D M Wilcock
Affiliation: Duke University Medical Center
- Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2Donna M Wilcock
Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 28:1537-45. 2008..These data show that removal of NOS2 from an APP transgenic mouse results in development of a much greater spectrum of AD-like pathology and behavioral impairments...
- Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trialsDonna M Wilcock
Duke University Medical Center, Department of Medicine Division of Neurology, Durham, NC 27710, USA
J Alzheimers Dis 15:555-69. 2008..Reports from the active immunization clinical trial indicated that, similarly to effects observed in mouse studies, amyloid levels in brain were reduced...
- Immunotherapy, vascular pathology, and microhemorrhages in transgenic miceDonna M Wilcock
Duke University Medical Center, Division of Neurology, Research Dr, Durham, NC 27710, USA
CNS Neurol Disord Drug Targets 8:50-64. 2009..Understanding the type of damage to the neurovascular unit caused by CAA in AD and the underlying cause of microhemorrhage after immunotherapy is essential to the success of therapeutic vaccines as a treatment for AD...
- Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's diseaseD M Wilcock
Duke University Medical Center, Division of Neurology, Bryan Research Building, Box 2900, Research Drive, Durham, NC 27710, USA
Neuroscience 159:1055-69. 2009..Together, these data suggest that damage to the neurovascular unit may be a factor in the pathogenesis of Alzheimer's disease...
- Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's diseaseDonna M Wilcock
Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 29:7957-65. 2009..Nevertheless, by providing evidence that reducing amyloid pathology also reduces nonmutant tau pathology and blocks neuron loss, these data support the development of amyloid-lowering therapies for disease-modifying treatment of AD...
- Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's diseaseH N Dawson
Division of Neurology, Duke University, Durham, NC 27710, USA
Neuroscience 169:516-31. 2010..1993; Terry, 1996; Stokin et al., 2005), and our current data suggests that loss of tau function may lead to neurodegeneration...
- Assessing activation states in microgliaCarol A Colton
Duke University Medical Center, Durham, NC 27710, USA
CNS Neurol Disord Drug Targets 9:174-91. 2010..A broad-based functional view is provided that is designed to more fully explore the balance between inflammo-toxic and inflammo-resolution factors that govern chronic disease progression...
- The effects of NOS2 gene deletion on mice expressing mutated human AbetaPPCarol A Colton
Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
J Alzheimers Dis 15:571-87. 2008..As APP/NOS2(-/-) bigenic mice more fully model the human AD disease pathology, they may serve as a tool to better understand disease progression in AD and the role of NO in altering chronic neurological disease processes...
- The usefulness and challenges of transgenic mouse models in the study of Alzheimer's diseaseDonna M Wilcock
Duke University Medical Center, Department of Medicine, Durham, NC 27710, USA
CNS Neurol Disord Drug Targets 9:386-94. 2010..It will also discuss the limitations associated with studying some of these mice and how transgenic mouse models have contributed to the development of therapeutics for the treatment of Alzheimer's disease...
- Dysregulation of the neurovascular unit in Alzheimer's Disease.Donna Wilcock; Fiscal Year: 2007..Overall, the studies to be performed in this research proposal will advance the understanding of the causes of microhemorrhage and the role of the neurovascular unit in Alzheimer's disease. ..