Research Topics
Species | Michelle WinnSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosisRasheed A Gbadegesin
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Kidney Int 81:94-9. 2012..Hence, screening for these mutations may represent a rapid, non-invasive and cost-effective method for the diagnosis of autosomal dominant FSGS...- 2007 Young Investigator Award: TRP'ing into a new era for glomerular diseaseMichelle P Winn
Department of Medicine and Center for Human Genetics, Duke University Medical Center, Duke Box 2903, Durham, NC 27705, USA
J Am Soc Nephrol 19:1071-5. 2008..This creates the intriguing possibility that blocking TRPC6 channels within the podocyte may translate into long-lasting clinical benefits in patients with FSGS... - Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?Michelle P Winn
Department of Medicine, Duke University Medical Center, Box 2903, Durham, NC 27710, USA
J Am Soc Nephrol 17:378-87. 2006 - A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosisMichelle P Winn
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Science 308:1801-4. 2005..Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease... - Pathogenesis and therapy of focal segmental glomerulosclerosis: an updateRasheed Gbadegesin
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Pediatr Nephrol 26:1001-15. 2011..This review focuses on recent advances in the molecular pathogenesis of FSGS and currently available therapeutic agents as well as potential novel therapies... - Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgeryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Am J Kidney Dis 45:519-30. 2005..Therefore, we tested the hypothesis that selected gene variants are associated with acute renal injury, reflected by a serum creatinine level increase after cardiac surgery... - Approach to the evaluation of heritable diseases and update on familial focal segmental glomerulosclerosisMichelle P Winn
Duke Medical Center, Division of Nephrology, Durham, North Carolina 27710, USA
Nephrol Dial Transplant 18:vi14-20. 2003..The existence of hereditary forms of FSGS permits the use of molecular genetics techniques to study the pathogenesis of this disorder... - Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous systemLaura P Svetkey
Duke University Medical Center, Durham, North Carolina, USA
Am J Hypertens 24:209-17. 2011..The purpose of this study was to identify genes that modulate BP response to dietary interventions... - A new locus for familial FSGS on chromosome 2pRasheed Gbadegesin
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
J Am Soc Nephrol 21:1390-7. 2010..These data support a new gene locus for familial FSGS on chromosome 2p15. Identification of the mutated gene at this locus may provide further insight into the disease mechanisms of FSGS... - Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGSRasheed Gbadegesin
Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA
Pediatr Nephrol 24:281-5. 2009..Kindreds appropriate for genome-wide screening are currently being subjected to analysis with the aim of identifying other genetic causes of FSGS... - Parkin mutations and susceptibility alleles in late-onset Parkinson's diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Ann Neurol 53:624-9. 2003..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease... - Therapeutic targets in focal and segmental glomerulosclerosisPeter J Lavin
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Nephrol Hypertens 17:386-92. 2008.... - TRPC6 and FSGS: the latest TRP channelopathyNirvan Mukerji
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Biochim Biophys Acta 1772:859-68. 2007..This creates the exciting possibility that blocking TRPC6 channels within the podocyte may translate into long-lasting clinical benefits in patients with FSGS... - Focal and segmental glomerulosclerosis: varying biologic mechanisms underlie a final histopathologic end pointNikki Daskalakis
Department of Medicine, and the Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Semin Nephrol 26:89-94. 2006..Mutations in cytoskeletal proteins that affect podocyte structure have been the target until recently. Here we review the current understanding of this glomerular disease and areas for future concentration... - TRPC6 enhances angiotensin II-induced albuminuriaJason Eckel
Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
J Am Soc Nephrol 22:526-35. 2011..Our findings suggest that TRPC6 promotes albuminuria, perhaps by promoting angiotensin II-dependent increases in Ca(2+), suggesting that TRPC6 blockade may be therapeutically beneficial in proteinuric kidney disease... - Linkage of a gene causing familial membranoproliferative glomerulonephritis type III to chromosome 1John J Neary
Departments of Nephrology, Beaumont Hospital, Dublin, Ireland
J Am Soc Nephrol 13:2052-7. 2002..The data provide evidence for a gene for familial MPGN on chromosome 1q... - Not all in the family: mutations of podocin in sporadic steroid-resistant nephrotic syndromeMichelle P Winn
J Am Soc Nephrol 13:577-9. 2002
Research Grants
- AUTOSOMAL DOMINANT FOCAL SEGMENTAL GLOMERULOSCLEROSISMichelle Winn; Fiscal Year: 2004..Information derived from this research will also allow a better understanding of the pathogenesis of nonhereditary forms of FSGS and may provide insights regarding management of the more common idiopathic forms of this disorder. ..
- GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSISMichelle Winn; Fiscal Year: 2005..New mutations found in the genes known to cause FSGS will enhance our understanding of the genetics and biology of thi., disorder, takin 9 advantage of our entire resource of families. ..
- Characterization of TRPC6 As A Cause for Focal and Segmental GlomerulosclerosisMichelle P Winn; Fiscal Year: 2010..Our original hypothesis suggests that the absence of TRPC6 may confer resistance to kidney injury and proteinuria. We will test this in models of induced renal disease. ..