Research Topics
Genomes and Genes
| Zhen YanSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivoZhen Yan
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
Exerc Sport Sci Rev 35:97-101. 2007..A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1alpha gene in skeletal muscle in vivo...- Highly coordinated gene regulation in mouse skeletal muscle regenerationZhen Yan
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:8826-36. 2003..This study identifies novel genes potentially important for muscle regeneration and reveals highly coordinated myogenic cell proliferation and differentiation programs in adult skeletal muscle regeneration in vivo... 
PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscleTuoyu Geng
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Am J Physiol Cell Physiol 298:C572-9. 2010..We conclude that PGC-1alpha is required for complete skeletal muscle adaptations induced by endurance exercise in mice...- Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathwayTakayuki Akimoto
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:19587-93. 2005..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation... - p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in miceAndrew R Pogozelski
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 4:e7934. 2009..These findings provide direct evidence for an obligated role of p38gamma MAPK-PGC-1alpha regulatory axis in endurance exercise-induced metabolic adaptation, but not contractile adaptation, in skeletal muscle... - Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growthPing Li
Department of Medicine, Duke University Medical Center, Independence Park Facility, 4321 Medical Park Dr, Durham, NC 27704, USA
Am J Physiol Cell Physiol 290:C1461-8. 2006..The origin of the angiogenic cells in this physiological exercise model remains to be determined... - Functional interaction of regulatory factors with the Pgc-1alpha promoter in response to exercise by in vivo imagingTakayuki Akimoto
Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
Am J Physiol Cell Physiol 295:C288-92. 2008..These findings provide in vivo evidence for functional interactions between PKD/HDAC5 and ATF2 regulatory factors and the Pgc-1alpha gene in adult skeletal muscle... - Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in micePing Li
Division of Cardiology, Department of Medicine, Duke University Medical Center, 4321 Medical Park Dr, Suite 200, Durham, NC 27704, USA
Am J Pathol 170:599-608. 2007..These findings suggest that exercise intolerance can occur in CHF without fiber type switching in skeletal muscle and that oxidative phenotype renders myofibers resistant to pathological insults induced by CHF... - Myocyte specific overexpression of myoglobin impairs angiogenesis after hind-limb ischemiaSurovi Hazarika
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Arterioscler Thromb Vasc Biol 28:2144-50. 2008..Myoglobin (Mb) is expressed exclusively in striated muscle cells. We hypothesized that myocyte specific overexpression of myoglobin attenuates ischemia-induced angiogenesis even in the presence of normal endothelium... - Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuliZengli Yu
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 3:e2086. 2008..Our studies reveal a novel protective mechanism in oxidative myofibers mediated by enhanced iNos and antioxidant gene expression and suggest a significant value of enhanced NO signaling as a new therapeutic strategy for cachexia... - Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient miceTakayuki Akimoto
Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
Am J Physiol Cell Physiol 287:C1311-9. 2004..Other protein kinases sharing substrates with constitutively active CaMKIV may function as endogenous mediators of activity-dependent changes in myofiber phenotype... - Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscleAnne A Wooldridge
Department of Pharmacology, Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 283:11850-9. 2008..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity... - Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscleRichard E Waters
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Cell Physiol 287:C1342-8. 2004..These findings suggest that endurance training induces angiogenesis in a subpopulation of type IIb + IId/x fibers before switching to type IIa fibers... - TRPC3 channels confer cellular memory of recent neuromuscular activityPaul Rosenberg
Department of Internal Medicin, Duke University Medical School, Durham, 27710, USA
Proc Natl Acad Sci U S A 101:9387-92. 2004..These data suggest a mechanism for cellular memory in skeletal muscles whereby repeated bouts of contractile activity drive progressively greater remodeling events... - Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living miceTakayuki Akimoto
Division of Cardiology, Dept. of Medicine, Duke University Medical Center, 4321 Medical Park Drive, Suite 200, Duke Univ. Independence Park Facility, Durham, NC 27704, USA
Am J Physiol Cell Physiol 287:C790-6. 2004..The experimental methods used in the present study have general applicability to studies of gene regulation in muscle... - Exercise, PGC-1alpha, and metabolic adaptation in skeletal muscleZhen Yan
