altered by invading pathogens and how these can be exploited to develop methods therapeutically to influence disease and vaccine outcomes...
Research Grants
- Immunotherapy for Epstein-Barr Virus-associated MalignanYiping Yang; Fiscal Year: 2004..These EBV-associated tumors are seen as models for other tumors in which tumor specific antigens have been identified and the development of novel therapeutic approaches. ..
- Novel Strategies for Cancer Immunotherapy in Stem Cell TransplantYiping Yang; Fiscal Year: 2010....
- Novel Strategies for Cancer Immunotherapy in Stem Cell TransplantYiping Yang; Fiscal Year: 2009....
- The Role of Toll-Like Receptors in Cancer ImmunotherapyYiping Yang; Fiscal Year: 2007..The outcome of these studies should have significant impact on the design of effective immunotherapeutic strategies for treating cancer. ..
- The Role of Toll-Like Receptors in Cancer ImmunotherapyYiping Yang; Fiscal Year: 2009..The outcome of these studies should have significant impact on the design of effective immunotherapeutic strategies for treating cancer. ..