William Wetsel

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Pro-GnRH processing
    William C Wetsel
    Departments of Psychiatry and Behavioral Sciences, Medicine Endocrinology, and Cell Biology, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Prog Brain Res 141:221-41. 2002
  2. ncbi request reprint Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene
    Vladimir M Pogorelov
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1818-31. 2005
  3. pmc Impaired fear response in mice lacking GIT1
    Robert Schmalzigaug
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 458:79-83. 2009
  4. pmc Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 12:R130. 2010
  5. doi request reprint Sensing hot and cold with TRP channels
    William C Wetsel
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 27:388-98. 2011
  6. doi request reprint Hyperthermic effects on behavior
    William C Wetsel
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 27:353-73. 2011
  7. pmc Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity
    Qiang Chen
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 356:733-8. 2007
  8. ncbi request reprint Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
  9. ncbi request reprint Methamphetamine induces long-term changes in GABAA receptor alpha2 subunit and GAD67 expression
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 351:300-5. 2006
  10. ncbi request reprint PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 340:1144-50. 2006

Research Grants

Collaborators

  • Marc G Caron
  • Tong H Lee
  • Xiuwu Zhang
  • EVERETT ELLINWOOD
  • R R Gainetdinov
  • Yu Zhang
  • Min Li
  • Lloyd Fricker
  • Ivan O Medvedev
  • Jozsef Haller
  • Robert Wightman
  • EDUARDO NILLNI
  • Ramona M Rodriguiz
  • Qiang Chen
  • Jean Martin Beaulieu
  • Kristy R Crooks
  • Kelli A McDowell
  • Timothy M Griffin
  • Robert Schmalzigaug
  • Tatyana D Sotnikova
  • Gregory A Taylor
  • Yingmiao Liu
  • Xueying Xiong
  • B Jill Venton
  • Neeta Pillai-Nair
  • Vladimir M Pogorelov
  • Sudha Srinivasan
  • Niamh X Cawley
  • Beverley Fermor
  • Krystal C Law
  • Janet L Huebner
  • James O McNamara
  • Christina L Williams
  • Farshid Guilak
  • Virginia B Kraus
  • Anne E West
  • Dan Su
  • Lori A Setton
  • Sarah J E Wong-Goodrich
  • Daniel T Kleven
  • Xiongzhao Zhu
  • Li Cao
  • Matthew M Presby
  • Ashley N Hutchinson
  • Richard T Premont
  • Pamela E Bonner
  • Collin E Davidson
  • Robert I Greene
  • Robert Kotloski
  • Lindsey E Phillips
  • S├ębastien Marion
  • Stanley C Henry
  • Robert J Lefkowitz
  • Michael J Cools
  • Xiaoju Daniell
  • Valentina Ghisi
  • Lino Tessarollo
  • Qi An Sun
  • Colin Davidson
  • Andrew T Seipel
  • Daniel Gitler
  • George J Augustine
  • Paul E M Phillips
  • Paul Greengard
  • Kelly L Gilmore
  • Josh Z Huang
  • Megan L Insco
  • Galina P Demyanenko
  • Patricia F Maness
  • Anitha K Panicker
  • Donna O Bunch
  • Daniel Abebe
  • Yun Feng
  • Edward M Eddy
  • Joanna M Hill
  • Sylvie Romboz
  • Guo X Luo
  • Richard Chu
  • Akira Arimura
  • Tulin Yanik
  • Jiechun Zhou
  • Roneka L Ravenell
  • Y Peng Loh