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Appl Physiol Nutr Metab 34:424-7. 2009..The signaling-transcription network that is responsible for exercise-induced skeletal muscle adaption remains to be fully elucidated... - Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiencyTimothy R Koves
Department of Medicine, and Sarah W Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 280:33588-98. 2005..We proposed that PGC1alpha enables muscle mitochondria to better cope with a high lipid load, possibly reflecting a fundamental metabolic benefit of exercise training... - Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivityChristoph Zechner
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Cell Metab 12:633-42. 2010..Taken together, we conclude that PGC-1 coactivators are necessary for the oxidative and mitochondrial programs of skeletal muscle but are dispensable for fundamental fiber type determination and insulin sensitivity... - Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapyBaodong Sun
Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Mol Ther 16:1366-71. 2008..In summary, AAV8 and AAV9-pseudotyped vectors containing the MHCK7 regulatory cassette achieved enhanced efficacy in Pompe disease mice... - Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signalingTakayuki Akimoto
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3 8 1, Meguro, Tokyo 153 8902, Japan
Biochem Biophys Res Commun 329:381-5. 2005..These findings provide evidence that mechanical stretch inhibits myoblast-to-adipocyte differentiation possibly through Wnt signaling... - Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefactionCinzia Perrino
Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 116:1547-60. 2006..Thus stress-induced activation of pathogenic signaling pathways, not the duration of stress or the hypertrophic growth per se, is the molecular trigger of cardiac dysfunction... - Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient miceOlujimi A Ajijola
Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
Antioxid Redox Signal 11:15-23. 2009..Elevated BM-EPCs seen in atherosclerotic conditions may be a marker of generalized vascular inflammation or injury, and decrease in response to exercise, along with other markers of inflammation... - Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscleZhen Yan
Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
J Appl Physiol 110:264-74. 2011.... - Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exerciseTimothy M Griffin
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 64:443-53. 2012.... - Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunitAnthony J Davis
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9041, USA
J Biol Chem 283:16104-14. 2008..These observations indicate that PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability... - Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiationIgor I Rybkin
Departments of Molecular Biology and Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Biol Chem 278:15927-34. 2003..The conditional expression of TAg in this manner permits propagation and regulated growth termination of cell types that are otherwise unable to be maintained in cell culture and may have applications for cardiac repair technologies... - Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligandsXiaocui Zhu
Molecular Biology Laboratory, Alliance for Cellular Signaling, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
J Immunol 173:7141-9. 2004.... - Transcriptional profiling in mouse skeletal muscle following a single bout of voluntary running: evidence of increased cell proliferationSangdun Choi
Division of Biology, California Institute of Technology, Pasadena, CA, USA
J Appl Physiol 99:2406-15. 2005..These findings suggest that a single bout of voluntary running activates the transcriptional network and promotes adaptive processes in skeletal muscle, including cell proliferation... - Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animalsChristoph Handschin
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:30014-21. 2007..Our data demonstrate a critical role for PGC-1alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion... - Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neuronsXiang Cai
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
J Physiol 540:743-59. 2002..This modulation provides a unique and flexible mechanism for 5-HT(4) receptors to dynamically regulate synaptic transmission and neuronal excitability in the PFC network... - An oligonucleotide decoy for nuclear factor-kappa B inhibits tumor necrosis factor-alpha-induced human umbilical cord vein endothelial cell tissue factor expression in vitroLinlin Wang
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Blood Coagul Fibrinolysis 15:483-90. 2004..Targeted genetic disruption of endothelial TF expression by NF-kappa B decoy may provide a possible therapeutic method for cardiovascular and thrombosis disease... - Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neuronsXiang Cai
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 277:36553-62. 2002..This modulation demonstrates the critical role of CaMKII in serotonergic regulation of PFC neuronal activity, which may explain the neuropsychiatric behavioral phenotypes seen in CaMKII knockout mice... - Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neuronsZhen Yan
