Lee G Wilke

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Rapid noninvasive optical imaging of tissue composition in breast tumor margins
    Lee G Wilke
    Department of Surgery, Duke University Health System, 3116 North Duke St, Durham, NC 27704, USA
    Am J Surg 198:566-74. 2009
  2. doi request reprint Breast self-examination: defining a cohort still in need
    Lee G Wilke
    Duke University, Department of Surgery, Durham, NC, USA
    Am J Surg 198:575-9. 2009
  3. pmc Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010
    Lee G Wilke
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 17:1989-94. 2010
  4. pmc CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis
    Shauna N Vasilatos
    Department of Medicine, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 18:901-14. 2009
  5. pmc Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways
    Catherine Ibarra-Drendall
    Division of Medical Oncology, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Breast Cancer Res Treat 132:487-98. 2012
  6. pmc Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins
    Torre M Bydlon
    Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC, 27708, USA
    Opt Express 18:8058-76. 2010
  7. pmc Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins
    J Quincy Brown
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 8:e69906. 2013
  8. pmc Sentinel node skills verification and surgeon performance: data from a multicenter clinical trial for early-stage breast cancer
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg 242:593-9; discussion 599-602. 2005
  9. pmc Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial
    Judy C Boughey
    Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
    JAMA 310:1455-61. 2013
  10. doi request reprint Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment
    NIMMI RAMANUJAM
    Biomedical Engineering Dept, Duke University, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6554-6. 2009

Detail Information

Publications31

  1. pmc Rapid noninvasive optical imaging of tissue composition in breast tumor margins
    Lee G Wilke
    Department of Surgery, Duke University Health System, 3116 North Duke St, Durham, NC 27704, USA
    Am J Surg 198:566-74. 2009
    ..Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors...
  2. doi request reprint Breast self-examination: defining a cohort still in need
    Lee G Wilke
    Duke University, Department of Surgery, Durham, NC, USA
    Am J Surg 198:575-9. 2009
    ..The value of breast self-examination (BSE) to detect early breast cancer is controversial...
  3. pmc Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010
    Lee G Wilke
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 17:1989-94. 2010
    ..We proposed to study the degree of adherence with these measures among participating institutions in a multi-institutional trial...
  4. pmc CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis
    Shauna N Vasilatos
    Department of Medicine, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 18:901-14. 2009
    ..Only 5% of all breast cancers are the result of BRCA1/2 mutations. Methylation silencing of tumor suppressor genes is well described in sporadic breast cancer; however, its role in familial breast cancer is not known...
  5. pmc Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways
    Catherine Ibarra-Drendall
    Division of Medical Oncology, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Breast Cancer Res Treat 132:487-98. 2012
    ....
  6. pmc Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins
    Torre M Bydlon
    Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC, 27708, USA
    Opt Express 18:8058-76. 2010
    ..The manuscript includes a discussion of how the speed of the system can be improved to work within the time constraints of an intra-operative setting...
  7. pmc Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins
    J Quincy Brown
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 8:e69906. 2013
    ..Superior performance was demonstrated in high MBD tissue, a population that typically has a higher percentage of involved margins...
  8. pmc Sentinel node skills verification and surgeon performance: data from a multicenter clinical trial for early-stage breast cancer
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg 242:593-9; discussion 599-602. 2005
    ..Based on previous reports and expert opinion, we predicted that 20 to 30 cases of SLND with axillary lymph node dissection (ALND) would enable surgeons to identify sentinel lymph nodes (SLN)...
  9. pmc Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial
    Judy C Boughey
    Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
    JAMA 310:1455-61. 2013
    ..The application of SLN surgery for staging the axilla following chemotherapy for women who initially had node-positive cN1 breast cancer is unclear because of high false-negative results reported in previous studies...
  10. doi request reprint Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment
    NIMMI RAMANUJAM
    Biomedical Engineering Dept, Duke University, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6554-6. 2009
    ..Preliminary data from this ongoing clinical study suggest that this technology could significantly reduce the number of unnecessary repeat breast conserving surgeries annually...
