Kunhong Xiao

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:12785-95. 2011
  2. pmc Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:6650-5. 2009
  3. pmc MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors
    Sang oh Han
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 199:817-30. 2012
  4. pmc Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
  5. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
  6. pmc Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:22166-76. 2008
  7. pmc A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
    Makoto R Hara
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 477:349-53. 2011
  8. pmc Multiple ligand-specific conformations of the β2-adrenergic receptor
    Alem W Kahsai
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Chem Biol 7:692-700. 2011
  9. pmc Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Trends Biochem Sci 36:457-69. 2011
  10. pmc Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
    Kelly N Nobles
    1Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Sci Signal 4:ra51. 2011

Collaborators

Detail Information

Publications19

  1. pmc Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:12785-95. 2011
    ....
  2. pmc Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:6650-5. 2009
    ..Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors...
  3. pmc MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors
    Sang oh Han
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 199:817-30. 2012
    ..In response to β blocker therapy with carvedilol, MARCH2 E3 ligase activity regulates cell surface β(2)AR expression and, consequently, its signaling...
  4. pmc Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
    ....
  5. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
    ..Thus, our data provide the first evidence of a functional link between β-arrestins and TRPV4 and uncovers an entirely novel mechanism to maintain appropriate intracellular Ca(2+) concentration to avoid excessive Ca(2+) signaling...
  6. pmc Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:22166-76. 2008
    ..Collectively, our findings indicate that the degradative fate of the beta(2)AR in the lysosomal compartments is dependent upon beta-arrestin2-mediated recruitment of Nedd4 to the activated receptor and Nedd4-catalyzed ubiquitination...
  7. pmc A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
    Makoto R Hara
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 477:349-53. 2011
    ..Our results highlight the emerging role of ARRB1 as an E3-ligase adaptor in the nucleus, and reveal how DNA damage may accumulate in response to chronic stress...
  8. pmc Multiple ligand-specific conformations of the β2-adrenergic receptor
    Alem W Kahsai
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Chem Biol 7:692-700. 2011
    ....
  9. pmc Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Trends Biochem Sci 36:457-69. 2011
    ..Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the β-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of β-arrestins in cellular signaling...
  10. pmc Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
    Kelly N Nobles
    1Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Sci Signal 4:ra51. 2011
    ....
  11. pmc Beta-arrestin-mediated localization of smoothened to the primary cilium
    Jeffrey J Kovacs
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 320:1777-81. 2008
    ..These results suggest roles for beta-arrestins in mediating the intracellular transport of a 7TMR to its obligate subcellular location for signaling...
  12. pmc Functional specialization of beta-arrestin interactions revealed by proteomic analysis
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:12011-6. 2007
    ..This study provides a comprehensive analysis of proteins that bind beta-arrestin isoforms and underscores their potentially broad regulatory roles in mammalian cellular physiology...
  13. pmc Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:15299-304. 2010
    ..This study provides a system-based view of beta-arrestin-mediated phosphorylation events downstream of a 7TMR and opens avenues for research in a rapidly evolving area of 7TMR signaling...
  14. pmc Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 497:137-41. 2013
    ..These results reveal, at high resolution, a receptor-interacting interface on β-arrestin, and they indicate a potentially general molecular mechanism for activation of these multifunctional signalling and regulatory proteins...
  15. ncbi request reprint Activation-dependent conformational changes in {beta}-arrestin 2
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:55744-53. 2004
    ....
  16. pmc Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL
    Liang Xie
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Sci Signal 2:ra33. 2009
    ..Our findings provide insight into GPCR regulation, broaden the functional scope of prolyl hydroxylation, and expand our understanding of the cellular response to hypoxia...
  17. ncbi request reprint The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2
    Kelly N Nobles
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:21370-81. 2007
    ..This study represents the first direct evidence that the "receptor-bound" conformations of beta-arrestins1 and 2 are different...
  18. pmc Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction
    Hao Tang
    Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA
    J Mol Cell Cardiol 54:101-11. 2013
    ..Using antisera to TNNI3K, we show that TNNI3K protein is located at the sarcomere Z disc. These combined data suggest that TNNI3K mediates cell signaling to modulate cardiac response to stress...
  19. ncbi request reprint beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor
    Sudha K Shenoy
    Howard Hughes Medical Institute at Duke University Medical Center, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 281:1261-73. 2006
    ..These findings demonstrate that the beta2AR can signal to ERK via a GRK5/6-beta-arrestin-dependent pathway, which is independent of G protein coupling...