Research Topics
| Kevin P WeinfurtSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Research participants' high expectations of benefit in early-phase oncology trials: are we asking the right question?Kevin P Weinfurt
Duke University, Durham, NC 27715, USA
J Clin Oncol 30:4396-400. 2012..To determine whether patients' expectations of benefit in early-phase oncology trials depend on how patients are queried and to explore whether expectations are associated with patient characteristics...
Understanding of an aggregate probability statement by patients who are offered participation in Phase I clinical trialsKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
Cancer 103:140-7. 2005..The authors sought to characterize a special form of numeracy among patients with advanced cancer who were offered participation in Phase I oncology clinical trials...
Effects of disclosing financial interests on participation in medical research: a randomized vignette trialKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Am Heart J 156:689-97. 2008..Little is known about the effects of investigators' financial disclosures on potential research participants...- Effects of disclosing financial interests on attitudes toward clinical researchKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
J Gen Intern Med 23:860-6. 2008..The effects of disclosing financial interests to potential research participants are not well understood... - Expectations of benefit in early-phase clinical trials: implications for assessing the adequacy of informed consentKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Med Decis Making 28:575-81. 2008..There is concern that participants misunderstand the trials to which they have consented, which is based on assumptions about what patients mean when responding to questions about likelihood of benefit... - The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancerK P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Ann Oncol 16:579-84. 2005..We examined the clinical relevance of skeletal-related events (SREs) for health state preferences, pain and health-related quality of life in patients with advanced prostate cancer and a history of bone metastases... - Value of high-cost cancer care: a behavioral science perspectiveKevin P Weinfurt
Center for Clinical and Genetic Econimics, Duke Clinical Research Institute, Durham, NC 27715, USA
J Clin Oncol 25:223-7. 2007..An appreciation of these psychological issues might improve the quality of debates concerning the rising costs of cancer care... - Policies of academic medical centers for disclosing financial conflicts of interest to potential research participantsKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
Acad Med 81:113-8. 2006.... - Consistency of financial interest disclosures in the biomedical literature: the case of coronary stentsKevin P Weinfurt
Duke Clinical Research Institute, Duke Translational Medicine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America
PLoS ONE 3:e2128. 2008..We examined whether authors' financial interests were disclosed consistently in articles on coronary stents published in 2006... - Effect of zoledronic acid on pain associated with bone metastasis in patients with prostate cancerK P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Ann Oncol 17:986-9. 2006..Findings of treatment group differences in pain early in treatment are less reliable. We used a recently recommended analytic approach to examine the effect of zoledronic acid on pain... - Views of potential research participants on financial conflicts of interest: barriers and opportunities for effective disclosureKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
J Gen Intern Med 21:901-6. 2006..There is little guidance regarding how to disclose researchers' financial interests to potential research participants... - Health-related quality of life among patients with breast cancer receiving zoledronic acid or pamidronate disodium for metastatic bone lesionsKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Med Care 42:164-75. 2004..Research on individual differences in health-related quality of life (HRQOL) can identify intervention targets and important covariates in analyses of treatment outcomes... - Measuring agreement between patient and proxy responses to multidimensional health-related quality-of-life measures in clinical trials. An application of psychometric profile analysisKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 17969 27715, USA
J Clin Epidemiol 55:608-18. 2002..Options for incorporating proxy responses into clinical trial analyses are discussed... - Patient expectations of benefit from phase I clinical trials: linguistic considerations in diagnosing a therapeutic misconceptionK P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, NC 27715, USA
Theor Med Bioeth 24:329-44. 2003..These sources of linguistic confusion should be considered in judging whether the patient's reported expectation is grounds for a bioethical concern that there has been a failure in the informed consent process... - The correlation between patient characteristics and expectations of benefit from Phase I clinical trialsKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
