Redford Williams

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Central nervous system serotonin function and cardiovascular responses to stress
    R B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 63:300-5. 2001
  2. ncbi request reprint Serotonin-related gene polymorphisms and central nervous system serotonin function
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3926, Durham, NC 27710, USA
    Neuropsychopharmacology 28:533-41. 2003
  3. ncbi request reprint Resolved: psychosocial interventions can improve clinical outcomes in organic disease (pro)
    Redford B Williams
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 64:552-7. 2002
  4. ncbi request reprint Resolved: psychosocial interventions can improve clinical outcomes in organic disease--rebuttals and closing arguments
    Redford Williams
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 64:564-7. 2002
  5. ncbi request reprint Low educational attainment, John Henryism, and cardiovascular reactivity to and recovery from personally relevant stress
    Marcellus M Merritt
    Psychiatry and Behavioral Sciences, Behavioral Medicine Research Center, Duke University Medical Center, Durham, NC, USA
    Psychosom Med 66:49-55. 2004
  6. doi request reprint Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 61:714-22. 2013
  7. pmc Socioeconomic status moderates the association between John Henryism and NEO PI-R personality domains
    Michael V Stanton
    Department of Psychology, Duke University, Durham, North Carolina, USA
    Psychosom Med 72:141-7. 2010
  8. pmc Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men
    Redford B Williams
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 72:601-7. 2010
  9. ncbi request reprint Discrimination, dispositions, and cardiovascular responses to stress
    Laura Smart Richman
    Department of Psychology and Neuroscience, Duke University, Flower Drive, Durham, NC 27708, USA
    Health Psychol 26:675-83. 2007
  10. pmc Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:34-43. 2008

