John W Williams
Affiliation: Duke University Medical Center
- Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new systemDavid Atkins
Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 540 Gaither Rd Rokville, MD 20852, USA
BMC Health Serv Res 5:25. 2005..The GRADE Working Group has developed an approach that addresses key shortcomings in these systems. The aim of this study was to pilot test and further develop the GRADE approach to grading evidence and recommendations...
- Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working GroupDavid Atkins
Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 540 Gaither Rd Rockville, MD 20852, USA
BMC Health Serv Res 4:38. 2004....
- How reviews covered the unfolding scientific story of gabapentin for bipolar disorderJohn W Williams
Center for Health Services Research in Primary Care, Durham VAMC and Center for Clinical Health Policy Research, Duke University, Durham, NC 27705, USA
Gen Hosp Psychiatry 31:279-87. 2009..Subsequent RCTs did not demonstrate efficacy for bipolar disorder (BD). We examined the characteristics of review articles to determine their potential role in the growth of gabapentin for BD...
- Identifying depression in primary care: a literature synthesis of case-finding instrumentsJohn W Williams
The South Texas Veterans Health Care System, Audie Murphy Division Veterans Evidence based Research Dissemination and Implementation, San Antonio, TX, USA
Gen Hosp Psychiatry 24:225-37. 2002....
- Is this patient clinically depressed?John W Williams
Department of Veterans Affairs Medical Center, 508 Fulton St, HSR and D, Bldg 6, Durham, NC 27705, USA
JAMA 287:1160-70. 2002..Depressive disorders are highly prevalent in the general population, but recognition and accurate diagnosis are made difficult by the lack of a simple confirmatory test...
- Systematic review of multifaceted interventions to improve depression careJohn W Williams
Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
Gen Hosp Psychiatry 29:91-116. 2007....
- The 13- and 20-item Hopkins Symptom Checklist Depression Scale: psychometric properties in primary care patients with minor depression or dysthymiaJohn W Williams
Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center, Duke University Medical Center, Durham, North Carolina 27705, USA
Int J Psychiatry Med 34:37-50. 2004..We evaluated the psychometric properties and responsiveness to clinical change of the 13- and 20-item versions of the Hopkins Symptom Checklist Depression Scale (HSCL-D)...
- Screening for cognitive impairment: comparing the performance of four instruments in primary careTracey Holsinger
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
J Am Geriatr Soc 60:1027-36. 2012..To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia...
- Improving depression outcomes in older adults with comorbid medical illnessLinda H Harpole
Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
Gen Hosp Psychiatry 27:4-12. 2005..Depression is common in older adults and often coexists with multiple chronic diseases, which may complicate its diagnosis and treatment...
- Depression and comorbid illness in elderly primary care patients: impact on multiple domains of health status and well-beingPolly Hitchcock Noel
VERDICT, an HSR and D Center of Excellence, South Texas Veterans Health Care System, 7400 Merton Minter Blvd 11C6, San Antonio, TX 78229 4404, USA
Ann Fam Med 2:555-62. 2004....
- The challenges of multimorbidity from the patient perspectivePolly Hitchcock Noel
VERDICT South Texas Veterans Healthcare System, 7400 Merton Minter Blvd, San Antonio, TX, USA
J Gen Intern Med 22:419-24. 2007..Although multiple co-occurring chronic illnesses within the same individual are increasingly common, few studies have examined the challenges of multimorbidity from the patient perspective...
- An evidence synthesis of care models to improve general medical outcomes for individuals with serious mental illness: a systematic reviewDaniel W Bradford
Psychosocial Rehabilitation and Recovery Center, Durham VA Medical Center, 1830 Hillandale Rd, Durham, NC 27705
J Clin Psychiatry 74:e754-64. 2013..To conduct a systematic review of studies of interventions that integrated medical and mental health care to improve general medical outcomes in individuals with serious mental illness...
- Pharmacologic and behavioral interventions to improve cardiovascular risk factors in adults with serious mental illness: a systematic review and meta-analysisJennifer M Gierisch
Center for Health Services Research in Primary Care, Durham Veteran Affairs Medical Center 152, 508 Fulton St, Durham, NC 27705
J Clin Psychiatry 75:e424-40. 2014..This systematic review was conducted to evaluate pharmacologic and behavioral interventions to reduce CVD risk in adults with serious mental illness...