Cancer 98:166-75. 2003..The authors examined a range of patient characteristics to determine which factors were associated with greater expectations of benefit from Phase I trials... - Outcomes research related to patient decision making in oncologyKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, and the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27715, USA
Clin Ther 25:671-83. 2003..Future research is needed to understand which aspects of the interventions work and for what types of patients. Research is also needed to better understand the decision making process of patients who do not use decision aids... - Oversight of financial conflicts of interest in commercially sponsored research in academic and nonacademic settingsKevin P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, PO Box 17969, Durham, NC 27715, USA
J Gen Intern Med 25:460-4. 2010..Studies of conflicts of interest in clinical research have focused on academic centers, but most clinical research takes place in nonacademic settings... - Patient reactions to confidentiality, liability, and financial aspects of informed consent in cardiology researchAlice K Fortune-Greeley
Center for Clinical and Genetic Economics, Duke University School of Medicine, Durham, NC 27715, USA
Circ Cardiovasc Qual Outcomes 3:151-8. 2010..We examined the relationship between patients' reactions to standard informed consent language and their willingness to participate in a hypothetical clinical trial... - Disclosing conflicts of interest in clinical research: views of institutional review boards, conflict of interest committees, and investigatorsKevin P Weinfurt
Duke University School of Medicine, USA
J Law Med Ethics 34:581-91, 481. 2006.... - Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trialKathryn E Flynn
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
JAMA 301:1451-9. 2009..Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent... - Sexual functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS®)Kathryn E Flynn
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Psychooncology 20:378-86. 2011..As part of an effort to improve measurement of self-reported sexual functioning, we explored the scope and importance of sexual functioning and intimacy to patients across cancer sites and along the continuum of care... - Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failureKathryn E Flynn
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Am Heart J 158:S64-71. 2009..We examined associations between patient-reported measures of health-related quality of life and clinical indicators of disease severity in a large, heterogeneous sample of patients with heart failure... - Patient experiences with communication about sex during and after treatment for cancerKathryn E Flynn
Duke Clinical Research Institute, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27715, USA
Psychooncology 21:594-601. 2012..We studied patients' experiences with oncology providers regarding communication about sexual issues during and after treatment for cancer... - Perceived racial/ethnic bias in healthcare in Durham County, North Carolina: a comparison of community and national samplesJoelle Y Friedman
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
N C Med J 66:267-75. 2005..We sought to compare findings of a national survey of perceptions of racial/ethnic discrimination in healthcare to those of a community survey, with emphasis on the perceptions of Latinos... - Racial differences in health concernCorrine I Voils
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St, Durham, NC 27705, USA
J Natl Med Assoc 98:36-42. 2006..Interventions to inform blacks and Latinos about their health risks must strike a balance between creating enough health concern to encourage health behavior but not so much that it interferes with health-promoting behaviors... - Comparison of conflict of interest policies and reported practices in academic medical centers in the United StatesMichaela A Dinan
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Account Res 13:325-42. 2006..Considerable differences in understanding of conflict of interest policies were observed between IRB and COIC officials... - Using cognitive interviews to evaluate items for measuring sexual functioning across cancer populations: improvements and remaining challengesAlice K Fortune-Greeley
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
Qual Life Res 18:1085-93. 2009..We describe how cognitive interviews improved the quality of the items and discuss remaining challenges to assessing sexual functioning in research with cancer populations... - Relationships between changes in patient-reported health status and functional capacity in outpatients with heart failureKathryn E Flynn
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 163:88-94.e3. 2012..Lack of formal assessments of the relationships between changes in multiple aspects of patient-reported health status and measures of functional capacity over time limits the ability to compare results across studies... - Developing model language for disclosing financial interests to potential clinical research participantsKevin P Weinfurt
