Yiping Yang

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eur J Immunol 34:1351-60. 2004
  2. pmc Targeting co-stimulatory pathways in gene therapy
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center Durham, NC, USA
    Front Microbiol 2:202. 2011
  3. pmc Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection
    Jennifer Martinez
    Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 6:e1000811. 2010
  4. ncbi request reprint Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    Yiping Yang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 5:508-15. 2004
  5. pmc The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 119:2388-98. 2009
  6. pmc A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
    Michael Quigley
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Blood 113:2256-64. 2009
  7. ncbi request reprint STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo
    Michael Quigley
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2158-64. 2008
  8. pmc Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:6442-7. 2010
  9. pmc Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation
    Ian Horkheimer
    Departments of Medicine, Duke University Medical Center, Durham, NC 2771, USA
    Blood 113:5330-9. 2009
  10. ncbi request reprint CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses
    Patricia Novy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:8243-51. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eur J Immunol 34:1351-60. 2004
    ..Further exploration of these mechanisms will have direct impact on the design of effective immunotherapy for autoimmune diseases, chronic infections and cancers...
  2. pmc Targeting co-stimulatory pathways in gene therapy
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center Durham, NC, USA
    Front Microbiol 2:202. 2011
    ..This review summarizes our current understanding of T cell co-stimulatory pathways, and strategies targeting these co-stimulatory pathways in gene therapy applications as well as potential future directions...
  3. pmc Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection
    Jennifer Martinez
    Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 6:e1000811. 2010
    ....
  4. ncbi request reprint Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    Yiping Yang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 5:508-15. 2004
    ..These results demonstrate that virus provides TLR signals required for bypassing regulatory T cell-mediated tolerance and emphasize the importance of persistent TLR signals for immunotherapy in the setting of established tolerance...
  5. pmc The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 119:2388-98. 2009
    ....
  6. pmc A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
    Michael Quigley
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Blood 113:2256-64. 2009
    ..These results identify a critical role for intrinsic TLR2-MyD88 signaling and PI3K-Akt pathway activation in CD8 T-cell clonal expansion and memory formation in vivo and could lead to the development of new vaccine approaches...
  7. ncbi request reprint STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo
    Michael Quigley
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2158-64. 2008
    ..These results identify a critical role for type I IFN-STAT1 signaling in multiple stages of CD8 T cell response in vivo and suggest that strategies to activate type I IFN-STAT1 signaling pathway may enhance vaccine potency...
  8. pmc Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:6442-7. 2010
    ..Collectively, our data are unique in demonstrating that TLR8 is required for sensing poly(A)/T-rich DNA in pDCs, and that murine TLR8 is functional in the context of a viral infection...
  9. pmc Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation
    Ian Horkheimer
    Departments of Medicine, Duke University Medical Center, Durham, NC 2771, USA
    Blood 113:5330-9. 2009
    ..Collectively, these results may suggest effective immunotherapeutic strategies for treating cancer after stem cell transplantation...
  10. ncbi request reprint CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses
    Patricia Novy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:8243-51. 2007
    ..Our study indicates that CD4 T cells play a crucial role in multiple stages of CD8 T cell response to vaccinia virus infection and may help to design effective vaccine strategies...
  11. pmc Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation
    David A Rizzieri
    Duke University Medical Center, Department of Medicine, Division of Cellular Therapy, Durham, North Carloina, 27705, USA
    Biol Blood Marrow Transplant 16:1107-14. 2010
    ..Future studies must assess whether the improved outcomes are the direct result of the high doses and improved NK cell function or other aspects of immune recovery...
  12. doi request reprint A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo
    Jiangao Zhu
    Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Ther 16:1300-7. 2008
    ....
  13. ncbi request reprint Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:1592-7. 2008
    ..Our findings may help design effective strategies for the control of poxviral infections in vivo...
  14. ncbi request reprint Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus
    Jiangao Zhu
    Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:3505-10. 2007
    ..The results may suggest potential strategies for improving adenovirus-mediated gene therapy in vivo and/or the design of effective vaccines for cancer and infectious diseases...
  15. pmc The development and function of memory regulatory T cells after acute viral infections
    Ana M Sanchez
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 189:2805-14. 2012