- Systematic review of disease-modifying antirheumatic drugs for juvenile idiopathic arthritisAlex R Kemper
Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
BMC Pediatr 12:29. 2012..g., non-steroidal anti-inflammatory drugs, intra-articular corticosteroids). The purpose of this systematic review was to evaluate the comparative effectiveness and safety of DMARDs versus conventional therapy and versus other DMARDs...
- Percutaneous heart valve replacement for aortic stenosis: state of the evidenceRemy R Coeytaux
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
Ann Intern Med 153:314-24. 2010..Pending publication of findings from that trial, the available evidence is inadequate to determine the most appropriate clinical role of PHVR or the specific patient populations for whom it might eventually be indicated...
- Acceptability of dementia screening in primary care patientsTracey Holsinger
Durham VA Medical Center, Duke University Medical Center, Durham, NC, USA
Int J Geriatr Psychiatry 26:373-9. 2011..To determine the acceptability of dementia screening in two populations of older adults in different primary care settings...
- ECG-based signal analysis technologies for evaluating patients with acute coronary syndrome: a systematic reviewPhilip J Leisy
Duke Evidence Based Practice Center, Duke Clinical Research Institute, Duke University, Durham, NC, USA
J Electrocardiol 46:92-7. 2013..The first test is often the standard, resting 12-lead ECG. Given its limitations, signal analysis enhancements have been proposed. We summarize the published evidence for commercially available ECG-based signal analysis technologies...
- Psychometric characteristics of outcome measures in juvenile idiopathic arthritis: a systematic reviewHeather A van Mater
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
Arthritis Care Res (Hoboken) 64:554-62. 2012....
- Depression and antidepressant use after stroke and transient ischemic attackNada El Husseini
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Stroke 43:1609-16. 2012..Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use...
- Collaborative mental health and primary care for bipolar disorderJohn W Williams
Duke University Medical Center, Durham VAMC, 2424 Erwin Road, Suite 1105, Durham, NC 27705, USA
J Psychiatr Pract 14:55-64. 2008..g., monitoring for weight gain, hyperglycemia, hyperlipidemia), and provision of bipolar-specific psychoeducation...
- The effectiveness of depression care management on diabetes-related outcomes in older patientsJohn W Williams
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, and Duke University School of Medicine, Durham, North Carolina 27705, USA
Ann Intern Med 140:1015-24. 2004..Depression frequently occurs in combination with diabetes mellitus, adversely affecting the course of illness...
- Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic reviewSoheir S Adam
Duke University Medical Center, Department of Medicine, Box 3939, Durham, NC 27710, USA
Ann Intern Med 157:796-807. 2012..New oral anticoagulants (NOACs), including direct thrombin inhibitors (DTIs) and factor Xa (FXa) inhibitors, are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE)...
- Effect of clinical decision-support systems: a systematic reviewTiffani J Bright
Duke Evidence Based Practice Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
Ann Intern Med 157:29-43. 2012..Despite increasing emphasis on the role of clinical decision-support systems (CDSSs) for improving care and reducing costs, evidence to support widespread use is lacking...
- Smoking cessation interventions for patients with depression: a systematic review and meta-analysisJennifer M Gierisch
Center for Health Services Research in Primary Care, Durham Veteran Affairs Medical Center 152, 508 Fulton Street, Durham, NC 27705, USA
J Gen Intern Med 27:351-60. 2012..e., history positive vs. current depression), and differential effects by gender...
- Systematic review: factors associated with risk for and possible prevention of cognitive decline in later lifeBrenda L Plassman
Duke University Medical Center, Durham, North Carolina 27701, USA
Ann Intern Med 153:182-93. 2010..Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline...
- Identifying depressed older adults in primary care: a secondary analysis of a multisite randomized controlled trialCorrine I Voils
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, and the Department of Medicine, Division of General Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA
Prim Care Companion J Clin Psychiatry 10:9-14. 2008..To determine whether a subset of depressive symptoms could be identified to facilitate diagnosis of depression in older adults in primary care...