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Physiol 540:761-70. 2002.... - Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's diseasePing Zhong
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
J Biol Chem 278:26888-96. 2003..These results show that the muscarinic regulation of GABA transmission is impaired in the AD model, probably due to the Abeta-mediated interference of mAChR activation of PKC... - D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neuronsViviana Davila
Department of Neurology, Columbia University, New York, NY 10032, USA
J Neurosci 23:5693-7. 2003..Thus, it appears that D3 activation of GIRK currents in SN neurons does not occur or is exceedingly rare... - Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortexGuojun Chen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
Proc Natl Acad Sci U S A 101:2596-600. 2004..These interactions may play an important role in modulating synaptic plasticity and thus in cognitive and emotional processes... - Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear diseaseShu-sheng Gong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, China
Ann Otol Rhinol Laryngol 111:275-80. 2002..The results suggest that the immune response of the inner ear induced the expression of hsp70 in the guinea pig cochleas... - Bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II activity by dopamine D4 receptors in prefrontal cortexZhenglin Gu
Department of Physiology and Biophysics, State University of New York at Buffalo, 14214, USA
Mol Pharmacol 66:948-55. 2004..This modulation provides a unique and flexible mechanism for D4 receptors to regulate CaMKII activity, which could lead to dynamic regulation of many targets of CaMKII by D4 receptors... - Myostatin DNA vaccine increases skeletal muscle mass and endurance in miceLiang Tang
Biotechnology Center, Fourth Military Medical University, 17 Changle West Road, 710032 Xi an, China
Muscle Nerve 36:342-8. 2007..In addition, body weight, muscle mass, and grip endurance of vaccinated mice were significantly increased. Our study provides a novel, pharmacological strategy for treatment of diseases associated with muscle wasting... - Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortexEunice Y Yuen
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
J Biol Chem 283:17194-204. 2008..These findings provide a framework for understanding the complex interactions between serotonin and NMDARs in PFC, which could be important for cognitive and emotional control in which both systems are highly involved... 
Amelioration of experimental autoimmune encephalomyelitis by BLyS autovaccineXiaochang Xue
Biotechnology Center of The Fourth Military Medical University, 17 Changle West Road, 710032 Xi an, People s Republic of China
Vaccine 26:2873-81. 2008..Our data suggest that the BLyS autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with the production of BLyS...- Microtubule regulation of N-methyl-D-aspartate receptor channels in neuronsEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 14214, USA
J Biol Chem 280:29420-7. 2005..Taken together, these results suggest that interfering with microtubule assembly suppresses NMDAR function through a mechanism dependent on kinesin-based dendritic transport of NMDA receptors... - Preclinical safety evaluation of IFNalpha2a-NGRJieru Meng
Biotechnology Center of The Fourth Military Medical University, 17 Changle West Road, 710032 Xi an, People s Republic of China
Regul Toxicol Pharmacol 50:294-302. 2008..In conclusion, preclinical safety studies that IFNalpha2a-NGR was well tolerated at pharmacologically active doses in mice, rats and monkeys... - Cdk5 modulates cocaine reward, motivation, and striatal neuron excitabilityDavid R Benavides
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:12967-76. 2007..These results suggest that Cdk5 acts as a negative regulator of neuronal excitability in the NAc and that Cdk5 may govern the behavioral effects of cocaine and motivation for reinforcement... - Regulation of N-methyl-D-aspartate receptors by calpain in cortical neuronsHai Yan Wu
Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
J Biol Chem 280:21588-93. 2005.... - The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscleDusan M Jeftinija
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
Muscle Nerve 36:482-90. 2007..2 and type IIa-positive fibers. Taken together, these data suggest that the Ca(V) 1.2 Ca(2+) channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype... - Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neuronsEunice Y Yuen
Department of Physiology and Biophysics, State University of New York at Buffalo, 124 Sherman Hall, Buffalo, NY 14214, USA
Mol Pharmacol 74:360-70. 2008..These data suggest that calpain activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo, and the susceptibility of NMDARs to calpain cleavage is controlled by PSD-95 and calcineurin...
Research Grants
- Exercise-Induced Mitochondrial BiogenesisZhen Yan; Fiscal Year: 2007..We anticipate important new information to emerge. Findings from this research will likely foster innovative approaches to improve skeletal muscle function and treat diseases related to skeletal muscle disorder. ..