E C Westman

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Int J Cardiol 110:212-6. 2006
  2. pmc Low carbohydrate diets in family practice: what can we learn from an internet-based support group
    Richard D Feinman
    Department of Biochemistry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Nutr J 5:26. 2006
  3. pmc The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nutr Metab (Lond) 5:36. 2008
  4. pmc Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature
    Bryan D Kraft
    Division of General Medicine, Department of Medicine, Duke University Medical Center, 4020 North Roxboro Street, Durham, NC 27704, USA
    Nutr Metab (Lond) 6:10. 2009
  5. pmc Has carbohydrate-restriction been forgotten as a treatment for diabetes mellitus? A perspective on the ACCORD study design
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nutr Metab (Lond) 5:10. 2008
  6. ncbi request reprint Oral nicotine solution for smoking cessation: a pilot tolerability study
    E C Westman
    Smoking Research Laboratory and Nicotine Research Program, Duke University and Durham VA Medical Centers, Department of Medicine, Duke University, North Carolina 27705, USA
    Nicotine Tob Res 3:391-6. 2001
  7. ncbi request reprint Low-carbohydrate nutrition and metabolism
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
    Am J Clin Nutr 86:276-84. 2007
  8. ncbi request reprint A review of low-carbohydrate ketogenic diets
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Box 50, Suite 200 B Wing, 2200 West Main Street, Durham, NC 27705, USA
    Curr Atheroscler Rep 5:476-83. 2003
  9. ncbi request reprint Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922)
    Eric C Westman
    Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Perspect Biol Med 49:77-83. 2006
  10. ncbi request reprint Effect of 6-month adherence to a very low carbohydrate diet program
    Eric C Westman
    Division of General Internal Medicine, Duke University, 2200 West Main Street, Durham, NC 27705, USA
    Am J Med 113:30-6. 2002

Detail Information

Publications53

  1. ncbi request reprint Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Int J Cardiol 110:212-6. 2006
    ..Low-carbohydrate, ketogenic diets (LCKD) are effective for weight loss, but concerns remain regarding cardiovascular risk. The purpose of this study was to determine the effect of an LCKD program on serum lipoprotein subclasses...
  2. pmc Low carbohydrate diets in family practice: what can we learn from an internet-based support group
    Richard D Feinman
    Department of Biochemistry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Nutr J 5:26. 2006
    ..It is reasonable for family practitioners to turn this observation into a recommendation for patients for weight control and other health problems...
  3. pmc The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nutr Metab (Lond) 5:36. 2008
    ..In this study, we tested the hypothesis that a diet lower in carbohydrate would lead to greater improvement in glycemic control over a 24-week period in patients with obesity and type 2 diabetes mellitus...
  4. pmc Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature
    Bryan D Kraft
    Division of General Medicine, Department of Medicine, Duke University Medical Center, 4020 North Roxboro Street, Durham, NC 27704, USA
    Nutr Metab (Lond) 6:10. 2009
    ..After a review of the literature, possible reasons for this include the metabolic consequences from the elimination of gluten from the diet, and the modulation of the disease of schizophrenia at the cellular level...
  5. pmc Has carbohydrate-restriction been forgotten as a treatment for diabetes mellitus? A perspective on the ACCORD study design
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nutr Metab (Lond) 5:10. 2008
    ..In this commentary we argue that carbohydrate-restriction should be reincorporated into contemporary treatment studies for diabetes mellitus...
  6. ncbi request reprint Oral nicotine solution for smoking cessation: a pilot tolerability study
    E C Westman
    Smoking Research Laboratory and Nicotine Research Program, Duke University and Durham VA Medical Centers, Department of Medicine, Duke University, North Carolina 27705, USA
    Nicotine Tob Res 3:391-6. 2001
    ..Further research to clarify appropriate dosages and optimal beverages for mixture, and controlled trials to assess safety and efficacy, appear in order...
  7. ncbi request reprint Low-carbohydrate nutrition and metabolism
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
    Am J Clin Nutr 86:276-84. 2007
    ....
  8. ncbi request reprint A review of low-carbohydrate ketogenic diets
    Eric C Westman
    Department of Medicine, Duke University Medical Center, Box 50, Suite 200 B Wing, 2200 West Main Street, Durham, NC 27705, USA
    Curr Atheroscler Rep 5:476-83. 2003
    ..This review summarizes the physiology and recent clinical studies regarding this type of diet...
  9. ncbi request reprint Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922)
    Eric C Westman
    Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Perspect Biol Med 49:77-83. 2006
    ..A reconsideration of the role of the high-fat, low-carbohydrate diet for the treatment of diabetes mellitus is in order...