Duke University School of Medicine, Durham, NC, USA
IRB 29:1-5. 2007 - Perspectives of clinical research coordinators on disclosing financial conflicts of interest to potential research participantsJoelle Y Friedman
Center for Clinical and Genetic Economics, Duke Clinical Research Institute
Clin Trials 4:272-8. 2007.... - Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancerVenita Depuy
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, P O Box 17969, Durham, NC 27715, USA
Support Care Cancer 15:869-76. 2007..We sought to quantify the longitudinal effects on patient-reported outcomes of skeletal-related events (SREs) and to ascertain the declines in health-related quality of life (HRQOL) and pain experienced by patients who experienced SREs... - Institutional review boards' use and understanding of certificates of confidentialityLaura M Beskow
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
PLoS ONE 7:e44050. 2012.... - Use of patient-reported outcomes in randomized, double-blind, placebo-controlled clinical trialsMichaela A Dinan
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Med Care 49:415-9. 2011.... - Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TrAllen E Atchley
Duke University Medical Center, Durham, NC 27710, USA
Am Heart J 158:S53-63. 2009..This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results... - A national survey of provisions in clinical-trial agreements between medical schools and industry sponsorsKevin A Schulman
Center for Clinical and Genetic Economics, Duke University Medical Center, Durham, NC, USA
N Engl J Med 347:1335-41. 2002..It is unclear whether research conducted at academic institutions adheres to these new standards... - Perspective: The case for research justice: inclusion of patients with limited English proficiency in clinical researchSeth W Glickman
University of North Carolina, Chapel Hill, North Carolina, USA
Acad Med 86:389-93. 2011..LEP individuals should have fair access to clinical research in order to fully realize individual and societal benefits of their participation and to ensure the generalizability of scientific discovery... - Developing a simplified consent form for biobankingLaura M Beskow
Center for Genome Ethics, Law and Policy, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
PLoS ONE 5:e13302. 2010..We then gathered preliminary data concerning its content from hypothetical biobank participants... 
Parents' reported preference scores for childhood atopic dermatitis disease statesJoelle Y Friedman
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715, USA
BMC Pediatr 4:21. 2004....- Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®))Kathryn E Flynn
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Psychooncology 19:1086-93. 2010..As part of an effort to improve measurement of sleep-wake functioning, we explored the scope of difficulties with sleep in a diverse group of patients diagnosed with cancer... - N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) studyG Michael Felker
Duke Clinical Research Institute, Durham, NC 27705, USA
Am Heart J 158:S37-44. 2009..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure... - Decision making and quality of life in the treatment of cancer: a reviewS Yousuf Zafar
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Support Care Cancer 17:117-27. 2009..We present an overview of the literature related to patient and physician decision making and quality of life in patients with advanced cancer, and we propose approaches to future decision-making models in cancer treatment... - Simplifying informed consent for biorepositories: stakeholder perspectivesLaura M Beskow
Center for Genome Ethics, Law and Policy, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
Genet Med 12:567-72. 2010.... - Resource use, costs, and quality of life among patients in the multinational Valsartan in Acute Myocardial Infarction Trial (VALIANT)Shelby D Reed
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Am Heart J 150:323-9. 2005..The difference will be smaller or nonexistent in settings where brand-name ACE inhibitors are prescribed... - Prospective study of factors predicting adherence to surveillance mammography in women treated for breast cancerRebecca A Shelby
Duke University Medical Center, Durham, NC 27705, USA
J Clin Oncol 30:813-9. 2012..This prospective study examined the factors that predicted sustained adherence to surveillance mammography in women treated for breast cancer... - Use and perceptions of clinical practice guidelines by internal medicine physiciansAlisa M Shea
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, NC 27715, USA
Am J Med Qual 22:170-6. 2007..5%), opinions were split as to whether this practice distracts from patient care or compromises physician autonomy... - Using item banks to construct measures of patient reported outcomes in clinical trials: investigator perceptionsKathryn E Flynn
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Clin Trials 5:575-86. 2008.... - Challenges in enrollment of minority, pediatric, and geriatric patients in emergency and acute care clinical researchSeth W Glickman
Division of Emergency Medicine, Department of Surgery, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
