Karen E Welty-Wolf

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Bacterial priming increases lung injury in gram-negative sepsis
    K E Welty-Wolf
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Crit Care Med 158:610-9. 1998
  2. ncbi Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons
    K E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 164:1988-96. 2001
  3. ncbi Coagulation and inflammation in acute lung injury
    Karen E Welty-Wolf
    Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA
    Thromb Haemost 88:17-25. 2002
  4. ncbi Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
    Karen E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L21-31. 2006
  5. ncbi Blockade of tissue factor: treatment for organ injury in established sepsis
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 167:1200-9. 2003
  6. ncbi Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice
    Hagir B Suliman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 48:736-46. 2010
  7. ncbi Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 19:1531-3. 2005
  8. ncbi Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
  9. ncbi Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1
    Hagir B Suliman
    Departments of Medicine, Anesthesiology, and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:41510-8. 2003
  10. ncbi Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice
    Janhavi Athale
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 53:1584-94. 2012

Research Grants

  1. Mitochondrial biogenesis in sepsis-induced organ dysfunction
    KAREN E contact WELTY WOLF; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi Bacterial priming increases lung injury in gram-negative sepsis
    K E Welty-Wolf
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Crit Care Med 158:610-9. 1998
    ..The morphologic evidence of increased lung injury in septic animals with prior exposure to heat-killed bacteria suggests that prior activation of systemic inflammatory responses is a contributing factor in the pathogenesis of ARDS...
  2. ncbi Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons
    K E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 164:1988-96. 2001
    ..The results show that TF-FVIIa complex contributes to organ injury in septic primates in part through selective stimulation of proinflammatory cytokine release and fibrin deposition...
  3. ncbi Coagulation and inflammation in acute lung injury
    Karen E Welty-Wolf
    Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA
    Thromb Haemost 88:17-25. 2002
    ....
  4. ncbi Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
    Karen E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L21-31. 2006
    ..Blockade of factor X binding to the tissue factor-factor VIIa complex attenuates lung and organ injuries in established E. coli sepsis by attenuating the neutrophilic response and inflammatory pathways...
  5. ncbi Blockade of tissue factor: treatment for organ injury in established sepsis
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 167:1200-9. 2003
    ..These results show that blockade of coagulation attenuates acute lung and renal injury in established Gram-negative sepsis accompanied by antiinflammatory effects of therapy...
  6. ncbi Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice
    Hagir B Suliman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 48:736-46. 2010
    ....
  7. ncbi Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 19:1531-3. 2005
    ..These data disclose the dual role of TLR4 in mtDNA damage and compensatory mitochondrial biogenic responses after innate immune activation...
  8. ncbi Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
    ....
  9. ncbi Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1
    Hagir B Suliman
    Departments of Medicine, Anesthesiology, and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:41510-8. 2003
    ..NRF-1 expression and growth were restored by exogenous oxidant exposure indicating that oxidative stress stimulates biogenesis in part via NRF-1 activation and corresponding to recovery events after LPS-induced liver damage...
  10. ncbi Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice
    Janhavi Athale
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 53:1584-94. 2012
    ..Absence of Nrf2 suppresses the alveolar transcriptional network for mitochondrial biogenesis and anti-inflammation, which worsens ALI. The findings link redox activation of mitochondrial biogenesis to ALI resolution...
  11. ncbi Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:16374-85. 2011
    ..These findings disclose a highly structured transcriptional network that couples mitochondrial biogenesis to counter-inflammation with major implications for immune suppression in sepsis...
  12. ncbi A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
    Timothy E Sweeney
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25249. 2011
    ..aureus sepsis that links TLR2 and TLR4 signaling in innate immunity to Ppargc1a/b gene regulation in a critical metabolic organ, the liver, by means of TRAM, TRIF, and IRF-7...
  13. ncbi Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis
    Douglas W Haden
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 176:768-77. 2007
    ..The extent, timing, and significance of mitochondrial injury and recovery in bacterial sepsis are poorly characterized, although oxidative and nitrosative mitochondrial damage have been implicated in the development of organ failure...
  14. ncbi Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis
    Martha S Carraway
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 10:269-75. 2008
    ..This finding indicates a unique and unexpected mechanism of metabolic adaptation to pulmonary fibrotic injuries...
  15. ncbi Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia
    Crystal M Reynolds
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 46:564-72. 2009
    ..These findings demonstrate the decisive participation of NOS2 induction by TLR4 in optimization of mitochondrial biogenesis and MHC expression after gram-negative challenge...
  16. ncbi The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 117:3730-41. 2007
    ..These findings imply that the therapeutic index of anthracycline cancer chemotherapeutics can be improved by the protection of cardiac mitochondrial biogenesis...
  17. ncbi Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 293:L229-38. 2007
    ..We propose that extrapulmonary, neurogenic events predominate in the pathogenesis of acute pulmonary oxygen toxicity in hyperbaric oxygenation, as nNOS activity drives lung injury by modulating the output of central autonomic pathways...
  18. ncbi Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, 0590 CR II Building, Duke South Hospital Trent Drive, Durham, NC 27710, USA
    Cardiovasc Res 64:279-88. 2004
    ..CONCLUSIONS: These novel findings disclose a duality of reactive oxygen species (ROS) effect in the heart's response to LPS in which oxidative mitochondrial damage is opposed by oxidant stimulation of biogenesis...
  19. ncbi Eastern equine encephalitis leading to multi-organ failure and sepsis
    Anita J Reddy
    Department of Medicine, Durham Veterans Administration and Duke University Medical Centers, Durham, NC 27710, United States
    J Clin Virol 42:418-21. 2008

Research Grants2

  1. Mitochondrial biogenesis in sepsis-induced organ dysfunction
    KAREN E contact WELTY WOLF; Fiscal Year: 2010
    ..These studies will investigate the role of mitochondrial injury and biogenesis in the pathogenesis of organ dysfunction in sepsis, and should lead to new therapies to enhance recovery from organ failures in sepsis. ..