  10. ncbi request reprint Effect of 6-month adherence to a very low carbohydrate diet program
    Eric C Westman
    Division of General Internal Medicine, Duke University, 2200 West Main Street, Durham, NC 27705, USA
    Am J Med 113:30-6. 2002
    ..A very low carbohydrate diet program led to sustained weight loss during a 6-month period. Further controlled research is warranted...
  11. ncbi request reprint Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy
    J E Rose
    Nicotine Research Program, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Exp Clin Psychopharmacol 6:331-43. 1998
    ..Moreover, the orthostatic decrease in blood pressure caused by mecamylamine was offset by nicotine. Mecamylamine before smoking cessation may be an effective adjunct to nicotine patch therapy...
  12. ncbi request reprint Dissociating the nicotine and airway sensory effects of smoking
    E C Westman
    Nicotine Research Laboratory, Durham Veterans Affairs Medical Center, NC 27705, USA
    Pharmacol Biochem Behav 53:309-15. 1996
    ..These data support the hypothesis that replacement of the sensory cues of smoking with "airway sensory replacement" may be useful for smoking cessation...
  13. ncbi request reprint Dissociating nicotine and nonnicotine components of cigarette smoking
    J E Rose
    VA Medical Center, Durham, NC, USA
    Pharmacol Biochem Behav 67:71-81. 2000
    ..Thus, addressing smokers' needs for both for the sensorimotor aspects of smoking as well as for the direct CNS effects of nicotine may be critical in enhancing smoking cessation treatment outcome...
  14. ncbi request reprint Naltrexone blockade of nicotine effects in cigarette smokers
    L H Brauer
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 143:339-46. 1999
    ..The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior...
  15. ncbi request reprint A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial
    William S Yancy
    Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center, and Duke University Medical Center, Durham, North Carolina 27705, USA
    Ann Intern Med 140:769-77. 2004
    ..Low-carbohydrate diets remain popular despite a paucity of scientific evidence on their effectiveness...
  16. ncbi request reprint Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction
    J E Rose
    Nicotine Research Program, Duke University and V A Medical Center, Durham, NC 27705, USA
    Drug Alcohol Depend 56:99-107. 1999
    ..These results have significant implications for theories of addiction to nicotine as well as other drugs such as cocaine that may be subject to binding by lung tissue...
  17. ncbi request reprint Acid-base analysis of individuals following two weight loss diets
    W S Yancy
    Department of Veterans Affairs Medical Center, Center for Health Services Research in Primary Care, Durham, NC 27705, USA
    Eur J Clin Nutr 61:1416-22. 2007
    ..To examine the effects of low-carbohydrate, ketogenic (LCKD) and low-fat (LFD) diets on acid-base status...
  18. ncbi request reprint Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking
    J E Rose
    V A Medical Center, Durham, NC 27705, USA
    Pharmacol Biochem Behav 68:187-97. 2001
    ....
  19. ncbi request reprint Precessation treatment with nicotine skin patch facilitates smoking cessation
    Jed E Rose
    Nicotine Research Program, VA Medical Center and Department of Psychiatry, Duke University Medical Center, Durham, NC 27705, USA
    Nicotine Tob Res 8:89-101. 2006
    ....
  20. ncbi request reprint Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 189:125-33. 2006
    ..Despite established links between nicotine dependence and depression, little research has examined the effects of nicotine on depression symptoms...
  21. doi request reprint Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment
    Jed E Rose
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Nicotine Tob Res 11:1067-75. 2009
    ..We hypothesized that smoking in the presence of continuous levels of nicotine would attenuate the reinforcing effects of cigarette smoking and lead to a decline in dependence on inhaled nicotine, thus facilitating cessation...
  22. ncbi request reprint The effects of foods, beverages, and other factors on cigarette palatability
    F Joseph McClernon
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27708, USA
    Nicotine Tob Res 9:505-10. 2007
    ..Clinical implications and directions for future research are discussed...
  23. doi request reprint Reinforcing effects of nicotine and non-nicotine components of cigarette smoke
    Jed E Rose
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 210:1-12. 2010
    ..Nicotine and non-nicotine components of cigarette smoke contribute to its reinforcing effects; however, the specific role of each component in maintaining behavior has not yet been elucidated...
  24. doi request reprint A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss
    William S Yancy
    Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center, Durham, North Carolina, USA
    Arch Intern Med 170:136-45. 2010
    ..Two potent weight loss therapies, a low-carbohydrate, ketogenic diet (LCKD) and orlistat therapy combined with a low-fat diet (O + LFD), are available to the public but, to our knowledge, have never been compared...