- Serving the health needs of our military and veteransJohn W Williams
Duke University Medical Center, Durham, NC, USA
N C Med J 69:23-6. 2008
- Does this patient have dementia?Tracey Holsinger
Department of Psychiatry, Durham VA Medical Center, Durham, NC, USA
JAMA 297:2391-404. 2007..While as many as 5 million individuals in the United States have dementia, many others have memory complaints. Brief tests to screen for cognitive impairment could help guide dementia diagnosis...
- Sustainable impact of a primary care depression interventionPamela W Lee
Dartmouth Medical School, Hanover, NH, USA
J Am Board Fam Med 20:427-33. 2007..The purpose of this study was to determine whether an integrated model of depression management continued to be used by primary care clinicians after the end of a randomized controlled trial (RCT)...
- A fidelity measure for integrated management of depression in primary careThomas E Oxman
Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Med Care 44:1030-7. 2006..Integrated models of primary care depression management improve outcomes. Subsequent dissemination efforts and their evaluation need a fidelity measure...
- Predictors of nonresponse to treatment in primary care patients with dysthymiaWayne Katon
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA, USA
Gen Hosp Psychiatry 24:20-7. 2002....
- Correlates of remission in primary care patients treated for minor depressionEllen Frank
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
Gen Hosp Psychiatry 24:12-9. 2002..46) of being a patient in the VA system. The remaining variables associated with higher probability of remission appear to reflect social advantage and lower severity or complexity of illness...
- Preventing suicide in primary care patients: the primary care physician's roleHerbert C Schulberg
Weill Medical College, Cornell University, White Plains, NY 10605, USA
Gen Hosp Psychiatry 26:337-45. 2004....
- Improving depression care for older, minority patients in primary carePatricia A Arean
Department of Psychiatry, University of California, San Francisco, California 94143, USA
Med Care 43:381-90. 2005..This study examines whether a collaborative care model for depression in primary care is as effective in older minorities as it is in nonminority elderly patients in improving depression treatment and outcomes...
- Low yield of thyroid-stimulating hormone testing in elderly patients with depressionShelagh A Fraser
Regenstrief Institute and Indiana University, 1050 Wishard Boulevard, RG 6, Indianapolis, IN 46202, USA
Gen Hosp Psychiatry 26:302-9. 2004..37) or SCID score (P=.44). These findings should caution physicians against acceptance of borderline TSH values as the primary cause of a patient's clinical depression...
- Collaborative care management of late-life depression in the primary care setting: a randomized controlled trialJurgen Unutzer
Center for Health Services Research, UCLA Neuropsychiatric Institute, 10920 Wilshire Blvd, Suite 300, Los Angeles, CA 90024, USA
JAMA 288:2836-45. 2002..Few depressed older adults receive effective treatment in primary care settings...
- Depression treatment in a sample of 1,801 depressed older adults in primary careJurgen Unutzer
Center for Health Services Research, UCLA Neuropsychiatric Institute, Los Angeles, California 90024, USA
J Am Geriatr Soc 51:505-14. 2003..To examine rates and predictors of lifetime and recent depression treatment in a sample of 1,801 depressed older primary care patients..
- Depression care attitudes and practices of newer obstetrician-gynecologists: a national surveyAllen J Dietrich
Department of Community and Family Medicine, Dartmouth Medical School, Hannover, NH 03755, USA
Am J Obstet Gynecol 189:267-73. 2003..The study was undertaken to assess attitudes and behavior of newer obstetricians/gynecologists in depression care...
- Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depressionMark D Sullivan
Department of Psychiatry, University of Washington, Seattle 98195, USA
J Am Board Fam Pract 16:22-31. 2003..Dysthymia and minor depression are common problems in primary care, but it is not known how patient health beliefs shape response to antidepressant treatment of these less severe forms of depression...
- Treatment of depression by mental health specialists and primary care physiciansAllen J Dietrich
JAMA 290:1991; author reply 1992-3. 2003
- A three-component model for reengineering systems for the treatment of depression in primary careThomas E Oxman
Department of Psychiatry, Dartmouth Medical School, NH 03756, USA
Psychosomatics 43:441-50. 2002..The three-component model is bound together by a common depression diagnostic and severity measure that facilitates communication and treatment decisions...
- Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trialElizabeth H B Lin
Center for Health Studies, Group Health Cooperative, Seattle, Wash 98101, USA
JAMA 290:2428-9. 2003..Depression and arthritis are disabling and common health problems in late life. Depression is also a risk factor for poor health outcomes among arthritis patients...
- Rational treatment choices for non-major depressions in primary care: an evidence-based reviewRonald T Ackermann
Robert Wood Johnson Clinical Scholars Program, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
J Gen Intern Med 17:293-301. 2002..Discussion is focused on premenstrual dysphoric disorder (PMDD) and minor depression because of their significant prevalence in the primary care setting and the lack of clear practice guidelines for addressing each illness...
- Suicidal ideation and risk levels among primary care patients with uncomplicated depressionHerbert C Schulberg
Weill Medical College of Cornell University, White Plains, NY 10605, USA
Ann Fam Med 3:523-8. 2005..We investigated the prevalence, severity, and course of passive and active suicidal ideation occurring in primary care patients with an uncomplicated depressive disorder...
- Going to scale: re-engineering systems for primary care treatment of depressionAllen J Dietrich
Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH 03755, USA
Ann Fam Med 2:301-4. 2004..Recent trials have shown improved depression outcomes with chronic care models. We report the methods of a project that assesses the sustainability and transportability of a chronic care model for depression and change strategy...
- Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes and depressionWayne Katon
Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195 6560, USA
Diabetes Care 29:265-70. 2006..To determine the incremental cost-effectiveness and net benefit of a depression collaborative care program compared with usual care for patients with diabetes and depression...
- Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary careEnid M Hunkeler
Kaiser Permanente, Division of Research, 2000 Broadway, 2nd Floor, Oakland, CA 94612, USA
BMJ 332:259-63. 2006..To determine the long term effectiveness of collaborative care management for depression in late life...
- Hispanic ethnicity, language, and depression: physician-patient communication and patient use of alternative treatmentsBetsy L Sleath
University of North Carolina at Chapel Hill, Center for Health Services Research, NC 27599 3386, USA
Int J Psychiatry Med 34:235-46. 2004..To examine the relationship between Hispanic ethnicity and language spoken with physician communication about depression and patient use of alternative treatments for depression...
- Impact of pain on the outcomes of depression treatment: results from the RESPECT trialKurt Kroenke
Indiana University School of Medicine and Regenstrief Institute, 1050 Wishard Boulevard RG 6, Indianapolis, IN 46202 2859, USA
Pain 134:209-15. 2008..Pain is prevalent in patients with depression. The purpose of this study was to determine the impact of pain on depression treatment outcomes...
- St John's for depression, worts and allJohn W Williams
BMJ 330:E350-1. 2005
- Adherence to mental health treatment in a primary care clinicJodi Gonzalez
VERDICT Center of Excellence, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
J Am Board Fam Pract 18:87-96. 2005..Patient nonadherence is common for the standard mental health treatments in primary care: antidepressants and referrals to specialty mental health treatment. This is one of few studies to prospectively identify predictors of nonadherence...
- Impact of comorbid panic and posttraumatic stress disorder on outcomes of collaborative care for late-life depression in primary careMark T Hegel
Center for Health Services Research, UCLA Neuropsychiatric Institute, Los Angeles, CA, USA
Am J Geriatr Psychiatry 13:48-58. 2005..The authors evaluated the effect of comorbid panic disorder and posttraumatic stress disorder (PTSD) on response to a collaborative-care intervention for late-life depression in primary care...
- Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trialAllen J Dietrich
Dartmouth Medical School, HB 7250, Hanover, NH 03755, USA
BMJ 329:602. 2004..To test the effectiveness of an evidence based model for management of depression in primary care with support from quality improvement resources...
- Reducing suicidal ideation in depressed older primary care patientsJurgen Unutzer
Department of Psychiatry, School of Medicine, University of Washington, Seattle, Washington 98195, USA
J Am Geriatr Soc 54:1550-6. 2006..To determine the effect of a primary care-based collaborative care program for depression on suicidal ideation in older adults...