Research Grants

  1. STRESS, SEROTONIN GENE & HEALTH DISPARITIES
    Redford Williams; Fiscal Year: 2004

Detail Information

Publications52

  1. ncbi request reprint Central nervous system serotonin function and cardiovascular responses to stress
    R B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 63:300-5. 2001
    ..The objective of this study was to evaluate the impact of indices of central nervous system (CNS) serotonin function on cardiovascular reactivity to mental stress...
  2. ncbi request reprint Serotonin-related gene polymorphisms and central nervous system serotonin function
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3926, Durham, NC 27710, USA
    Neuropsychopharmacology 28:533-41. 2003
    ....
  3. ncbi request reprint Resolved: psychosocial interventions can improve clinical outcomes in organic disease (pro)
    Redford B Williams
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 64:552-7. 2002
  4. ncbi request reprint Resolved: psychosocial interventions can improve clinical outcomes in organic disease--rebuttals and closing arguments
    Redford Williams
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 64:564-7. 2002
  5. ncbi request reprint Low educational attainment, John Henryism, and cardiovascular reactivity to and recovery from personally relevant stress
    Marcellus M Merritt
    Psychiatry and Behavioral Sciences, Behavioral Medicine Research Center, Duke University Medical Center, Durham, NC, USA
    Psychosom Med 66:49-55. 2004
    ..The objectives of the present study were to determine whether high JH and low SES (education, income, job status, and job strain) were associated with increased cardiovascular responses to laboratory social stressors...
  6. doi request reprint Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 61:714-22. 2013
    ..The goal of this study was to evaluate the prevalence and clinical characteristics of mental stress-induced myocardial ischemia...
  7. pmc Socioeconomic status moderates the association between John Henryism and NEO PI-R personality domains
    Michael V Stanton
    Department of Psychology, Duke University, Durham, North Carolina, USA
    Psychosom Med 72:141-7. 2010
    ..Unfavorable personality profiles have also been frequently linked to poor health; however, no studies have yet examined what global personality traits characterize JH...
  8. pmc Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men
    Redford B Williams
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 72:601-7. 2010
    ....
  9. ncbi request reprint Discrimination, dispositions, and cardiovascular responses to stress
    Laura Smart Richman
    Department of Psychology and Neuroscience, Duke University, Flower Drive, Durham, NC 27708, USA
    Health Psychol 26:675-83. 2007
    ..The authors examined how race and trait levels of hostility and optimism interact with past exposure to discrimination to predict physiological reactivity and recovery during an anger recall task...
  10. pmc Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:34-43. 2008
    ..Findings from two independent samples suggest that the association of 5-HTTLPR with depression varies according to gender and stressful life events...
  11. ncbi request reprint Psychosocial and biobehavioral factors and their interplay in coronary heart disease
    Redford B Williams
    Behavioral Medicine Research Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Clin Psychol 4:349-65. 2008
    ....
  12. ncbi request reprint Depressive symptoms, race, and glucose concentrations: the role of cortisol as mediator
    Stephen H Boyle
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27745, USA
    Diabetes Care 30:2484-8. 2007
    ..This study examined the associations of depressive symptoms with glucose concentrations and morning cortisol levels in 665 African-American and 4,216 Caucasian Vietnam-era veterans...
  13. pmc Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:396-401. 2007
    ..MAOA-uVNTR genotype has been associated with both psychological and physical measures...
  14. ncbi request reprint Facets of openness predict mortality in patients with cardiac disease
    Charles R Jonassaint
    Department of Psychiatry, Duke University, Durham, North Carolina, USA
    Psychosom Med 69:319-22. 2007
    ..To examine the NEO Personality Inventory (NEO PI) Openness to Experience (O) domain and its facets as predictors of cardiac deaths and all-cause mortality...
  15. pmc Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 72:333-9. 2010
    ..Depressive symptoms moderate the effect of trait hostility on circulating levels of CRP and IL-6...
  16. ncbi request reprint Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Box 3926, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:32-9. 2008
    ..We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers...
  17. pmc Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Monit 14:CR57-61. 2008
    ..Allelic variation in MAOA-uVNTR has been associated with body mass index (BMI). We extended previous work by examining relations among this polymorphism and serum lipid levels...
  18. pmc Associations among central nervous system serotonergic function and neuroticism are moderated by gender
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychol 78:200-3. 2008
    ..Remaining personality domains were not related to prolactin levels. Findings add to literature suggesting the serotonin system functions differently, in important ways, in males and females...
  19. pmc HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychol 79:250-5. 2008
    ..5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress...
  20. pmc 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:476-83. 2008
    ..013), and trended towards predicting anger-hostility (P = .084). Males in the HiHi group had greater increases in negative affect during infusion, compared to all groups except LoLo females, who also showed increased negative affect...
  21. pmc Hostility and fasting glucose in African American women
    Anastasia Georgiades
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Psychosom Med 71:642-5. 2009
    ..HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevalent in women and in African American (AA) individuals...
  22. pmc Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c
    Beverly H Brummett
    Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    J Psychiatr Res 44:373-7. 2010
    ....
  23. pmc Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls
    Sofia I Iqbal Kring
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Psychosom Med 72:427-33. 2010
    ..Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations...
  24. pmc Caregiving, residence, race, and depressive symptoms
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Aging Ment Health 14:771-8. 2010
    ..To conclude, all the parameters such as race, living arrangements, and the components of depression need to be taken into account to understand the impact of caregiving on the emotional health of caregivers...
  25. ncbi request reprint Perceived racism and cardiovascular reactivity and recovery to personally relevant stress
    Marcellus M Merritt
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Health Psychol 25:364-9. 2006
    ..03). The notable elevation in CVR in response to an ambiguous event extends current models of racism suggesting that subtle racism is a psychosocial stressor that erodes health through chronically elevated CVR...
  26. ncbi request reprint Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and noncaregivers
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Health Psychol 25:220-5. 2006
    ..The structural model accounted for approximately 43% of the variance in sleep quality. The present findings may be useful in the development of successful sleep interventions for caregivers...
  27. ncbi request reprint Predictors of smoking cessation in patients with a diagnosis of coronary artery disease
    Beverly H Brummett
    Behavioral Medicine Research Center and the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiopulm Rehabil 22:143-7. 2002
    ..This study aimed to examine demographic, psychosocial, and clinical variables as predictors of smoking cessation in patients with coronary artery disease...
  28. ncbi request reprint Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study