  11. pmc Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data
    Patrick G Pilie
    Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 20:476-82. 2011
    ....
  12. pmc Tumor biology correlates with rates of breast-conserving surgery and pathologic complete response after neoadjuvant chemotherapy for breast cancer: findings from the ACOSOG Z1071 (Alliance) Prospective Multicenter Clinical Trial
    Judy C Boughey
    Department of Surgery, Mayo Clinic, Rochester, MN Alliance Statistics and Data Center, Duke University, Durham, NC Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston Department of Surgery, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA Department of Surgery, University of Wisconsin Madison, Madison Department of Surgery, Columbia University Medical Center, NY Department of Surgery, University of Texas Southwestern Medical Center, Dallas and Department of Surgery, Carolinas Medical Center, Charlotte, NC
    Ann Surg 260:608-14; discussion 614-6. 2014
    ..To determine the impact of tumor biology on rates of breast-conserving surgery and pathologic complete response (pCR) after neoadjuvant chemotherapy...
  13. pmc Advancing optical imaging for breast margin assessment: an analysis of excisional time, cautery, and patent blue dye on underlying sources of contrast
    Torre M Bydlon
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    PLoS ONE 7:e51418. 2012
    ....
  14. ncbi request reprint Hypermethylation of the breast cancer-associated gene 1 promoter does not predict cytologic atypia or correlate with surrogate end points of breast cancer risk
    Gregory R Bean
    Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 16:50-6. 2007
    ....
  15. pmc ESR1 promoter hypermethylation does not predict atypia in RPFNA nor persistent atypia after 12 months tamoxifen chemoprevention
    Joseph C Baker
    Duke University Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 17:1884-90. 2008
    ..Currently, we lack biomarkers to predict whether high-risk women with mammary atypia will respond to tamoxifen chemoprevention...
  16. doi request reprint Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance)
    Judy C Boughey
    Judy C Boughey, Mayo Clinic Karla V Ballman, Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN Kelly K Hunt, Elizabeth A Mittendorf, and Huong T Le Petross, The University of Texas MD Anderson Cancer Center, Houston, TX Linda M McCall, Alliance Statistics and Data Center, Duke University, Durham, NC Gretchen M Ahrendt, University of Pittsburgh Cancer Institute, Pittsburgh, PA and Lee G Wilke, University of Wisconsin Hospital and Clinics, Madison, WI
    J Clin Oncol 33:3386-93. 2015
    ....
  17. pmc Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy
    Lee W Jones
    Duke Cancer Institute, Duke University Medical Center, Box 3085, Durham, NC 27710, USA
    Cancer Prev Res (Phila) 6:925-37. 2013
    ..Data from this exploratory study provide initial evidence that AET can modulate several host- and tumor-related pathways during standard chemotherapy. The biologic and clinical implications remain to be determined...
  18. doi request reprint Impact of axillary ultrasound and core needle biopsy on the utility of intraoperative frozen section analysis and treatment decision making in women with invasive breast cancer
    Holly Caretta-Weyer
    Department of Surgery, Division of Surgical Oncology, University of Wisconsin, Madison, WI 53792 7375, USA
    Am J Surg 204:308-14. 2012
    ..A secondary aim was to evaluate the impact on the utility of intraoperative sentinel lymph node (SLN) frozen section...
  19. pmc Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo
    J Quincy Brown
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Cancer Res 69:2919-26. 2009
    ..Diffuse reflectance spectroscopy could aid in prognosis and prediction in breast cancer via quantitative assessment of tumor physiology at the time of diagnostic biopsy...
  20. pmc Reproducibility of random periareolar fine needle aspiration in a multi-institutional Cancer and Leukemia Group B (CALGB) cross-sectional study
    Catherine Ibarra-Drendall
    Duke University Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 18:1379-85. 2009
    ..To address these key limitations, the Cancer and Leukemia Group B (CALGB) Prevention Group tested the reproducibility of RPFNA in a multi-institutional cross-sectional study...