  25. ncbi request reprint Carbohydrate-restricted diets for obesity and related diseases: an update
    Christy L Boling
    Center for Health Services Research in Primary Care, Veterans Affairs Medical Center 152, Durham, NC 27705, USA
    Curr Atheroscler Rep 11:462-9. 2009
    ..This review synthesizes important clinical and physiologic studies on CRDs published between January 2007 and May 2009...
  26. doi request reprint Effects of two weight-loss diets on health-related quality of life
    William S Yancy
    Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC, 27705, USA
    Qual Life Res 18:281-9. 2009
    ..To compare the effects of two diets on health-related quality of life (HRQOL)...
  27. ncbi request reprint Does binge eating disorder impact weight-related quality of life?
    Ronette L Kolotkin
    Obesity and Quality of Life Consulting, 1004 Norwood Avenue, Durham, NC 27707, USA
    Obes Res 12:999-1005. 2004
    ....
  28. ncbi request reprint PET studies of the influences of nicotine on neural systems in cigarette smokers
    Jed E Rose
    Veterans Affairs Medical Center, Durham, NC, USA
    Am J Psychiatry 160:323-33. 2003
    ..The effects of acute nicotine administration and smoking on brain function were investigated in two studies, with the primary goal of identifying neural systems that mediate these effects...
  29. ncbi request reprint Relationship between obesity and health-related quality of life in men
    William S Yancy
    Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center, Durham, North Carolina, USA
    Obes Res 10:1057-64. 2002
    ..Furthermore, most studies have not adequately considered comorbid illness. The goal of this study was to examine the relationship between body mass index (BMI) and HRQOL in male outpatients while considering comorbid illness...
  30. ncbi request reprint Pharmacologic and sensorimotor components of satiation in cigarette smoking
    Jed E Rose
    VA Medical Center, Durham, NC 27705, USA
    Pharmacol Biochem Behav 76:243-50. 2003
    ..v. nicotine and denicotinized smoke approximated the effects of the usual brand. The results of this study underscore the importance of both sensorimotor aspects of smoking and the pharmacologic effects of nicotine in tobacco dependence...
  31. ncbi request reprint Mecamylamine acutely increases human intravenous nicotine self-administration
    Jed E Rose
    VA Medical Center, Durham, NC 27705, USA
    Pharmacol Biochem Behav 76:307-13. 2003
    ..Thus, animal models of nicotine dependence may need to be employed in conjunction with self-administration procedures in order to duplicate the effects of mecamylamine observed in studies of human smokers...
  32. ncbi request reprint Binge eating, quality of life and physical activity improve after Roux-en-Y gastric bypass for morbid obesity
    Jarol Boan
    Weight Loss Surgery Center, Duke University Medical Center, Durham, NC 27705, USA
    Obes Surg 14:341-8. 2004
    ..Severe obesity has been associated with disordered eating, impaired quality of life (QoL), and decreased physical activity. This study examines changes in these variables 6 months after Roux-en-Y gastric bypass (RYGBP)...
  33. ncbi request reprint The effects of controlled deep breathing on smoking withdrawal symptoms in dependent smokers
    F Joseph McClernon
    Department of Psychiatry, Nicotine Research Program, Duke University and Durham VA Medical Centers, 2200 W Main St, B 150, Durham, NC 27705, USA
    Addict Behav 29:765-72. 2004
    ..The results of this preliminary study suggest that controlled deep breathing may be useful for relieving symptoms of smoking withdrawal...
  34. ncbi request reprint Individual differences in smoking reward from de-nicotinized cigarettes
    L H Brauer
    Department of Psychiatry, Duke University Medical Center, USA
    Nicotine Tob Res 3:101-9. 2001
    ..The implications of these findings for smoking cessation treatment and for future research are discussed...
  35. ncbi request reprint The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Suite 210 B Wing, 2200 West Main Street, Durham, NC 27705, USA
    Obesity (Silver Spring) 15:182-7. 2007
    ..To investigate the effects of weight loss diets on mood, food cravings, and other self-reported symptoms...
  36. ncbi request reprint Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: five brief case reports
    W S Yancy
    Center for Health Services Research in Primary Care, Veterans' Affairs Medical Center, Division of General Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Altern Ther Health Med 7:120, 116-9. 2001
    ..Trials that control for all of the confounders mentioned above and that contain objective endpoints are needed to further investigate these issues...