Detail Information

Publications24

  1. ncbi request reprint Pro-GnRH processing
    William C Wetsel
    Departments of Psychiatry and Behavioral Sciences, Medicine Endocrinology, and Cell Biology, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Prog Brain Res 141:221-41. 2002
  2. ncbi request reprint Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene
    Vladimir M Pogorelov
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1818-31. 2005
    ....
  3. pmc Impaired fear response in mice lacking GIT1
    Robert Schmalzigaug
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 458:79-83. 2009
    ..However, GIT1-KO mice show impaired responses to fear conditioning and fear-potentiated startle. Overall, these findings suggest that GIT1 is involved in the regulation of amygdala-mediated experience-based emotional behaviors...
  4. pmc Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 12:R130. 2010
    ..In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet...
  5. doi request reprint Sensing hot and cold with TRP channels
    William C Wetsel
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 27:388-98. 2011
    ..These channels have important implications for hyperthermia research and may help to identify previously unexplored mechanisms in different tissues that are responsive to thermal stress...
  6. doi request reprint Hyperthermic effects on behavior
    William C Wetsel
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 27:353-73. 2011
    ..Nevertheless, thermal changes appear to account for almost all of the behavioral effects reported...
  7. pmc Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity
    Qiang Chen
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 356:733-8. 2007
    ..These results suggest that reversal of cocaine-induced behavioral sensitization is associated with reversal of region-specific changes in GABA function and PKC activity in the striatum...
  8. ncbi request reprint Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
    ..To the extent that sensitization plays a role in chronic cocaine abuse, a combination of these clinically available drugs may be useful in treatment of the disorder...
  9. ncbi request reprint Methamphetamine induces long-term changes in GABAA receptor alpha2 subunit and GAD67 expression
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 351:300-5. 2006
    ..These data suggest that inhibition of GABA transmission in the NAc is related to METH behavioral sensitization, whereas activation of GABA transmission in the caudate is associated with METH-induced neurotoxicity...
  10. ncbi request reprint PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 340:1144-50. 2006
    ..To the extent cocaine sensitization is an important factor in human cocaine abuse, pharmacological interventions targeted toward the NAc shell PI3K alteration may be useful in cocaine abuse treatment...
  11. ncbi request reprint Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice
    Sudha Srinivasan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 145:2023-34. 2004
    ..Together, these findings show that CPE is a key enzyme for pro-GnRH processing in vivo; however, the reproductive deficits in Cpe(fat/fat) males appear to be due primarily to abnormal sexual behavior...
  12. pmc Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency
    Jean Martin Beaulieu
    Department of Cell Biology, Mouse Behavioral and Neuroendocrine Analyses Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:1333-8. 2008
    ..Targeting GSK3beta and related signaling events may afford therapeutic advantages for the management of certain 5-HT-related psychiatric conditions...
  13. pmc Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation
    Qiang Chen
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3870, Durham, NC 27710, USA
    J Mol Neurosci 40:284-94. 2010
    ..Together, these data suggest that ILK exerts pleiotropic actions by regulating pre- and postsynaptic neural plasticities within the NAc core in response to repeated cocaine exposure...
  14. pmc TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine
    Kristy R Crooks
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropharmacology 58:1067-77. 2010
    ....
  15. doi request reprint Neural plasticity and addiction: integrin-linked kinase and cocaine behavioral sensitization
    Qiang Chen
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 107:679-89. 2008
    ....
  16. pmc Behavioral characterization of P311 knockout mice
    Gregory A Taylor
    Geriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC, USA
    Genes Brain Behav 7:786-95. 2008
    ..Together, these data establish P311 as playing an important role in learning and memory processes and emotional responses...
  17. ncbi request reprint Aberrant responses in social interaction of dopamine transporter knockout mice
    Ramona M Rodriguiz
    Department of Psychiatry, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 148:185-98. 2004
    ..These data suggest that KO mice may serve as a useful animal model for understanding not only how DA dysfunction contributes to social abnormalities, but also how behavioral inflexibility distorts their social responses...
  18. doi request reprint A beta-arrestin 2 signaling complex mediates lithium action on behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Cell 132:125-36. 2008
    ..These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes...
  19. pmc Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice
    Kelli A McDowell
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 30:7453-65. 2010
    ..Together, these data reveal novel roles for CaRF in the organization and/or function of neural circuits that underlie essential aspects of learning and memory...
  20. ncbi request reprint Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior
    Neeta Pillai-Nair
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    J Neurosci 25:4659-71. 2005
    ..These results suggested that elevated shedding of NCAM perturbs synaptic connectivity of GABAergic interneurons and produces abnormal behaviors that may be relevant to schizophrenia and other neuropsychiatric disorders...
  21. ncbi request reprint Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice
    Eduardo A Nillni
    Department of Medicine, Division of Endocrinology, Brown University, Rhode Island Hospital, Providence 02903, USA
    J Biol Chem 277:48587-95. 2002
    ....
  22. ncbi request reprint The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits
    Niamh X Cawley
    Section on Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 145:5807-19. 2004
    ....
  23. ncbi request reprint Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool
    B Jill Venton
    Department of Chemistry, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 26:3206-9. 2006
    ..This capacity to enhance exocytotic release of dopamine may be important for the psychostimulant actions of cocaine...
  24. ncbi request reprint Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression
    Jozsef Haller
    Institute of Experimental Medicine, Hungarian Academy of Science, Budapest, Hungary
    Brain Res Bull 58:279-84. 2002
    ..Tentatively, our data suggest that enhanced noradrenergic function does not prevent situation-specific social learning but impedes the generalization of depression to heterotypic circumstances...

Research Grants5

  1. GENETIC RESCUE OF PRO-LHRH PROCESSING IN CPE FAT MICE
    William Wetsel; Fiscal Year: 2002
    ....