Ann Emerg Med 51:775-780.e3. 2008..The objective of this study is to assess how emergency clinical care and research processes, informed consent, and patient demographic factors (age, sex, and ethnicity/race) affect enrollment and consent in clinical research in the ED... - Who trusts healthcare institutions? Results from a community-based sampleCorrine I Voils
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, NC 27705, USA
Ethn Dis 15:97-103. 2005..The goal of this research was to examine racial differences in trust in various healthcare institutions... - Practitioner acceptance of the dofetilide risk-management programNancy M Allen LaPointe
Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Pharmacotherapy 22:1041-6. 2002..To assess the opinions and knowledge retention of practitioners after participation in the dofetilide risk-management program... - Relationship between CD4 count, viral burden, and quality of life over time in HIV-1-infected patientsK P Weinfurt
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
Med Care 38:404-10. 2000..This study investigated how changes in CD4/mm3 and viral burden (RNA copies/mL) are related to changes in HRQOL as indexed by the Medical Outcomes Study HIV Health Survey (MOS-HIV-30)... - Using Central IRBs for Multicenter Clinical Trials in the United StatesKathryn E Flynn
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
PLoS ONE 8:e54999. 2013..The ultimate goal is to increase the nation's capacity to efficiently conduct the large number of high-quality trials... - Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research studyEric L Eisenstein
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
J Med Syst 35:1521-30. 2011..The requirements identified in this study serve as a framework for future investigators in the design, development, implementation, and operation of PROMIS Tool Kit technologies... - Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trialCHRISTOPHER M O'CONNOR
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 301:1439-50. 2009..Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes... - Perceived discrimination and reported delay of pharmacy prescriptions and medical testsCourtney Harold Van Houtven
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
J Gen Intern Med 20:578-83. 2005..Access to health care varies according to a person's race and ethnicity. Delaying treatment is one measure of access with important health consequences... - Can prospect theory explain risk-seeking behavior by terminally ill patients?Emma B Rasiel
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Med Decis Making 25:609-13. 2005.... - Treatment patterns and costs associated with sessile colorectal polypsJane E Onken
Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
Am J Gastroenterol 97:2896-901. 2002..Finally, patients with polyps > or = 2 cm incurred almost half the total costs while accounting for only 22% of the sample. The greatest economic gains could be made by improving efficiency of polyp removal for these patients... - An exploration of relative health stock in advanced cancer patientsDarrell J Gaskin
Department of Health Policy and Management, Johns Hopkins University, Baltimore, Maryland 21205, USA
Med Decis Making 24:614-24. 2004..Specifically, they estimated the effect of relative health stock on advanced cancer patients' decisions to participate in phase I clinical trials... - Perceptions of patients and physicians regarding phase I cancer clinical trials: implications for physician-patient communicationNeal J Meropol
Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Clin Oncol 21:2589-96. 2003..To describe and compare the perceptions of cancer patients and their physicians regarding phase I clinical trials... - Using health communication best practices to develop a web-based provider-patient communication aid: the CONNECT studyLinda Fleisher
Fox Chase Cancer Center, Philadelphia, PA 19012, United States
Patient Educ Couns 71:378-87. 2008..This paper highlights the development of a theory-guided, web-based communication aid (CONNECT), designed to facilitate treatment decision-making among patients with advanced cancer... - For the patient. Who trusts healthcare institutions? Results from a community-based sampleCorrine I Voils
Ethn Dis 15:150. 2005 - Validity of a simple ST-elevation acute myocardial infarction risk index: are randomized trial prognostic estimates generalizable to elderly patients?Saif S Rathore
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn, USA
Circulation 107:811-6. 2003..A simple risk-stratification index for patients with ST-segment elevation myocardial infarction derived from an RCT population was recently proposed, but it has not been validated in a community-based cohort... - Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patientsSaif S Rathore
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8088, USA
Am Heart J 150:402-10. 2005..Our findings highlight the difficulties in applying risk scores developed in randomized controlled trial cohorts to elderly patients... - Welfare reform and Latinas' use of perinatal health careDamon M Seils
Am J Public Health 92:699-700; author reply 700. 2002