  37. pmc The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model
    John C Mavropoulos
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Prev Res (Phila) 2:557-65. 2009
    ....
  38. ncbi request reprint The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study
    David Tendler
    Division of Gastroenterology, Department of Medicine, Duke University Health System, Durham, NC, USA
    Dig Dis Sci 52:589-93. 2007
    ..02) inflammatory grade (P=.02), and fibrosis (P=.07). Six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease. Further research is into this approach is warranted...
  39. ncbi request reprint Diet therapy for narcolepsy
    A M Husain
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Neurology 62:2300-2. 2004
    ..The NSSQ-Total score decreased by 18% from 161.9 to 133.5 (p = 0.0019) over 8 weeks. Patients with narcolepsy experienced modest improvements in daytime sleepiness on an LCKD...
  40. pmc Residential smoking therapy
    Amanda Green
    Received from Ambulatory Care Service, Durham VA Medical Center, Durham, NC 27705, USA
    J Gen Intern Med 18:275-80. 2003
    ..To evaluate a pilot 4-day residential smoking treatment program for smokers who had relapsed after participation in an outpatient smoking program...
  41. ncbi request reprint Diets and clinical coronary events: the truth is out there
    William S Yancy
    Division of General Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Circulation 107:10-6. 2003
  42. ncbi request reprint Clinical experience using appetite suppressants and SSRIs
    W Alan Rader
    Duke University Medical Center, Durham, NC 27704, USA
    J Okla State Med Assoc 101:180-1. 2008
    ..The monitored use of the combination of these medicines by trained practitioners is justifiable...
  43. pmc Comparison of a low carbohydrate and low fat diet for weight maintenance in overweight or obese adults enrolled in a clinical weight management program
    James D LeCheminant
    Department of Kinesiology and Health Education, Southern Illinois University Edwardsville, Edwardsville, USA
    Nutr J 6:36. 2007
    ..The purpose of this study was to compare body weight (BW) for participants in a clinical weight management program, consuming a LC or LF weight maintenance diet for 6 months following weight loss...
  44. ncbi request reprint Asthma exacerbation after administration of nicotine nasal spray for smoking cessation
    Mary T Roth
    Division of Pharmacotherapy, School of Pharmacy, University of North Carolina at Chapel Hill, 27599, USA
    Pharmacotherapy 22:779-82. 2002
    ..Patients should be counseled on the potential adverse effects of treatment and proper administration techniques in order to minimize these effects...
  45. ncbi request reprint Very-low-carbohydrate weight-loss diets revisited
    Jeff S Volek
    Department of Kinesiology, University of Connecticut, Storrs 06269 1110, USA
    Cleve Clin J Med 69:849, 853, 856-8 passim. 2002
    ..We believe that very-low-carbohydrate diets merit further study for weight loss, and that criticisms of these diets lack scientific evidence...
  46. ncbi request reprint Outcomes from an outpatient smoking-cessation clinic
    Mary T Roth
    Division of Pharmacotherapy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Pharmacotherapy 25:279-88. 2005
    ..We also sought to determine whether smoking abstinence rates differed among various smoking-cessation products...
  47. ncbi request reprint Postprandial triglycerides in response to high fat: role of dietary carbohydrate
    Eric C Westman
    Eur J Clin Invest 34:74; author reply 75. 2004
  48. ncbi request reprint Is a low-carb, low-fat diet optimal?
    Eric C Westman
    Arch Intern Med 165:1071-2. 2005
  49. ncbi request reprint Is dietary carbohydrate essential for human nutrition?
    Eric C Westman
    Am J Clin Nutr 75:951-3; author reply 953-4. 2002
  50. ncbi request reprint Nonfasting triglycerides and cardiovascular risk
    William S Yancy
    JAMA 298:2004; author reply 2005-6. 2007
  51. ncbi request reprint Comment: Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets
    J Cory Kalvass
    Ann Pharmacother 39:1371-2; author reply 1372. 2005
  52. ncbi request reprint Carbohydrate restriction is effective in improving atherogenic dyslipidemia even in the absence of weight loss
    Eric C Westman
    Am J Clin Nutr 84:1549; author reply 1550. 2006
  53. ncbi request reprint A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms
    Gregory L Austin
    Division of Gastroenterology and Hepatology and the Center for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, North Carolina, USA
    Dig Dis Sci 51:1307-12. 2006
    ..5% (P=0.022). Mean GSAS-ds score decreased from 1.28 to 0.72 (P=0.0004). These data suggest that a very low-carbohydrate diet in obese individuals with GERD significantly reduces distal esophageal acid exposure and improves symptoms...