    John C Barefoot
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Clin Nutr 76:466-72. 2002
    ..Moderate alcohol intake is related to better health, and additional benefits may be associated with wine. However, beverage preference may be confounded by lifestyle factors related to health...
  29. ncbi request reprint Effect of smoking and sedentary behavior on the association between depressive symptoms and mortality from coronary heart disease
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Durham, North Carolina 27710, USA
    Am J Cardiol 92:529-32. 2003
    ..Results indicated that smoking and/or sedentary behavior may partially mediate the relation between depressive symptoms and mortality. No evidence for moderation was found...
  30. ncbi request reprint Patterns of change in hostility from college to midlife in the UNC Alumni Heart Study predict high-risk status
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences and Behavioral Medicine Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 65:738-45. 2003
    ..To examine hostility measured in college and patterns of change in hostility from college to midlife as predictors of high health-related risk later in midlife...
  31. ncbi request reprint Invited commentary: socioeconomic status, hostility, and health behaviors--does it matter which comes first?
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Epidemiol 158:743-6. 2003
  32. ncbi request reprint Hostility, race, and glucose metabolism in nondiabetic individuals
    Richard S Surwit
    Department of Psychiatry, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Diabetes Care 25:835-9. 2002
    ..The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians...
  33. ncbi request reprint Hostility as a predictor of survival in patients with coronary artery disease
    Stephen H Boyle
    Department of Psychiatry, Duke University Medical Center, Box 2969, Durham, NC, USA
    Psychosom Med 66:629-32. 2004
    ..This study examined the ability of the total CMHS and an abbreviated form of the CMHS (ACM) to predict survival in a sample of patients with documented coronary artery disease (CAD) with increased statistical power...
  34. ncbi request reprint Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Psychosom Med 67:40-5. 2005
    ....
  35. ncbi request reprint Ratings of positive and depressive emotion as predictors of mortality in coronary patients
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Cardiol 100:213-6. 2005
    ..An extensive body of research has demonstrated an association between negative affective states and health outcomes. Positive emotions may also influence physical health, however, their examination has received far less attention...
  36. ncbi request reprint Hostility, age, and mortality in a sample of cardiac patients
    Stephen H Boyle
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 96:64-6. 2005
    ..After controlling for disease severity, there was a significant interaction between age and hostility. Hostility was significantly associated with poorer survival but only in younger (<61.2 years) patients...
  37. ncbi request reprint Neighborhood characteristics moderate effects of caregiving on glucose functioning
    Beverly H Brummett
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Psychosom Med 67:752-8. 2005
    ....
  38. pmc Sleep quality varies as a function of 5-HTTLPR genotype and stress
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:621-4. 2007
    ..A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro...
  39. ncbi request reprint Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression
    Xiaodong Zhang
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 45:11-6. 2005
    ..Identification of a loss-of-function mutation in hTPH2 suggests that defect in brain serotonin synthesis may represent an important risk factor for unipolar major depression...
  40. ncbi request reprint Psychosocial benefits of three formats of a standardized behavioral stress management program
    Elizabeth D Kirby
    Williams LifeSkills, Inc, Durham, North Carolina, USA
    Psychosom Med 68:816-23. 2006
    ....
  41. pmc The association of optimism and perceived discrimination with health care utilization in adults with sickle cell disease
    Michael V Stanton
    Department of Psychology and Neuroscience, Duke University Medical Center, Durham, North Carolina, USA
    J Natl Med Assoc 102:1056-63. 2010
    ..We evaluated the effect of perceived discrimination, optimism, and their interaction on health care utilization among African American adults with sickle cell disease (SCD)...
  42. doi request reprint Effects of LifeSkills training on medical students' performance in dealing with complex clinical cases
    Ana E Campo
    Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33101, USA
    Acad Psychiatry 32:188-93. 2008
    ..The authors consider the effect of personality characteristics (hostility, anger, cynicism) on clinical judgment and whether a brief intervention can affect this process...
  43. ncbi request reprint Community recruitment process by race, gender, and SES gradient: lessons learned from the Community Health and Stress Evaluation (CHASE) Study experience
    Angela R Burroughs
    RTI International, Durham, NC, USA
    J Community Health 28:421-37. 2003
    ..We present an evaluation of the community recruitment component, why we think differences occurred, and the lessons learned from the experiences that may be applied to similar studies...
  44. pmc Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am Heart J 163:20-6. 2012
    ..Depression is a risk factor of MSIMI. The REMIT trial investigates whether selective serotonin reuptake inhibitor (SSRI) treatment can improve MSIMI. The rationale and outline of the study are described...
  45. pmc Personality and inflammation: the protective effect of openness to experience
    Charles R Jonassaint
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, USA
    Ethn Dis 20:11-4. 2010
    ....
  46. ncbi request reprint Psychosocial risk factors for cardiovascular disease: more than one culprit at work
    Redford B Williams
    JAMA 290:2190-2. 2003
  47. ncbi request reprint Effect of race on cultural justifications for caregiving
    Peggye Dilworth-Anderson
    Center for Aging and Diversity, University of North Carolina Institute on Aging, 720 Airport Road, Suite 100, CB 1030, Chapel Hill, NC 27599 1030, USA
    J Gerontol B Psychol Sci Soc Sci 60:S257-62. 2005
    ..Our objective in this study was to explore the effects of caregiver characteristics on cultural reasons given for providing care to dependent elderly family members...
  48. ncbi request reprint Blood pressure reactivity to psychological stress: a new risk factor for coronary disease?
    Redford B Williams
    Hypertension 47:329-30. 2006
  49. ncbi request reprint Lower central nervous system serotonergic function and risk of cardiovascular disease: where are we, what's next?
    Redford B Williams
    Stroke 38:2213-4. 2007
  50. ncbi request reprint Psychosocial considerations in the European guidelines for prevention of cardiovascular diseases in clinical practice: Third Joint Task Force
    Kristina Orth-Gomer
    Karolinska Institutet, Stolkholm, Sweden
    Int J Behav Med 12:132-41. 2005
    ....
  51. ncbi request reprint Psychosocial treatment within sex by ethnicity subgroups in the Enhancing Recovery in Coronary Heart Disease clinical trial
    Neil Schneiderman
    Department of Psychology, University of Miami, P O Box 248185, Coral Gables, FL 33124 2070, USA
    Psychosom Med 66:475-83. 2004
    ..The purpose of the present investigation was to conduct post hoc analyses on sex and ethnic minority subgroups to assess whether any treatment subgroup is at reduced or increased risk of greater morbidity/mortality...
  52. ncbi request reprint Treating depression after myocardial infarction: can selecting patients on the basis of genetic susceptibility improve psychiatric and medical outcomes?
    Redford B Williams
    Am Heart J 150:617-9. 2005

Research Grants6

  1. STRESS, SEROTONIN GENE & HEALTH DISPARITIES
    Redford Williams; Fiscal Year: 2004
    ..In addition to increasing understanding of biobehavioral mechanisms responsible for health disparities, the findings could point to targets for specific interventions aimed at ameliorating these disparities. ..