    ..Our work reveals a memory Treg population that develops after acute viral infections and may help in the design of effective strategies to circumvent excessive immunopathological effects...
  16. pmc Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation
    Todd V Brennan
    Department of Surgery, Duke University, Durham, NC 27710, USA
    Blood 120:2899-908. 2012
    ..These results identify a critical role for HS in promoting acute GVHD after allo-HSCT, and they suggest that modulation of HS release may have therapeutic potential for the control of clinical GVHD...
  17. pmc Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection
    Patricia Novy
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 186:2729-38. 2011
    ..These results identify a critical role for intrinsic IL-21 signaling in CD8 T cell responses to an acute viral infection in vivo and may help design effective vaccine strategies...
  18. pmc Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
    J Virol 81:3170-80. 2007
    ..Our results that suggest strategies to interfere with type I IFN pathway may improve the outcome of adenovirus-mediated gene therapy, whereas approaches to activate the type I IFN pathway may enhance vaccine potency...
  19. pmc NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 185:7480-6. 2010
    ....
  20. pmc Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
    Blood 109:619-25. 2007
    ....
  21. pmc Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus
    Carl Fortin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 191:363-8. 2013
    ....
  22. pmc NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cells
    Carl Fortin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 189:1843-9. 2012
    ....
  23. ncbi request reprint Extent of stimulation controls the formation of memory CD8 T cells
    Michael Quigley
    Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:5768-77. 2007
    ..Collectively, our data suggest that the extent of stimulation controls CD8 memory formation via activation of Akt and may provide important insights into the design of effective vaccines...
  24. pmc The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulation
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Immunology 118:361-71. 2006
    ..Furthermore, protective immunity against tumour cannot develop in the persisting antigen environment. These results suggest that removal of persisting antigen by other means might be a prerequisite for effective immunotherapy in cancer...
  25. pmc Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses
    Xiaopei Huang
    Duke University Medical Center, Department of Medicine, Durham, NC 27710, USA
    Expert Opin Ther Targets 14:787-96. 2010
    ..Recent advances also reveal a crucial role for TLRs in shaping adaptive immune responses, conferring a potential therapeutic value to their modulation in the treatment of diseases...
  26. pmc Innate immune recognition of viruses and viral vectors
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hum Gene Ther 20:293-301. 2009
    ..In this review we first discuss our current understanding of innate immune recognition of viruses in general, and then focus on the innate immune responses to viral vectors for gene therapy...
  27. ncbi request reprint Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta
    Xiaopei Huang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:4283-91. 2005
    ....
  28. pmc Natural killer cell responses to viral infection
    Joshua D Brandstadter
    Molecular Cancer Biology Program, Duke University Medical Center, Durham, NC 27710, USA
    J Innate Immun 3:274-9. 2011
    ..We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells...
  29. pmc The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis
    Mariana Verdelho Machado
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    J Clin Invest 123:115-7. 2013
    ..Their results suggest that IL-13 plays an unexpected role in the regulation of glucose homeostasis by modulating gluconeogenesis and may be a useful therapeutic target for treatment of diabetes and metabolic syndrome...
  30. pmc Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors
    David A Rizzieri
    Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Invest 29:56-61. 2011
    ..The primary objective of this pilot study was to evaluate the feasibility of administering IL-2 following a T-cell-depleted nonmyeloablative hematopoietic stem cell transplant...
  31. pmc The role of natural regulatory T cells in infection
    Ana M Sanchez
    Department of Immunology, Duke University Medical Center, Box 103005, Durham, NC 27710, USA
    Immunol Res 49:124-34. 2011
    ..Finally, we discuss the ways in which the T(Reg) function can be altered by invading pathogens and how these can be exploited to develop methods therapeutically to influence disease and vaccine outcomes...

Research Grants12

  1. Immunotherapy for Epstein-Barr Virus-associated Malignan
    Yiping Yang; Fiscal Year: 2004
    ..These EBV-associated tumors are seen as models for other tumors in which tumor specific antigens have been identified and the development of novel therapeutic approaches. ..
  2. The Role of Toll-Like Receptors in Cancer Immunotherapy
    Yiping Yang; Fiscal Year: 2007
    ..The outcome of these studies should have significant impact on the design of effective immunotherapeutic strategies for treating cancer. ..
  3. Novel Strategies for Cancer Immunotherapy in Stem Cell Transplant
    Yiping Yang; Fiscal Year: 2009
    ....
  4. The Role of Toll-Like Receptors in Cancer Immunotherapy
    Yiping Yang; Fiscal Year: 2009
    ..The outcome of these studies should have significant impact on the design of effective immunotherapeutic strategies for treating cancer. ..
  5. Novel Strategies for Cancer Immunotherapy in Stem Cell Transplant
    Yiping Yang; Fiscal Year: 2010
    ....