  21. pmc Impact of neoadjuvant chemotherapy on wound complications after breast surgery
    Marquita R Decker
    Wisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Surgery 152:382-8. 2012
    ..Use of neoadjuvant chemotherapy for breast cancer is increasing. The objective was to examine risk of postoperative wound complications in patients receiving neoadjuvant chemotherapy for breast cancer...
  22. ncbi request reprint Sentinel lymph node dissection and the current status of American trials on breast lymphatic mapping
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Semin Oncol 31:426-36. 2004
    ..Surgeon participation is crucial to the ongoing success of clinical trials in the field of breast cancer surgery...
  23. ncbi request reprint Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF
    Gregory R Bean
    Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 13:6834-41. 2007
    ..These data suggest that cells that lack p16(INK4a) activity would be at high risk for breast cancer development and may exhibit an increased frequency of DNA methylation events in early cancer...
  24. doi request reprint A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins
    Brandon S Nichols
    Department of Biomedical Engineering, Duke University, Durham, NC, United States of America
    PLoS ONE 10:e0127525. 2015
    ..The optimizations presented in this work provide an avenue to rapidly survey large tissue areas on intra-operative time scales with improved sensitivity to regions of focal disease that may otherwise be overlooked...
  25. doi request reprint Oncologists' Perspectives of Their Roles and Responsibilities During Multi-disciplinary Breast Cancer Follow-Up
    Heather B Neuman
    Wisconsin Surgical Outcomes Research Program, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Ann Surg Oncol 23:708-14. 2016
    ..Our objective was to provide insight into why different types of oncologists believe their participation in follow-up is necessary...
  26. doi request reprint Early results from a novel quality outcomes program: the American Society Of Breast Surgeons' Mastery of Breast Surgery
    Edward J Clifford
    Department of Surgery, Baylor Medical Center at Irving, TX, USA
    Ann Surg Oncol 17:233-41. 2010
    ..In 2008, the American Society for Breast Surgeons launched its Mastery in Breast Surgery Pilot Program to demonstrate feasibility of a Web-based tool for breast surgeons to document and monitor quality outcomes...
  27. doi request reprint Commentary on the Canadian National Breast Screening study
    Kimberly J Van Zee
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 21:4397-8. 2014
    ..Further investigation is warranted to develop better screening methods and to determine optimal screening schedules for women based on their risk of future breast cancer and their imaging characteristics...
  28. doi request reprint Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: a phase II randomized trial
    Whitney E Hornsby
    Duke University Medical Center, Durham, North Carolina, USA
    Acta Oncol 53:65-74. 2014
    ..To evaluate the safety and efficacy of moderate-to-high intensity aerobic training in breast cancer patients receiving neoadjuvant chemotherapy...
  29. doi request reprint Risk of invasive breast cancer and ductal carcinoma in situ in women with atypical papillary lesions of the breast
    Kyle C Cuneo
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Breast J 18:475-8. 2012
    ..Patients with a papillary lesion with atypia were more likely to develop invasive or in situ breast cancer with a 5 year risk of 13.0% versus 4.6% in patients with no atypia (p = 0.03)...
  30. ncbi request reprint Retinoic acid receptor-beta2 promoter methylation in random periareolar fine needle aspiration
    Gregory R Bean
    Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 14:790-8. 2005
    ..Results from this study indicate that the RARbeta2 P2 promoter is frequently methylated (69%) in primary breast cancers and shows a positive association with increasing cytologic abnormality in RPFNA...
  31. ncbi request reprint Sentinel lymph node biopsy in patients with early-stage breast cancer: status of the National Clinical Trials
    Lee G Wilke
    Department of Surgery, Duke University Health System, Durham, NC, USA
    Surg Clin North Am 83:901-10. 2003
    ..In keeping with past successes, the continued participation of surgeons in clinical trials contributes to the advancement of evidence-based therapeutic strategies for patients diagnosed with breast cancer...